Table of Contents
Finding Opportunities in a Changing Competitive and Patent Landscape
This research service evaluates the U.S. qPCR reagents market from 2010 to 2017. The mature qPCR reagents market remains dynamic due to a period of patent expirations, competitive expansion, and pricing pressure. This research service offers a discussion of the key market drivers and restraints, a detailed analysis of the changing competitive landscape, revenue forecasts, and the important trends affecting growth. Further discussed are selected end-user data on qPCR reagents usage, researchers' desired workflow improvements, and details on detection chemistries and assays utilized. Lastly, this analysis presents major market dynamics and strategic recommendations for competitors.
Major Market Metrics—qPCR Reagents
• The quantitative real-time polymerase chain reaction (qPCR) reagents market is a mature market within the life sciences industry, with a compound annual growth rate (CAGR) ofX percent expected during the period from 2012 to 2017. This moderate growth reflects the necessity of qPCR reagents in laboratories that utilize this workhorse technology and in a growing installed base of digital PCR (dPCR) instruments, but that remains limited by the maturity of the market, overall laboratory budget constraints, and pricing pressures.
• Instrumentation markets, such as the ancillary qPCR and dPCR instrumentation markets, remain more vulnerable to economic downturns than reagent markets. Researchers may delay instrument replacements or forgo adoption of new technologies because of budget constraints; however, reagents remain necessary for a laboratory to function.
• Approximately 40 companies competed in the U.S. qPCR reagents market in 2012, with Life Technologies, Qiagen, Roche, and Bio-Rad leading the way. Beyond these four market share leaders, share remains highly fragmented in this large competitor base as the quality gap between competitors’ products continues to narrow.
• Despite its maturity, the qPCR market will continue to experience a period of competitive expansion, as several suppliers entered the instruments markets over the past three years and followed suit with reagents to complement them. Over the next five years, the expiration of various qPCR reagents patents is expected to attract new entrants, particularly companies that could not afford patent licenses and international suppliers looking to enter the U.S. market.
• These new entries are likely to undercut the average market price for reagents to compete, effectively driving down the cost of qPCR reagents and limiting the overall market.
• However, the growing installed base of digital PCR instruments will drive reagent usage and offset pricing pressures to maintain a healthy qPCR reagents market CAGR of X percent.
1. Necessity of qPCR reagents creates stable market growth of X to X percent.
2. Patent expiration will spur competitive expansion, including international companies entering the U.S. market.
3. Pricing pressure from new competitors will continue to drive down the value of qPCR.
4. Digital PCR instrumentation CAGR of X percent from 2011 to 2016 drives qPCR reagent use and offsets pricing.
5. Market share concentration among top suppliers is unlikely to extensively erode due to high customer satisfaction.
Quantitative real-time polymerase chain reaction (qPCR, qRT-PCR, or RT-PCR) is a technique used to amplify and quantify a known targeted deoxyribonucleic acid (DNA) sequence within a sample. In real-time PCR, the amplified DNA is detected as the reaction occurs. The technology can be used for a broad range of applications, including gene expression analysis, genotyping, pathogen detection, single nucleotide polymorphism (SNP) analysis, viral quantification, siRNA/RNAi experiments, DNA methylation analysis, high resolution melting analysis, DNA fingerprinting, HLA compatibility typing, and allelic prevalence, among several others.
To perform qPCR, researchers use either probe-based assays or dye-based protocols. The most common probe-based technology is Life Technologies’ Taqman® chemistry, which uses a fluorogenic probe. The most popular dye-based protocol uses SYBR Green, a highly specific, double-stranded DNA binding dye. Both methods enable the detection of a specific PCR product as it accumulates during PCR cycles. Probe-based products are generally viewed as more specific—but more expensive—than dye-based products. Quantitative PCR can be formed in a singleplex or multiplex manner with multiple colors. Digital PCR is performed with qPCR reagents and, therefore, reagents used for this ancillary technology are included as part of the qPCR reagents market.
End users of qPCR reagents include academic and government research laboratories, pharmaceutical and biotechnology research and development laboratories, clinical research laboratories, forensic laboratories, and applied laboratories. Reagents used for diagnostic purposes are excluded in this analysis.
The qPCR reagents market includes real-time quantitative PCR (qPCR, qRT-PCR, or RT-PCR) reagents used for research only in academic, pharmaceutical/biotechnology, applied, and clinical research laboratories. This study solely analyzes qPCR reagents and excludes qPCR instruments, traditional thermal cyclers, qPCR reagents, assays, software, and qPCR reagents used for clinical diagnostic purposes. This study analyzes the real-time qPCR reagents market within the United States, estimated at X percent of the global market. The qPCR reagent suppliers included in this study reflect this geographic segmentation.
Key Questions This Study Will Answer
• How has the qPCR reagents market fared compared with the instrumentation market?
• How will market dynamics and the competitor base change as qPCR patents near expiration?
• What is the expected effect of the emerging digital PCR market on the qPCR reagents market?
• Which market competitors are gaining share on the well-established market leader?
• Which detection chemistries and fluorophores do researchers use most often?
• What strategies should market competitors employ to gain share in the very mature qPCR reagents market?
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