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INTRODUCTION

STUDY OBJECTIVES

BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for cell and tissue analysis products. The key objective is to present a comprehensive analysis of the future direction of cell and tissue products that will serve as a valuable tool for their use of.

This report explores present and future strategies within the cell and tissue analysis market, including biospecimen-preparing techniques, cell and tissue separation, and cell and tissue characterization products. The market’s improvisation, setbacks and needs are also discussed. The classifications, comparisons and usage of cell and tissue analysis products are also presented in this report.

A detailed analysis of the cell and tissue analysis industry structure has been conducted. Revenues are broken down by region, and sales figures are estimated for the five-year period from 2012 through 2017.

Applications for cell and tissue analysis products are discussed separately. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

Extensive research in the field of cell and tissue analysis products has revealed their specific functionality in providing specific analysis for the healthcare and the biopharmaceutical industries. Modern industries have begun to explore the advantages of cell and tissue analysis products in their productions and processes, leading to the steady market in this area.

R&D spending, increasing competition, patent expiries and new technologies are leading this market in a new direction. The new advancements, new product launches and changing lifestyles have influenced the market to grow in the foreseeable future. This study looks at many of the systems affected by these factors.

Acquisition strategies and company collaborations are covered in this report. This study also discusses the strength and weaknesses of each type of technology in light of the new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE

This study contributes to the areas of market growth in cell and tissue analysis manufacturers and users. It will be of interest to pharmaceutical companies, biotechnical companies, research institutes and physicians.

SCOPE OF THE STUDY

The scope of this study encompasses cell and tissue analysis products in the pharmaceutical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology, market projection and market share. Technological issues include the latest trends and developments. The emerging markets for enzyme inhibitors include India, China, Japan, South Korea, Taiwan, Canada, Africa, Australia and New Zealand.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals, as well as many other sources. Data were collected through interviews and correspondence with manufacturers of cell and tissue analysis products technical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Numerous companies were surveyed to obtain data for this study, including manufacturers and end users of kinase inhibitors in therapeutic categories and various disease sectors. Data were gathered from various industry sources. BCC researchers spoke with officials within the industry and also consulted newsletters; company literature; product literature; and a host of technical articles, journals, indices and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

This study was carried out by a team of professionals in the biotechnology industry. Shalini S. Dewan, the project manager, holds a Master’s degree in pharmaceutical chemistry and has more than 14 years of industry experience. She has covered such research topics as compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Her other reports with BCC include Reagents for Chromatography; Spectroscopy: An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

