Micro and Nano Technologies for Point-of-Care Testing

• Publication date: October 2012
• Report size: 185 pages

Micro and nanotechnologies are set to transform point-of-care diagnostics. Miniaturization of testing methods, advances in lab-on-a-chip microfluidic methodologies, improvements in detection technologies and novel biosensors are leading the way.Identify micro and nanotechnologies driving the development of next-generation point-of-care diagnostics to benefit from...

Micro and nanotechnologies are set to transform point-of-care diagnostics. Miniaturization of testing methods, advances in lab-on-a-chip microfluidic methodologies, improvements in detection technologies and novel biosensors are leading the way.Identify micro and nanotechnologies driving the development of next-generation point-of-care diagnostics to benefit from opportunities being created.Discover which analytes/diseases are currently being targeted by profiled companies to formulate your own diagnostic product development strategies.Assess the evolving POC testing market with the aid of market forecasts for individual market segments to prepare for future growth in this area.Forecast key point-of-care testing market segments to 2016.Various proprietary technologies identified in this report underpin POC testing products in development. These technologies represent valid alternative approaches to challenges such as multiplexing, liquid transport in miniaturized systems, integration of assay procedures, and limitations associated with the use of traditional fluorescent labels.The microfluidic lab-on-a-chip (LoC) is now firmly established as an attractive miniaturized platform for POC testing. Maturing of LoC technologies is stimulating efforts to incorporate miniaturized biosensors into portable LoC systems to accelerate the development of portable and handheld testing systemsMost of the products discussed in this report are being developed for healthcare professional-based testing. Four professional-based POCT market sectors - infectious disease; cardiac marker; coagulation (including pharmacogenomics); and cancer screening/pharmacogenomics - are forecast to grow at CAGRs of 14%, 22%, 19% and 30% respectively.Which micro and nano technologies in development offer the attributes of miniaturization, fast readout time, multiplexing, and cost-effectiveness?What drivers and restraints operate in the nascent market for POC testing products based on micro and nanotechnologies?Who is developing new POC testing products based on micro and nanotechnologies and which clinical applications are they targeting?How will POC testing products based on micro and nanotechnologies impact areas inadequately served by current products and areas of unmet need?What are the estimated current market sizes and 5-year growth forecasts for the sectors of the POC testing market currently targeted?

In Vitro Diagnostic Industry

EXECUTIVE SUMMARY
•Key findings - The effects of evolving diagnostic technologies


Current POCT technologies and applications•Summary
•Introduction
•Enabling IVDT technologies - Immunoassays
- Probe-based nucleic acid testing
- Mass spectrometry

•Regulation of IVDs
•Current POCT systems - Multi-channel immunoanalyzers

•Micro- and nanotechnologies for POCT

Micro- and nanoarrays•Summary
•Introduction
•Developments in DNA microarrays - High density microarrays
- Low or medium density microarrays
- Microarray platforms

•Developments in protein microarrays
•Focus on detection technologies - Label-based technologies
- Label-free technologies

•Innovations in nanoarrays - Nanofabrication techniques
- Applications


Microfluidics ? based LoC systems•Summary
•Mirofluidic devices and technologies
•Microfluidic NAT systems - Integrated LoC commercial systems

•Microfluidic immunoassays - Substrate materials for microfluidic immunoassays
- Immobilization methods for immunoassays

•Liquid transport control strategies - Micropneumatic pumping
- Multilayer soft lithography
- Centrifugal force
- Phaseguide technology
- Electrokinetics
- Electrowetting
- Other approaches

•Detection methods - Optical detection using labels
- Non-optical label-free technologies


Advances in biosensors•Summary
•Introduction
•Advances in optical detection - Signal intensification technologies
- Optical fiber technology
- Electrochemical sensors

•Piezoelectric sensors
•Nanomaterial-based biosensors - Challenge of non-specific protein adsorption

•Nanoparticles for sensor devices - Quantum dots and gold nanoparticles
- Magnetic nanoparticles
- Nanoelectrodes
- Nanotubes
- Nanowires

•Nanopore sensors - Biological nanopores
- Solid-state and hybrid nanopores

•Artificial olfaction sensors
•Other sensors

Company profiles•Introduction
•Advanced Liquid Logic - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•Akonni Biosystems - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•Applied Nanodetectors - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Aquila Diagnostic Systems - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•ArcDia International - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•BioCartis - Overview of company business
- Proprietary micro/nanotechnologies
- Recent POCT-related collaborations

•BioForce Nanosciences - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Bio-Rad Laboratories - Company description
- Proprietary micro/nanotechnologies (acquired from QuantaLife)
- POCT products

•Biosurfit - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Biosystems International - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•Cambridge Biomagnetics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•DNA Electronics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•Epocal - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•Fluidigm - Overview of company business
- Proprietary micro/nanotechnologies

•FluimediX - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Fluigent - Overview of company business
- Proprietary micro/nanotechnologies

•GenMark Diagnostics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Integrated Nano-Technologies - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Kumetrix - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Luminex Corporation - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•MagArray - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Micronics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Molecular Vision - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•NanoIVD - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Nanomix - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Nanosphere - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•NVE Corporation - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•OJ-Bio - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Oxford Nanopore Technologies - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•PLC Diagnostics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Royal Philips Electronics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products
- Recent POCT-related collaborations

•PLC Diagnostics - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Sirigen - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•T2 Biosystems - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•TIRF Technologies - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products

•Vivacta - Overview of company business
- Proprietary micro/nanotechnologies
- POCT products


Market trends and forecasts•Summary
•Technologies poised to transform POCT - The future: early treatment and prevention

•Characteristics of the IVD industry
•Challenges for developers of novel POCT products
•POCT market forecasts by selected application - Infectious disease testing
- Cardiac marker testing
- Coagulation testing and pharmacogenomics
- Cancer screening and pharmacogenomics



APPENDIX
•Contributors - Managing analyst

•Scope
•Methodology
•Glossary/abbreviations
•Bibliography/references - Websites of companies mentioned in this report

•Disclaimer


TABLES
•Table: Selected companies developing microfluidic POC lab-on-a-chip systems
•Table: Selected companies developing biosensors for POCT applications
•Table: Global POCT market forecasts by reviewed segment, 2011–16


FIGURES
•Figure: Schematic of a typical lateral flow device
•Figure: Customizable features of the ESE-Quant lateral flow system
•Figure: Akonni Systems’ TruArray gel microarray
•Figure: PLC Diagnostics’ In-plane parallel scanning
•Figure: A typical lab-on-a-chip for POC testing with associated instrumentation
•Figure: PCR analysis on Advanced Liquid Logic’s electrowetting chip
•Figure: Schematic of a lab-on-a-chip for fluorescence analysis
•Figure: Molecular Vision's polymer detection system and credit card-sized LoC device
•Figure: GenMark Diagnostics’ eSensor technology
•Figure: NVE Corporation’s spintronic sensor
•Figure: Schematic of a Surface Generated Acoustic Wave (SGAW) sensor


Companies Mentioned

Abbott Laboratories, Amer Sports Corporation, Arrayit Corporation, Arriva plc, Banco Santander, S.A., Brossard SA, Cepheid, Dairy Farm International Holdings Limited, Delta Air Lines, Inc., F. Hoffmann-La Roche Ltd, GlaxoSmithKline Plc, Hutchison 3G UK Limited, Informa plc, International Finance Corporation, Janssen Pharmaceuticals, Inc., Koninklijke Philips Electronics N.V., Luminex Corporation, Nordea Bank AB, NVE Corporation, Publicis Groupe SA, Schindler Holding Ltd., Sony Corporation, WPP plc