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STUDY OBJECTIVES

BCC’s goal in conducting this study is to provide an overview of the current and future characteristics of the global markets and technologies for molecular, nanoscale and atomic imaging. The key objective is to present the future direction and comprehensive analysis for the molecular, nanoscale and atomic imaging technologies markets, and their positions in the overall global imaging market.

This report explores present and future strategies within the global markets and technologies for molecular, nanoscale and atomic imaging, including the electron and ion microscope market, the imaging probes market, the scanning probe market and the optical and thermal imaging market. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. The comparisons, usage and the advantages and disadvantages of different types of technologies related to molecular, nanoscale and atomic imaging are also portrayed in this report.

A detailed analysis based on the global markets and technologies of molecular, nanoscale and atomic imaging’s industry structure has also been conducted. Revenues are broken down by type, application and region. Sales figures are estimated for the five-year period from 2012 through 2017.
Applications for the different technologies associated with molecular, nanoscale and atomic imaging are also discussed separately in the report, with emphasis of the usage of the molecular, nanoscale and atomic imaging in various commercial and industrial fields. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

Extensive research in the fields of molecular, nanoscale and atomic imaging has allowed for an overall growth in the technological advancements in the markets. This has led to the availability and accessibility of high-resolution imaging modalities.

R&D spending, along with increasing competition, patent expiries and new technologies are directing this in a new direction. The overall revenue for the market has seen a steady increase from 2010 to 2012 mainly due to new advancements, new product launches and to meet the demands of new end-user industries. This study looks at almost all of the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strengths and weaknesses of each type/ technology in light of new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE

This study contributes to the areas of market growth in the overall area of imaging modalities, including molecular, nanoscale and atomic imaging markets. It also contributes to specific areas of market growth within the imaging market including the electron and ion microscope market, the imaging probes market, the scanning probe market and the optical and thermal imaging market. Pharmaceutical biotechnical companies, research institutes and physicians will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the global markets and technologies of the molecular, nanoscale and atomic imaging markets in pharmaceutical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments. The emerging market for molecular, nanoscale and atomic imaging includes countries such as India, China, Japan, Korea, Taiwan, Africa, Australia and New Zealand.

METHODOLOGY

BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with manufacturers and technical experts of molecular, nanoscale and atomic imaging. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of molecular, nanoscale and atomic imaging. Data were gathered from various industry sources. BCC spoke with officials within the industry and consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

The study has been carried out by a team of professionals in the biotechnology industry. The project manager for this project was Shalini S. Dewan, who holds a master’s degree in pharmaceutical chemistry and has over 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy: An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in life sciences. She has a number of research publications in her credit, including her thesis, which was given an award of excellence.

REPORT HIGHLIGHTS

This report provides:
• An overview of the global market for molecular, nanoscale, and atomic imaging, with a focus on optical and thermal microscopy.
• Analyses of global market trends, with data from 2010 through 2012, and projections of compound annual growth rates (CAGRs) through 2017.
• Descriptions of imaging equipment and technologies for examining materials, electronics, and biological samples.
• Coverage of technological issues, including novel molecular, nanometer, and atomic imaging capabilities.
• Examination of research activities and areas of interest related to imaging applications.
• Comprehensive company profiles of major players.

Table Of Contents

Global Markets and Technologies for Molecular, Nanoscale and Atomic Imaging -- Focus on Optical and Thermal Microscopy
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 3
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 4
BCC ONLINE SERVICES 4
DISCLAIMER 5

CHAPTER 2 EXECUTIVE SUMMARY 7

SUMMARY TABLE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND NANOSCALE
IMAGING, THROUGH 2017 ($ MILLIONS) 8
SUMMARY FIGURE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND NANOSCALE
IMAGING, 2010-2017 ($ MILLIONS) 8