Table Of Contents

Global Markets and Technologies for Cell and Tissue Analysis -- Focus on Cell and Tissue Characterization
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 1
SCOPE OF THE STUDY 1
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 2
RELATED BCC RESEARCH REPORTS 2
BCC ONLINE SERVICES 3
DISCLAIMER 3
CHAPTER 2 SUMMARY 5
SUMMARY TABLE GLOBAL CELL AND TISSUE ANALYSIS MARKET BY PRODUCT TYPE,
THROUGH 2017 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL CELL AND TISSUE ANALYSIS MARKET BY PRODUCT TYPE,
2010-2017 ($ MILLIONS) 6
CHAPTER 3 OVERVIEW 8
INTRODUCTION 8
CELLS 8
CELL TYPES 8
TABLE 1 DIFFERENCES BETWEEN PROKARYOTIC CELLS AND EUKARYOTIC CELLS 9
Plant and Animal Cell Characteristics 9
TABLE 2 PLANT AND ANIMAL CELL DIFFERENCES 9
TISSUE 10
Tissue Types 10
TABLE 3 TISSUE TYPES 10
ANTIBODIES 11
ANTIGENS 11
EPITOPES 11
APOPTOSIS 12
BIOMARKERS 12
BIOSPECIMENS 12
CLASSIFICATION OF TECHNIQUES USED IN CELL AND TISSUE ANALYSIS 12
TABLE 4 CELL AND TISSUE ANALYSIS CLASSIFICATION TECHNIQUES 13
BIOSPECIMEN TECHNIQUES 15
Microarray 15
Tissue Microarrays 15
DNA Microarray (DNA Chip and Biochip) 15
Protein Microarray 15
Peptide Microarray (Peptide Chip/Peptide Epitope Microarray) 15
Cellular Microarray 16
CELL-SEPARATION TECHNIQUES 16
Mechanical Dissociators 16
Enzymes Used for Cell Dissociation 16
Laser-Capture Micro-Dissection 17
Florescence-Activated Cell Sorting 18
FIGURE 1 SCHEMATIC REPRESENTATION OF A FLOW CYTOMETER 18
Magnetism-Activated Cell Sorting 19
FIGURE 2 SCHEMATIC REPRESENTATION OF THE QUADRUPOLE MAGNETIC SORTER 20
CELL AND TISSUE CHARACTERIZATION 21
Cell-Based Assays 21
Components for Cell-Based Assay Automation 22
Antibody-Based Assay 22
High-Content Screening 23
Immunoassay 24
CHAPTER 4 REGULATORY ISSUES 26
CODE OF FEDERAL REGULATIONS 26
CLASS I: GENERAL CONTROLS 26
CLASS II: GENERAL CONTROLS WITH SPECIAL CONTROLS 26
CLASS III: GENERAL CONTROLS AND PREMARKET APPROVAL 26
DRUG APPROVALS 27
TABLE 5 FDA-APPROVED CELL AND TISSUE ANALYSIS PRODUCTS, 2010-MAY 2012 27
RECALLS 28
TABLE 6 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2012 29
TABLE 7 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2011 29
TABLE 8 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2010 32
TABLE 9 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2009 34
CHAPTER 5 NEW DEVELOPMENTS 36
TABLE 10 CELL AND TISSUE ANALYSIS PRODUCTS IN THE PIPELINE 36
TABLE 11 NEW DEVELOPMENTS AND ADVANCEMENTS, 2012 38
TABLE 12 NEW DEVELOPMENTS AND ADVANCEMENTS, 2011 40
TABLE 13 NEW DEVELOPMENTS AND ADVANCEMENTS, 2010 40
CHAPTER 6 GLOBAL MARKETS 42
MARKETS BY TYPE 42
MARKET OVERVIEW 42
MARKET REVENUE 43
TABLE 14 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY TYPE, THROUGH
2017 ($ MILLIONS) 44
FIGURE 3 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 44
MARKET SHARE 44
TABLE 15 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY TYPE, 2011 (%) 45
FIGURE 4 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY TYPE, 2011 (%) 45
BIOSPECIMEN-PREPARING TECHNIQUES 45
MARKET OVERVIEW 46
MARKET REVENUE 47
TABLE 16 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET BY TYPE,
THROUGH 2017 ($ MILLIONS) 47
FIGURE 5 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET BY TYPE,
2010-2017 ($ MILLIONS) 47
CELL AND TISSUE SEPARATION PRODUCTS 48
MARKET OVERVIEW 48
MARKET REVENUE 49
TABLE 17 CELL AND TISSUE SEPARATION PRODUCT MARKET BY TYPE, THROUGH 2017 ($
MILLIONS) 50
FIGURE 6 CELL AND TISSUE SEPARATION PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 50
CELL AND TISSUE CHARACTERIZATION PRODUCTS 51
