Bioinformatics: Technologies and Global Markets

  • April 2013
  • -
  • BCC Research
  • -
  • 123 pages

STUDY GOALS AND OBJECTIVES

BCC Research’s goal for this study is to provide a comprehensive analysis of the bioinformatic market by reviewing the recent advances in high-throughput ‘omic technologies and computer-enabled technologies that have driven the field forward. It examines the market trends and analysis regarding industry service providers, software solution developers, and IT and bioinformatics service providers that support the pharma industry.

The report’s main focus is on identifying the challenges and opportunities that exist in the bioinformatic market following the adoption of high- throughput technologies and the generation of big data. It aims to identify innovative companies and institutes that are extending the boundaries of science and technology to develop innovative solutions and enable knowledge to be extracted from burgeoning data so that it may be put to use for the greater good.

REASONS FOR DOING THE STUDY

Since the Human Genome Project was completed in April 2003, genome-wide association studies (GWAS) have contributed toward a greater understanding of the genetic basis of complex diseases and advances in high-throughput technologies. This has enabled researchers to rapidly map the genome of vertebrates, invertebrates and pathogens through cost-effective methods.

More recently, improvements in cloud computing capabilities and advances in data-analysis software services have helped to expand the evaluation of available datasets, allowing researchers to build systems biology models of various diseases. Still, the challenge to translate this wealth of information into tangible clinical benefits, to support the development of new therapeutic interventions and to reduce the current prohibitively high cost of drug development remains.

SCOPE OF REPORT

The scope of the study encompasses the global bioinformatic market based on geography, category and application. It provides a detailed analysis of recent advances in ‘omic technologies and examines their impact on the bioinformatics market. It discusses the ways in which bioinformatics have been utilized by the pharma and biotech industries to streamline the research and development (R&D) process and improve efficiencies. It provides a detailed analysis of leading countries, companies and technologies that will drive the field forward.

INTENDED AUDIENCE

The study provides a detailed analysis of the economic, technological and potential application of bioinformatics; it also examines the market factors and identifies the market potential through the year 2017. The study is aimed at the pharmaceutical industry, biotechnology firms, research laboratories and individuals interested in exploiting the commercial opportunities offered in this field.

METHODOLOGY AND INFORMATION SOURCES

Both primary and secondary sources were used in preparing this study. This analysis of bioinformatics breaks down the market by geography, category and application, and also analyzes current and potential opportunities for bioinformatic business. It includes market sizes from 2011 and forecasts market revenues through 2017.

Primary research involved e-mail correspondence and telephone interviews for each market, category, segment and sub-segment across geographies. BCC Research extends its thanks those who took part in interviews for this report, especially the following, who gave so generously of their time:
• Paul Clemons, PhD, Director of Computational Chemical Biology Research Broad Institute, U.S.
• Rolf Apweiler, PhD, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, U.K.
• John Atack, PhD, Translational Drug Discovery Group, School of Life Science, University of Sussex, U.K.
• Tom Schwei, Vice President, CFO and General Manager DNASTAR Inc., U.S.
• Simon M. Lin, MD, Editor-in-Chief at the Journal of Computer Science and System Biology, BIRC, U.S.

Secondary research was performed on internal and external sources to acquire qualitative and quantitative information for this report. These sources include:
• Company websites, annual reports, financial reports and investor presentations.
• Industry trade journals, scientific journals and other technical literature.
• Relevant patent and regulatory databases.
• National government documents, statistical databases and market reports.
• News articles, press releases and webcasts specific to the companies.

ANALYST CREDENTIALS

Dr. C.L. Barton has more than 10 years’ practical pharmaceutical research experience with a leading pharmaceutical company and has served as a Pan-European Pharmaceutical analyst with a European bank. Dr. C. L. Barton Ltd. aims to provide independent, tailor-made, pharmaceutical thematic research to investment houses. Research reports combine independent scientific analysis with patients- and prescription-based models to forecast the potential sales growth of key developmental drugs and to isolate the key drivers within the pharmaceutical sector.

REPORT HIGHLIGHTS

The report provides:
• An overview of the global market for bioinformatics.
• Analyses of global market trends, with data from 2011 and 2012, and projections of compound annual growth rates (CAGRs) through 2017.
• Technological descriptions and patenting trends in bioinformatics.
• Examination of the economic environment affecting the deployment of bioinformatics.
• Discussion of other influential factors, such as R&D spending in the pharmaceutical sector, the growth of agrobiotechnology, and the expanded use of microbial genomics.