CHAPTER 3 OVERVIEW 10

DEFINITIONS 10
HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 11
TABLE 1 HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 12
CLASSIFICATION OF IMAGING TECHNIQUES 13
OPTICAL AND THERMAL IMAGING 13
Bioluminescent and Fluorescent Microscopy 14
Fluorescent and Bioluminescence Proteins 14
Applications of Fluorescent Proteins 15
Applications of Bioluminescence Proteins 16
Infrared Thermal Imaging 16
Applications of Infrared Thermal Imaging 16
TABLE 2 ADVANTAGES AND DISADVANTAGES OF INFRARED THERMAL IMAGING 17
ELECTRON AND ION MICROSCOPY 17
Transmission Electron Microscope (TEM) 18
Applications of Transmission Electron Microscope 18
TABLE 3 ADVANTAGES AND DISADVANTAGES OF TRANSMISSION ELECTRON
MICROSCOPES 19
Scanning Electron Microscope (SEM) 19
Applications of Scanning Electron Microscopes 19
TABLE 4 ADVANTAGES AND DISADVANTAGES OF SCANNING ELECTRON
MICROSCOPES 20
Field Ion Microscopy 20
Applications of Field Ion Microscopy 21
TABLE 5 ADVANTAGES AND DISADVANTAGES OF FIELD ION MICROSCOPY 21
SCANNING PROBE MICROSCOPY (SPM) 21
Scanning Tunneling Microscope (STM) 22
Applications of Scanning Tunneling Microscope 22
TABLE 6 ADVANTAGES AND DISADVANTAGES OF SCANNING TUNNELING
MICROSCOPES 23
Atomic Force Microscopy (AFM) 23
Modes of Operation 23
Applications of Atomic Force Microscopy 24
TABLE 7 ADVANTAGES AND DISADVANTAGES OF ATOMIC FORCE MICROSCOPY 25
Magnetic Force Microscopy (MFM) 25
Applications of Magnetic Force Microscopy 25
TABLE 8 ADVANTAGES AND DISADVANTAGES OF MAGNETIC FORCE MICROSCOPY 26
Near-Field Scanning Optical Microscopy (NSOM) 26
Applications of Near-Field Scanning Optical Microscopy 26
TABLE 9 ADVANTAGES AND DISADVANTAGES OF NEAR-FIELD SCANNING OPTICAL
MICROSCOPY 27
PROBES 27
MOLECULAR PROBES 28
NANOPARTICLES 28
QUANTUM DOTS 30

CHAPTER 4 REGULATORY ASPECTS 33

TABLE 10 MEMBER AGENCIES OF NATIONAL NANOTECHNOLOGY INITIATIVE 33
NANOTECHNOLOGY PROGRAMS AT THE FDA 36
CENTER FOR BIOLOGICS EVALUATION AND RESEARCH (CBER) PROGRAMS 36
Center for Drug Evaluation and Research (CDER) Nanotechnology
Programs 37
Center for Devices and Radiological Health (CDRH) Nanotechnology
Programs 37
Center for Food Safety and Applied Nutrition (CFSAN)
Nanotechnology Programs 37
Center for Veterinary Medicine (CVM) Nanotechnology Programs 38
National Center for Toxicological Research (NCTR) Nanotechnology
Programs 38
EPA AND NANOTECHNOLOGY 38

CHAPTER 5 NEW DEVELOPMENTS 41

NEW DEVELOPMENTS IN IMAGING SYSTEMS 41
TABLE 11 NEW DEVELOPMENTS IN OPTICAL AND THERMAL MICROSCOPY 42
TABLE 12 NEW DEVELOPMENTS IN ELECTRON AND ION MICROSCOPY 43
TABLE 13 NEW DEVELOPMENTS IN SCANNING PROBE MICROSCOPY 46
NEW DEVELOPMENTS IN THE FIELD OF PROBES 47

