Apheresis is a process wherein blood is collected and separated into different components, leveraging on centrifugation and membrane separation technology. The global market is valued at $1,140.8 million in 2012 and is expected to reach $1,922.4 million by 2017, growing at a CAGR of 11% from 2012 to 2017.

The market studied in this report is segmented by procedure, application, technology, product type, and end-user. Based on the rationale of the apheresis procedure, the market is segmented as automated blood collection (donor) and therapeutic apheresis. Automated blood collection accounts for the largest share of the global market, by procedure, in 2012. The application market is divided into plasmapheresis, plateletpheresis, erythrocytapheresis, leukapheresis and others, while technology market is classified as centrifugation & membrane separation/filtration in which the former leads the market in 2012. This share can be attributed to the use of centrifugation apheresis devices, mostly by blood banks for collection, and for therapeutics as well due to the advantages offered by centrifugation technology over membrane separation. Centrifugation is used for the apheresis of any blood component whereas the use of membrane separation is limited to plasma exchange. The product types used in this market are majorly classified as devices and disposables.

Increasing blood shortage, advantages of apheresis collection over whole blood and increasing demand for plasma from biopharmaceutical companies are the major drivers that are slated to propel this market. However, donor recruitment and high cost of the apheresis are the major challenges for the growth. The application of therapeutic apheresis for pediatric treatment is an uncaptured market and represents a prospective opportunity in the future.

North America holds the largest market share of close to 50%, followed by Europe in 2012. In the next five years, emerging countries are estimated to register the highest growth rate, primarily due to increasing investments and huge demand for blood components from countries like China and India with large population.

The key players in the market are Haemonetics Corporation (U.S.), FRESENIUS MEDICAL CARE (Germany), Terumo BCT, Inc. (U.S.), Asahi Kasei Medical Co., Ltd. (Japan), Kawasumi Laboratories Inc (Japan), and HemaCare Corporation (U.S.), with Haemonetics leading the pack.

Plasmapheresis segment leads the apheresis application market in 2012, due to the huge demand for human plasma from biopharmaceutical companies for the production of plasma-derived proteins.

Table Of Contents

1 INTRODUCTION 16

1.1 KEY TAKE AWAYS 16
1.2 REPORT DESCRIPTION 16
1.3 MARKETS COVERED 18
1.4 STAKEHOLDERS 19
1.5 RESEARCH METHODOLOGY 20
1.5.1 MARKET SIZE 20
1.5.2 MARKET SHARE 20
1.5.3 KEY DATA POINTS FROM SECONDARY SOURCES 20
1.5.4 ASSUMPTIONS 21

2 EXECUTIVE SUMMARY 22

3 MARKET OVERVIEW 25

3.1 INTRODUCTION 26
3.2 MARKET SEGMENTATION 27
3.3 MARKET DYNAMICS 28
3.3.1 DRIVERS 28
3.3.1.1 Blood shortage and blood safety to increase the demand for apheresis blood 28
3.3.1.2 Advantage of apheresis collection over whole blood collection to boost the growth 29
3.3.1.3 Increasing demand for plasma derived products to spur the apheresis market 29
3.3.1.4 Increase in aging population demands growth of apheresis 29
3.3.2 RESTRAINTS 30
3.3.2.1 Lack of awareness and challenges in donor recruitment to restrict the growth of apheresis 30
3.3.2.2 High cost of apheresis procedures to hinder the acceptability 30
3.3.3 OPPORTUNITIES 30
3.3.3.1 Extending reach of apheresis 30
3.3.3.2 Untapped pediatric segment can soon gain importance in apheresis 31
3.4 MARKET SHARE ANALYSIS 32
3.5 END-USER ANALYSIS 33