Table Of Contents

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
SCOPE OF REPORT 2
INTENDED AUDIENCE 3
METHODOLOGY AND INFORMATION SOURCES 3
ANALYST CREDENTIALS 3
RELATED BCC REPORTS 4
BCC ON-LINE SERVICES 4
DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 6
SUMMARY FIGURE BIOINFORMATICS MARKET BY REGION, 2011-2017 ($ MILLIONS) 6

CHAPTER 3 CONVERTING DATA INTO KNOWLEDGE 10

INTRODUCTION TO BIOINFORMATICS 10
FIGURE 1 BIOINFORMATIC RELATIONSHIP TO 'OMIC TECHNOLOGIES 10
BIOLOGICAL DATA SOURCES 11
BIOINFORMATICS IN TRANSLATIONAL MEDICINE: A SYSTEM BIOLOGY
APPROACH 13
FIGURE 2 SYSTEMS BIOLOGY PRINCIPAL APPROACHES 13
BIOINFORMATICS IN DRUG DEVELOPMENT 14
MARKET DRIVERS 15
MARKET RESISTORS 16
CURRENT MARKET 17
MARKET BY REGION 17
TABLE 1 BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 17
MARKET BY CATEGORY 18
TABLE 2 BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($ MILLIONS) 19
MARKET BY APPLICATION 19
TABLE 3 BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($ MILLIONS) 20

CHAPTER 4 BIOINFORMATICS: DATA GENERATION AND DATA MANAGEMENT 22

POST-GENOME ERA 22
ADVANCES IN GENOMICS 22
SEQUENCING GENOMICS 22
FUNCTIONAL GENOMICS 23
ADVANCES IN PROTEOMICS 24
FIGURE 3 KEY ASPECTS OF PROTEOMICS 24
QUALITATIVE PROTEOMICS 25
QUANTITATIVE PROTEOMICS 26
STRUCTURAL PROTEOMICS 26
INTERACTION PROTEOMICS 26
TRANSCRIPTOMIC ADVANCES 27
METABOLOMIC ADVANCES 28
CHEMINFORMATIC ADVANCES 29
TABLE 4 CHEMOINFORMATIC SOFTWARE SOLUTIONS FOR DRUG RESEARCH AND
DEVELOPMENT 31
EMERGING TECHNOLOGIES 32
PHARMACOGENOMIC ADVANCES 32
TOXICOGENOMIC ADVANCES 34
EPIGENOMIC ADVANCES 35
DATABASE MANAGEMENT SERVICES 36
TABLE 5 ARCHIVAL DATABASE EXAMPLES 37
TABLE 6 CURATIVE DATABASE EXAMPLES 39
TABLE 7 COMMERCIALLY AVAILABLE DATABASE EXAMPLES 40
MARKET DYNAMICS 41

CHAPTER 5 BIOINFORMATICS: DATA ANALYSIS AND SOFTWARE 44

INTRODUCTION 44
INTERPRETOMICS 44
SEQUENCING, GENOTYPING AND NEXT-GENERATION DATA 44
TABLE 8 EUROPEAN BIOINFORMATICS INSTITUTE BIOINFORMATIC TOOLS FOR
SEQUENCE, ALIGNMENT STRUCTURE AND FUNCTION ANALYSIS 45
TABLE 9 BIOINFORMATIC TOOLS FOR NEXT-GENERATION SEQUENCING ANALYSIS 46
TABLE 10 COMMERCIAL BIOINFORMATIC TOOLS FOR NEXT-GENERATION
SEQUENCING ANALYSIS EXAMPLES 47
COMMERCIAL ANALYTICAL SOFTWARE 48
ACCELYRS PIPELINE PILOT 48
BIOMATTERS INC. GENEIOUS PRO 48
CLC BIO'S CLC GENOMICS WORKBENCH 49
TABLE 11 CLC GENOMICS WORKBENCH 49
DNASTAR LARSGENE CORE SUITE 50
TABLE 12 DNASTAR LARSGENE CORE SUITE 50
GENOMATIX'S (GENOMATIC SOFTWARE SUITE) 51
TABLE 13 GENOMATIX SOFTWARE SUITE 51
MARKET ANALYSIS 51

CHAPTER 6 BIOINFORMATICS: DATA PROCESSING AND STORAGE 54

INTRODUCTION 54
FIGURE 4 EVOLUTION OF INFORMATION TECHNOLOGY INFRASTRUCTURE 54
INFORMATION TECHNOLOGY INFRASTRUCTURE 55
HIGH-PERFORMANCE COMPUTING 55
TABLE 14 TOP 200 SUPERCOMPUTERS, 2008-2012 56
HIGH-PERFORMANCE COMPUTER CLUSTERS 57
CLOUD COMPUTING 57
FIGURE 5 CLOUD COMPUTING SCHEMATIC 57
DATA AS A SERVICE 58
SOFTWARE AS A SERVICE 59
TABLE 15 SOFTWARE AS A SERVICE RESOURCES 59
PLATFORM AS A SERVICE 60
INFRASTRUCTURE AS A SERVICE 60
CLOUD COMPUTING ISSUES 60
FUTURE OF CLOUD COMPUTING 61
MARKET ANALYSIS 61