CHAPTER 6 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE

AND ATOMIC IMAGING 51
MARKET BY TYPE 51
MARKET OVERVIEW 52
MARKET REVENUE 55
TABLE 14 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY TYPE, THROUGH 2017 ($ MILLIONS) 55
FIGURE 1 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY TYPE, 2010-2017 ($ MILLIONS) 55
MARKET SHARE 56
TABLE 15 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY TYPE, 2011 (%) 56
FIGURE 2 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY TYPE, 2011 (%) 56
MARKET BY REGION 57
MARKET OVERVIEW 58
MARKET REVENUE 60
TABLE 16 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, THROUGH 2017 ($ MILLIONS) 60
FIGURE 3 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2010-2017 ($ MILLIONS) 60
MARKET SHARE 61
TABLE 17 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2011 (%) 61
FIGURE 4 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2011 (%) 61
MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION 62
MARKET OVERVIEW 62
MARKET REVENUE 63
TABLE 18 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION,
THROUGH 2017 ($ MILLIONS) 64
FIGURE 5 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION,
2010-2017 ($ MILLIONS) 64
MARKET SHARE 64
TABLE 19 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION, 2011
(%) 65
FIGURE 6 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION, 2011
(%) 65
MARKET FOR IMAGING PROBES BY REGION 65
MARKET OVERVIEW 66
MARKET REVENUE 66
TABLE 20 GLOBAL MARKET FOR IMAGING PROBES BY REGION, THROUGH 2017 ($
MILLIONS) 67
FIGURE 7 GLOBAL MARKET FOR IMAGING PROBES BY REGION, 2010-2017 ($
MILLIONS) 67
MARKET SHARE 67
TABLE 21 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68
FIGURE 8 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68
MARKET FOR SCANNING PROBE MICROSCOPE BY REGION 68
MARKET OVERVIEW 69
MARKET REVENUE 69
TABLE 22 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,
THROUGH 2017 ($ MILLIONS) 70
FIGURE 9 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,
2010-2017 ($ MILLIONS) 70
MARKET SHARE 70
TABLE 23 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION, 2011 (%) 71
FIGURE 10 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION, 2011
(%) 71
MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION 71
MARKET OVERVIEW 72
MARKET REVENUE 72
TABLE 24 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
THROUGH 2017 ($ MILLIONS) 72
FIGURE 11 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
2010-2017 ($ MILLIONS) 72
MARKET SHARE 73
TABLE 25 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 73
FIGURE 12 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 73
MARKET BY APPLICATIONS 74
MARKET OVERVIEW 74
MARKET REVENUE 76
TABLE 26 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY APPLICATIONS, THROUGH 2017 ($ MILLIONS) 76
FIGURE 13 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY APPLICATIONS, 2010-2017 ($ MILLIONS) 76
MARKET SHARE 77
TABLE 27 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING, BY APPLICATIONS, 2011 (%) 77
FIGURE 14 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, 2011 (%) 77

CHAPTER 7 MARKET ANALYSIS OF OPTICAL AND THERMAL MICROSCOPY 79

MARKET BY TYPE 79
MARKET OVERVIEW 79
MARKET REVENUE 81
TABLE 28 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,
THROUGH 2017 ($ MILLIONS) 82
FIGURE 15 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,
2010-2017 ($ MILLIONS) 82
MARKET SHARE 82
TABLE 29 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83
FIGURE 16 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83
MARKET BY REGION 83
MARKET OVERVIEW 83
MARKET REVENUE 84
TABLE 30 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
THROUGH 2017 ($ MILLIONS) 85
FIGURE 17 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
2010-2017 ($ MILLIONS) 85
MARKET SHARE 85
TABLE 31 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 86
FIGURE 18 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 86
MARKET FOR OPTICAL IMAGING BY REGION 86
MARKET OVERVIEW 86
MARKET REVENUE 87
TABLE 32 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, THROUGH 2017 ($
MILLIONS) 87
FIGURE 19 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, 2010-2017 ($
MILLIONS) 88
MARKET SHARE 88
TABLE 33 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88
FIGURE 20 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88
MARKET FOR THERMAL IMAGING BY REGION 89
MARKET OVERVIEW 89
MARKET REVENUE 90
TABLE 34 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, THROUGH 2017 ($
MILLIONS) 90
FIGURE 21 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, 2010-2017 ($
MILLIONS) 91
MARKET SHARE 91
TABLE 35 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91
FIGURE 22 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91
MARKET BY APPLICATIONS 92
TABLE 36 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY
APPLICATION, THROUGH 2017 ($ MILLIONS) 92
FIGURE 23 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY
APPLICATION, 2010-2017 ($ MILLIONS) 93
OPTICAL IMAGING 93
Market Revenue 94
TABLE 37 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION, THROUGH
2017 ($ MILLIONS) 94
FIGURE 24 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION, 2010-2017
($ MILLIONS) 94
THERMAL IMAGING 95
Market Revenue 96
TABLE 38 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION, THROUGH
2017 ($ MILLIONS) 96
FIGURE 25 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION, 2010-2017
($ MILLIONS) 96
MARKET SHARE 97
TABLE 39 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY APPLICATION,
2011 (%) 97
FIGURE 26 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY APPLICATION,
2011 (%) 97
INDUSTRY STRUCTURE 98
OPTICAL IMAGING (FLUORESCENCE AND BIOLUMINESCENCE IMAGING) 98
Market Leaders 98
TABLE 40 LEADING MANUFACTURERS OF OPTICAL IMAGING 98
Market Shares 99
TABLE 41 GLOBAL MARKET SHARES OF FLUORESCENCE AND BIOLUMINESCENCE
MICROSCOPES, 2011 (%) 100
FIGURE 27 GLOBAL MARKET SHARES OF FLUORESCENCE AND BIOLUMINESCENCE
MICROSCOPES, 2011 (%) 100
THERMAL IMAGING 101
Market Leaders 101
TABLE 42 LEADING MANUFACTURERS OF THERMAL IMAGING SYSTEMS 101
Market Shares 102
TABLE 43 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011 (%) 103
FIGURE 28 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011 (%) 103

