INTRODUCTION
STUDY OBJECTIVES
The purpose of this study, conducted by BCC, is to offer a synopsis of the current characteristics of the global market for chromatography reagents in order to forecast its future. The key intent is to provide an extensive analysis of the current market and the future trends for the chromatography reagents market. The report offers analysis on the market size, market leaders, and factors affecting the market of chromatography reagents from the perspective of its end users, which includes the pharma and biotech, food and beverages, environmental agencies and other sectors.
This report investigates current and future strategies within the chromatography techniques and reagents market. The report takes a close look at the market’s inventiveness, its setbacks and future needs. The comparisons, usage and the advantages and disadvantages of different types of chromatography products and reagents are also covered in this report.
A comprehensive analysis of chromatography reagents sales is given, broken down by regions—North America, Europe and emerging markets. Sales figures are forecast for the five-year period from 2012 through 2017.
REASONS FOR DOING THIS STUDY
Chromatography techniques and reagents are being used extensively in pharmaceutical and biotechnology industries in the development of pure drug compounds. The primary usage of chromatography techniques is for quality assurance of drug products wherein chromatography separation techniques can, in some cases, assure up to 99.9% purity level and can reveal the impurities to 0.1% or even smaller. These separations or analysis techniques use chromatography reagents for the measurement of the drug purity, which has led to the growing market of the reagents. The study thus focuses on the usage of these reagents in various industries across the global markets.
Most of the techniques of chromatography and their reagents are discussed in this report. The fast-changing scenarios and developmental landscape of various technologies in the market justify focusing on this segment. Along with the end users—pharmaceutical and biotech, food and beverage, environmental agencies and other industries—merger and acquisition and collaborations of companies are also covered in this report. This study also discusses the strengths and weaknesses of each reagent type/technology in light of new technologies, growing competition and changing customer needs.
CONTRIBUTIONS OF THE STUDY AND ITS AUDIENCE
This study contributes to knowledge and understanding of market growth and setbacks for chromatography reagents from the manufacturer and end user perspectives. Pharmaceutical, biochemical, chemical, petrochemical, food and beverage industries, clinics, forensics and environmental agencies will find this study to be of interest.
SCOPE OF THE STUDY
The scope of this study comprises the markets of reagents of chromatography along with various chromatography techniques. BCC analyzes each market; the different types of chromatographic techniques and reagents; the regulatory aspects; the end users of the chromatographic reagents and market projections, its market leaders and market share. The study also offers details of technological refinements including the latest trends and developments.
METHODOLOGY
Both primary and secondary research methodologies were used in preparing this study. BCC carried out a comprehensive literature search that included technical newsletters, journals, technical blogs and research papers as well as many other sources. The data were collected through interviews and correspondence with various pharmaceutical, biotechnical, food and beverage and environment experts. Projections were based on estimates such as the current number of end users, potential end users, likely unit prices, rates of consumption and market trends.
INFORMATION SOURCES
BCC surveyed various companies within the industry to obtain data for this study. They were reputed manufacturers and end users of chromatographic reagents in pharmaceutical, chemical, biotechnology, food & beverages and other relevant industries. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature, technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were done. In addition, data were compiled from current financial, trade and governmental sources.
ABOUT THE AUTHOR
The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project is Shalini S. Dewan, who holds a master’s degree in pharmaceutical chemistry and has more than 14 years of industry experience. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems, Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.
