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Metabolomics: Technologies and Global Markets

  • November 2015
  • -
  • BCC Research
  • -
  • 202 pages

This BCC report details the recent key technical advances in metabolomic methods, analytical equipment, assay kits, bioinformatics solutions and clinical biomarker applications. Includes forecast through 2020.

Use this report to:

Assess the growth potential of the metabolomic market over the five-year period from 2015 to 2020.
Understand current market adoption in terms of both scope and maturity.
Learn about technology developments including the latest trends and other influential factors such as screening strategies for pharmaceuticals.
Receive information about major applications being developed with regard to the industry, academic researchers and their commercialization offices, and government agencies.

Highlights

The global metabolomic market totaled $5.9 billion in 2014, and should total $6.8 billion in 2015 and $12.5 billion by 2020, registering a compound annual growth rate (CAGR) of 13.0%.
The clinical biomarker metabolomic applications market should total $4.1 billion in 2015 and $7.9 billion by 2020, increasing at a five-year CAGR of 13.8% through 2020.
The metabolomic assay applications market should grow from $1.6 billion in 2015 to $3.1 billion by 2020, with a CAGR of 14.4%.

STUDY GOALS AND OBJECTIVES

BCC Research’s goal in conducting this study was to update the status of the metabolomic market and assess its growth potential over the five-year period from 2015 to 2020. Particularly focus was placed on understanding the current market adoption and analyzing drivers for increasing this in terms of both scope (i.e., more applications) and maturity in terms of user adoption, collaboration with regulators and the emergence of standards.

In addition, BCC Research was interested in understanding the impact of these methods on different research sectors, specifically cancer, toxicology and safety testing; as well as the clinical application of biomarkers in cancer, cardiology, and liver and metabolic disease.

REASONS FOR DOING THE STUDY

Metabolomics is a fairly new field relative to genomics and proteomics, which are more mature, but it promises much needed breakthroughs by virtue of being more descriptive of the actual phenotype or working conditions of the human body. Whereas genomics describes the body’s code and proteomics the application of that code into
the proteins that do the work, metabolomics describes and measures the resultant interaction of an individual’s unique body with those proteins and with the environment.
This report details the recent key technical advances in metabolomic methods, analytical equipment, assay kits, bioinformatics solutions and clinical biomarker applications.

SCOPE OF REPORT

The scope of the report encompasses the major metabolomic technology types that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.



