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INTRODUCTION

STUDY OBJECTIVES

BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global market for medical imaging technologies, which includes both the imaging systems and the contrast agents. The key objective is to present a comprehensive analysis and future direction of imaging techniques as an important tool for the usage in medical diagnostic procedures.

This report explores present and future strategies within the medical imaging technology market, which includes X-ray imaging, ultrasound, computed tomography, magnetic resonance imaging and positron emission tomography. The improvisation of the market as well as the setbacks and needs of the market are discussed in this report. The classifications, comparisons, advantages and disadvantages and usage of these types of diagnostic methods are also listed in this report.

A detailed analysis of medical imaging industry structure has been conducted. Revenues are broken down by the region and sales figures are estimated for the five-year period from 2011 through 2017.

Applications for medical imaging technologies are also discussed separately in the report, with an emphasis of the usage of the inhibitors in therapeutic categories and various disease sectors. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

Extensive research and new developments in the field of medical imaging technology has improved their usage in being able to be used as a prime diagnostic tool for various diseases and other medical conditions. Modern industries continue to explore the advantages of medical imaging technologies, leading to the steady market growth due to higher production of the imaging systems. This study is an update to the one published in January 2010.

R&D spending, along with increasing competition, new technologies, new advancements and new product launches have influenced the market to grow in the foreseeable future. This study looks at many of the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each type/ technology in light of new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE

This study contributes to the areas of market growth in medical imaging (imaging systems and contrast agents) product manufacturers and users. Pharmaceutical, biotechnical companies, research institutes, hospitals and physicians will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses imaging technology in the field of medicine. BCC analyzes each imaging market and its applications, regulatory environment, technology, market projections and market shares. Technological issues include the latest trends and developments. The emerging market for enzyme inhibitors includes countries such as India, China, Japan, Korea, Taiwan, Canada, Africa, Australia and New Zealand, among others.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with manufacturers of imaging systems and contrast agents technical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies were surveyed to obtain data for this study. Included were manufacturers and end users of medical imaging technologies in various types of disease sectors industries. Data were gathered from various industry sources. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