Global Diagnostics Industry
TABLE OF CONTENTS
CHAPTER 1 INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
CONTRIBUTIONS OF THE STUDY AND ITS AUDIENCE 1
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 2
RELATED BCC RESEARCH REPORTS 2
BCC ON-LINE SERVICES 3
DISCLAIMER 3
CHAPTER 2 SUMMARY 5
SUMMARY TABLE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES
OF CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 6
CHAPTER 3 OVERVIEW 9
DEFINITIONS 9
REAGENTS FOR CHROMATOGRAPHY 9
TYPES OF REAGENTS 10
Silylation Reagents 10
TABLE 1 ADVANTAGES AND DISADVANTAGES OF SILYLATION 10
TABLE 2 SILYLATION REAGENTS 10
Alkylation Reagents 11
TABLE 3 ADVANTAGES AND DISADVANTAGES OF ALKYLATION 11
TABLE 4 ALKYLATING REAGENTS 11
Acylation Reagents 12
TABLE 5 ADVANTAGES AND DISADVANTAGES OF ACYLATION 12
TABLE 6 ACYLATING REAGENTS 13
Ion-Pairing Reagents 13
TABLE 7 ADVANTAGES AND DISADVANTAGES OF ION-PAIRING CHROMATOGRAPHY 13
TABLE 8 ION-PAIRING REAGENTS 14
Solvents 14
TABLE 9 EXAMPLES OF SOLVENTS USED IN CHROMATOGRAPHY 14
Buffers 14
TABLE 10 BUFFERS USED IN CHROMATOGRAPHY 15
Adsorbents 15
TABLE 11 ADSORBENTS USED IN GAS-SOLID AND LIQUID-SOLID CHROMATOGRAPHY 15
CLASSIFICATION OF CHROMATOGRAPHY 16
TYPES OF CHROMATOGRAPHY WITH THE USE REAGENTS AND THEIR APPLICATIONS 16
GAS CHROMATOGRAPHY (GC) 16
TABLE 12 ADVANTAGES AND DISADVANTAGES OF GAS CHROMATOGRAPHY 16
Reagents Used in Gas Chromatography 17
TABLE 13 REAGENTS USED IN GAS CHROMATOGRAPHY 17
Applications of Gas Chromatography 17
TABLE 14 APPLICATIONS OF GAS CHROMATOGRAPHY 17
LIQUID CHROMATOGRAPHY (LC) 18
Paper Chromatography (PC) 18
TABLE 15 ADVANTAGES AND DISADVANTAGES OF PAPER CHROMATOGRAPHY 18
Applications of Paper Chromatography 19
Thin Layer Chromatography (TLC) 19
TABLE 16 ADVANTAGES AND DISADVANTAGES OF THIN LAYER CHROMATOGRAPHY 19
TABLE 17 REAGENTS USED IN THIN LAYER CHROMATOGRAPHY 19
Applications of Thin Layer Chromatography 20
High-Performance Liquid Chromatography (HPLC) 20
Ultra High-Performance Liquid Chromatography (UHPLC) 20
Fast Protein Liquid Chromatography (FPLC) 20
TABLE 18 ADVANTAGES AND DISADVANTAGES OF HIGH-PERFORMANCE LIQUID
CHROMATOGRAPHY 20
Reagents used in HPLC 21
TABLE 19 REAGENTS USED IN HPLC CHROMATOGRAPHY 21
Applications of HPLC 21
TABLE 20 APPLICATIONS OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 21
SORPTION CHROMATOGRAPHY 21
Adsorption Chromatography 21
TABLE 21 ADVANTAGES AND DISADVANTAGES OF ADSORPTION CHROMATOGRAPHY 22
Reagents Used in Adsorption Chromatography 22
TABLE 22 REAGENTS USED IN ADSORPTION CHROMATOGRAPHY 22
Applications of Adsorption Chromatography 22
Partition Chromatography 22
Reverse Phase Partition Chromatography 23
Normal Phase Partition Chromatography 23
TABLE 23 ADVANTAGES AND DISADVANTAGES OF PARTITION CHROMATOGRAPHY 23
Reagents used in Partition Chromatography 23
Applications of Adsorption Chromatography 23
SIZE EXCLUSION CHROMATOGRAPHY 23
TABLE 24 ADVANTAGES AND DISADVANTAGES OF SIZE EXCLUSION CHROMATOGRAPHY 24
Reagents Used in Size Exclusion Chromatography 24
Applications of Size Exclusion Chromatography 24
ION EXCHANGE CHROMATOGRAPHY 24
Cation Exchange 24
Anion exchange 24
TABLE 25 ADVANTAGES AND DISADVANTAGES OF ION EXCHANGE CHROMATOGRAPHY 25
Reagents Used in Ion Exchange Chromatography 25
TABLE 26 REAGENTS USED IN ION EXCHANGE CHROMATOGRAPHY 25
Applications of Ion Exchange Chromatography 25