Table Of Contents

Metabolomics: Technologies and Global Markets
.laverty@bccresearch.com
CHAPTER 1 INTRODUCTION 1
STUDY GOALS AND OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
SCOPE AND FORMAT 2
METHODOLOGY AND INFORMATION SOURCES 2
INTENDED AUDIENCE 2
ANALYST CREDENTIALS 2
RELATED REPORTS 3
BCC ON-LINE SERVICES 3
DISCLAIMER 3
CHAPTER 2 SUMMARY 5
SUMMARY TABLE GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES
AND APPLICATIONS, THROUGH-2017 ($ MILLIONS) 6
SUMMARY FIGURE GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES
AND APPLICATIONS, 2010-2017 ($ MILLIONS) 6
CHAPTER 3 OVERVIEW 9
TABLE 1 NUMBER OF PUBLICATIONS FROM 2000-2012 USING THE
KEYWORD "METABOLOMICS" IN THE SEARCH 11
FIGURE 1 NUMBER OF PUBLICATIONS FROM 2000-2012 USING THE
KEYWORD "METABOLOMICS" IN THE SEARCH 11
STRATEGIES IN METABOLOMICS RESEARCH 12
TABLE 2 MAIN APPROACHES IN METABOLOMICS RESEARCH 12
TARGETED ANALYSIS 12
METABOLIC FINGERPRINTING 13
METABOLITE PROFILING 13
TECHNOLOGIES AND ANALYTICAL APPROACHES IN METABOLOMICS
RESEARCH 14
FIGURE 2 SCHEMATIC REPRESENTATION OF EXPERIMENTAL
METABOLOMIC APPROACHES 14
IMPORTANCE OF BIOINFORMATICS RESOURCES FOR
METABOLOMICS RESEARCH 15
APPLICATIONS OF METABOLOMICS RESEARCH 15
CHAPTER 4 SEPARATION, ANALYTICAL TOOLS AND TECHNOLOGIES IN
METABOLOMICS RESEARCH 19
OVERVIEW 19
FIGURE 3 SCHEMATIC REPRESENTATION OF METABOLOMIC ANALYSIS 19
PROCEDURES IN METABOLOMIC ANALYSIS 19
SAMPLE PREPARATION 19
EXTRACTION PROCEDURE 20
DERIVATIZATION 21
SEPARATION AND DETECTION 21
DATA ANALYSIS 21
MARKET FOR PROCEDURES IN METABOLOMIC ANALYSIS 22
MARKET FOR EXTRACTION PROCEDURE PRODUCTS 22
MARKET FOR SEPARATION AND DETECTION TECHNIQUES AND
PRODUCTS FOR METABOLOMIC RESEARCH 23
TABLE 3 COMMON ANALYTICAL PLATFORMS IN METABOLOMICS RESEARCH 23
MAIN SEPARATION PLATFORMS AND TECHNOLOGIES 24
LIQUID CHROMATOGRAPHY 24
Sample Injectors 25
Pumps 26
Columns 26
TABLE 4 GLOBAL HIGH-PERFORMANCE (OR HIGH-PRESSURE) LIQUID
CHROMATOGRAPHY MARKET, THROUGH 2017 ($ BILLIONS) 27
TABLE 5 CUSTOMER DISTRIBUTION IN COLUMN SEPARATION MARKET,
2011 (%) 27
GAS CHROMATOGRAPHY (GC) 28
CAPILLARY ELECTROPHORESIS 31
MAIN DETECTION PLATFORMS AND TECHNOLOGIES 32
MASS SPECTROMETRY AS DETECTION PROCEDURE IN
METABOLOMICS STUDIES 33
Mass Spectrometry Instruments 33
Ionization Procedure 33
Matrix-Assisted Laser Desorption/Ionization (MALDI) 33
Electrospray Ionization (ESI) 34
Atmospheric Pressure Chemical Ionization (APCI) 34
Mass Analyzers 34
Quadrupole 34
Ion Trap Mass Spectroscopy 35
Time-of-Flight Mass Spectrometry (TOF) 35
Quadrupole-Time-of-Flight (Q-TOF) 36
Orbitrap 36
TABLE 6 EXAMPLES OF MASS SPECTROMETRY ANALYZERS 37
Market Overview for Mass Spectrometry 37
TABLE 7 GLOBAL MASS SPECTROMETRY MARKET, THROUGH 2017 ($
BILLIONS) 37
Main Players in the Mass Spectrometry Industry 38