A team of professionals in the biotechnology industry carried out this study. The project manager is Shalini S. Dewan, who holds a master’s degree in pharmaceutical chemistry and has over 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy: An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit.

Table Of Contents

Global Markets for Medical Imaging Reagents and Analysis Equipment -- Focus on X-Ray and Computed Tomography
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 1
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 2
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 3
CHAPTER 2 SUMMARY 5
SUMMARY TABLE GLOBAL REVENUE OF MEDICAL IMAGING MARKET, THROUGH 2017 ($
MILLIONS) 6
SUMMARY FIGURE GLOBAL REVENUE OF MEDICAL IMAGING MARKET, 2010-2017 ($
MILLIONS) 6
CHAPTER 3 OVERVIEW 8
DEFINITIONS 8
TYPES OF MEDICAL IMAGING 8
X-RAY IMAGING 8
History and Development of X-ray Imaging 9
TABLE 1 HISTORY AND DEVELOPMENT OF X-RAY IMAGING 9
Properties of X-ray 10
Applications of X-ray in Medicine 10
Advantages and Disadvantages of X-ray 11
TABLE 2 ADVANTAGES AND DISADVANTAGES OF X-RAY 11
ULTRASOUND 11
History and Development of Ultrasound 12
TABLE 3 HISTORY AND DEVELOPMENT OF ULTRASOUND 12
Diagnostic Applications of Ultrasound 13
Therapeutic Applications of Ultrasound 13
Advantages and Disadvantages of Ultrasound 14
TABLE 4 ADVANTAGES AND DISADVANTAGES OF ULTRASOUND 14
MAGNETIC RESONANCE IMAGING 14
History and Development of Magnetic Resonance Imaging 15
TABLE 5 HISTORY AND DEVELOPMENT OF MRI 15
Applications of Magnetic Resonance Imaging 15
Advantages and Disadvantages of MRI 16
TABLE 6 ADVANTAGES AND DISADVANTAGES OF MRI 16
COMPUTED TOMOGRAPHY 16
Applications of Computed Tomography 17
Advantages and Disadvantages of Computed Tomography 18
TABLE 7 ADVANTAGES AND DISADVANTAGES OF COMPUTED TOMOGRAPHY 18
POSITRON EMISSION TOMOGRAPHY 18
History and Development of Positron Emission Technology 19
TABLE 8 HISTORY AND DEVELOPMENT OF POSITRON EMISSION TECHNOLOGY 19
Advantages and Disadvantages of PET 20
TABLE 9 ADVANTAGES AND DISADVANTAGES OF PET 20
COMPARISON OF VARIOUS IMAGING MODALITIES 21
TABLE 10 DIFFERENCES BETWEEN CT AND MRI 21
TABLE 11 DIFFERENCES BETWEEN CT AND ULTRASOUND 22
TABLE 12 DIFFERENCES BETWEEN CT AND PET 22
TABLE 13 DIFFERENCES BETWEEN MRI AND X-RAY 23
CONTRAST AGENTS 23
PROPERTIES OF AN IDEAL CONTRAST AGENT 23
UNDESIRABLE EFFECTS OF CONTRAST AGENTS 23
Allergic Reactions 23
Acute Renal Failure 24
Aspiration 24
Pulmonary Edema 24
Seizure 24
CLASSIFICATION OF CONTRAST AGENTS BASED ON THEIR PROPERTIES 24
Positive Contrast Agents 24
Negative Contrast Agents 24
CLASSIFICATION OF CONTRAST AGENTS BASED ON THE TYPE OF IMAGING
TECHNIQUE 25
Contrast Agents for X-ray 25
TABLE 14 ADVANTAGES AND DISADVANTAGES OF BARIUM AS CONTRAST MEDIUM 25
Contrast Agents for Magnetic Resonance Imaging 26