ION PAIR CHROMATOGRAPHY 25
TABLE 27 ADVANTAGES AND DISADVANTAGES OF ION PAIR CHROMATOGRAPHY 25
Reagents Used in Ion Pair Chromatography 26
TABLE 28 REAGENTS USED IN ION PAIR CHROMATOGRAPHY 26
Applications of Ion Pair Chromatography 26
AFFINITY CHROMATOGRAPHY 26
TABLE 29 ADVANTAGES AND DISADVANTAGES OF AFFINITY CHROMATOGRAPHY 26
Reagents Used in Affinity Chromatography 26
TABLE 30 REAGENTS USED IN AFFINITY CHROMATOGRAPHY 26
Applications of Affinity Chromatography 27
COLUMN CHROMATOGRAPHY 27
TABLE 31 ADVANTAGES AND DISADVANTAGES OF COLUMN CHROMATOGRAPHY 27
Reagents Used in Column Chromatography 27
TABLE 32 REAGENTS USED IN COLUMN CHROMATOGRAPHY 27
Applications of Column Chromatography 28
OPEN BED OR PLANAR CHROMATOGRAPHY 28
TABLE 33 ADVANTAGES AND DISADVANTAGES OF OPEN BED OR PLANAR
CHROMATOGRAPHY 28
Reagents Used in Open Bed or Planar Chromatography 28
TABLE 34 REAGENTS USED IN PLANAR CHROMATOGRAPHY 28
Applications of Open Bed or Planar Chromatography 29
SIMULATED MOVING BED CHROMATOGRAPHY (SMB) 29
TABLE 35 ADVANTAGES AND DISADVANTAGES OF SIMULATED MOVING BED
CHROMATOGRAPHY 29
Reagents Used in SMB Chromatography 29
TABLE 36 REAGENTS USED IN SMB CHROMATOGRAPHY 29
Applications of SMB Chromatography 30
TABLE 37 APPLICATIONS OF SMB CHROMATOGRAPHY 30
SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) 30
TABLE 38 ADVANTAGES AND DISADVANTAGES OF SUPERCRITICAL FLUID
CHROMATOGRAPHY 30
Reagents Used in Supercritical Fluid Chromatography 30
TABLE 39 REAGENTS USED IN SFC CHROMATOGRAPHY 30
TABLE 40 CRITICAL PROPERTIES OF COMMONLY USED SCFS (SUPERCRITICAL FLUID
SOLVENTS) 31
Applications of Supercritical Fluid Chromatography 31
CAPILLARY ELECTROPHORESIS 31
TABLE 41 ADVANTAGES AND DISADVANTAGES OF CAPILLARY ELECTROPHORESIS 32
Reagents Used in Capillary Electrophoresis 32
TABLE 42 REAGENTS USED IN CAPILLARY ELECTROPHORESIS 32
Applications of Capillary Electrophoresis 32
TABLE 43 APPLICATIONS OF CAPILLARY ELECTROPHORESIS 32
CHAPTER 4 REGULATORY ASPECTS 35
INTRODUCTION 35
TABLE 44 CLASSES OF SOLVENTS AS PER FDA 36
ACETONE 37
CHLOROFORM 37
BENZENE 37
METHANOL 37
PHENOL 37
PYRIDINE 38
TOLUENE 38
1,2,3-TRICHLOROPROPANE 38
METHYLENE CHLORIDE 38
2 -BUTANONE 39
CHAPTER 5 NEW DEVELOPMENTS 41
CHAPTER 6 GLOBAL MARKETS 45
MARKETS BY TECHNOLOGY 45
MARKET OVERVIEW 45
MARKET REVENUE 46
TABLE 45 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 46
FIGURE 1 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 46
MARKET SHARE 47
TABLE 46 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48
FIGURE 2 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48
MARKETS BY TYPES OF REAGENTS 48
MARKET OVERVIEW 49
MARKET REVENUE 50
TABLE 47 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,
THROUGH 2017 ($ MILLIONS) 50
FIGURE 3 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,
2010-2017 ($ MILLIONS) 50
MARKET SHARE 51
TABLE 48 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN
CHROMATOGRAPHY, 2011 (%) 51
FIGURE 4 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN
CHROMATOGRAPHY, 2011 (%) 52
MARKET BY REGION 52
MARKET OVERVIEW 53
MARKET REVENUE FOR SOLVENTS 54
TABLE 49 SALES OF SOLVENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 54
FIGURE 5 SALES OF SOLVENTS USED IN CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 55
MARKET REVENUE FOR CHEMICALS 55
TABLE 50 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 55