NMR as Detection Procedure in Metabolomics Studies 38
TABLE 8 PERCENTAGE OF TOTAL NUCLEAR MAGNETIC RESONANCE
APPLICATIONS IN VARIOUS INDUSTRIES (%) 39
TABLE 9 GLOBAL NUCLEAR MAGNETIC RESONANCE MARKET, THROUGH
2017 ($ MILLIONS) 40
Fourier Transform Infrared Spectroscopy in Metabolomics
Studies 40
COMPARISON OF TECHNOLOGIES AND PLATFORMS IN
METABOLOMICS RESEARCH 42
Gas Chromatography-Mass Spectrometry (GC-MS) 42
Liquid Chromatography-Mass Spectrometry (LC-MS) 42
Capillary Electrophoresis-Mass Spectrometry (CE-MS) 43
Nuclear Magnetic Resonance (NMR) 43
Mass Spectrometry (MS) 43
Additional Technologies 44
TABLE 10 COMMON TECHNIQUES IN METABOLOMICS RESEARCH 44
TABLE 11 PERCENTAGE OF SEPARATION TECHNIQUES USED IN
METABOLOMIC RESEARCH OTHER THAN CONVENTIONAL HPLC AND GC (%) 46
TABLE 12 PERCENTAGE OF RESPONDENTS THAT USE SPECIFIC
METABOLOMIC INSTRUMENTATION (%) 47
MARKET PARTICIPANTS FOR SEPARATION/DETECTION PLATFORMS
IN METABOLOMICS STUDIES 47
TABLE 13 MARKET DISTRIBUTION OF GC-MS VENDORS, 2012 (%) 48
TABLE 14 BIOANALYTICAL MEASUREMENT PRODUCT REVENUES OF SELECT
COMPANIES, 2009-2011 ($ BILLIONS) 49
TABLE 15 GLOBAL MARKET FOR BIOANALYTICAL INSTRUMENTS AND
EQUIPMENT FOR METABOLOMICS RESEARCH, THROUGH 2017 ($ MILLIONS) 50
FIGURE 4 GLOBAL MARKET FOR BIOANALYTICAL INSTRUMENTS AND
EQUIPMENT FOR METABOLOMICS RESEARCH, 2010-2017 ($ MILLIONS) 50
TABLE 16 GEOGRAPHICAL DISTRIBUTION OF BIOANALYTICAL
INSTRUMENTS AND EQUIPMENT MARKET FOR METABOLOMICS RESEARCH
(%)
51
CHAPTER 5 BIOINFORMATICS AS AN INFLUENTIAL SEGMENT IN
METABOLOMICS RESEARCH 53
OVERVIEW 53
FIGURE 5 SCHEMATIC REPRESENTATION OF EXPERIMENTAL
METABOLOMIC DATA ANALYSIS AND PROCESSING 53
TABLE 17 SELECTED COMMERCIAL SOFTWARE FOR METABOLOMICS
STUDIES 56
TABLE 18 EXAMPLES OF OPEN ACCESS TOOLS FOR METABOLOMICS
STUDIES 57
TABLE 19 EXAMPLES OF DATABASES ESSENTIAL FOR METABOLIC
RECONSTRUCTION 58
DATABASE MANAGEMENT IN METABOLOMICS RESEARCH 61
TABLE 20 EXAMPLES OF DATABASES, DATA MANAGEMENT, ANALYSIS AND
VISUALIZATION TOOLS FOR METABOLOMICS 62
TABLE 21 STATISTICS FOR CHALLENGING ASPECTS IN THE METABOLOMICS
BIOINFORMATICS MARKET (%) 63
MARKET PARTICIPANTS IN THE METABOLOMICS BIOINFORMATICS
SEGMENT 64
Vendors and Equipment Manufacturers 64
Metabolite Profiling Companies 69
Bioinformatics Companies with a Specific Focus on Metabolomics
Research 70
Bioinformatics Companies with Focus on Different Biological
Disciplines, Including Metabolomics 70
SYSTEMS BIOLOGY AS AN ESSENTIAL COMPONENT OF
METABOLOMICS RESEARCH 74
TABLE 22 ESTIMATED VALUE OF SYSTEMS BIOLOGY MARKET, THROUGH
2017 ($ MILLIONS) 75
TABLE 23 EXAMPLES OF MARKET PARTICIPANTS IN THE METABOLOMICS
BIOINFORMATICS SEGMENT 77
TABLE 24 GLOBAL MARKET FOR BIOINFORMATICS TOOLS IN
METABOLOMICS RESEARCH, THROUGH 2017 ($ MILLIONS) 78
