Liquid Chromatography Markets (LC, HPLC and UHPLC)

Keywords : liquid chromatography, diagnostic , Diagnostics, chromatography

The liquid chromatography (LC) market has been relatively mature for quite a while, with a slow evolution of products and applications over the last few decades. High performance liquid chromatography (HPLC) has used essentially the same types of components since the 1980s. However, the market has seen an extraordinary amount of technological change in the last few years as companies have continued to introduce new systems performing fast LC an...

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The liquid chromatography (LC) market has been relatively mature for quite a while, with a slow evolution of products and applications over the last few decades. High performance liquid chromatography (HPLC) has used essentially the same types of components since the 1980s. However, the market has seen an extraordinary amount of technological change in the last few years as companies have continued to introduce new systems performing fast LC and ultra HPLC (UHPLC).



This report, Liquid Chromatography Markets,, represents Kalorama's most comprehensive look at this dynamic market. This report covers liquid chromatography systems, hardware, software, consumables, and related services, with a focus on HPLC. Both analytical and purification applications are included, but the emphasis leans towards analytical techniques. With quantitative data, a discussion of trends, and expert analysis, the report is perfect for those seeking and understanding of the LC industyr. Included the report is the following:

• Market Forecasts


• Overview of the LC Market


• Product Offerings by Company


• Breadown of LC Market by Region (US, Europe, Asia, ROW)


• Detail of Trends and How They Will Impact Market


• List of Major LC-related Deals since 2003.


• Company Profiles


• Details from the HPLC 2008 Convention


• Seven key Strategic Recommendations for Success in this Market


• Discussion of the Role of Liquid Chromatography in Food Testing

The research for this report combined a variety of primary and secondary sources. Primary sources included end-users, LC suppliers’ personnel, and other pertinent individuals. Secondary sources included suppliers’ financial statements, websites, journals, trade publications, and other periodicals.


Companies profiled in this report include the following:

• Agilent Technologies


• Bio-Rad


• Dionex


• Eksigent Technologies


• ESA Biosciences


• GE Healthcare


• Grace Davison Discovery Sciences (W.R. Grace & Co.)


• Hitachi High Technologies


• Proxeon Biosystems


• Shimadzu


• Thermo Fisher Scientific


• Varian


• Waters Corp.

Global Diagnostics Industry

CHAPTER ONE: EXECUTIVE SUMMARY

Applications and Industries

Scope and Methodology

CHAPTER TWO: INTRODUCTION

Background and Definitions

Pumps

Columns

Detectors

Other Accessories and Consumables

Applications and Industries

Scope and Methodology

CHAPTER THREE: MARKET TRENDS

Collaborations, M&A Activity, Regional Expansion

Rise of Diagnostics and Other Clinical Applications

HPLC Spreading Into Niches in Clinical Labs

Advantages and Disadvantages of LC-MS in Clinical Applications

Detection of Doping Agents Using LC-MS

Therapeutic Drug Monitoring of Fentanyl in Urine With LC-MS-MS

Forensic Toxicology Using LC-MS-MS

Discovery and Detection of Genetic Variation by DHPLC

Measuring the Level of Vitamin D in Blood

Increased Global Focus on Food Safety

Introduction

European Union Updates Maximum Residue Levels for Pesticides

Japan Establishes Positive List System

Melamine Contamination of Pet Foods and Dairy

FDA Publishes Laboratory Information Bulletin on Melamine, May 2007

FDA Publishes Laboratory Information Bulletin on Melamine, October 2008

Agilent Technologies Addresses Melamine in Food

Green, Eco-friendly Trends Affecting LC Market

Production Scale LC and Process Analytical LC Gaining Momentum

LC, GC, SFC Applications Blurring

Chiral Separations Gaining Importance

FDA Issues Policy Statements on Chiral Drugs

LC Products for Chiral Separations Proliferate

Hydrophilic Interaction Chromatography (HILIC) Experiencing Rapid Growth

Nano-LC and Nano-electrospray Find Strong Niche Markets

Protein Analysis, Proteomics Driving Market

UHPLC and Fast LC Technology

Shaking Up a Mature Market

Decreasing Particle Size and the van Deemter Curve

UHPLC and Fast LC Product Introductions Stimulate Market

Advances Create Market for New Parts, Consumables, Ancillary Products

Alternative or Intermediate Forms of Fast, Faster LC

Using Standard Pressures for Fast LC

High Temperature LC

Particle Sizes of 2 um to 3 µm

Superficially Porous Particles

Optimizing Extra-Column Volume, Other Paramaters

CHAPTER FOUR: PRODUCTS

Advanced Materials Technology, Inc.

Halo HPLC Columns

Agilent Technologies

1200 Series Rapid Resolution LC (RRLC)

HPLC-Chips

Bio-Rad

Eksigent Technologies

expressHT-Ultra

ESA Biosciences

Corona Charged Aerosol Detector (CAD)

Coulochem and CoulArray Detectors

Hitachi High Technologies

LaChromUltra

Thermo Fisher Scientific

TurboFlow Columns

Varian

920-LC

Waters

Acquity UPLC

CHAPTER FIVE: DEALS

CHAPTER SIX: REVENUES FORECAST AND COMPETITIVE ANALYSIS

Assumptions

Competitive Analysis

CHAPTER SEVEN: CORPORATE PROFILES

Agilent Technologies

Bio-Rad

Dionex

Eksigent Technologies

ESA Biosciences

GE Healthcare

Grace Davison Discovery Sciences (W.R. Grace & Co.)

