The coronary stents industry is a highly competitive one in which innovation occurs rapidly and the technology landscape evolves at a fast pace. As the global population is aging and has a longer life expectancy, the prevalence of coronary heart disease and co-morbid conditions such as hypertension, diabetes and obesity is projected to rise and stimulate the demand for coronary stents. Additionally, a growing acceptance of drug-eluting stents as a more effective treatment for coronary heart disease, along with increasing awareness about coronary stents among patients, is expected to boost procedural volumes. New technologies, such as bioresorbable scaffolds, and bifurcation and biodegradable polymers stents, are projected to enter major markets in the next years and increase the utilization of stents in interventional cardiology.



Despite the challenging environment, opportunities still exist in the global market for coronary stents, as there is still a high need for non-invasive therapies with enhanced safety and efficacy, and there are various niches of the market, such as bifurcation and complex lesions, that require more extensive treatment options. Additionally, the new bioresorbable stents have the potential to eliminate the negative issues of durable polymer stents, and are therefore expected to induce a significant shift in the treatment of coronary heart disease, encouraging also more patients to undergo stent implantation surgery.



This Report, The World Market for Stents (Drug Eluting and Bare Metal Product Markets in U.S., E.U., Japan, China, India and ROW) provides a complete overview of cardiovascular disease, the role of stents in treatment, the success of bare metal and drug-eluting products, as well as market sizes and forecasts to 2017. Included in this reports coverage:

  • Market Size and Forecast -Cardiovascular Disease Statistics (Mortality, Morbidity, Cost by Country)

  • Regional Breakout of Bare Metal and Drug-Eluting Stent Markets (U.S., E.U., Japan, China, India, ROW)

  • Categorization of Drug-Eluting Stents by Polymer, Drug, Platform

  • Coronary Stents Using Biodegradable Polymers, Novel Coating and Direct Drug Application

  • Assessment of Bioresorbable Stents

  • Dedicated Bifurcation, Dedicated Small Vessel Stent Products

  • Major Competitors Market Share

  • Significant Trends in Market and Near and Long-Term Impact

  • Recent Mergers and Acquisitions

  • Key Company Profiles


The major markets of US, Europe, and Japan experienced significant challenges in recent years, including price declines, decreasing volumes of percutaneous coronary interventions, and lower penetration rates for drug-eluting stents resulted from cost constraints and reductions in healthcare budgets. Additionally, the intensified competition among manufacturers also contributed to the decline in average stent selling prices in these regions. Despite that, the market potential for coronary stents in these regions remains quite attractive, given the aging population and high longevity. However, the decreasing reimbursement rates and the intensifying competition for market share are expected to continue to lead to price declines and hamper significantly the market growth.



As part of its coverage of the stents industry, the following companies are profiled:

  • Abbott Laboratories

  • Biosensors International

  • Boston Scientific

  • Biotronik SE & Co.KG

  • CID Vascular

  • Elixir Medical Corporation

  • Medtronic

  • Meril Life Sciences Pvt. Ltd.

  • MicroPort Medical (Shanghai) Co., Ltd Minvasys

  • OrbusNeich

  • REVA Medical

  • Stentys S.A.