MARKET OVERVIEW 51
MARKET REVENUE 54
TABLE 18 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, THROUGH
2017 ($ MILLIONS) 54
FIGURE 7 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 54
MARKET BY REGION 55
TABLE 19 CELL AND TISSUE ANALYSIS PRODUCT MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 55
FIGURE 8 CELL AND TISSUE ANALYSIS PRODUCT MARKET BY REGION, 2010-2017 ($
MILLIONS) 56
MARKET SHARE 56
TABLE 20 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY REGION, 2011 (%) 56
FIGURE 9 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY REGION, 2011 (%) 56
BIOSPECIMEN-PREPARING TECHNIQUES 57
MARKET OVERVIEW 57
MARKET REVENUE 57
TABLE 21 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE MARKET BY REGION, THROUGH
2017 ($ MILLIONS) 58
North America 58
Europe 58
Emerging Markets 58
FIGURE 10 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET BY
REGION, 2010-2017 ($ MILLIONS) 59
MARKET SHARE 59
TABLE 22 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET SHARE BY REGION,
2011 (%) 59
FIGURE 11 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET SHARE BY REGION,
2011 (%) 59
CELL AND TISSUE SEPARATION PRODUCTS 60
MARKET OVERVIEW 60
MARKET REVENUE 60
TABLE 23 GLOBAL CELL AND TISSUE SEPARATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 60
North America 61
Europe 61
Emerging Markets 61
FIGURE 12 GLOBAL CELL AND TISSUE SEPARATION PRODUCT MARKET BY REGION,
2010-2017 ($ MILLIONS) 61
MARKET SHARE 62
TABLE 24 CELL AND TISSUE SEPARATION PRODUCT MARKET SHARE BY REGION, 2010 (%) 62
FIGURE 13 CELL AND TISSUE SEPARATION PRODUCT MARKET SHARE BY REGION, 2010 (%) 62
CELL AND TISSUE CHARACTERIZATION 63
MARKET OVERVIEW 63
MARKET REVENUE 63
TABLE 25 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 64
North America 64
Europe 64
Emerging Markets 64
FIGURE 14 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 65
MARKET SHARE 65
TABLE 26 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET SHARE BY
REGION, 2011 (%) 65
FIGURE 15 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET SHARE BY
REGION, 2011 (%) 65
MARKET BY END USERS 66
Market Overview 66
CELL AND TISSUE ANALYSIS 67
MARKET REVENUE 67
TABLE 27 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY END USER,
THROUGH 2017 ($ MILLIONS) 67
FIGURE 16 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END
USER, 2010-2017 ($ MILLIONS) 67
MARKET SHARE 68
TABLE 28 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY END USER, 2011 (%) 68
FIGURE 17 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY END USER, 2011 (%) 68
RESEARCH AND ACADEMICS 68
MARKET OVERVIEW 68
MARKET REVENUE 69
TABLE 29 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN RESEARCH AND
ACADEMICS BY REGION, THROUGH 2017 ($ MILLIONS) 70
FIGURE 18 CELL AND TISSUE ANALYSIS PRODUCTION CONSUMPTION IN RESEARCH AND
ACADEMICS BY REGION, 2010-2017 ($ MILLIONS) 70
MARKET SHARE 70
TABLE 30 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN RESEARCH AND
ACADEMICS BY REGION, 2011 (%) 71
FIGURE 19 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN RESEARCH AND
ACADEMICS BY REGION, 2011 (%) 71
BIOPHARMACEUTICALS 71
MARKET OVERVIEW 71
MARKET REVENUE 72
TABLE 31 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, THROUGH 2017 ($ MILLIONS) 73
FIGURE 20 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, 2010-2017 ($ MILLIONS) 73
MARKET SHARE 73
TABLE 22 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET SHARE BY REGION,
2011 (%) 74
FIGURE 21 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN
BIOPHARMACEUTICALS BY REGION, 2011 (%) 74
HEALTHCARE AND CLINICAL 74
MARKET OVERVIEW 74
MARKET REVENUE 75
TABLE 33 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, THROUGH 2017 ($ MILLIONS) 75
FIGURE 22 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, 2010-2017 ($ MILLIONS) 76
MARKET SHARE 76
TABLE 34 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, 2011 (%) 76
FIGURE 23 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, 2011 (%) 76
CHAPTER 7 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET ANALYSIS 79
MARKET BY TYPE 79
TABLE 35 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, THROUGH
2017 ($ MILLIONS) 80
FIGURE 24 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, 2010-2017
($ MILLIONS) 80
RESEARCH ANTIBODIES 80
MARKET OVERVIEW 81
MARKET REVENUE 81
TABLE 36 RESEARCH ANTIBODIES USED IN THE CELL AND TISSUE CHARACTERIZATION
MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 82
FIGURE 25 RESEARCH ANTIBODIES USED IN THE CELL AND TISSUE CHARACTERIZATION
MARKET BY REGION, 2010-2017 ($ MILLIONS) 82
HIGH-CONTENT SCREENING 83
MARKET OVERVIEW 83
MARKET REVENUE 84
TABLE 37 HIGH-CONTENT SCREENING PRODUCTS USED IN CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 85
FIGURE 26 HIGH-CONTENT SCREENING PRODUCTS USED IN CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, 2010-2017 ($ MILLIONS) 85
CELL-BASED ASSAYS 85
MARKET OVERVIEW 86
MARKET REVENUE 87
TABLE 38 CELL-BASED ASSAY PRODUCTS USED IN THE CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 87
FIGURE 27 CELL-BASED ASSAY PRODUCTS USED IN THE CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, 2010-2017 ($ MILLIONS) 88
MARKET BY REGION 88
TABLE 39 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 88
FIGURE 28 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
2010-2017 ($ MILLIONS) 89
North America 89
TABLE 40 NORTH AMERICAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, THROUGH 2017 ($ MILLIONS) 90
FIGURE 29 NORTH AMERICAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, 2010-2017 ($ MILLIONS) 90
Europe 90
TABLE 41 EUROPEAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE,
THROUGH 2017 ($ MILLIONS) 91
FIGURE 30 EUROPEAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE,
2010-2017 ($ MILLIONS) 91
Emerging Markets 91
TABLE 42 EMERGING MARKETS CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, THROUGH 2017 ($ MILLIONS) 92
FIGURE 31 EMERGING MARKETS CELL AND TISSUE CHARACTERIZATION PRODUCT
MARKET BY TYPE, 2010-2017 ($ MILLIONS) 92
MARKET BY END USERS 93
TABLE 43 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END USER,
THROUGH 2017 ($ MILLIONS) 93
FIGURE 32 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END USER,
2010-2017 ($ MILLIONS) 93
RESEARCH AND ACADEMIC 94
Market Overview 94
Market Revenue 94
TABLE 44 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN RESEARCH
AND ACADEMICS BY REGION, THROUGH 2017 ($ MILLIONS) 95
FIGURE 33 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN
RESEARCH AND ACADEMICS BY REGION, 2010-2017 ($ MILLIONS) 95
BIOPHARMACEUTICALS 95
TABLE 45 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, THROUGH 2017 ($ MILLIONS) 96
FIGURE 34 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, 2010- 2017 ($ MILLIONS) 96
HEALTHCARE AND CLINICAL 97
TABLE 46 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN THE
HEALTHCARE AND CLINICAL INDUSTRY BY REGION, THROUGH 2017 ($ MILLIONS) 98
FIGURE 35 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN THE
HEALTHCARE AND CLINICAL INDUSTRY BY REGION, 2010-2017 ($ MILLIONS) 98