FIGURE 6 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 55
MARKET REVENUE FOR GASES 56
TABLE 51 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 56
FIGURE 7 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 56
MARKET REVENUE FOR ADSORBENTS 57
TABLE 52 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 57
FIGURE 8 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 57
MARKET REVENUE FOR MEMBRANES 58
TABLE 53 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 58
FIGURE 9 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 58
MARKET REVENUE FOR CAPILLARIES 59
TABLE 54 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 59
FIGURE 10 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 59
MARKET REVENUE FOR PLATES 60
TABLE 55 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 60
FIGURE 11 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 60
MARKET REVENUE FOR FLUIDS 61
TABLE 56 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID
CHROMATOGRAPHY BY REGION, THROUGH 2017 ($ MILLIONS) 61
FIGURE 12 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID
CHROMATOGRAPHY BY REGION, 2010-2017 ($ MILLIONS) 61
MARKET SHARE 62
TABLE 57 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED
IN CHROMATOGRAPHY, 2011 (%) 62
FIGURE 13 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS
USED IN CHROMATOGRAPHY, 2011 (%) 62
MARKET BY INDUSTRIAL END USERS 63
PHARMACEUTICAL AND BIOTECHNOLOGY 63
Market Overview 64
TABLE 58 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN
PHARMACEUTICAL INDUSTRY, THROUGH 2017 ($ MILLIONS) 65
FIGURE 14 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN
PHARMACEUTICAL INDUSTRY, 2010-2017 ($ MILLIONS) 65
Market Share 66
TABLE 59 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 66
FIGURE 15 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 66
FOOD AND BEVERAGE 67
Market Overview 67
TABLE 60 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN THE FOOD
AND BEVERAGE INDUSTRY, THROUGH 2017 ($ MILLIONS) 68
FIGURE 16 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN FOOD AND
BEVERAGE INDUSTRY, 2010-2017 ($ MILLIONS) 68
Market Share 69
TABLE 61 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69
FIGURE 17 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69
ENVIRONMENTAL AGENCIES 70
Market Overview 70
TABLE 62 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN
ENVIRONMENTAL AGENCIES, THROUGH 2017 ($ MILLIONS) 71
FIGURE 18 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN
ENVIRONMENTAL AGENCIES, 2010-2017 ($ MILLIONS) 71
Market Share 72
TABLE 63 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72
FIGURE 19 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72
OTHERS 73
Market Overview 73
TABLE 64 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER
INDUSTRIES, THROUGH 2017 ($ MILLIONS) 74
FIGURE 20 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER
INDUSTRIES, 2010-2017 ($ MILLIONS) 74
Market Share 75
TABLE 65 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75
FIGURE 21 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75
CHAPTER 7 GAS CHROMATOGRAPHY REAGENTS - MARKET ANALYSIS 77
MARKET BY REAGENTS 77
MARKET OVERVIEW 77
MARKET REVENUE 78
TABLE 66 SALES OF REAGENTS IN GAS CHROMATOGRAPHY, THROUGH 2017 ($ MILLIONS) 78