FIGURE 6 GLOBAL MARKET FOR BIOINFORMATICS TOOLS IN
METABOLOMICS RESEARCH, 2010-2017 ($ MILLIONS) 78
CHAPTER 6 METABOLOMIC APPLICATIONS AND METABOLITE PROFILING
COMPANIES AS A SEGMENT OF THE METABOLOMICS MARKET 81
OVERVIEW 81
TABLE 25 EXAMPLES OF COSTS FOR DIFFERENT METABOLOMICS
PROCEDURES AT UC DAVIS METABOLOMICS CENTRAL SERVICE CORE
LABORATORY ($)
83
TYPES OF COMMERCIAL METABOLOMICS SERVICE PROVIDERS 83
METABOLITE PROFILING SERVICES COMPANIES 83
Chenomx 83
Biocrates AG Life Sciences 84
Metabolon 85
TABLE 26 METABOLON REVENUES, 2009-2011 ($ MILLIONS) 85
TABLE 27 EXAMPLES OF PRICING FOR METABOLOMICS PROFILING
SERVICES PROVIDED BY COMPANIES ($) 86
TABLE 28 PERCENTAGE OF SPECIFIC TYPES OF SERVICES OFFERED BY
METABOLOMICS COMPANIES (%) 86
METABOLOMICS DIAGNOSTICS AND BIOMARKER DEVELOPMENT
COMPANIES 87
TABLE 29 GLOBAL BIOMARKERS MARKET, THROUGH 2015 ($ BILLIONS) 88
TABLE 30 SELECTED METABOLOMICS-DERIVED BIOMARKERS 88
TABLE 31 NUMBER OF PUBLICATIONS ON METABOLOMICS BASED ON
VARIOUS SEARCH CRITERIA, AS OF FEBRUARY 2013 89
TABLE 32 EXAMPLES OF THE USE OF METABOLOMICS TO IMPROVE THE
DETECTION OF CANCER 90
BG Medicine 90
TABLE 33 BG MEDICINE REVENUES, 2009-2011 ($ MILLIONS) 93
Metabolon 93
Metabolomic Diagnostics Ltd. 94
Metabolomic Technologies Inc. 95
LipoScience Inc. 96
Metabolomx 97
TOXICOLOGY AND PHARMACOKINETIC ANALYSIS OF METABOLITES
COMPANIES 99
Cyprotex 100
CiToxLAB/Stemina Biomarker Discovery 101
Xceleron 102
XenoTech 102
TABLE 34 CYPROTEX REVENUES, 2009-2011 ($ MILLIONS) 103
METABOLOMIC TECHNOLOGIES DEVELOPMENT COMPANIES 103
SiDMAP 103
NextGen Metabolomics 104
COMPANIES SUPPORTING DRUG DISCOVERY RESEARCH 105
TABLE 35 EXAMPLES OF PARTICIPANTS IN THE METABOLOMICS MARKET 106
ADDITIONAL METABOLOMICS APPLICATION MARKET PARTICIPANTS 107
Avogadro 108
Berg Diagnostics 108
Drumetix Laboratories 108
GERSTEL GmbH and Co. KG 109
HepatoChem 109
Human Metabolome Technologies 110
Huntingdon Life Sciences 110
Metabolomics Australia 111
Metabolomic Discoveries GmbH 111
Metabolys SAS 111
Metanomics Health 112
Novatia 112
Stemina Biomarker Discovery 112
Phenomenome Discoveries Inc. 113
MARKET EVALUATION OF THE METABOLOMIC APPLICATIONS
SEGMENT 114
TABLE 36 ESTIMATED REVENUES OF SELECT METABOLOMICS COMPANIES
($ MILLIONS) 114
TABLE 37 GLOBAL MARKET FOR METABOLOMICS APPLICATIONS, THROUGH
2017 ($ MILLIONS) 115
FIGURE 7 GLOBAL MARKET FOR METABOLOMICS APPLICATIONS, 2011-2017
($ MILLIONS) 115
New Technologies and Products Will Positively Drive This Segment. 116
Further Development of Bioinformatics, Chemometrics Studies and
Systems Biology Tools 116
CHAPTER 7 ADDITIONAL APPLICATIONS AND MARKETS IN METABOLOMICS
RESEARCH AND PRODUCT DEVELOPMENT 119
METABOLOMICS APPLICATIONS IN THE AGRICULTURE AND
ENVIRONMENTAL INDUSTRIES 119
TABLE 38 BIOINFORMATIC RESOURCES FOR METABOLOMICS RESEARCH IN