Nonspecific Extracellular Agents 26
TABLE 15 NONSPECIFIC EXTRACELLULAR CONTRAST AGENTS 26
Tissue-Specific Contrast Agents 27
TABLE 16 LIVER-SPECIFIC CONTRAST AGENTS 27
Contrast Agents for Ultrasound 27
PET Radiopharmaceuticals 28
TABLE 17 COMMONLY USED RADIOPHARMACEUTICALS 28
IMAGING EQUIPMENT 29
X-RAY IMAGING SYSTEM 29
FLUOROSCOPY EQUIPMENT 30
COMPUTED TOMOGRAPHY SCANNER 30
Types of Computed Tomography Scanning 30
Advances in CT Scanners /Types of CT Scanners 30
ULTRASOUND MACHINES 31
MAGNETIC RESONANCE IMAGING SYSTEM 32
POSITRON EMISSION TOMOGRAPHY EQUIPMENT 33
CHAPTER 4 REGULATORY ISSUES 35
APPROVALS IN THE FIELD OF MEDICAL IMAGING 35
NEW APPROVALS 35
TABLE 18 NEW APPROVAL OF IMAGING SYSTEMS, 2008-AUGUST 2012 35
510(K) APPROVALS 36
TABLE 19 510(K) APPROVALS FOR ULTRASOUND SYSTEMS, 2008-AUGUST 2012 36
TABLE 20 510(K) APPROVALS FOR MRI SYSTEMS, 2008-AUGUST 2012 42
TABLE 21 510(K) APPROVALS FOR X-RAY/CT SYSTEMS, 2008-AUGUST 2012 43
TABLE 22 510(K) APPROVALS FOR PET SYSTEMS, 2008-AUGUST 2012 46
RECALLS 46
TABLE 23 RECALLS FOR MAGNETIC RESONANCE IMAGING SYSTEMS 46
TABLE 24 RECALLS FOR X-RAY AND COMPUTED TOMOGRAPHY SYSTEMS,
2008—SEPTEMBER 2012 48
TABLE 25 RECALLS FOR ULTRASOUND SYSTEMS, 2008-SEPTEMBER 2012 52
TABLE 26 RECALLS FOR PET SYSTEMS, 2008—SEPTEMBER 2012 56
APPROVALS FOR CONTRAST AGENTS 57
TABLE 27 APPROVAL OF CONTRAST AGENTS 58
SAFETY ALERTS 59
TABLE 28 SAFETY ALERTS FOR CONTRAST AGENTS, 2008—SEPTEMBER 2012 59
CHAPTER 5 NEW DEVELOPMENTS/ TECHNOLOGICAL INNOVATIONS 62
TABLE 29 NEW DEVELOPMENTS IN CONTRAST AGENTS 62
TABLE 30 NEW DEVELOPMENTS IN COMPUTED TOMOGRAPHY 62
TABLE 31 NEW DEVELOPMENTS IN MAGNETIC RESONANCE IMAGING 63
TABLE 32 NEW DEVELOPMENTS IN POSITRON EMISSION TOMOGRAPHY 63
TABLE 33 NEW DEVELOPMENTS IN ULTRASOUND 64
TABLE 34 NEW DEVELOPMENTS IN RADIOGRAPHY (X-RAY, MAMMOGRAPHY AND
FLUOROSCOPY) 66
CHAPTER 6 GLOBAL MARKET ANALYSIS FOR IMAGING TECHNOLOGIES 68
MARKET FOR CONTRAST AGENTS BY IMAGING TECHNOLOGY 69
MARKET OVERVIEW 69
MARKET REVENUE 71
TABLE 35 GLOBAL MARKET FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY,
THROUGH 2017 ($ MILLIONS) 71
FIGURE 1 GLOBAL MARKET FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY,
2010-2017 ($ MILLIONS) 71
MARKET SHARE 72
TABLE 36 GLOBAL MARKET SHARES FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY
2011 (%) 72
FIGURE 2 GLOBAL MARKET SHARES FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY,
2011 (%) 72
MARKET FOR IMAGING SYSTEMS BY IMAGING TECHNOLOGY 73
MARKET OVERVIEW 73
MARKET REVENUE 76
TABLE 37 GLOBAL MARKET FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, THROUGH
2017 ($ MILLIONS) 77
FIGURE 3 GLOBAL MARKET FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2010-2017
($ MILLIONS) 77
MARKET SHARE 77
TABLE 38 MARKET SHARE FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2011 (%) 78
FIGURE 4 MARKET SHARE FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2011 (%) 78
GLOBAL MARKET FOR CONTRAST AGENTS BY REGION 78
MARKET OVERVIEW 79
MARKET REVENUE 81
TABLE 39 GLOBAL MARKET FOR CONTRAST AGENTS, BY REGION, THROUGH 2017 ($