4 GLOBAL APHERESIS MARKET, BY PROCEDURE 38

4.1 INTRODUCTION 39
4.2 AUTOMATED/APHERESIS BLOOD COLLECTION (DONOR APHERESIS) 40
4.3 THERAPEUTIC APHERESIS 42
4.3.1 NEUROLOGIC DISORDERS 47
4.3.2 BLOOD DISORDERS 49
4.3.3 RENAL DISORDERS 54
4.3.4 METABOLIC DISORDERS 55
4.3.5 OTHER DISORDERS 56

5 GLOBAL APHERESIS MARKET, BY PRODUCT TYPE 57

5.1 INTRODUCTION 58
5.2 DEVICES 59
5.3 DISPOSABLES 65

6 GLOBAL APHERESIS MARKET, BY TECHNOLOGY 67

6.1 INTRODUCTION 68
6.2 CENTRIFUGATION 69
6.2.1 DRIVER and RESTRAINT 72
6.2.1.1 Advantages offered by centrifugation technology over membrane separation 72
6.2.1.2 Centrifugation apheresis process is time-consuming 72
6.3 MEMBRANE SEPARATION 78

7 GLOBAL APHERESIS MARKET, BY APPLICATION 85

7.1 INTRODUCTION 86
7.2 PLASMAPHERESIS 87
7.2.1 DRIVERS 87
7.2.1.1 Huge demand for plasma from biopharmaceutical companies 87
7.2.1.2 New applications and opportunities in developing countries 88
7.3 PLATELETPHERESIS 90
7.4 ERYTHROCYTAPHERESIS 92
7.5 LEUKAPHERESIS 94
7.6 OTHERS 96

8 GEOGRAPHIC ANALYSIS 98

8.1 INTRODUCTION 99
8.2 NORTH AMERICA 100
8.3 EUROPE 105
8.4 ASIA 111
8.5 ROW (REST OF THE WORLD) 116

9 COMPETITIVE LANDSCAPE 121

9.1 INTRODUCTION 121
9.2 MERGERS and ACQUISITIONS 123
9.3 AGREEMENTS, PARTNERSHIPS, COLLABORATIONS and
JOINT VENTURES 127
9.4 PRODUCTS LAUNCH 133
9.5 EXPANSIONS 135
9.6 OTHER DEVELOPMENTS 136
9.7 APPROVALS 137

10 COMPANY PROFILES 139 (Overview, Financials, Products and Services, Strategy, and Developments)*

10.1 ASAHI KASEI MEDICAL CO., LTD. (A SUBSIDIARY OF
10.2 B. BRAUN MELSUNGEN AG 143
10.3 CERUS CORPORATION 148
10.4 FENWAL, INC. 152
10.5 FRESENIUS MEDICAL CARE AG and CO. KGAA 156
10.6 HAEMONETICS CORPORATION 162
10.7 HEMACARE CORPORATION 170
10.8 KANEKA CORPORATION 173
10.9 KAWASUMI LABORATORIES, INC. 177
10.10 MEDICA S.P.A 181
10.11 NIKKISO CO., LTD. 184
10.12 TERUMO BCT, INC. 188
10.13 THERAKOS, INC. 192
*Details on financials, product and services, strategy, and developments might not be captured in case of unlisted companies.