CHAPTER 7 APPLICATION OF BIOINFORMATICS IN PHARMA RESEARCH AND
DEVELOPMENT 64

INTRODUCTION 64
PRECLINICAL RESEARCH 64
LABORATORY INFORMATION MANAGEMENT SYSTEMS 64
TABLE 16 LEADING LABORATORY INFORMATION MANAGEMENT SYSTEM
PROVIDERS 65
FIGURE 6 ACCELRYS ENTERPRISE LAB MANAGEMENT SOFTWARE SCHEMATIC 65
ELECTRONIC LABORATORY NOTEBOOKS 66
TABLE 17 LEADING ELECTRONIC NOTE SUPPLIERS 67
COMPUTATIONAL CHEMISTRY 68
COMPUTATIONAL MODELS 69
TABLE 18 COMPUTER SIMULATION PLATFORMS 69
CLINICAL RESEARCH 71
CLINICAL TRIAL MANAGEMENT SYSTEMS 71
CLINICAL TRIAL SIMULATIONS 72
ELECTRONIC HEALTH RECORDS 72
MOBILE HEALTH TECHNOLOGIES 73
CLINICAL INFORMATICS 74
RECENT ALLIANCES AND PARTNERSHIPS 75
TABLE 19 RECENT PHARMA AND BIOINFORMATIC PARTNERSHIPS AND ALLIANCES,
2011-2013 76
CONCLUSIONS 80

CHAPTER 8 MARKET TRENDS AND ANALYSIS 83

NORTH AMERICA 83
TABLE 20 NORTH AMERICAN BIOINFORMATICS MARKET BY REGION, THROUGH
2017 ($ MILLIONS) 83
U.S. 83
TABLE 21 LEADING U.S. BIOINFORMATIC COMPANIES* 84
TABLE 22 U.S. BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 87
TABLE 23 U.S. BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 88
CANADA 88
TABLE 24 CANADIAN BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 89
TABLE 25 LEADING CANADIAN BIOINFORMATIC COMPANIES 90
TABLE 26 CANADIAN BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017
($ MILLIONS) 90
EUROPE 91
TABLE 27 EUROPEAN BIOINFORMATICS MARKET BY REGION, THROUGH 2017 91
TABLE 28 LEADING EUROPEAN BIOINFORMATICS COMPANIES* 91
U.K. 93
TABLE 29 TABLE 29 U.K. BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017
($ MILLIONS) 94
TABLE 30 U.K. BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 95
GERMANY 95
TABLE 31 GERMAN BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 96
TABLE 32 GERMAN BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 97
SWITZERLAND 97
TABLE 33 SWISS BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 98
TABLE 34 SWISS BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 98
ASIA-PACIFIC MARKET TRENDS AND ANALYSIS 99
TABLE 35 ASIA-PACIFIC BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 99
CHINA 99
TABLE 36 CHINESE BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 101
TABLE 37 CHINESE BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 101
INDIA 101
TABLE 38 INDIAN BIOTECHNOLOGY MARKET BY SEGMENT, 2011 VERSUS 2010 ($
MILLIONS) 102
TABLE 39 INDIA BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 103
TABLE 40 LEADING INDIAN BIOINFORMATIC COMPANIES 103
TABLE 41 INDIA BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 104
CONCLUSIONS 105

CHAPTER 9 COMPANY PROFILES 107

3RD MILLENNIUM INC. 107
ACCELRYS INC. 107
AGILENT TECHNOLOGIES INC. 108
ASTRID BIOSCIENCE GMBH 109
BGI 109
BIOBASE GMBH 110
BIOMATTERS LTD. 111
BIOTIQUE SYSTEMS INC. 111
CARTAGENIA N.V. 112
CLC BIOINFORMATICS 112
CONEXIO GENOMICS 113
COMPUGEN 114
DNASTAR INC. 114
GEOSPIZA 115
GENOMATIX SOFTWARE GMBH 115
GVK BIOSCIENCES 116
GENOLOGICS LIFE SCIENCES SOFTWARE INC. 117
GENEDATA AG 117
GENEVA BIOFORMATICS SA 118
GNS HEALTHCARE 118
IBM LIFE SCIENCES 119
ILLUMINA INC. 119
MOLECULAR CONNECTION 120
MOLECULAR NETWORKS GMBH 121
NONLINEAR DYNAMICS LTD. 121
OCIMUM BIOSOLUTIONS LTD. 122
PERKIN ELMER INFORMATICS 122
PERSONALIS 123
SMARTGENE SERVICES SARL 123
REAL TIME GENOMICS INC. 124