MILLIONS) 81
FIGURE 5 GLOBAL MARKET FOR CONTRAST AGENTS, BY REGION, 2010-2017 ($ MILLIONS) 81
MARKET SHARE 82
TABLE 40 GLOBAL MARKET SHARE FOR CONTRAST AGENTS, BY REGION, 2011 (%) 82
FIGURE 6 GLOBAL MARKET SHARE FOR CONTRAST AGENTS, BY REGION, 2011 (%) 82
MARKET FOR IMAGING SYSTEMS BY REGION 82
MARKET OVERVIEW 83
MARKET REVENUE 85
TABLE 41 GLOBAL MARKET FOR IMAGING SYSTEMS, BY REGION, THROUGH 2017 ($
MILLIONS) 86
FIGURE 7 GLOBAL MARKET FOR IMAGING SYSTEMS, BY REGION, 2010-2017 ($ MILLIONS) 86
MARKET SHARE 86
TABLE 42 GLOBAL MARKET SHARES FOR IMAGING SYSTEMS, BY REGION, 2011 (%) 87
FIGURE 8 GLOBAL MARKET SHARE FOR IMAGING SYSTEMS BY REGION, 2011 (%) 87
MARKET BY APPLICATIONS 87
TABLE 43 GLOBAL REVENUE FOR IMAGING CONTRAST AGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 92
FIGURE 9 GLOBAL REVENUE FOR IMAGING CONTRAST AGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, 2010-2017 ($ MILLIONS) 92
MARKET SHARE 93
TABLE 44 GLOBAL REVENUE MARKET SHARE FOR IMAGING CONTRAST AGENTS AND
SYSTEMS USED FOR VARIOUS DISEASES, 2011 (%) 94
FIGURE 10 GLOBAL REVENUE MARKET SHARE FOR IMAGING CONTRAST AGENTS AND
SYSTEMS USED FOR VARIOUS DISEASES, 2011 (%) 94
CHAPTER 7 MARKET ANALYSIS FOR X-RAYS AND COMPUTED TOMOGRAPHY 96
MARKET FOR CONTRAST AGENTS BY REGION 96
MARKET OVERVIEW 96
MARKET REVENUE 97
TABLE 45 GLOBAL MARKET FOR X-RAY AND CT AGENTS BY REGION, THROUGH 2017 ($
MILLIONS) 98
FIGURE 11 GLOBAL MARKET FOR X-RAY AND CT AGENTS BY REGION, 2010-2017 ($
MILLIONS) 98
MARKET SHARE 98
TABLE 46 MARKET SHARE OF X-RAY AND CT REAGENTS BY REGION, 2011 (%) 99
FIGURE 12 MARKET SHARE OF X-RAY AND CT REAGENTS BY REGION, 2011 (%) 99
MARKET BY TYPE OF IMAGING SYSTEMS 99
MARKET OVERVIEW 99
MARKET REVENUE 100
TABLE 47 GLOBAL MARKET FOR IMAGING SYSTEMS, BY TYPE, THROUGH 2017 ($ MILLIONS) 100
FIGURE 13 GLOBAL MARKET FOR IMAGING SYSTEMS, BY TYPE, THROUGH 2017 ($
MILLIONS) 100
MARKET SHARE 101
TABLE 48 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 101
FIGURE 14 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 101
MARKET FOR X-RAY IMAGING SYSTEMS BY REGION 102
MARKET OVERVIEW 102
MARKET REVENUE 103
TABLE 49 GLOBAL MARKET FOR X-RAY SYSTEMS BY REGION, THROUGH 2017 ($ MILLIONS) 104
FIGURE 15 GLOBAL MARKET FOR X-RAY SYSTEMS BY REGION, 2010-2017 ($ MILLIONS) 104
MARKET SHARE 104
TABLE 50 MARKET SHARE OF X-RAY SYSTEMS BY REGION, 2011 (%) 105
FIGURE 16 MARKET SHARE OF X-RAY SYSTEMS BY REGION, 2011 (%) 105
MARKET FOR CT IMAGING SYSTEMS BY REGION 105
MARKET OVERVIEW 106
MARKET REVENUE 107
TABLE 51 GLOBAL MARKET FOR COMPUTED TOMOGRAPHY SYSTEMS BY REGION,
THROUGH 2017 ($ MILLIONS) 107
FIGURE 17 GLOBAL MARKET FOR COMPUTED TOMOGRAPHY SYSTEMS BY REGION,
2010-2017 ($ MILLIONS) 107
MARKET SHARE 108
TABLE 52 MARKET SHARE OF COMPUTED TOMOGRAPHY SYSTEMS BY REGION, 2011 (%) 108
FIGURE 18 MARKET SHARE OF COMPUTED TOMOGRAPHY SYSTEMS BY REGION, 2011 (%) 109
MARKET BY APPLICATIONS 109
TABLE 53 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 109
FIGURE 19 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, 2010-2017 ($ MILLIONS) 109