CHAPTER 8 PATENT ANALYSIS 105

PATENT ANALYSIS OF IMAGING SYSTEMS 106
PATENTS BY YEAR 106
TABLE 44 NUMBER OF PATENTS BY YEAR, 2008-2012 (NUMBER/%) 106
FIGURE 29 NUMBER OF PATENTS, BY YEAR, 2008-2012 106
FIGURE 30 NUMBER OF PATENTS, BY YEAR, 2008-2012 (%) 106
PATENTS BY TYPE 107
TABLE 45 NUMBER OF PATENTS BY TYPE, 2008-2012 107
FIGURE 31 NUMBER OF PATENTS BY TYPE, 2008-2012 (NUMBER) 107
PATENTS BY COUNTRY 108
TABLE 46 NUMBER OF PATENTS BY COUNTRY, 2008-2012 109
FIGURE 32 NUMBER OF PATENTS BY COUNTRY, 2008-2012 109
PATENTS BY COMPANY 110
TABLE 47 NUMBER OF PATENTS BY COMPANY, 2008-2012 110
PATENTS BY ASSIGNEE 111
TABLE 48 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 112
FIGURE 33 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 112
PATENT ANALYSIS OF IMAGING PROBES 112
PATENTS BY YEAR 112
TABLE 49 NUMBER OF PATENTS BY YEAR, 2008-2012 113
FIGURE 34 NUMBER OF PATENTS BY YEAR, 2008-2012 113
FIGURE 35 NUMBER OF PATENTS BY YEAR, 2008-2012 (%) 113
PATENTS BY TYPE 114
TABLE 50 NUMBER OF PATENTS BY TYPE, 2008-2012 114
FIGURE 36 NUMBER OF PATENTS BY TYPE, 2008-2012 114
PATENTS BY COUNTRY 114
TABLE 51 NUMBER OF PATENTS BY COUNTRY, 2008-2012 115
PATENTS BY COMPANY 115
TABLE 52 NUMBER OF PATENTS BY COMPANY, 2008-2012 116
PATENTS BY ASSIGNEE 116
TABLE 53 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 116

CHAPTER 9 CURRENT SITUATION 118

TRENDS IN MOLECULAR, ATOMIC AND NANOSCALE IMAGING 118
CONSIDERABLE GROWTH IN ELECTRON AND SCANNING PROBE
MICROSCOPES 118
ASIA PACIFIC REGIONS: KEY REGIONS OF GROWTH 119
FACTORS AFFECTING THE MARKET 119
PRODUCT INNOVATIONS 119
DEVELOPMENT OF HYBRID SYSTEMS 119
MINIATURIZATION OF ELECTRONIC DEVICES 120
NEED OF QUALITY CONTROL IN ELECTRONICS 120
BABY-BOOMER GENERATION 120
INCREASING INCIDENCE OF LIFE-THREATENING DISEASES 120
IMPROVING ECONOMIC CONDITIONS OF EMERGING COUNTRIES 121
GOVERNMENT SUPPORT 121

CHAPTER 10 COMPANY PROFILES 123

AFFYMETRIX 123
AGILENT TECHNOLOGIES INC. 123
ANASPEC INC. 124
A.P.E. RESEARCH 125
APPLIED NANOTECH HOLDINGS INC. 125
AXIS COMMUNICATIONS AB 126
BECTON DICKINSON COMPANY 126
BIOSEARCH TECHNOLOGIES INC. 127
BRUKER CORPORATION 127
CARL ZEISS MICROSCOPY GMBH 128
CLONTECH LABORATORIES 129
DANAHAR CORPORATION 130
FEI COMPANY 131
FLIR SYSTEMS INC. 131
FLUKE CORPORATION 132
HAMAMATSU CORPORATION 133
HITACHI HIGH-TECHNOLOGIES 133
JEOL LTD. 134
LAMBERT INSTRUMENTS 135
LIFE TECHNOLOGIES 135
NANOCO GROUP PLC 136
NANOPHASE TECHNOLOGIES CORPORATION 136
NIKON CORPORATION 137
NT-MDT COMPANY 137
OLYMPUS CORPORATION 138
OXFORD INSTRUMENTS 138
PERKIN ELMER 139
PROMEGA 140
RHK TECHNOLOGY INC. 140
SIGMA-ALDRICH 140
THERMO FISHER SCIENTIFIC 141
WITEC FOCUS INNOVATIONS 142
XENICS INFRARED SOLUTIONS 142

