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Complicated Intra-Abdominal Infections - Pipeline Review, H1 2014

  • March 2014
  • -
  • Global Markets Direct
  • -
  • 73 pages

Complicated Intra-Abdominal Infections - Pipeline Review, H1 2014

Summary

Global Markets Direct’s, ‘Complicated Intra-Abdominal Infections - Pipeline Review, H1 2014’, provides an overview of the Complicated Intra-Abdominal Infections’s therapeutic pipeline.

This report provides comprehensive information on the therapeutic development for Complicated Intra-Abdominal Infections, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Complicated Intra-Abdominal Infections and special features on late-stage and discontinued projects.

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct’s team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis.

The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products.

Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease.

Scope

- The report provides a snapshot of the global therapeutic landscape of Complicated Intra-Abdominal Infections
- The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in the therapeutics development for Complicated Intra-Abdominal Infections and enlists all their major and minor projects
- The report summarizes all the dormant and discontinued pipeline projects
- A review of the Complicated Intra-Abdominal Infections products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- A detailed assessment of monotherapy and combination therapy pipeline projects
- Coverage of the Complicated Intra-Abdominal Infections pipeline on the basis of target, MoA, route of administration and molecule type
- Latest news and deals relating related to pipeline products

Reasons to buy

- Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Develop strategic initiatives by understanding the focus areas of leading companies
- Identify and understand important and diverse types of therapeutics under development for Complicated Intra-Abdominal Infections
- Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline
- Devise corrective measures for pipeline projects by understanding Complicated Intra-Abdominal Infections pipeline depth and focus of Indication therapeutics
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
- Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline

Table Of Contents

Complicated Intra-Abdominal Infections - Pipeline Review, H1 2014
Table of Contents
Table of Contents 2
List of Tables 4
List of Figures 5
Introduction 6
Global Markets Direct Report Coverage 6
Complicated Intra-Abdominal Infections Overview 7
Therapeutics Development 8
Pipeline Products for Complicated Intra-Abdominal Infections - Overview 8
Pipeline Products for Complicated Intra-Abdominal Infections - Comparative Analysis 9
Complicated Intra-Abdominal Infections - Therapeutics under Development by Companies 10
Complicated Intra-Abdominal Infections - Pipeline Products Glance 12
Late Stage Products 12
Clinical Stage Products 13
Early Stage Products 14
Unknown Stage Products 15
Complicated Intra-Abdominal Infections - Products under Development by Companies 16
Complicated Intra-Abdominal Infections - Companies Involved in Therapeutics Development 17
AstraZeneca PLC 17
Merck and Co., Inc. 18
Melinta Therapeutics, Inc 19
Cubist Pharmaceuticals, Inc. 20
MerLion Pharmaceuticals Pte Ltd 21
Atox Bio Inc. 22
Tetraphase Pharmaceuticals Inc. 23
Biota Pharmaceuticals, Inc. 24
Complicated Intra-Abdominal Infections - Therapeutics Assessment 25
Assessment by Monotherapy Products 25
Assessment by Combination Products 26
Assessment by Target 27
Assessment by Mechanism of Action 29
Assessment by Route of Administration 31
Assessment by Molecule Type 33
Drug Profiles 35
(ceftolozane + tazobactam) - Drug Profile 35
Product Description 35
Mechanism of Action 35
RandD Progress 35
eravacycline - Drug Profile 37
Product Description 37
Mechanism of Action 37
RandD Progress 37
(ceftazidime + avibactam) - Drug Profile 39
Product Description 39
Mechanism of Action 39
RandD Progress 39
delafloxacin - Drug Profile 41
Product Description 41
Mechanism of Action 41
RandD Progress 41
MK-7655 - Drug Profile 44
Product Description 44
Mechanism of Action 44
RandD Progress 44
AB-103 - Drug Profile 46
Product Description 46
Mechanism of Action 46
RandD Progress 46
GyrB/ParE Antibiotic - Drug Profile 48
Product Description 48
Mechanism of Action 48
RandD Progress 48
finafloxacin - Drug Profile 49
Product Description 49
Mechanism of Action 49
RandD Progress 49
Complicated Intra-Abdominal Infections - Recent Pipeline Updates 51
Complicated Intra-Abdominal Infections - Discontinued Products 63
Complicated Intra-Abdominal Infections - Product Development Milestones 64
Featured News and Press Releases 64
Dec 16, 2013: Cubist Announces Positive Top-Line Results from Phase 3 Trial of Ceftolozane/Tazobactam in Intra-Abdominal Infections 64
Sep 12, 2013: Ceftazidime/avibactam Combination Receives Qualified Infectious Disease Product (QIDP) Designation from FDA 65
Sep 04, 2013: Tetraphase to Present Data at ICAAC Supporting Its Lead Antibiotic Candidate Eravacycline's Effectiveness against Multi-drug Resistant Pathogens 66
Sep 03, 2013: Tetraphase Doses First Patient in Phase 3 Clinical Trial of Eravacycline in Complicated Intra-abdominal Infections 67
Jul 15, 2013: FDA Grants QIDP Designation to Eravacycline, Tetraphase's Lead Antibiotic Product Candidate 68
May 07, 2013: Cubist's Late-stage Antibiotic Candidate CXA-201 Receives FDA Fast Track Designation 68
Jan 07, 2013: Cubist Pharma Provides Update On Infectious Disease Drug Candidate, Ceftolozane 69
Dec 06, 2012: Cubist Pharma's Antibiotic Candidate Ceftolozane Obtains QIDP Designation From FDA 69
Sep 12, 2012: Tetraphase Pharma Announces Positive Phase II Data For Eravacycline In Patients With Complicated Intra-Abdominal Infections 70
Sep 05, 2012: Tetraphase Pharma To Present New Clinical And Preclinical Research On Antibiotic Portfolio At ICAAC 2012 71
Appendix 72
Methodology 72
Coverage 72
Secondary Research 72
Primary Research 72
Expert Panel Validation 72
Contact Us 73
Disclaimer 73