FIGURE 22 SALES OF REAGENTS IN GAS CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 78
MARKET SHARE 79
TABLE 67 MARKET SHARE OF GAS REAGENTS BY TYPE, 2011 (%) 79
FIGURE 23 MARKET SHARE OF GAS REAGENTS BY TYPE, 2011 (%) 79
MARKET BY REGION 80
TABLE 68 SALES FOR SOLVENTS USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 81
FIGURE 24 SALES FOR SOLVENTS USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017
($ MILLIONS) 81
TABLE 69 SALES OF CHEMICALS USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 82
FIGURE 25 SALES OF CHEMICALS USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017
($ MILLIONS) 82
TABLE 70 SALES OF GASES USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 83
FIGURE 26 SALES OF GASES USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 83
MARKET SHARE 84
TABLE 71 MARKET SHARE OF GAS REAGENTS BY REGION, 2011 (%) 84
FIGURE 27 MARKET SHARE OF GAS REAGENTS BY REGION, 2011 (%) 84
MARKET BY END USERS 84
PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRY 85
FOOD AND BEVERAGE INDUSTRY 85
ENVIRONMENTAL ANALYSIS 86
OTHERS 87
TABLE 72 CONSUMPTION OF REAGENTS BY END USERS IN GAS CHROMATOGRAPHY,
THROUGH 2017 ($ MILLIONS) 87
FIGURE 28 CONSUMPTION OF REAGENTS BY END USERS IN GAS CHROMATOGRAPHY,
2010-2017 ($ MILLIONS) 87
MARKET SHARE 88
TABLE 73 MARKET SHARE OF GAS REAGENTS BY END USERS, 2011 (%) 89
FIGURE 29 MARKET SHARE OF GAS REAGENTS BY END USERS, 2011 (%) 89
MARKET LEADERS AND THEIR SHARES 89
TABLE 74 MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF GAS CHROMATOGRAPHY
REAGENTS, 2011 (%) 90
FIGURE 30 MARKET SHARE OF MANUFACTURERS/ SUPPLIERS OF GAS CHROMATOGRAPHY
REAGENTS, 2011 (%) 90
CHAPTER 8 PATENT ANALYSIS 92
PATENTS BY YEAR 92
TABLE 75 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 92
FIGURE 31 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 92
PATENTS BY TYPE OF REAGENTS 93
TABLE 76 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF
PATENTS) 93
FIGURE 32 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF
PATENTS) 93
PATENTS BY TYPE OF CHROMATOGRAPHY 94
TABLE 77 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 94
FIGURE 33 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 95
PATENTS BY COUNTRY 95
TABLE 78 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,
2008–2012 96
FIGURE 34 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,
2008-2012 (NUMBER OF PATENTS) 96
TABLE 79 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS 2008-2012
(NO./%) 97
FIGURE 35 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS, 2008-2012
(%) 97
PATENTS BY COMPANY 98
TABLE 80 NUMBER OF U.S. PATENTS BY COMPANY FOR CHROMATOGRAPHY REAGENTS,
2008-2012 98
PATENTS BY ASSIGNEE 99
TABLE 81 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS, 2008-2012 100
FIGURE 36 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS 2008-2012 100
CHAPTER 9 CURRENT SITUATION 102
CONSUMERS OF CHROMATOGRAPHY REAGENTS 102
PHARMACEUTICAL INDUSTRY 102
Drug Discovery 102
Drug Development 103
Purification and Isolation 103
Manufacturing and Quality Assurance/Quality Control (QA/QC) 103
Biopharmaceuticals 104
ENVIRONMENTAL AGENCIES 104
FOOD AND BEVERAGE 104
FOOD LABORATORIES 105
NUTRACEUTICAL INDUSTRY 105
CLINICS AND FORENSICS 106
MERGERS AND ACQUISITIONS/LATEST DEVELOPMENTS 106
FACTORS GOVERNING THE CHROMATOGRAPHY REAGENTS MARKET 108
INCREASE FOCUS ON PROTEIN PURIFICATION 108
