Pharmaceutical Analysis & Statistics, July 2014 (p50)

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Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2014

Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. There are today 245 companies plus partners developing 385 Alpha6Beta4 integrin pathway ...

  • Industries : Drug Discovery and Development
IL-2 Signaling Pathway in Oncology Drug Pipeline Update 2014

IL-2 Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The IL-2 signaling pathway activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Akt signaling modules. There are today 244 companies plus partners developing 370 IL-2 pathway targeting drugs in 1307 developmental ...

  • Industries : Drug Discovery and Development
IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2014

IL-3 Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The IL-3 signaling pathway activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. There are today 184 companies plus partners developing 261 IL-3 pathway targeting drugs in 971 developmental projects ...

  • Industries : Drug Discovery and Development
IL-4 Signaling Pathway in Oncology Drug Pipeline Update 2014

IL-4 Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The IL-4 signaling pathway stimulates the JAK/STAT and MAPK signaling modules. There are today 149 companies plus partners developing 217 IL-4 pathway targeting drugs in 724 developmental projects in cancer. ...

  • Industries : Drug Discovery and Development
IL-5 Signaling Pathway in Oncology Drug Pipeline Update 2014

IL-5 Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The IL-5 singaling pathway activates the JAK/STAT and Raf/MAPK signaling modules. There are today 124 companies plus partners developing 167 IL-5 pathway targeting drugs in 667 developmental projects in ...

  • Industries : Drug Discovery and Development
IL-6 Signaling Pathway in Oncology Drug Pipeline Update 2014

IL-6 Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The IL-6 signaling pathway activates the Jak/STAT, Ras/Raf/MAPK and PI 3-kinase signaling modules. There are today 261 companies plus partners developing 362 IL-6 pathway targeting drugs in 1210 developmental ...

  • Industries : Drug Discovery and Development
Kit Receptor Signaling Pathway in Oncology Drug Pipeline Update 2014

Kit Receptor Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The Kit receptor signaling pathway includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include ...

  • Industries : Drug Discovery and Development
Leptin Signaling Pathway in Oncology Drug Pipeline Update 2014

Leptin Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The binding of Leptin to its receptor, LEPR induces various signaling modules such as JAK/STAT, RAS/RAF/MAPK, IRS/PI-3K and AMPK/ACC. There are today 271 companies plus partners developing 392 Leptin pathway ...

  • Industries : Drug Discovery and Development
Nucleic Acid Therapies in Oncology Drug Pipeline Update 2014

Nucleic Acid Therapies in Oncology Drug Pipeline Update 2014

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  • July 2014
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Nucleic acid therapies in oncology includes: Gene Therapy, DNA vaccine, Other DNA technologies, RNA Interference (RNAi), Small interfering RNA (siRNA), Antisense RNA and Ribozymes. There are today 229 ...

  • Industries : Therapy
FSH Signaling Pathway in Oncology Drug Pipeline Update 2014

FSH Signaling Pathway in Oncology Drug Pipeline Update 2014

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Follicle stimulating hormone (FSH) binds to FSH-receptor which is coupled to Gs protein that in turn activates cAMP dependent protein kinases (PKA) and thus triggers FSH signaling which continues furthe ...

  • Industries : Drug Discovery and Development
TSH Signaling Pathway in Oncology Drug Pipeline Update 2014

TSH Signaling Pathway in Oncology Drug Pipeline Update 2014

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Human thyroid stimulating hormone (TSH) exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give ...

  • Industries : Drug Discovery and Development
TSLP Signaling Pathway in Oncology Drug Pipeline Update 2014

TSLP Signaling Pathway in Oncology Drug Pipeline Update 2014

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Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that play various roles in a broad spectrum of biological procedures. TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP ...

  • Industries : Drug Discovery and Development
Adherens Junction Targeting in Oncology Drug Pipeline Update 2014

Adherens Junction Targeting in Oncology Drug Pipeline Update 2014

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  • July 2014
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Cell-cell adherens junctions, the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. There are ...

  • Industries : Drug Discovery and Development
Calcium Signaling Pathway in Cancer Drug Pipeline Update 2014

Calcium Signaling Pathway in Cancer Drug Pipeline Update 2014

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  • July 2014
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There are today 168 companies plus partners developing 222 calcium signaling pathway targeting drugs in 838 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated ...