INDUSTRY STRUCTURE 99
Market Leaders 99
TABLE 47 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET LEADERS 99
Market Share 100
TABLE 48 TISSUE CHARACTERIZATION PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 100
FIGURE 36 TISSUE CHARACTERIZATION PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 (%) 100
RESEARCH ANTIBODIES 101
Market Leaders 101
TABLE 49 RESEARCH ANTIBODIES MARKET LEADERS 101
Market Share 102
TABLE 50 RESEARCH ANTIBODY MANUFACTURERS AND DISTRIBUTORS BY MARKET
SHARE, 2011 (%) 103
FIGURE 37 RESEARCH ANTIBODY MANUFACTURERS AND DISTRIBUTORS BY MARKET
SHARE, 2011 (%) 104
HIGH-CONTENT SCREENING 104
Market Leaders 104
TABLE 51 HIGH-CONTENT SCREENING MARKET LEADERS 104
Market Share 105
TABLE 52 HIGH-CONTENT SCREENING PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 (%) 105
FIGURE 38 HIGH-CONTENT SCREENING PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 (%) 106
CELL-BASED ASSAYS 106
Market Leaders 106
TABLE 53 CELL-BASED ASSAY MARKET LEADERS 106
TABLE 54 CELL-BASED ASSAY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 107
FIGURE 39 CELL-BASED ASSAY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 107
CHAPTER 8 PATENT ANALYSIS 109
PATENTS BY YEAR 109
TABLE 55 CELL AND TISSUE ANALYSIS, 2008-2012 (NO. OF PATENTS) 109
FIGURE 40 CELL AND TISSUE ANALYSIS, 2008â??2012 (NO. OF PATENTS) 109
FIGURE 41 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY YEAR, 2008â??2012 (%) 110
PATENTS BY CATEGORY 111
TABLE 56 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY TYPE, 2008â??2012 111
FIGURE 42 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY TYPE, 2008-2012 112
PATENTS BY COMPANY 112
TABLE 57 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COMPANY,
2008â??2012 112
PATENTS BY COUNTRY 114
TABLE 58 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COUNTRY,
2008â??2012 114
FIGURE 43 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COUNTRY,
2008-2012 115
TABLE 59 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY COUNTRY,
2010â??2011 (%) 115
FIGURE 44 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY COUNTRY,
2010â??2011 (%) 116
PATENTS BY ASSIGNEE 116
TABLE 60 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY ASSIGNEE TYPE,
2008â??2012 117
FIGURE 45 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY ASSIGNEE TYPE,
2008â??2012 117
TABLE 61 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY ASSIGNEE TYPE,
2010â??2011 (NO./%) 118
FIGURE 46 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY ASSIGNEE TYPE,
2010â??2011 (%) 118
CHAPTER 9 CURRENT SITUATION 120
CELL AND TISSUE ANALYSIS TECHNIQUES AS DIAGNOSTIC TOOLS 120
CURRENT CHALLENGES FOR THE CLINICAL USE AND MARKETING OF
MICROARRAYS 121
FUTURE PERSPECTIVE 122
CHAPTER 10 COMPANY PROFILES 124
ABCAM, PLC. 124
ABNOVA 124
ACCURI CYTOMETERS INC. 124
AFFYMETRIX 125
ANALYTICAL BIOLOGICAL SERVICES INC. 125
ARRAYIT CORPORATION 125
BD BIOSCIENCES 126
BECKMAN COULTER INC. 126
CARL ZEISS MICROIMAGING GMBH 127
CLONTECH LABORATORIES 127
CYBRDI INC. 128
EBIOSCIENCE INC. 128
EUROGENTEC S.A. 128
GE HEALTHCARE 129
ILLUMINA INC. 129
INVITROGEN CORPORATION 130
LC SCIENCES 130
LEICA MICROSYSTMS 130
MDS ANALYTICAL TECHNOLOGIES 131
MEDIX BIOCHEMICA 131
MERCK SERONO SA 132
MILTENYI BIOTEC 132
MILLIPORE 132
PARTEC GMBH 133
PERKIN ELMER INC. 133
ROCHE APPLIED SCIENCE 134
SIGMA-ALDRICH INC. 134
SOUTHERN BIOTECH 134
STEM CELL TECHNOLOGIES 135
STRATIGIC DIAGNOSTICS 135
TGA SCIENCES 136
THERMO FISHER SCIENTIFIC 136
WORTHINGTON BIOCHEMICAL CORPORATION 137
CHAPTER 11 APPENDIX: ABBREVIATIONS 139