X-RAY 110
TABLE 54 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 112
FIGURE 20 GLOBAL REVENUE FOR X-RAY REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, 2010-2017 ($ MILLIONS) 112
Market Share 113
TABLE 55 X-RAY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 113
FIGURE 21 X-RAY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 113
COMPUTED TOMOGRAPHY 113
TABLE 56 GLOBAL REVENUE FOR CT REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, THROUGH 2017 ($ MILLIONS) 115
FIGURE 22 GLOBAL REVENUE FOR CT REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, 2010-2017 ($ MILLIONS) 115
Market Share 116
TABLE 57 COMPUTED TOMOGRAPHY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 116
FIGURE 23 COMPUTED TOMOGRAPHY IMAGING MARKET SHARES, BY APPLICATION, 2011
(%) 116
INDUSTRY STRUCTURE 117
X-RAY AND COMPUTED TOMOGRAPHY CONTRAST AGENTS 117
Market Leaders 117
TABLE 58 LEADING MANUFACTURERS OF X-RAY AND COMPUTED TOMOGRAPHY
CONTRAST AGENTS 117
Market Shares 117
TABLE 59 GLOBAL MARKET SHARES OF X-RAY AND COMPUTED TOMOGRAPHY CONTRAST
AGENTS, 2011 (%) 118
FIGURE 24 GLOBAL MARKET SHARES OF X-RAY AND COMPUTED TOMOGRAPHY CONTRAST
AGENTS, 2011 (%) 118
X-RAY IMAGING SYSTEMS 118
Market Leaders 118
TABLE 60 LEADING MANUFACTURERS OF RADIOGRAPHY (X-RAY, FLUOROSCOPY AND
MAMMOGRAPHY) IMAGING SYSTEMS 119
Market Shares 122
TABLE 61 GLOBAL MARKET SHARES OF X-RAY IMAGING SYSTEMS, 2011 (%) 122
FIGURE 25 GLOBAL MARKET SHARES OF X-RAY IMAGING SYSTEMS, 2011 (%) 122
COMPUTED TOMOGRAPHY SYSTEMS 123
Market Leaders 123
TABLE 62 LEADING MANUFACTURERS OF COMPUTED TOMOGRAPHY SYSTEMS 123
Market Shares 124
TABLE 63 WORLDWIDE MARKET SHARES OF COMPUTED TOMOGRAPHY SYSTEMS, 2011 (%) 124
FIGURE 26 WORLDWIDE MARKET SHARES OF COMPUTED TOMOGRAPHY SYSTEMS, 2011 (%) 124
CHAPTER 8 PATENT ANALYSIS 126
CONTRAST AGENTS 126
BY YEAR 126
TABLE 64 TOTAL NUMBER OF PATENTS FOR CONTRAST AGENTS, FROM 2008-JULY 2012 126
BY IMAGING MODALITY 126
TABLE 65 NUMBER OF PATENTS FOR CONTRAST AGENTS BY IMAGING MODALITY, FROM
2008-JULY 2012 127
BY COMPANY 127
TABLE 66 NUMBER OF PATENTS BY COMPANY FROM 2008-JULY 2012 127
BY COUNTRY 127
TABLE 67 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 128
BY ASSIGNEE 128
TABLE 68 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 128
IMAGING SYSTEMS 128
BY YEAR 128
TABLE 69 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012 129
FIGURE 27 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012 129
FIGURE 28 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012
(%) 129
BY IMAGING MODALITY 130
TABLE 70 NUMBER OF PATENTS BY IMAGING MODALITY FROM JANUARY 2008-JULY 2012 130
FIGURE 29 NUMBER OF PATENTS BY IMAGING MODALITY FROM JANUARY 2008-JULY 2012 130
BY COMPANY 130
TABLE 71 NUMBER OF PATENTS BY COMPANY FROM 2008-JULY 2012 131
BY COUNTRY 132
TABLE 72 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 133
FIGURE 30 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 133
BY ASSIGNEE 134
TABLE 73 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 134
FIGURE 31 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 134