INCREASED R&D EXPENDITURE 108
CURRENT MARKET DRIVERS 109
CHAPTER 10 COMPANY PROFILES 112
AGILENT TECHNOLOGIES 112
AVANTOR PERFORMANCE MATERIALS 112
BECKMAN COULTER, INC 113
BIO-RAD LABORATORIES, INC. 113
DANAHER CORPORATION 114
DIONEX CORPORATION 114
GE HEALTHCARE LIFE SCIENCES 115
HELENA LABORATORIES 115
HICHROM LIMITED 116
HOEFER INC. 117
LONZA GROUP LTD. 117
MILLIPORE CORPORATION 118
NACALAI TESQUE 118
REGIS TECHNOLOGIES 119
SEBIA 119
SERVA ELECTROPHORESIS GMBH 120
SIGMA-ALDRICH CORPORATION 120
THERMO FISHER SCIENTIFIC INC. 121
TOSOH BIOSCIENCES LLC 121
VWR INTERNATIONAL 122
W. R. GRACE & CO. 122
CHAPTER 11 APPENDIX I-ABBREVIATIONS 125
LIST OF TABLES
SUMMARY TABLE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 6
TABLE 1 ADVANTAGES AND DISADVANTAGES OF SILYLATION 10
TABLE 2 SILYLATION REAGENTS 10
TABLE 3 ADVANTAGES AND DISADVANTAGES OF ALKYLATION 11
TABLE 4 ALKYLATING REAGENTS 11
TABLE 5 ADVANTAGES AND DISADVANTAGES OF ACYLATION 12
TABLE 6 ACYLATING REAGENTS 13
TABLE 7 ADVANTAGES AND DISADVANTAGES OF ION-PAIRING CHROMATOGRAPHY 13
TABLE 8 ION-PAIRING REAGENTS 14
TABLE 9 EXAMPLES OF SOLVENTS USED IN CHROMATOGRAPHY 14
TABLE 10 BUFFERS USED IN CHROMATOGRAPHY 15
TABLE 11 ADSORBENTS USED IN GAS-SOLID AND LIQUID-SOLID CHROMATOGRAPHY 15
TABLE 12 ADVANTAGES AND DISADVANTAGES OF GAS CHROMATOGRAPHY 16
TABLE 13 REAGENTS USED IN GAS CHROMATOGRAPHY 17
TABLE 14 APPLICATIONS OF GAS CHROMATOGRAPHY 17
TABLE 15 ADVANTAGES AND DISADVANTAGES OF PAPER CHROMATOGRAPHY 18
TABLE 16 ADVANTAGES AND DISADVANTAGES OF THIN LAYER CHROMATOGRAPHY 19
TABLE 17 REAGENTS USED IN THIN LAYER CHROMATOGRAPHY 19
TABLE 18 ADVANTAGES AND DISADVANTAGES OF HIGH-PERFORMANCE LIQUID
CHROMATOGRAPHY 20
TABLE 19 REAGENTS USED IN HPLC CHROMATOGRAPHY 21
TABLE 20 APPLICATIONS OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 21
TABLE 21 ADVANTAGES AND DISADVANTAGES OF ADSORPTION CHROMATOGRAPHY 22
TABLE 22 REAGENTS USED IN ADSORPTION CHROMATOGRAPHY 22
TABLE 23 ADVANTAGES AND DISADVANTAGES OF PARTITION CHROMATOGRAPHY 23
TABLE 24 ADVANTAGES AND DISADVANTAGES OF SIZE EXCLUSION CHROMATOGRAPHY 24
TABLE 25 ADVANTAGES AND DISADVANTAGES OF ION EXCHANGE CHROMATOGRAPHY 25
TABLE 26 REAGENTS USED IN ION EXCHANGE CHROMATOGRAPHY 25
TABLE 27 ADVANTAGES AND DISADVANTAGES OF ION PAIR CHROMATOGRAPHY 25
TABLE 28 REAGENTS USED IN ION PAIR CHROMATOGRAPHY 26
TABLE 29 ADVANTAGES AND DISADVANTAGES OF AFFINITY CHROMATOGRAPHY 26
TABLE 30 REAGENTS USED IN AFFINITY CHROMATOGRAPHY 26
TABLE 31 ADVANTAGES AND DISADVANTAGES OF COLUMN CHROMATOGRAPHY 27
TABLE 32 REAGENTS USED IN COLUMN CHROMATOGRAPHY 27
TABLE 33 ADVANTAGES AND DISADVANTAGES OF OPEN BED OR PLANAR
CHROMATOGRAPHY 28
TABLE 34 REAGENTS USED IN PLANAR CHROMATOGRAPHY 28
TABLE 35 ADVANTAGES AND DISADVANTAGES OF SIMULATED MOVING BED
CHROMATOGRAPHY 29
TABLE 36 REAGENTS USED IN SMB CHROMATOGRAPHY 29
TABLE 37 APPLICATIONS OF SMB CHROMATOGRAPHY 30
TABLE 38 ADVANTAGES AND DISADVANTAGES OF SUPERCRITICAL FLUID
CHROMATOGRAPHY 30
TABLE 39 REAGENTS USED IN SFC CHROMATOGRAPHY 30
TABLE 40 CRITICAL PROPERTIES OF COMMONLY USED SCFS (SUPERCRITICAL FLUID
SOLVENTS) 31
TABLE 41 ADVANTAGES AND DISADVANTAGES OF CAPILLARY ELECTROPHORESIS 32
TABLE 42 REAGENTS USED IN CAPILLARY ELECTROPHORESIS 32
TABLE 43 APPLICATIONS OF CAPILLARY ELECTROPHORESIS 32
TABLE 44 CLASSES OF SOLVENTS AS PER FDA 36
TABLE 45 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, THROUGH 2017 ($ MILLIONS) 46