CHAPTER 10 ACRONYMS 126

CHAPTER 11 REFERENCES 130



LIST OF TABLES

SUMMARY TABLE BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 6
TABLE 1 BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($ MILLIONS) 17
TABLE 2 BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($ MILLIONS) 19
TABLE 3 BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($ MILLIONS) 20
TABLE 4 CHEMOINFORMATIC SOFTWARE SOLUTIONS FOR DRUG RESEARCH AND
DEVELOPMENT 31
TABLE 5 ARCHIVAL DATABASE EXAMPLES 37
TABLE 6 CURATIVE DATABASE EXAMPLES 39
TABLE 7 COMMERCIALLY AVAILABLE DATABASE EXAMPLES 40
TABLE 8 EUROPEAN BIOINFORMATICS INSTITUTE BIOINFORMATIC TOOLS FOR
SEQUENCE, ALIGNMENT STRUCTURE AND FUNCTION ANALYSIS 45
TABLE 9 BIOINFORMATIC TOOLS FOR NEXT-GENERATION SEQUENCING ANALYSIS 46
TABLE 10 COMMERCIAL BIOINFORMATIC TOOLS FOR NEXT-GENERATION
SEQUENCING ANALYSIS EXAMPLES 47
TABLE 11 CLC GENOMICS WORKBENCH 49
TABLE 12 DNASTAR LARSGENE CORE SUITE 50
TABLE 13 GENOMATIX SOFTWARE SUITE 51
TABLE 14 TOP 200 SUPERCOMPUTERS, 2008-2012 56
TABLE 15 SOFTWARE AS A SERVICE RESOURCES 59
TABLE 16 LEADING LABORATORY INFORMATION MANAGEMENT SYSTEM PROVIDERS 65
TABLE 17 LEADING ELECTRONIC NOTE SUPPLIERS 67
TABLE 18 COMPUTER SIMULATION PLATFORMS 69
TABLE 19 RECENT PHARMA AND BIOINFORMATIC PARTNERSHIPS AND ALLIANCES,
2011-2013 76
TABLE 20 NORTH AMERICAN BIOINFORMATICS MARKET BY REGION, THROUGH 2017
($ MILLIONS) 83
TABLE 21 LEADING U.S. BIOINFORMATIC COMPANIES* 84
TABLE 22 U.S. BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 87
TABLE 23 U.S. BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 88
TABLE 24 CANADIAN BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 89
TABLE 25 LEADING CANADIAN BIOINFORMATIC COMPANIES 90
TABLE 26 CANADIAN BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 90
TABLE 27 EUROPEAN BIOINFORMATICS MARKET BY REGION, THROUGH 2017 91
TABLE 28 LEADING EUROPEAN BIOINFORMATICS COMPANIES* 91
TABLE 29 TABLE 29 U.K. BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017
($ MILLIONS) 94
TABLE 30 U.K. BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 95
TABLE 31 GERMAN BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 96
TABLE 32 GERMAN BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 97
TABLE 33 SWISS BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 98
TABLE 34 SWISS BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 98
TABLE 35 ASIA-PACIFIC BIOINFORMATICS MARKET BY REGION, THROUGH 2017 ($
MILLIONS) 99
TABLE 36 CHINESE BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 101
TABLE 37 CHINESE BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 101
TABLE 38 INDIAN BIOTECHNOLOGY MARKET BY SEGMENT, 2011 VERSUS 2010 ($
MILLIONS) 102
TABLE 39 INDIA BIOINFORMATICS MARKET BY CATEGORY, THROUGH 2017 ($
MILLIONS) 103
TABLE 40 LEADING INDIAN BIOINFORMATIC COMPANIES 103
TABLE 41 INDIA BIOINFORMATICS MARKET BY APPLICATION, THROUGH 2017 ($
MILLIONS) 104



LIST OF FIGURES

SUMMARY FIGURE BIOINFORMATICS MARKET BY REGION, 2011-2017 ($ MILLIONS) 6
FIGURE 1 BIOINFORMATIC RELATIONSHIP TO 'OMIC TECHNOLOGIES 10
FIGURE 2 SYSTEMS BIOLOGY PRINCIPAL APPROACHES 13
FIGURE 3 KEY ASPECTS OF PROTEOMICS 24
FIGURE 4 EVOLUTION OF INFORMATION TECHNOLOGY INFRASTRUCTURE 54
FIGURE 5 CLOUD COMPUTING SCHEMATIC 57
FIGURE 6 ACCELRYS ENTERPRISE LAB MANAGEMENT SOFTWARE SCHEMATIC 65

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