Hitachi High Technologies

Proxeon Biosystems

Shimadzu

Thermo Fisher Scientific

Varian

Waters Corp.

CHAPTER EIGHT: CHALLENGES AND STRATEGIC RECOMMENDATIONS

Challenges

Advances in Competing Technologies Erode Growth

Clinical Applications Require Adjustment for Companies

Diminishing Returns in Ultra and Fast LC Technologies

Precedence in Purchasing Decisions

Routine Applications Demand Different Types of Systems

Customers’ Experiencing Budget Restrictions or Flat Funding

Customers’ Uncertainty Regarding UHPLC and Fast LC

Strategic Recommendations

Position for Shift Towards Protein Therapeutics

Expand into Related Applications and Products

Incorporate or Enable Green Features

Address Broader Mass Spectometry Adoption

Target Niche Applications Through Differentiation of Products

Strengthen and Emphasize Service and Support

Increase User-Friendliness and Standardization of Software

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Factors Driving Green Initiatives at Labs(Factor, Percent of Respondents)

Figure 1-2: Factors Driving Green Initiatives at Labs (Factor, Percent of Respondents)

CHAPTER THREE: MARKET TRENDS

Table 3-1: Factors Driving Green Initiatives at Labs(Factor, Percent of Respondents)

Figure 3-1: Factors Driving Green Initiatives at Labs (Factor, Percent of Respondents)

Table 3-2: Nano-LC Systems, 2008 (Company, System)

Table 3-3: UHPLC and Fast LC Systems along with Type of Technology and Pressure Limits

Table 3-4: Columns with 2.0 and sub-2 um Totally Porous Particles, 2008

Table 3-5: Columns Designed for High Temperature LC (HTLC)

Table 3-6: Columns with 2 to 3 um Totally Porous Particles, 2008 (Company, Product, Base Material, Stationary Phases, Tmax (C))

Table 3-7: Papers presented at HPLC 2007 and HPLC 2008

Figure 3-2: Application Areas of Papers Presented at HPLC 2007 and 2008

Table 3-8: Particle Size usage, 1997 & 2007

Figure 3-3: Particle Size Usage, 1997 & 2007

Table 3-9: Stationary Phase Used, 2008 (Stationary Phase, Percent of Labs)

Figure 3-4: Stationary Phase Usage in HPLC, 2008 (Stationary Phase, Percent of Labs)

Table 3-10: Stationary Phase Used in RP-HPLC, 2007 (Stationary Phase, Percent of Labs)

Figure 3-4: Stationary Phase Used in Reverse-Phase HPLC, 2007 (Stationary Phase, Percent of Labs)

Table 3-11: Analytical HPLC Mode and Stationary Phase Usage, 2007 (Stationary Phase, Percent of Labs)

Figure 3-5: Analytical HPLC Mode and Stationary Phase Usage, 2007

Table 3-12: Papers Presented at HPLC 2008

Figure 3-6: Detection Techniques Used in Presentations at HPLC 2008

Table 3-13: Number of Sample Injections During Column Life

Figure 3-6: Average Number of Injections During Column Life, 1997 & 2007

Table 3-14: Average Analytical Column Lifetime

Figure 3-7: Average Analytical Column Lifetime, 1997 & 2007

Table 3-15: Sources for HPLC Columns Purchase

Figure 3-8: Sources for HPLC Columns Purchase, 1997 & 2007

Figure 3-9: Top Factors When Selecting HPLC Column Supplier, 2007

Table 3-16: Factors Driving Green Initiatives at Labs

Figure 3-10: Factors Driving Green Initiatives at Laboratories

Table 3-17: Column Developments of Interest in the Future

Figure 3-11: Column Technology Developments of Interest in the Future, 2007

Table 3-18: Anticipated Usage & Impact of UPLC/UHPLC in Next 5-8 Years, 2008

Figure 3-12: Anticipated Usage and Impact of UPLC/UHPLC in Next 5-8 Years, 2008

CHAPTER FOUR: PRODUCTS

Table 4-1: Pressure Necessary for the Halo Column to Achieve Needed Flow Rates

Figure 4-1: The van Deemter Plot of the Fused Core Particles Compared to Other Particles

CHAPTER FIVE: DEALS

Table 5-1 Deals (Company 1, Company 2, Date, Comments)

CHAPTER SIX: REVENUES FORECAST AND COMPETITIVE ANALYSIS

Table 6-1: World LC Market, 2007-2013

Figure 6-1: World Liquid Chromatorgraphy Market Revenues, 2007-2013

Table 6-2: World Liquid Chromatorgraphy Market Revenues, (US, Europe, Asia, Rest of World), 2007-2013

Figure 6-2: World Liquid Chromatorgraphy Market, Growth Rate, 2007-2013

Table 6-3: Top Factors When Selecting HPLC Column Supplier, 2007

Table 6-4: Market Shares of LC Suppliers, 2007

Figure 6-3: Figure 6-3 Market Shares of LC Suppliers, 2007

Figure 6-4: LC Revenues of Leading Suppliers, 2007

Figure 6-5: Waters Corp. Revenues by Quarter, 2002 - 2008

Figure 6-6: Waters Corp. Revenues by Region, 2002 & 2007