TABLE 46 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48
TABLE 47 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,
THROUGH 2017 ($ MILLIONS) 50
TABLE 48 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN
CHROMATOGRAPHY, 2011 (%) 51
TABLE 49 SALES OF SOLVENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 54
TABLE 50 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 55
TABLE 51 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 56
TABLE 52 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 57
TABLE 53 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 58
TABLE 54 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017
($ MILLIONS) 59
TABLE 55 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 60
TABLE 56 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID
CHROMATOGRAPHY BY REGION, THROUGH 2017 ($ MILLIONS) 61
TABLE 57 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED
IN CHROMATOGRAPHY, 2011 (%) 62
TABLE 58 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN
PHARMACEUTICAL INDUSTRY, THROUGH 2017 ($ MILLIONS) 65
TABLE 59 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY TECHNOLOGY)
IN PHARMACEUTICAL COMPANIES, 2011 (%) 66
TABLE 60 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN THE FOOD
AND BEVERAGE INDUSTRY, THROUGH 2017 ($ MILLIONS) 68
TABLE 61 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69
TABLE 62 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN
ENVIRONMENTAL AGENCIES, THROUGH 2017 ($ MILLIONS) 71
TABLE 63 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72
TABLE 64 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER
INDUSTRIES, THROUGH 2017 ($ MILLIONS) 74
TABLE 65 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75
TABLE 66 SALES OF REAGENTS IN GAS CHROMATOGRAPHY, THROUGH 2017 ($ MILLIONS) 78
TABLE 67 MARKET SHARE OF GAS REAGENTS BY TYPE, 2011 (%) 79
TABLE 68 SALES FOR SOLVENTS USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 81
TABLE 69 SALES OF CHEMICALS USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH
2017 ($ MILLIONS) 82
TABLE 70 SALES OF GASES USED IN GAS CHROMATOGRAPHY BY REGION, THROUGH 2017 ($
MILLIONS) 83
MST056A - Global Markets for Reagents for Chromatography -- Focus on Gas Chromatography
Copyright © BCC Research, Wellesley MA USA, Website: www.bccresearch.com
TABLE HEADING PAGE NO.
TABLE 71 MARKET SHARE OF GAS REAGENTS BY REGION, 2011 (%) 84
TABLE 72 CONSUMPTION OF REAGENTS BY END USERS IN GAS CHROMATOGRAPHY,
THROUGH 2017 ($ MILLIONS) 87
TABLE 73 MARKET SHARE OF GAS REAGENTS BY END USERS, 2011 (%) 89
TABLE 74 MARKET SHARE OF MANUFACTURERS/SUPPLIERS OF GAS CHROMATOGRAPHY
REAGENTS, 2011 (%) 90
TABLE 75 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 92
TABLE 76 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF
PATENTS) 93
TABLE 77 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 94
TABLE 78 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,
2008–2012 96
TABLE 79 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS 2008-2012
(NO./%) 97
TABLE 80 NUMBER OF U.S. PATENTS BY COMPANY FOR CHROMATOGRAPHY REAGENTS,
2008-2012 98
TABLE 81 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS, 2008-2012 100
LIST OF FIGURES
SUMMARY FIGURE GLOBAL REVENUES FOR THE REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 6