  • Industries : Drug and Medication
Cell Cycle Targeting in Cancer Drug Pipeline Update 2014

Cell Cycle Targeting in Cancer Drug Pipeline Update 2014

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  • July 2014
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There are today 144 companies plus partners developing 164 targeting the cell cycle drugs in 552 developmental projects in cancer. In addition, there are 2 suspended drugs and the accumulated number of ...

  • Industries : Drug and Medication
Fc Epsilon RI Signaling Pathway in Oncology Drug Pipeline Update 2014

Fc Epsilon RI Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways ...

  • Industries : Drug Discovery and Development
Targeting Focal Adhesion for the Treatment of Cancer Drug Pipeline Update 2014

Targeting Focal Adhesion for the Treatment of Cancer Drug Pipeline Update 2014

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  • July 2014
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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the ...

  • Industries : Drug and Medication
Gap Junctions in Oncology Drug Pipeline Update 2014

Gap Junctions in Oncology Drug Pipeline Update 2014

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  • July 2014
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Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', ...

  • Industries : Drug Discovery and Development
GnRH Signaling Pathway in Oncology Drug Pipeline Update 2014

GnRH Signaling Pathway in Oncology Drug Pipeline Update 2014

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Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. There are ...

  • Industries : Drug Discovery and Development
Jak-STAT Signaling Pathway in Oncology Drug Pipeline Update 2014

Jak-STAT Signaling Pathway in Oncology Drug Pipeline Update 2014

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The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis ...

  • Industries : Drug Discovery and Development
The MAPK Signaling Pathway in Oncology Drug Pipeline Update 2014

The MAPK Signaling Pathway in Oncology Drug Pipeline Update 2014

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The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. There are today ...

  • Industries : Drug Discovery and Development
mTOR Signaling Pathway in Oncology Drug Pipeline Update 2014

mTOR Signaling Pathway in Oncology Drug Pipeline Update 2014

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  • July 2014
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The mammalian target of rapamycin (mTOR) is an intracellular kinase that controls the production of proteins through its regulation of translational machinery. mTOR-activated proteins promote several hallmarks ...

  • Industries : Drug Discovery and Development
Targeting Natural Killer Cell Mediated Cytotoxicity in Cancer Drug Pipeline Update 2014

Targeting Natural Killer Cell Mediated Cytotoxicity in Cancer Drug Pipeline Update 2014

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Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, ...

  • Industries : Drug and Medication
Modulators of the Actin Cytoskeleton for the Treatment of Cancer Drug Pipeline Update 2014

Modulators of the Actin Cytoskeleton for the Treatment of Cancer Drug Pipeline Update 2014

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  • July 2014
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There are today 183 companies plus partners developing 319 targeting actin cytoskeleton modulators drugs in 1200 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated ...

  • Industries : Drug and Medication
Toll-Like Receptor Signaling Pathway in Cancer Drug Pipeline Update 2014

Toll-Like Receptor Signaling Pathway in Cancer Drug Pipeline Update 2014

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  • July 2014
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Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified ...

  • Industries : Drug and Medication
VEGF Signaling Pathway in Cancer Drug Pipeline Update 2014

VEGF Signaling Pathway in Cancer Drug Pipeline Update 2014

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  • July 2014
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There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. ...

  • Industries : Drug and Medication
Targeting Metabolic Pathways in Cancer Drug Pipeline Update 2014

Targeting Metabolic Pathways in Cancer Drug Pipeline Update 2014

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  • July 2014
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There are today 149 companies plus partners developing 156 metabolic pathways targeting drugs in 436 developmental projects in cancer. In addition, there are 2 suspended drugs and the accumulated numbe ...

  • Industries : Drug and Medication
ErbB Signaling Pathway in Cancer Drug Pipeline Update 2014

ErbB Signaling Pathway in Cancer Drug Pipeline Update 2014

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  • July 2014
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The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, ...

  • Industries : Drug and Medication
Chemokine Signaling Pathway in Cancer Drug Pipeline Update 2014

Chemokine Signaling Pathway in Cancer Drug Pipeline Update 2014

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  • July 2014
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Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the ...

  • Industries : Drug and Medication
Transcriptional Misregulation in Cancer Drug Pipeline Update 2014

Transcriptional Misregulation in Cancer Drug Pipeline Update 2014

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  • July 2014
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There are today 222 companies plus partners developing 297 transcriptional misregulation targeting drugs in 1186 developmental projects in cancer. In addition, there are 3 suspended drugs and the accumulated ...

  • Industries : Drug and Medication
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