  • Terumo Corporation

Table Of Contents

CHAPTER ONE: EXECUTIVE SUMMARY

Disease Overview

Cardiovascular Disease



Market Overview

Revenue Forecast



CHAPTER TWO: CARDIOVASCULAR DISEASE OVERVIEW

Disease Overview

Top Ten Causes of Death

World Cardiovascular Disease Statistics

Mortality Rates for IHD



Economic Burden of Cardiovascular Disease

Expenditure on Cardiovascular Disease, Worldwide

Prevalence of Ischemic Heart Disease



CHAPTER THREE: CORONARY STENTS OVERVIEW

Overview

Restenosis



Types of Stents

Bare Metal Stents

First Generation of Bare Metal Stents

Second Generation of Bare Metal Stents

Third Generation of Bare Metal Stents

Omega Platinum-Chromium Stent

Nuloy Molybdenum-Rhenium Stent



Safety Issues of Bare Metal Stents



Drug-Eluting Stents

Types of Drugs Used on Drug-Eluting Stents

Paclitaxel

Sirolimus

Everolimus

Tacrolimus

Biolimus A9

Novolimus

Other Drug Classes



Types of Polymers

Safety Concerns of Drug-Eluting Stents

Late Stent Thrombosis

Mechanical Problems of Polymers





CHAPTER FOUR: RECENT ADVANCES IN CORONARY STENTS TECHNOLOGIES

Reduced Polymer Coatings

Biodegradable Polymers

Advantages and Disadvantages of Biodegradable Polymers

Current Biodegradable Polymers Stents

BioMatrix

Nobori

Supralimus

Infinnium

DESyne BD stent

Synergy

MiStent

BioMime

Abrax



Polymer-Free and Novel Coatings Drug-eluting Stents

Optima Jet

Cre8

Orsiro Hybrid DES

EPC Capturing Technology



Direct Application of Drug on Stent Surface

Amazonia Pax

Yukon DES

BioFreedom

Mitsu

Medtronic S10 platform

Catania stent

MGuard Prime

Titan-2



Bioresorbable Stents

Drawbacks of Bioresorbable Polymeric Stents

Selected Bioresorbable Coronary Stents

The Absorb stent

Biotronik’s Dreams stent

DESolve stent

ReZolve Stent

IDEAL stent

Other bioresorbable stents





Lesion Specific Stents

Dedicated Bifurcated Stents

Axxess

Nile Pax

Stentys Self-Apposing stent

Taxus Petal

Xience Side Branch Access

Sparrow

Taxus Liberte Atom

Xience nano





CHAPTER FIVE: INDUSTRY STRUCTURE andamp; TRENDS


Sales and Marketing Capabilities


Differentiation Strategies

Improved Stent Materials

Reduced DAPT Duration



Lesion-Specific Stents

Extended Indications



Significant Trends In The Coronary Stents Market



Market Drivers

New devices Expanded Indications

Acute Myocardial Infarction and Diabetes



Emerging Markets Are Expected To Spur The Overall Market Growth.



Market Restraints

Price decline hampers growth in the overall market.

Cost Constraints

Difficult Economic Conditions



Notable Recent Industry Events

Recent Mergers and Acquisitions

Biosensors International acquired CardioMind and Devax

Medtronic Acquired Invatec

Xenogenics Corporation Acquired Bioabsorbable Therapeutics



Market Exits



CHAPTER SIX: MARKET REVENUES AND FORECAST

Market by Type of Stent

Drug Eluting Stents Market

Market Snapshot



Products Analysis

Xience V

Promus Element/Plus

Resolute Integrity

Market Dynamics in the Drug-Eluting Stents Segment





Revenue Forecast

Bare Metal Stents Market

Market Snapshot

Market Dynamics

Revenue Forecast



United States

Market Snapshot

Revenue Forecast



Europe

Market snapshot

Revenue Forecast



Japan

Market snapshot

Revenue forecast



China

Market Snapshot

Revenue forecast



India

Market snapshot

Revenue Forecast



Rest of the World

Revenue Forecast





CHAPTER SEVEN: COMPANY PROFILES

Abbott Laboratories

Biosensors International

Boston Scientific

Biotronik SE andamp; Co.KG

CID Vascular

Elixir Medical Corporation

Medtronic

Meril Life Sciences Pvt. Ltd.

MicroPort Medical (Shanghai) Co., Ltd

Minvasys

OrbusNeich

REVA Medical

Stentys S.A.

Terumo Corporation

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Top Ten Causes of Death in the World by Development Level, 2008

Figure 1-1: Global Market Revenues Forecast 2010-2017

(Bare Metal Stents, Drug Eluding Stents, Total)