FIGURE 1 GLOBAL REVENUES FOR REAGENTS USED IN DIFFERENT TYPES OF
CHROMATOGRAPHY TECHNIQUES, 2010-2017 ($ MILLIONS) 46
FIGURE 2 ESTIMATED MARKET SHARE OF REAGENTS BY TECHNOLOGY, 2011 (%) 48
FIGURE 3 GLOBAL SALES OF MAJOR CLASSES OF REAGENTS USED IN CHROMATOGRAPHY,
2010-2017 ($ MILLIONS) 50
FIGURE 4 ESTIMATED MARKET SHARE OF MAJOR CLASSES OF REAGENTS USED IN
CHROMATOGRAPHY, 2011 (%) 52
FIGURE 5 SALES OF SOLVENTS USED IN CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 55
FIGURE 6 SALES OF CHEMICALS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 55
FIGURE 7 SALES OF GASES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 56
FIGURE 8 SALES OF ADSORBENTS USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 57
FIGURE 9 SALES OF MEMBRANES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 58
FIGURE 10 SALES OF CAPILLARIES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 59
FIGURE 11 SALES OF PLATES USED IN CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 60
FIGURE 12 SALES OF FLUIDS AND REAGENTS USED IN SUPERCRITICAL FLUID
CHROMATOGRAPHY BY REGION, 2010-2017 ($ MILLIONS) 61
FIGURE 13 ESTIMATED NORTH AMERICAN DEMAND FOR MAJOR TYPES OF REAGENTS USED
IN CHROMATOGRAPHY, 2011 (%) 62
FIGURE 14 GLOBAL CONSUMPTION OF THE REAGENTS (BY TECHNOLOGY) USED IN
PHARMACEUTICAL INDUSTRY, 2010-2017 ($ MILLIONS) 65
FIGURE 15 GLOBAL DEMAND OF VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN PHARMACEUTICAL COMPANIES, 2011 (%) 66
FIGURE 16 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN FOOD AND
BEVERAGE INDUSTRY, 2010-2017 ($ MILLIONS) 68
FIGURE 17 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN FOOD AND BEVERAGE COMPANIES, 2011 (%) 69
FIGURE 18 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN
ENVIRONMENTAL AGENCIES, 2010-2017 ($ MILLIONS) 71
FIGURE 19 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN ENVIRONMENTAL AGENCIES, 2011 (%) 72
FIGURE 20 GLOBAL CONSUMPTION OF REAGENTS (BY TECHNOLOGY) USED IN OTHER
INDUSTRIES, 2010-2017 ($ MILLIONS) 74
FIGURE 21 GLOBAL DEMAND FOR VARIOUS CHROMATOGRAPHIC REAGENTS (BY
TECHNOLOGY) IN OTHER INDUSTRIES, 2011 (%) 75
FIGURE 22 SALES OF REAGENTS IN GAS CHROMATOGRAPHY, 2010-2017 ($ MILLIONS) 78
FIGURE 23 MARKET SHARE OF GAS REAGENTS BY TYPE, 2011 (%) 79
FIGURE 24 SALES FOR SOLVENTS USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017
($ MILLIONS) 81
FIGURE 25 SALES OF CHEMICALS USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017
($ MILLIONS) 82
FIGURE 26 SALES OF GASES USED IN GAS CHROMATOGRAPHY BY REGION, 2010-2017 ($
MILLIONS) 83
FIGURE 27 MARKET SHARE OF GAS REAGENTS BY REGION, 2011 (%) 84
FIGURE 28 CONSUMPTION OF REAGENTS BY END USERS IN GAS CHROMATOGRAPHY,
2010-2017 ($ MILLIONS) 87
FIGURE 29 MARKET SHARE OF GAS REAGENTS BY END USERS, 2011 (%) 89
FIGURE 30 MARKET SHARE OF MANUFACTURERS/ SUPPLIERS OF GAS CHROMATOGRAPHY
REAGENTS, 2011 (%) 90
FIGURE 31 NUMBER OF PATENTS BY YEAR, 2008-2012 (NO.) 92
FIGURE 32 PATENTS BY TYPE FOR CHROMATOGRAPHY REAGENTS 2008-2012 (NUMBER OF
PATENTS) 93
FIGURE 33 PATENTS BY TYPE OF CHROMATOGRAPHY 2008-2012 (NUMBER OF PATENTS) 95
FIGURE 34 NUMBER OF U.S. PATENTS BY COUNTRY FOR CHROMATOGRAPHY REAGENTS,
2008-2012 (NUMBER OF PATENTS) 96
FIGURE 35 PATENT SHARES BY COUNTRY FOR CHROMATOGRAPHY REAGENTS, 2008-2012 (%) 97
FIGURE 36 PATENTS BY ASSIGNEE FOR CHROMATOGRAPHY REAGENTS 2008-2012 100