CHAPTER 9 DEMAND AND USE 136
CONTRAST AGENTS MARKET 136
REGULATORY ISSUES 136
BABY BOOMER GENERATION 136
INCREASING INCIDENCE OF LIFE-THREATENING DISEASES 136
COMPETITION 137
TECHNOLOGICAL ADVANCEMENTS 137
SETBACKS IN INDUSTRY 137
TRENDS IN THE IMAGING SYSTEMS MARKET 137
CHAPTER 10 COMPANY PROFILES 141
AMAG PHARMACEUTICALS INC. 141
ANALOGIC CORPORATION 141
BAYER HEALTHCARE PHARMACEUTICALS 142
BRACCO IMAGING SPA 142
COVIDIEN 142
ECHOSON SA (PL) 143
ESAOTE S.P.A 143
FONAR CORPORATION 144
GE HEALTHCARE 144
GUERBET LLC 145
HITACHI MEDICAL CORPORATION 145
HOLOGIC INC 146
LANTHEUS MEDICAL IMAGING 146
MILLENIUM TECHNOLOGIES LTD. 146
NORDION 147
PARADIGM MEDICAL INDUSTRIES INC. 147
PARAMED MEDICAL SYSTEMS INC. 148
PHILIPS HEALTHCARE 148
POSITRON CORPORATION 148
SAMSUNG MEDISON AMERICA INC 149
SHIMADZU CORPORATION 149
SIEMENS AG 150
SONOSITE INC 150
TELEMED LTD. 151
TERASON ULTRASOUND 151
TIME MEDICAL INC. 152
TOMTEC IMAGING SYSTEMS 152
TOSHIBA MEDICAL SYSTEMS CORPORATIONS 153
TRIAD ISOTOPES INC. 153
ULTRASONIX MEDICAL CORP. 153
VOLCANO CORPORATION 154
ZONARE MEDICAL SYSTEMS INC. 154
CHAPTER 11 APPENDIX I-ABBREVIATIONS 157

LIST OF TABLES
SUMMARY TABLE GLOBAL REVENUE OF MEDICAL IMAGING MARKET, THROUGH 2017 ($
MILLIONS) 6
TABLE 1 HISTORY AND DEVELOPMENT OF X-RAY IMAGING 9
TABLE 2 ADVANTAGES AND DISADVANTAGES OF X-RAY 11
TABLE 3 HISTORY AND DEVELOPMENT OF ULTRASOUND 12
TABLE 4 ADVANTAGES AND DISADVANTAGES OF ULTRASOUND 14
TABLE 5 HISTORY AND DEVELOPMENT OF MRI 15
TABLE 6 ADVANTAGES AND DISADVANTAGES OF MRI 16
TABLE 7 ADVANTAGES AND DISADVANTAGES OF COMPUTED TOMOGRAPHY 18
TABLE 8 HISTORY AND DEVELOPMENT OF POSITRON EMISSION TECHNOLOGY 19
TABLE 9 ADVANTAGES AND DISADVANTAGES OF PET 20
TABLE 10 DIFFERENCES BETWEEN CT AND MRI 21
TABLE 11 DIFFERENCES BETWEEN CT AND ULTRASOUND 22
TABLE 12 DIFFERENCES BETWEEN CT AND PET 22
TABLE 13 DIFFERENCES BETWEEN MRI AND X-RAY 23
TABLE 14 ADVANTAGES AND DISADVANTAGES OF BARIUM AS CONTRAST MEDIUM 25
TABLE 15 NONSPECIFIC EXTRACELLULAR CONTRAST AGENTS 26
TABLE 16 LIVER-SPECIFIC CONTRAST AGENTS 27
TABLE 17 COMMONLY USED RADIOPHARMACEUTICALS 28
TABLE 18 NEW APPROVAL OF IMAGING SYSTEMS, 2008-AUGUST 2012 35
TABLE 19 510(K) APPROVALS FOR ULTRASOUND SYSTEMS, 2008-AUGUST 2012 36
TABLE 20 510(K) APPROVALS FOR MRI SYSTEMS, 2008-AUGUST 2012 42
TABLE 21 510(K) APPROVALS FOR X-RAY/CT SYSTEMS, 2008-AUGUST 2012 43
TABLE 22 510(K) APPROVALS FOR PET SYSTEMS, 2008-AUGUST 2012 46
TABLE 23 RECALLS FOR MAGNETIC RESONANCE IMAGING SYSTEMS 46
TABLE 24 RECALLS FOR X-RAY AND COMPUTED TOMOGRAPHY SYSTEMS, 2008—SEPTEMBER
2012 48
TABLE 25 RECALLS FOR ULTRASOUND SYSTEMS, 2008-SEPTEMBER 2012 52
TABLE 26 RECALLS FOR PET SYSTEMS, 2008—SEPTEMBER 2012 56
TABLE 27 APPROVAL OF CONTRAST AGENTS 58
TABLE 28 SAFETY ALERTS FOR CONTRAST AGENTS, 2008—SEPTEMBER 2012 59
TABLE 29 NEW DEVELOPMENTS IN CONTRAST AGENTS 62
TABLE 30 NEW DEVELOPMENTS IN COMPUTED TOMOGRAPHY 62
TABLE 31 NEW DEVELOPMENTS IN MAGNETIC RESONANCE IMAGING 63
TABLE 32 NEW DEVELOPMENTS IN POSITRON EMISSION TOMOGRAPHY 63