CHAPTER TWO: CARDIOVASCULAR DISEASE OVERVIEW

Table 2-1: Top Ten Causes of Death in the World by Geographical Region, 2008

Table 2-2: Top Ten Causes of Death in the World by Development Level, 2008

Table 2-3: Top Ten Causes of Death in the World in High Income Countries, 2008

Table 2-4: Top Ten Causes of Death in the World in Middle Income Countries, 2008

Table 2-5: Top Ten Causes of Death in the World in Low Income Countries, 2008

Figure 2-1: Percentage of Deaths Related to Cardiovascular Disease in

the Seven Major World Markets, 2008

Table 2-6: Projected Deaths from Ischemic Heart Disease (IHD) and Acute

Myocardial Infarction (AMI) in the Seven Major World Markets, 2012

Table 2-7: Age-Standardized Mortality Rates for Ischemic Heart Disease (IHD)

and Acute Myocardial Infarction (AMI) by Gender in the Seven Major

World Markets, 2009

Table 2-8: Estimated Total Cost of Cardiovascular Disease in Europe, 2006

Table 2-9: Estimated Total Cost of Cardiovascular Disease in Major Markets, 2012

CHAPTER THREE: CORONARY STENTS OVERVIEW

Table 3-1: Selected Marketed Bare Metal Stents, 2012

Table 3-2: Selected Bare Metal Coronary Stents, 2012

Table 3-3: Selected Marketed Drug-Eluting Stents, 2012

Table 3-4: Selected Features of Different Generations of Commercially

Available Drug-eluting Stents

CHAPTER FOUR: RECENT ADVANCES IN CORONARY STENTS

TECHNOLOGIES

Table 4-1: Selected Coronary Stents using Biodegradable Polymers, 2012

Table 4-2: Selected Coronary Polymer-free and Novel Coating Stents, 2012

Table 4-3: Selected Direct Drug Application Coronary Stents, 2012

Table 4-4: Selected Coronary Polymer and Drug-free Coating Stents, 2012

Table 4-5: Advantages and Disadvantages of Bioresorbable Stents

Table 4-6: Selected Bioresorbable Coronary Stents, 2012

Table 4-7: Selected Dedicated Bifurcation Coronary Drug-Eluting Stents, 2012

Table 4-8: Selected Dedicated Small Vessels Coronary Drug-Eluting Stents, 2012

Table 4-9: Drug Release Parameters of Selected Drug-Eluting Stents

CHAPTER FIVE: INDUSTRY STRUCTURE

Table 5-1: Industry Structure - Major Competitors and Selected

Marketed Products, 2012

Table 5-2: Significant Trends in the Coronary Stents Market, 2012

CHAPTER SIX: MARKET REVENUES AND FORECAST

Table 6-1: Coronary Stents Estimated Global Market Shares, 2011

Figure 6-1: Stents Market Share, 2011

Table 6-2: Global Market Revenues for Coronary Stents ($ Millions)

Figure 6-2: Global Stents Market Forecast

Figure 6-3: Market Breakdown by Type of Stent (BMS, DES)

Figure 6-4: Drug Eluting Stents Market Shre, 2011

Table 6-3: Global Market Revenues for Coronary Stents ($ Millions)

Figure 6-5: Global Market Revenues Forecast ($ Billions)Drug-Eluting Stents, 2010-2017

Figure 6-6: Market Breakdown by Type of Stent (BMS, DES)

Figure 6-7: Market Share Bare Metal Stents

Table 6-4: Global Market Revenues for Coronary Bare Metal Stents, 2010-2017 (Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-8: Bare Metal Stents Market 2010-2017

Figure 6-9: United States Share of World Market

Table 6-5: U.S. Market Revenues for Coronary Stents (Bare Metal Stent, Drug Eluding Stent,Total)

Figure 6-10: U.S. Market Revenues for Coronary Stents(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-11: Europe Share of World Stents Market

Table 6-6: European Market Revenues for Coronary Stents(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-12: European Market Revenues for Coronary Stents(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-13: Japan Share of World Stents Market

Table 6-7: Japanese Market Revenues for Coronary Stents(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-14: Japanese Market Revenues for Coronary Stents(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-15: China Share of World Stents Market

Table 6-8: Market Revenues for Coronary Stents in China(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-15: Market Revenues for Coronary Stents in China(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-16: India Share of World Market

Table 6-9: Market Revenues for Coronary Stents in India(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-17: Market Revenues for Coronary Stents in India(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-18: Rest of World Share of World Stents Market

Table 6-10: Market Revenues for Coronary Stents in the Rest of the World(Bare Metal Stent, Drug Eluding Stent, Total)

Figure 6-19: Market Revenues for Coronary Stents in the Rest of the World(Bare Metal Stent, Drug Eluding Stent, Total)


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