AGRICULTURE 121
METABOLOMICS IN THE ENVIRONMENTAL SCIENCES 123
TABLE 39 U.S. MARKET FOR FOOD SAFETY, THROUGH 2017 ($ BILLIONS) 126
IMPACT OF METABOLOMICS ON FOOD QUALITY AND NUTRITION
MARKETS 128
Improved Crops as Sources of Healthier Foods 129
Metabolomics Approach in Nutrigenomics Science 130
TABLE 40 GLOBAL MARKET FOR NUTRIGENOMIC TESTING, THROUGH 2017
($ MILLIONS) 133
Metabolomics Approach in the Nutraceutical Market 133
BIOFUELS AS A NEW TARGET MARKET FOR METABOLOMICS
DEVELOPMENT 136
TABLE 41 GLOBAL MARKET FOR BIOFUELS, THROUGH 2017 ($ BILLIONS) 137
TABLE 42 AMYRIS REVENUES, 2009-2011 ($ MILLIONS) 140
CHAPTER 8 IMPORTANCE OF PATENTS IN METABOLOMICS RESEARCH AND
PRODUCT DEVELOPMENT 144
TABLE 43 WORLDWIDE PATENTS AND PATENT APPLICATIONS SEARCH IN
METABOLOMICS AREA USING SPECIFIC KEYWORDS, 2009-2012 (NO.) 144
TABLE 44 PATENTS AND PATENT APPLICATIONS IN METABOLOMICS
RESEARCH BY SELECT ASSIGNEES (NO.) 146
CHAPTER 9 MARKET SUMMARY 149
TABLE 45 SURVEY QUESTION: DESCRIBE YOUR CURRENT INTEREST IN
METABOLOMICS RESEARCH OR APPLICATIONS. AMONG RESPONDENTS* (%) 150
TABLE 46 SURVEY QUESTION: WHAT DO YOU PERCEIVE AS THE PRIMARY
BOTTLENECKS IN METABOLOMICS? (%) 150
TABLE 47 SURVEY QUESTION: WHAT IS THE PRIMARY NATURE OF
METABOLOMICS EXPERIMENTS PERFORMED IN YOUR LABORATORY? (%) 151
TABLE 48 SURVEY QUESTION: WHAT IS THE PRACTICAL AREA OF
APPLICATION OF METABOLOMICS DATA ACQUIRED IN YOUR LAB? (%) 151
TABLE 49 GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES AND
APPLICATIONS, THROUGH 2017 ($ MILLIONS) 156
FIGURE 8 GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES AND
APPLICATIONS, 2010-2017 ($ MILLIONS) 156
CHAPTER 10 COMPANY PROFILES 160
AGILENT TECHNOLOGIES 160
BG MEDICINE INC. 161
BIOCRATES LIFE SCIENCES AG 162
CHENOMX 163
HUMAN METABOLOME TECHNOLOGIES 164
LECO CORP. 166
METABOLON INC. 167
WATERS CORP. 168
CHAPTER 11 DIRECTORY OF COMPANIES MENTIONED IN REPORT 171
ACUREOMICS AB 171
AGILENT TECHNOLOGIES 171
AVOGADRO, INC. 171
BERG DIAGNOSTICS 171
BG MEDICINE INC. 171
BIOCRATES LIFE SCIENCES AG 172
CHENOMX 172
CITOXLAB NORTH AMERICA 172
CLINMET INC. 172
CYPROTEX 172
DRUMETIX LABORATORIES LLC 172
GERSTEL GMBH and CO. KG 173
GLAXOSMITHKLINE U.S. 173
HEPATOCHEM 173
HUMAN METABOLOME TECHNOLOGIES 173
HUNTINGDON LIFE SCIENCES 173
LECO CORP. 174
LIFE TECHNOLOGIES CORP. 174
LIPOSCIENCE INC. 174
MERCK 174
METABOLOMIC DIAGNOSTICS 174
METABOLOMIC DISCOVERIES 175
METABOLOMIC TECHNOLOGIES INC. 175
METABOLOMX 175
METABOLON INC. 175
METABOLYS SAS 175
METANOMICS HEALTH GMBH 176
NEXTGEN METABOLOMICS 176
NOVARTIS INTERNATIONAL AG 176
NOVATIA LLC 176
PFIZER 176
PHENOMENOME DISCOVERIES INC. 176
SIDMAP 177
SIGMA-ALDRICH 177
STEMINA BIOMARKER DISCOVERY 177
THERMO FISHER SCIENTIFIC INC. 177
WATERS CORP. 177
XCELERON INC. 177
XENOTECH LLC 178