List of Tables

Number of Products under Development for Complicated Intra-Abdominal Infections, H1 2014 8
Number of Products under Development for Complicated Intra-Abdominal Infections - Comparative Analysis, H1 2014 9
Number of Products under Development by Companies, H1 2014 11
Comparative Analysis by Late Stage Development, H1 2014 12
Comparative Analysis by Clinical Stage Development, H1 2014 13
Comparative Analysis by Early Stage Development, H1 2014 14
Comparative Analysis by Unknown Stage Development, H1 2014 15
Products under Development by Companies, H1 2014 16
Complicated Intra-Abdominal Infections - Pipeline by AstraZeneca PLC, H1 2014 17
Complicated Intra-Abdominal Infections - Pipeline by Merck and Co., Inc., H1 2014 18
Complicated Intra-Abdominal Infections - Pipeline by Melinta Therapeutics, Inc, H1 2014 19
Complicated Intra-Abdominal Infections - Pipeline by Cubist Pharmaceuticals, Inc., H1 2014 20
Complicated Intra-Abdominal Infections - Pipeline by MerLion Pharmaceuticals Pte Ltd, H1 2014 21
Complicated Intra-Abdominal Infections - Pipeline by Atox Bio Inc., H1 2014 22
Complicated Intra-Abdominal Infections - Pipeline by Tetraphase Pharmaceuticals Inc., H1 2014 23
Complicated Intra-Abdominal Infections - Pipeline by Biota Pharmaceuticals, Inc., H1 2014 24
Assessment by Monotherapy Products, H1 2014 25
Assessment by Combination Products, H1 2014 26
Number of Products by Stage and Target, H1 2014 28
Number of Products by Stage and Mechanism of Action, H1 2014 30
Number of Products by Stage and Route of Administration, H1 2014 32
Number of Products by Stage and Molecule Type, H1 2014 34
Complicated Intra-Abdominal Infections Therapeutics - Recent Pipeline Updates, H1 2014 51
Complicated Intra-Abdominal Infections - Discontinued Products, H1 2014 63

List of Figures

Number of Products under Development for Complicated Intra-Abdominal Infections, H1 2014 8
Number of Products under Development for Complicated Intra-Abdominal Infections - Comparative Analysis, H1 2014 9
Number of Products under Development by Companies, H1 2014 10
Assessment by Monotherapy Products, H1 2014 25
Number of Products by Top 10 Target, H1 2014 27
Number of Products by Stage and Top 10 Target, H1 2014 28
Number of Products by Top 10 Mechanism of Action, H1 2014 29
Number of Products by Stage and Top 10 Mechanism of Action, H1 2014 30
Number of Products by Top 10 Route of Administration, H1 2014 31
Number of Products by Stage and Top 10 Route of Administration, H1 2014 32
Number of Products by Top 10 Molecule Type, H1 2014 33
Number of Products by Stage and Top 10 Molecule Type, H1 2014 34

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