LIST OF TABLES
SUMMARY TABLE GLOBAL CELL AND TISSUE ANALYSIS MARKET BY PRODUCT TYPE,
THROUGH 2017 ($ MILLIONS) 6
TABLE 1 DIFFERENCES BETWEEN PROKARYOTIC CELLS AND EUKARYOTIC CELLS 9
TABLE 2 PLANT AND ANIMAL CELL DIFFERENCES 9
TABLE 3 TISSUE TYPES 10
TABLE 4 CELL AND TISSUE ANALYSIS CLASSIFICATION TECHNIQUES 13
TABLE 5 FDA-APPROVED CELL AND TISSUE ANALYSIS PRODUCTS, 2010-MAY 2012 27
TABLE 6 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2012 29
TABLE 7 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2011 29
TABLE 8 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2010 32
TABLE 9 FDA PRODUCT RECALLS FOR CELL AND TISSUE ANALYSIS PRODUCTS, 2009 34
TABLE 10 CELL AND TISSUE ANALYSIS PRODUCTS IN THE PIPELINE 36
TABLE 11 NEW DEVELOPMENTS AND ADVANCEMENTS, 2012 38
TABLE 12 NEW DEVELOPMENTS AND ADVANCEMENTS, 2011 40
TABLE 13 NEW DEVELOPMENTS AND ADVANCEMENTS, 2010 40
TABLE 14 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY TYPE, THROUGH 2017
($ MILLIONS) 44
TABLE 15 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY TYPE, 2011 (%) 45
TABLE 16 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET BY TYPE,
THROUGH 2017 ($ MILLIONS) 47
TABLE 17 CELL AND TISSUE SEPARATION PRODUCT MARKET BY TYPE, THROUGH 2017 ($
MILLIONS) 50
TABLE 18 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, THROUGH
2017 ($ MILLIONS) 54
TABLE 19 CELL AND TISSUE ANALYSIS PRODUCT MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 55
TABLE 20 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY REGION, 2011 (%) 56
TABLE 21 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE MARKET BY REGION, THROUGH
2017 ($ MILLIONS) 58
TABLE 22 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET SHARE BY REGION,
2011 (%) 59
TABLE 23 GLOBAL CELL AND TISSUE SEPARATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 60
TABLE 24 CELL AND TISSUE SEPARATION PRODUCT MARKET SHARE BY REGION, 2010 (%) 62
TABLE 25 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 64
TABLE 26 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET SHARE BY
REGION, 2011 (%) 65
TABLE 27 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY END USER, THROUGH
2017 ($ MILLIONS) 67
TABLE 28 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY END USER, 2011 (%) 68
TABLE 29 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN RESEARCH AND
ACADEMICS BY REGION, THROUGH 2017 ($ MILLIONS) 70
TABLE 30 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN RESEARCH AND
ACADEMICS BY REGION, 2011 (%) 71
TABLE 31 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN BIOPHARMACEUTICALS
BY REGION, THROUGH 2017 ($ MILLIONS) 73
TABLE 22 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET SHARE BY REGION,