TABLE 33 NEW DEVELOPMENTS IN ULTRASOUND 64
TABLE 34 NEW DEVELOPMENTS IN RADIOGRAPHY (X-RAY, MAMMOGRAPHY AND
FLUOROSCOPY) 66
TABLE 35 GLOBAL MARKET FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY, THROUGH
2017 ($ MILLIONS) 71
TABLE 36 GLOBAL MARKET SHARES FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY
2011 (%) 72
TABLE 37 GLOBAL MARKET FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, THROUGH
2017 ($ MILLIONS) 77
TABLE 38 MARKET SHARE FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2011 (%) 78
TABLE 39 GLOBAL MARKET FOR CONTRAST AGENTS, BY REGION, THROUGH 2017 ($
MILLIONS) 81
TABLE 40 GLOBAL MARKET SHARE FOR CONTRAST AGENTS, BY REGION, 2011 (%) 82
TABLE 41 GLOBAL MARKET FOR IMAGING SYSTEMS, BY REGION, THROUGH 2017 ($
MILLIONS) 86
TABLE 42 GLOBAL MARKET SHARES FOR IMAGING SYSTEMS, BY REGION, 2011 (%) 87
TABLE 43 GLOBAL REVENUE FOR IMAGING CONTRAST AGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 92
TABLE 44 GLOBAL REVENUE MARKET SHARE FOR IMAGING CONTRAST AGENTS AND
SYSTEMS USED FOR VARIOUS DISEASES, 2011 (%) 94
TABLE 45 GLOBAL MARKET FOR X-RAY AND CT AGENTS BY REGION, THROUGH 2017 ($
MILLIONS) 98
TABLE 46 MARKET SHARE OF X-RAY AND CT REAGENTS BY REGION, 2011 (%) 99
TABLE 47 GLOBAL MARKET FOR IMAGING SYSTEMS, BY TYPE, THROUGH 2017 ($ MILLIONS) 100
TABLE 48 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 101
TABLE 49 GLOBAL MARKET FOR X-RAY SYSTEMS BY REGION, THROUGH 2017 ($ MILLIONS) 104
TABLE 50 MARKET SHARE OF X-RAY SYSTEMS BY REGION, 2011 (%) 105
TABLE 51 GLOBAL MARKET FOR COMPUTED TOMOGRAPHY SYSTEMS BY REGION, THROUGH
2017 ($ MILLIONS) 107
TABLE 52 MARKET SHARE OF COMPUTED TOMOGRAPHY SYSTEMS BY REGION, 2011 (%) 108
TABLE 53 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 109
TABLE 54 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, THROUGH 2017 ($ MILLIONS) 112
TABLE 55 X-RAY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 113
TABLE 56 GLOBAL REVENUE FOR CT REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, THROUGH 2017 ($ MILLIONS) 115
TABLE 57 COMPUTED TOMOGRAPHY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 116
TABLE 58 LEADING MANUFACTURERS OF X-RAY AND COMPUTED TOMOGRAPHY CONTRAST
AGENTS 117
TABLE 59 GLOBAL MARKET SHARES OF X-RAY AND COMPUTED TOMOGRAPHY CONTRAST
AGENTS, 2011 (%) 118
TABLE 60 LEADING MANUFACTURERS OF RADIOGRAPHY (X-RAY, FLUOROSCOPY AND
MAMMOGRAPHY) IMAGING SYSTEMS 119
TABLE 61 GLOBAL MARKET SHARES OF X-RAY IMAGING SYSTEMS, 2011 (%) 122
TABLE 62 LEADING MANUFACTURERS OF COMPUTED TOMOGRAPHY SYSTEMS 123
TABLE 63 WORLDWIDE MARKET SHARES OF COMPUTED TOMOGRAPHY SYSTEMS, 2011 (%) 124
TABLE 64 TOTAL NUMBER OF PATENTS FOR CONTRAST AGENTS, FROM 2008-JULY 2012 126
TABLE 65 NUMBER OF PATENTS FOR CONTRAST AGENTS BY IMAGING MODALITY, FROM
2008-JULY 2012 127
TABLE 66 NUMBER OF PATENTS BY COMPANY FROM 2008-JULY 2012 127
TABLE 67 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 128
TABLE 68 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 128
TABLE 69 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012 129