LIST OF TABLES

TABLE 1 GLOBAL APHERESIS MARKET, BY PROCEDURE, 2010 - 2017 ($MILLION) 22
TABLE 2 PEDIATRIC TRANSFUSIONS IN U.S. BY BLOOD CENTERS AND HOSPITALS IN 2008 (THOUSANDS OF UNITS) 31
TABLE 3 GLOBAL APHERESIS MARKET, BY END-USER, 2010 - 2017 ($MILLION) 34
TABLE 4 BLOOD BANKS and BLOOD COLLECTION CENTERS APHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 35
TABLE 5 HOSPITALS and HOSPITAL ATTACHED BLOOD BANKS APHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 36
TABLE 6 OTHERS APHERESIS END-USER MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 37
TABLE 7 GLOBAL APHERESIS (DONOR and THERAPEUTIC APHERESIS) MARKET,
BY PROCEDURE, 2010 - 2017 ($MILLION) 39
TABLE 8 AUTOMATED BLOOD COLLECTION MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 41
TABLE 9 TYPES OF THERAPEUTIC APHERESIS PROCEDURES 42
TABLE 10 THERAPEUTIC APHERESIS MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 44
TABLE 11 DISEASE/DISORDER TREATED BY THERAPEUTIC APHERESIS 45
TABLE 12 GLOBAL THERAPEUTIC APHERESIS MARKET, BY DISEASE,
2010 - 2017 ($MILLION) 46
TABLE 13 NEUROLOGIC DISORDERS - THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 48
TABLE 14 BLOOD DISORDERS - THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 49
TABLE 15 BLOOD DISORDERS THERAPEUTIC APHERESIS MARKET,
BY DISEASES, 2010 - 2017 ($MILLION) 50
TABLE 16 TTP THERAPEUTIC APHERESIS MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 51
TABLE 17 LEUKEMIA THERAPEUTIC APHERESIS MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 52
TABLE 18 OTHER BLOOD DISORDER THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 53
TABLE 19 RENAL DISORDERS - THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 54
TABLE 20 METABOLIC DISORDERS - THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 55
TABLE 21 OTHER DISORDERS - THERAPEUTIC APHERESIS MARKET,
BY GEOGRAPHY, 2010 - 2017 ($MILLION) 56
TABLE 22 GLOBAL APHERESIS MARKET, BY PRODUCT TYPE,
2010 - 2017 ($MILLION) 58
TABLE 23 APHERESIS DEVICES MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 60
TABLE 24 APHERESIS DEVICES MARKET, BY APPLICATIONS,
2010 - 2017 ($MILLION) 61
TABLE 25 APHERESIS DEVICES/SYSTEMS IN THE MARKET 61
TABLE 26 APHERESIS DISPOSABLES MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 65
TABLE 27 GLOBAL APHERESIS DISPOSABLES MARKET, BY APPLICATION,
2010 - 2017 ($MILLION) 66
TABLE 28 GLOBAL APHERESIS MARKET, BY TECHNOLOGY,
2010 - 2017 ($MILLION) 69
TABLE 29 DENSITY OF BLOOD COMPONENTS (KG/L) 70
TABLE 30 CENTRIFUGATION TECHNOLOGY BASED APHERESIS DEVICES 71
TABLE 31 CENTRIFUGATION-BASED APHERESIS MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 73
TABLE 32 NORTH AMERICA: CENTRIFUGATION APHERESIS MARKET,
BY COUNTRY, 2010 - 2017 ($MILLION) 74
TABLE 33 EUROPE: CENTRIFUGATION APHERESIS MARKET, BY COUNTRY,
2010 - 2017 ($MILLION) 75
TABLE 34 ASIA: CENTRIFUGATION APHERESIS MARKET, BY COUNTRY,