TABLE 33 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN THE HEALTHCARE AND
CLINICAL INDUSTRY BY REGION, THROUGH 2017 ($ MILLIONS) 75
TABLE 34 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN THE HEALTHCARE AND
CLINICAL INDUSTRY BY REGION, 2011 (%) 76
TABLE 35 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, THROUGH
2017 ($ MILLIONS) 80
TABLE 36 RESEARCH ANTIBODIES USED IN THE CELL AND TISSUE CHARACTERIZATION
MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 82
TABLE 37 HIGH-CONTENT SCREENING PRODUCTS USED IN CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 85
TABLE 38 CELL-BASED ASSAY PRODUCTS USED IN THE CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 87
TABLE 39 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION, THROUGH
2017 ($ MILLIONS) 88
TABLE 40 NORTH AMERICAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY
TYPE, THROUGH 2017 ($ MILLIONS) 90
TABLE 41 EUROPEAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE,
THROUGH 2017 ($ MILLIONS) 91
TABLE 42 EMERGING MARKETS CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, THROUGH 2017 ($ MILLIONS) 92
TABLE 43 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END USER,
THROUGH 2017 ($ MILLIONS) 93
TABLE 44 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN RESEARCH
AND ACADEMICS BY REGION, THROUGH 2017 ($ MILLIONS) 95
TABLE 45 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, THROUGH 2017 ($ MILLIONS) 96
TABLE 46 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN THE
HEALTHCARE AND CLINICAL INDUSTRY BY REGION, THROUGH 2017 ($ MILLIONS) 98
TABLE 47 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET LEADERS 99
TABLE 48 TISSUE CHARACTERIZATION PRODUCT MANUFACTURERS AND DISTRIBUTORS BY
MARKET SHARE, 2011 100
TABLE 49 RESEARCH ANTIBODIES MARKET LEADERS 101
TABLE 50 RESEARCH ANTIBODY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 103
TABLE 51 HIGH-CONTENT SCREENING MARKET LEADERS 104
TABLE 52 HIGH-CONTENT SCREENING PRODUCT MANUFACTURERS AND DISTRIBUTORS BY
MARKET SHARE, 2011 (%) 105
TABLE 53 CELL-BASED ASSAY MARKET LEADERS 106
TABLE 54 CELL-BASED ASSAY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 107
TABLE 55 CELL AND TISSUE ANALYSIS, 2008-2012 (NO. OF PATENTS) 109
TABLE 56 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY TYPE, 2008â??2012 111
TABLE 57 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COMPANY,
2008â??2012 112
TABLE 58 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COUNTRY,
2008â??2012 114
TABLE 59 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY COUNTRY,
2010â??2011 (%) 115
TABLE 60 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY ASSIGNEE TYPE, 2008â??2012 117
TABLE 61 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY ASSIGNEE TYPE,
2010â??2011 (NO./%) 118