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES
AND APPLICATIONS, THROUGH-2017 ($ MILLIONS) 6
TABLE 1 NUMBER OF PUBLICATIONS FROM 2000-2012 USING THE KEYWORD
"METABOLOMICS" IN THE SEARCH 11
TABLE 2 MAIN APPROACHES IN METABOLOMICS RESEARCH 12
TABLE 3 COMMON ANALYTICAL PLATFORMS IN METABOLOMICS RESEARCH 23
TABLE 4 GLOBAL HIGH-PERFORMANCE (OR HIGH-PRESSURE) LIQUID
CHROMATOGRAPHY MARKET, THROUGH 2017 ($ BILLIONS) 27
TABLE 5 CUSTOMER DISTRIBUTION IN COLUMN SEPARATION MARKET, 2011
(%) 27
TABLE 6 EXAMPLES OF MASS SPECTROMETRY ANALYZERS 37
TABLE 7 GLOBAL MASS SPECTROMETRY MARKET, THROUGH 2017 ($
BILLIONS) 37
TABLE 8 PERCENTAGE OF TOTAL NUCLEAR MAGNETIC RESONANCE
APPLICATIONS IN VARIOUS INDUSTRIES (%) 39
TABLE 9 GLOBAL NUCLEAR MAGNETIC RESONANCE MARKET, THROUGH
2017 ($ MILLIONS) 40
TABLE 10 COMMON TECHNIQUES IN METABOLOMICS RESEARCH 44
TABLE 11 PERCENTAGE OF SEPARATION TECHNIQUES USED IN
METABOLOMIC RESEARCH OTHER THAN CONVENTIONAL HPLC AND GC (%) 46
TABLE 12 PERCENTAGE OF RESPONDENTS THAT USE SPECIFIC
METABOLOMIC INSTRUMENTATION (%) 47
TABLE 13 MARKET DISTRIBUTION OF GC-MS VENDORS, 2012 (%) 48
TABLE 14 BIOANALYTICAL MEASUREMENT PRODUCT REVENUES OF SELECT
COMPANIES, 2009-2011 ($ BILLIONS) 49
TABLE 15 GLOBAL MARKET FOR BIOANALYTICAL INSTRUMENTS AND
EQUIPMENT FOR METABOLOMICS RESEARCH, THROUGH 2017 ($ MILLIONS) 50
TABLE 16 GEOGRAPHICAL DISTRIBUTION OF BIOANALYTICAL INSTRUMENTS
AND EQUIPMENT MARKET FOR METABOLOMICS RESEARCH (%) 51
TABLE 17 SELECTED COMMERCIAL SOFTWARE FOR METABOLOMICS
STUDIES 56
TABLE 18 EXAMPLES OF OPEN ACCESS TOOLS FOR METABOLOMICS STUDIES 57
TABLE 19 EXAMPLES OF DATABASES ESSENTIAL FOR METABOLIC
RECONSTRUCTION 58
TABLE 20 EXAMPLES OF DATABASES, DATA MANAGEMENT, ANALYSIS AND
VISUALIZATION TOOLS FOR METABOLOMICS 62
TABLE 21 STATISTICS FOR CHALLENGING ASPECTS IN THE METABOLOMICS
BIOINFORMATICS MARKET (%) 63
TABLE 22 ESTIMATED VALUE OF SYSTEMS BIOLOGY MARKET, THROUGH 2017
($ MILLIONS) 75
TABLE 23 EXAMPLES OF MARKET PARTICIPANTS IN THE METABOLOMICS
BIOINFORMATICS SEGMENT 77
TABLE 24 GLOBAL MARKET FOR BIOINFORMATICS TOOLS IN METABOLOMICS
RESEARCH, THROUGH 2017 ($ MILLIONS) 78
TABLE 25 EXAMPLES OF COSTS FOR DIFFERENT METABOLOMICS
PROCEDURES AT UC DAVIS METABOLOMICS CENTRAL SERVICE CORE
LABORATORY ($)
83
TABLE 26 METABOLON REVENUES, 2009-2011 ($ MILLIONS) 85
TABLE 27 EXAMPLES OF PRICING FOR METABOLOMICS PROFILING SERVICES
PROVIDED BY COMPANIES ($) 86
TABLE 28 PERCENTAGE OF SPECIFIC TYPES OF SERVICES OFFERED BY
METABOLOMICS COMPANIES (%) 86
TABLE 29 GLOBAL BIOMARKERS MARKET, THROUGH 2015 ($ BILLIONS) 88
TABLE 30 SELECTED METABOLOMICS-DERIVED BIOMARKERS 88
TABLE 31 NUMBER OF PUBLICATIONS ON METABOLOMICS BASED ON
VARIOUS SEARCH CRITERIA, AS OF FEBRUARY 2013 89
TABLE 32 EXAMPLES OF THE USE OF METABOLOMICS TO IMPROVE THE
DETECTION OF CANCER 90
TABLE 33 BG MEDICINE REVENUES, 2009-2011 ($ MILLIONS) 93
TABLE 34 CYPROTEX REVENUES, 2009-2011 ($ MILLIONS) 103
TABLE 35 EXAMPLES OF PARTICIPANTS IN THE METABOLOMICS MARKET 106
TABLE 36 ESTIMATED REVENUES OF SELECT METABOLOMICS COMPANIES ($
MILLIONS) 114
TABLE 37 GLOBAL MARKET FOR METABOLOMICS APPLICATIONS, THROUGH
2017 ($ MILLIONS) 115
TABLE 38 BIOINFORMATIC RESOURCES FOR METABOLOMICS RESEARCH IN
AGRICULTURE 121
TABLE 39 U.S. MARKET FOR FOOD SAFETY, THROUGH 2017 ($ BILLIONS) 126
TABLE 40 GLOBAL MARKET FOR NUTRIGENOMIC TESTING, THROUGH 2017 ($
MILLIONS) 133
TABLE 41 GLOBAL MARKET FOR BIOFUELS, THROUGH 2017 ($ BILLIONS) 137
TABLE 42 AMYRIS REVENUES, 2009-2011 ($ MILLIONS) 140
TABLE 43 WORLDWIDE PATENTS AND PATENT APPLICATIONS SEARCH IN
METABOLOMICS AREA USING SPECIFIC KEYWORDS, 2009-2012 (NO.) 144
TABLE 44 PATENTS AND PATENT APPLICATIONS IN METABOLOMICS
RESEARCH BY SELECT ASSIGNEES (NO.) 146
TABLE 45 SURVEY QUESTION: DESCRIBE YOUR CURRENT INTEREST IN
METABOLOMICS RESEARCH OR APPLICATIONS. AMONG RESPONDENTS* (%) 150
TABLE 46 SURVEY QUESTION: WHAT DO YOU PERCEIVE AS THE PRIMARY
BOTTLENECKS IN METABOLOMICS? (%) 150
TABLE 47 SURVEY QUESTION: WHAT IS THE PRIMARY NATURE OF
METABOLOMICS EXPERIMENTS PERFORMED IN YOUR LABORATORY? (%) 151
TABLE 48 SURVEY QUESTION: WHAT IS THE PRACTICAL AREA OF
APPLICATION OF METABOLOMICS DATA ACQUIRED IN YOUR LAB? (%) 151
TABLE 49 GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES AND
APPLICATIONS, THROUGH 2017 ($ MILLIONS) 156

LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES
AND APPLICATIONS, 2010-2017 ($ MILLIONS) 6
FIGURE 1 NUMBER OF PUBLICATIONS FROM 2000-2012 USING THE
KEYWORD "METABOLOMICS" IN THE SEARCH 11
FIGURE 2 SCHEMATIC REPRESENTATION OF EXPERIMENTAL METABOLOMIC
APPROACHES 14
FIGURE 3 SCHEMATIC REPRESENTATION OF METABOLOMIC ANALYSIS 19
FIGURE 4 GLOBAL MARKET FOR BIOANALYTICAL INSTRUMENTS AND
EQUIPMENT FOR METABOLOMICS RESEARCH, 2010-2017 ($ MILLIONS) 50
FIGURE 5 SCHEMATIC REPRESENTATION OF EXPERIMENTAL METABOLOMIC
DATA ANALYSIS AND PROCESSING 53
FIGURE 6 GLOBAL MARKET FOR BIOINFORMATICS TOOLS IN METABOLOMICS
RESEARCH, 2010-2017 ($ MILLIONS) 78
FIGURE 7 GLOBAL MARKET FOR METABOLOMICS APPLICATIONS, 2011-2017
($ MILLIONS) 115
FIGURE 8 GLOBAL MARKET FOR METABOLOMICS TECHNOLOGIES AND
APPLICATIONS, 2010-2017 ($ MILLIONS) 156

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