2010 - 2017 ($MILLION) 76
TABLE 35 ROW: CENTRIFUGATION APHERESIS MARKET, BY COUNTRY,
2010 - 2017 ($MILLION) 77
TABLE 36 SIZE OF BLOOD COMPONENTS 78
TABLE 37 MEMBRANE SEPARATION APHERESIS DEVICES 79
TABLE 38 MEMBRANE SEPARATION-BASED APHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 80
TABLE 39 NORTH AMERICA: MEMBRANE SEPARATION APHERESIS MARKET,
BY COUNTRY, 2010 - 2017 ($MILLION) 81
TABLE 40 EUROPE: MEMBRANE SEPARATION APHERESIS MARKET,
BY COUNTRY, 2010 - 2017 ($MILLION) 82
TABLE 41 ASIA: MEMBRANE SEPARATION APHERESIS MARKET, BY COUNTRY, 2010 - 2017 ($MILLION) 83
TABLE 42 ROW: MEMBRANE SEPARATION APHERESIS MARKET, BY COUNTRY, 2010 - 2017 ($MILLION) 84
TABLE 43 GLOBAL APHERESIS MARKET, BY APPLICATION,
2010 - 2017 ($MILLION) 86
TABLE 44 PLASMA COLLECTION IN UNITED STATES FROM 2005 TO 2010 (THOUSAND LITERS) 88
TABLE 45 PLASMAPHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 89
TABLE 46 GLOBAL PLASMAPHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 90
TABLE 47 PLATELETPHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 91
TABLE 48 GLOBAL PLATELETPHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 92
TABLE 49 ERYTHROCYTAPHERESIS MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 93
TABLE 50 GLOBAL ERYTHROCYTAPHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 94
TABLE 51 LEUKAPHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 95
TABLE 52 GLOBAL LEUKAPHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 96
TABLE 53 OTHER APHERESIS APPLICATION MARKET, BY GEOGRAPHY,
2010 - 2017 ($MILLION) 97
TABLE 54 APHERESIS MARKET, BY GEOGRAPHY, 2010 - 2017 ($MILLION) 99
TABLE 55 NORTH AMERICA: APHERESIS MARKET, BY COUNTRY,
2010 - 2017 ($MILLION) 101
TABLE 56 NORTH AMERICA: APHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 101
TABLE 57 NORTH AMERICA: APHERESIS MARKET, BY APPLICATION,
2010 - 2017 ($MILLION) 102
TABLE 58 NORTH AMERICA: APHERESIS MARKET, BY TECHNOLOGY,
2010 - 2017 ($MILLION) 103
TABLE 59 NORTH AMERICA: APHERESIS MARKET, BY PRODUCT TYPE,
2010 - 2017 ($MILLION) 103
TABLE 60 NORTH AMERICA: APHERESIS MARKET, BY END-USER,
2010 - 2017 ($MILLION) 104
TABLE 61 EUROPE: APHERESIS MARKET, BY COUNTRY, 2010 - 2017 ($MILLION) 106
TABLE 62 EUROPE: APHERESIS MARKET, BY PROCEDURE,
2010 - 2017 ($MILLION) 107
TABLE 63 EUROPE: APHERESIS MARKET, BY APPLICATION,
2010 - 2017 ($MILLION) 108
TABLE 64 EUROPE: APHERESIS MARKET, BY TECHNOLOGY,
2010 - 2017 ($MILLION) 109
TABLE 65 EUROPE: APHERESIS MARKET, BY PRODUCT TYPE,
2010 - 2017 ($MILLION) 109
TABLE 66 EUROPE: APHERESIS MARKET, BY END-USER, 2010 - 2017 ($MILLION) 110
TABLE 67 ASIA: APHERESIS MARKET, BY COUNTRY, 2010 - 2017 ($MILLION) 111
TABLE 68 ASIA: APHERESIS MARKET, BY PROCEDURE, 2010 - 2017 ($MILLION) 112
TABLE 69 ASIA: APHERESIS MARKET, BY APPLICATION, 2010 - 2017 ($MILLION) 113