TABLE 70 NUMBER OF PATENTS BY IMAGING MODALITY FROM JANUARY 2008-JULY 2012 130
TABLE 71 NUMBER OF PATENTS BY COMPANY FROM 2008-JULY 2012 131
TABLE 72 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 133
TABLE 73 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 134

LIST OF FIGURES
SUMMARY FIGURE GLOBAL REVENUE OF MEDICAL IMAGING MARKET, 2010-2017 ($
MILLIONS) 6
FIGURE 1 GLOBAL MARKET FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY, 2010-2017
($ MILLIONS) 71
FIGURE 2 GLOBAL MARKET SHARES FOR CONTRAST AGENTS, BY IMAGING TECHNOLOGY,
2011 (%) 72
FIGURE 3 GLOBAL MARKET FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2010-2017
($ MILLIONS) 77
FIGURE 4 MARKET SHARE FOR IMAGING SYSTEMS, BY IMAGING TECHNOLOGY, 2011 (%) 78
FIGURE 5 GLOBAL MARKET FOR CONTRAST AGENTS, BY REGION, 2010-2017 ($ MILLIONS) 81
FIGURE 6 GLOBAL MARKET SHARE FOR CONTRAST AGENTS, BY REGION, 2011 (%) 82
FIGURE 7 GLOBAL MARKET FOR IMAGING SYSTEMS, BY REGION, 2010-2017 ($ MILLIONS) 86
FIGURE 8 GLOBAL MARKET SHARE FOR IMAGING SYSTEMS BY REGION, 2011 (%) 87
FIGURE 9 GLOBAL REVENUE FOR IMAGING CONTRAST AGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, 2010-2017 ($ MILLIONS) 92
FIGURE 10 GLOBAL REVENUE MARKET SHARE FOR IMAGING CONTRAST AGENTS AND
SYSTEMS USED FOR VARIOUS DISEASES, 2011 (%) 94
FIGURE 11 GLOBAL MARKET FOR X-RAY AND CT AGENTS BY REGION, 2010-2017 ($ MILLIONS) 98
FIGURE 12 MARKET SHARE OF X-RAY AND CT REAGENTS BY REGION, 2011 (%) 99
FIGURE 13 GLOBAL MARKET FOR IMAGING SYSTEMS, BY TYPE, THROUGH 2017 ($ MILLIONS) 100
FIGURE 14 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 101
FIGURE 15 GLOBAL MARKET FOR X-RAY SYSTEMS BY REGION, 2010-2017 ($ MILLIONS) 104
FIGURE 16 MARKET SHARE OF X-RAY SYSTEMS BY REGION, 2011 (%) 105
FIGURE 17 GLOBAL MARKET FOR COMPUTED TOMOGRAPHY SYSTEMS BY REGION,
2010-2017 ($ MILLIONS) 107
FIGURE 18 MARKET SHARE OF COMPUTED TOMOGRAPHY SYSTEMS BY REGION, 2011 (%) 109
FIGURE 19 GLOBAL REVENUE FOR X-RAY AND CT REAGENTS AND SYSTEMS USED FOR
VARIOUS DISEASES, 2010-2017 ($ MILLIONS) 109
FIGURE 20 GLOBAL REVENUE FOR X-RAY REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, 2010-2017 ($ MILLIONS) 112
FIGURE 21 X-RAY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 113
FIGURE 22 GLOBAL REVENUE FOR CT REAGENTS AND SYSTEMS USED FOR VARIOUS
DISEASES, 2010-2017 ($ MILLIONS) 115
FIGURE 23 COMPUTED TOMOGRAPHY IMAGING MARKET SHARES, BY APPLICATION, 2011 (%) 116
FIGURE 24 GLOBAL MARKET SHARES OF X-RAY AND COMPUTED TOMOGRAPHY CONTRAST
AGENTS, 2011 (%) 118
FIGURE 25 GLOBAL MARKET SHARES OF X-RAY IMAGING SYSTEMS, 2011 (%) 122
FIGURE 26 WORLDWIDE MARKET SHARES OF COMPUTED TOMOGRAPHY SYSTEMS, 2011 (%) 124
FIGURE 27 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012 129
FIGURE 28 TOTAL NUMBER OF PATENTS FOR IMAGING MODALITIES FROM 2008-JULY 2012
(%) 129
FIGURE 29 NUMBER OF PATENTS BY IMAGING MODALITY FROM JANUARY 2008-JULY 2012 130
FIGURE 30 NUMBER OF PATENTS BY COUNTRY FROM 2008-JULY 2012 133
FIGURE 31 NUMBER OF PATENTS BY ASSIGNEE FROM 2008-JULY 2012 134

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