LIST OF FIGURES
SUMMARY FIGURE GLOBAL CELL AND TISSUE ANALYSIS MARKET BY PRODUCT TYPE,
2010-2017 ($ MILLIONS) 6
FIGURE 1 SCHEMATIC REPRESENTATION OF A FLOW CYTOMETER 18
FIGURE 2 SCHEMATIC REPRESENTATION OF THE QUADRUPOLE MAGNETIC SORTER 20
FIGURE 3 GLOBAL CELL AND TISSUE ANALYSIS PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 44
FIGURE 4 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY TYPE, 2011 (%) 45
FIGURE 5 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET BY TYPE,
2010-2017 ($ MILLIONS) 47
FIGURE 6 CELL AND TISSUE SEPARATION PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 50
FIGURE 7 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 54
FIGURE 8 CELL AND TISSUE ANALYSIS PRODUCT MARKET BY REGION, 2010-2017 ($
MILLIONS) 56
FIGURE 9 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY REGION, 2011 (%) 56
FIGURE 10 GLOBAL BIOSPECIMEN-PREPARING TECHNIQUE PRODUCTS MARKET BY REGION,
2010-2017 ($ MILLIONS) 59
FIGURE 11 BIOSPECIMEN-PREPARING TECHNIQUE PRODUCT MARKET SHARE BY REGION,
2011 (%) 59
FIGURE 12 GLOBAL CELL AND TISSUE SEPARATION PRODUCT MARKET BY REGION,
2010-2017 ($ MILLIONS) 61
FIGURE 13 CELL AND TISSUE SEPARATION PRODUCT MARKET SHARE BY REGION, 2010 (%) 62
FIGURE 14 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
THROUGH 2017 ($ MILLIONS) 65
FIGURE 15 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET SHARE BY
REGION, 2011 (%) 65
FIGURE 16 GLOBAL CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END
USER, 2010-2017 ($ MILLIONS) 67
FIGURE 17 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE BY END USER, 2011 (%) 68
FIGURE 18 CELL AND TISSUE ANALYSIS PRODUCTION CONSUMPTION IN RESEARCH AND
ACADEMICS BY REGION, 2010-2017 ($ MILLIONS) 70
FIGURE 19 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN RESEARCH AND
ACADEMICS BY REGION, 2011 (%) 71
FIGURE 20 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, 2010-2017 ($ MILLIONS) 73
FIGURE 21 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN
BIOPHARMACEUTICALS BY REGION, 2011 (%) 74
FIGURE 22 CELL AND TISSUE ANALYSIS PRODUCT CONSUMPTION IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, 2010-2017 ($ MILLIONS) 76
FIGURE 23 CELL AND TISSUE ANALYSIS PRODUCT MARKET SHARE IN THE HEALTHCARE
AND CLINICAL INDUSTRY BY REGION, 2011 (%) 76
FIGURE 24 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE, 2010-2017 ($
MILLIONS) 80
FIGURE 25 RESEARCH ANTIBODIES USED IN THE CELL AND TISSUE CHARACTERIZATION
MARKET BY REGION, 2010-2017 ($ MILLIONS) 82
FIGURE 26 HIGH-CONTENT SCREENING PRODUCTS USED IN CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, 2010-2017 ($ MILLIONS) 85
FIGURE 27 CELL-BASED ASSAY PRODUCTS USED IN THE CELL AND TISSUE
CHARACTERIZATION MARKET BY REGION, 2010-2017 ($ MILLIONS) 88
FIGURE 28 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY REGION,
2010-2017 ($ MILLIONS) 89
FIGURE 29 NORTH AMERICAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, 2010-2017 ($ MILLIONS) 90
FIGURE 30 EUROPEAN CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY TYPE,
2010-2017 ($ MILLIONS) 91
FIGURE 31 EMERGING MARKETS CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET
BY TYPE, 2010-2017 ($ MILLIONS) 92
FIGURE 32 CELL AND TISSUE CHARACTERIZATION PRODUCT MARKET BY END USER,
2010-2017 ($ MILLIONS) 93
FIGURE 33 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN RESEARCH
AND ACADEMICS BY REGION, 2010-2017 ($ MILLIONS) 95
FIGURE 34 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN
BIOPHARMACEUTICALS BY REGION, 2010- 2017 ($ MILLIONS) 96
FIGURE 35 CELL AND TISSUE CHARACTERIZATION PRODUCT CONSUMPTION IN THE
HEALTHCARE AND CLINICAL INDUSTRY BY REGION, 2010-2017 ($ MILLIONS) 98
FIGURE 36 TISSUE CHARACTERIZATION PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 (%) 100
FIGURE 37 RESEARCH ANTIBODY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 104
FIGURE 38 HIGH-CONTENT SCREENING PRODUCT MANUFACTURERS AND DISTRIBUTORS
BY MARKET SHARE, 2011 (%) 106
FIGURE 39 CELL-BASED ASSAY MANUFACTURERS AND DISTRIBUTORS BY MARKET SHARE,
2011 (%) 107
FIGURE 40 CELL AND TISSUE ANALYSIS, 2008â??2012 (NO. OF PATENTS) 109
FIGURE 41 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY YEAR, 2008â??2012 (%) 110
FIGURE 42 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY TYPE, 2008-2012 112
FIGURE 43 U.S. PATENTS FOR CELL AND TISSUE ANALYSIS PRODUCTS BY COUNTRY,
2008-2012 115
FIGURE 44 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY COUNTRY,
2010â??2011 (%) 116
FIGURE 45 CELL AND TISSUE ANALYSIS PRODUCT PATENTS BY ASSIGNEE TYPE,
2008â??2012 117
FIGURE 46 CELL AND TISSUE ANALYSIS PRODUCT PATENT SHARES BY ASSIGNEE TYPE,
2010â??2011 (%) 118

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