TABLE 70 ASIA: APHERESIS MARKET, BY TECHNOLOGY, 2010 - 2017 ($MILLION) 114
TABLE 71 ASIA: APHERESIS MARKET, BY PRODUCT TYPE,
2010 - 2017 ($MILLION) 114
TABLE 72 ASIA: APHERESIS MARKET, BY END-USER, 2010 - 2017 ($MILLION) 115
TABLE 73 ROW: APHERESIS MARKET, BY REGION, 2010 - 2017 ($MILLION) 116
TABLE 74 ROW: APHERESIS MARKET, BY PROCEDURE, 2010 - 2017 ($MILLION) 117
TABLE 75 ROW: APHERESIS MARKET, BY APPLICATION, 2010 - 2017 ($MILLION) 118
TABLE 76 ROW: APHERESIS MARKET, BY TECHNOLOGY, 2010 - 2017 ($MILLION) 119
TABLE 77 ROW: APHERESIS MARKET, BY PRODUCT TYPE,
2010 - 2017 ($MILLION) 119
TABLE 78 ROW: APHERESIS MARKET, BY END-USER, 2010 - 2017 ($MILLION) 120
TABLE 79 MERGERS and ACQUISITIONS, 2010 - 2012 123
TABLE 80 AGREEMENTS, PARTNERSHIPS, COLLABORATIONS and JOINT VENTURES, 2010 - 2012 127
TABLE 81 PRODUCTS LAUNCH, 2010 - 2012 133
TABLE 82 EXPANSIONS, 2010 -2012 135
TABLE 83 OTHER DEVELOPMENTS, 2010 - 2012 136
TABLE 84 APPROVALS, 2010 - 2012 137
TABLE 85 ASAHI KASEI MEDICAL CO., LTD: TOTAL REVENUE AND RandD EXPENDITURE, 2009 - 2011 ($MILLION) 140
TABLE 86 B. BRAUN MELSUNGEN AG: TOTAL REVENUE AND RandD EXPENDITURE, 2009 - 2011 ($MILLION) 144
TABLE 87 B. BRAUN MELSUNGEN AG: TOTAL REVENUE, BY SEGMENT,
2009 - 2011 ($MILLION) 144
TABLE 88 B. BRAUN MELSUNGEN AG: TOTAL REVENUE, BY GEOGRAPHY,
2009 - 2011 ($MILLION) 145
TABLE 89 CERUS CORPORATION: TOTAL REVENUE AND RandD EXPENDITURE,
2009 - 2011 ($MILLION) 149
TABLE 90 FRESENIUS MEDICAL CARE AG: TOTAL REVENUE AND RandD EXPENDITURE, 2009 - 2011 ($MILLION) 157
TABLE 91 FRESENIUS MEDICAL CARE AG: TOTAL REVENUE, BY SEGMENT,
2009 - 2011 ($MILLION) 158
TABLE 92 FRESENIUS MEDICAL CARE AG: TOTAL REVENUE, BY GEOGRAPHY, 2009 - 2011 ($MILLION) 158
TABLE 93 HAEMONETICS: TOTAL REVENUE AND RandD EXPENDITURE,
2009 - 2011 ($MILLION) 163
TABLE 94 HAEMONETICS: TOTAL REVENUE, BY SEGMENT,
2009 - 2011 ($MILLION) 164
TABLE 95 HAEMONETICS: DISPOSABLES REVENUE, BY PRODUCT TYPE,
2009 - 2011 ($MILLION) 164
TABLE 96 HAEMONETICS: TOTAL REVENUE, BY GEOGRAPHY,
2009 - 2011 ($MILLION) 165
TABLE 97 KANEKA CORPORATION: TOTAL REVENUE, BY SEGMENT,
2010 - 2012 ($MILLION) 174
TABLE 98 KAWASUMI LABORATORIES, INC.: TOTAL REVENUE AND RandD EXPENDITURE, 2008 - 2010 ($MILLION) 178
TABLE 99 KAWASUMI LABORATORIES, INC.: TOTAL REVENUE, BY SEGMENT,
2008 - 2010 ($MILLION) 178
TABLE 100 NIKKISO CO., LTD: TOTAL REVENUE AND RandD EXPENDITURE,
2010 - 2012 ($MILLION) 185
TABLE 101 NIKKISO CO., LTD: TOTAL REVENUE, BY GEOGRAPHY,
2010 - 2012 ($MILLION) 185

LIST OF FIGURES

FIGURE 1 GLOBAL APHERESIS MARKET, BY APPLICATION, 2012 23
FIGURE 2 BLOOD INDUSTRY VALUE CHAIN 26
FIGURE 3 APHERESIS MARKET SEGMENTATION 27
FIGURE 4 APHERESIS MARKET - DRIVERS and RESTRAINTS 28
FIGURE 5 GLOBAL APHERESIS MARKET SHARE ANALYSIS, BY KEY PLAYERS, 2011 32
FIGURE 6 KEY GROWTH STRATEGIES, 2010 - 2012 121

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