CHAPTER 11 APPENDIX: ABBREVIATIONS 145



LIST OF TABLES

SUMMARY TABLE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND NANOSCALE
IMAGING, THROUGH 2017 ($ MILLIONS) 8
TABLE 1 HISTORY AND DEVELOPMENT OF IMAGING TECHNIQUES 12
TABLE 2 ADVANTAGES AND DISADVANTAGES OF INFRARED THERMAL IMAGING 17
TABLE 3 ADVANTAGES AND DISADVANTAGES OF TRANSMISSION ELECTRON
MICROSCOPES 19
TABLE 4 ADVANTAGES AND DISADVANTAGES OF SCANNING ELECTRON
MICROSCOPES 20
TABLE 5 ADVANTAGES AND DISADVANTAGES OF FIELD ION MICROSCOPY 21
TABLE 6 ADVANTAGES AND DISADVANTAGES OF SCANNING TUNNELING
MICROSCOPES 23
TABLE 7 ADVANTAGES AND DISADVANTAGES OF ATOMIC FORCE MICROSCOPY 25
TABLE 8 ADVANTAGES AND DISADVANTAGES OF MAGNETIC FORCE MICROSCOPY 26
TABLE 9 ADVANTAGES AND DISADVANTAGES OF NEAR-FIELD SCANNING OPTICAL
MICROSCOPY 27
TABLE 10 MEMBER AGENCIES OF NATIONAL NANOTECHNOLOGY INITIATIVE 33
TABLE 11 NEW DEVELOPMENTS IN OPTICAL AND THERMAL MICROSCOPY 42
TABLE 12 NEW DEVELOPMENTS IN ELECTRON AND ION MICROSCOPY 43
TABLE 13 NEW DEVELOPMENTS IN SCANNING PROBE MICROSCOPY 46
TABLE 14 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY TYPE, THROUGH 2017 ($ MILLIONS) 55
TABLE 15 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY TYPE, 2011 (%) 56
TABLE 16 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, THROUGH 2017 ($ MILLIONS) 60
TABLE 17 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2011 (%) 61
TABLE 18 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION,
THROUGH 2017 ($ MILLIONS) 64
TABLE 19 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION, 2011
(%) 65
TABLE 20 GLOBAL MARKET FOR IMAGING PROBES BY REGION, THROUGH 2017 ($
MILLIONS) 67
TABLE 21 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68
TABLE 22 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,
THROUGH 2017 ($ MILLIONS) 70
TABLE 23 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION, 2011 (%) 71
TABLE 24 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
THROUGH 2017 ($ MILLIONS) 72
TABLE 25 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011 (%) 73
TABLE 26 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY APPLICATIONS, THROUGH 2017 ($ MILLIONS) 76
TABLE 27 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING, BY APPLICATIONS, 2011 (%) 77
TABLE 28 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,
THROUGH 2017 ($ MILLIONS) 82
TABLE 29 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83
TABLE 30 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
THROUGH 2017 ($ MILLIONS) 85
TABLE 31 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011 (%) 86
TABLE 32 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, THROUGH 2017 ($
MILLIONS) 87
TABLE 33 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88
TABLE 34 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, THROUGH 2017 ($
MILLIONS) 90
TABLE 35 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91
TABLE 36 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY APPLICATION,
THROUGH 2017 ($ MILLIONS) 92
TABLE 37 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION, THROUGH
2017 ($ MILLIONS) 94
TABLE 38 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION, THROUGH
2017 ($ MILLIONS) 96
TABLE 39 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY APPLICATION,
2011 (%) 97
TABLE 40 LEADING MANUFACTURERS OF OPTICAL IMAGING 98
TABLE 41 GLOBAL MARKET SHARES OF FLUORESCENCE AND BIOLUMINESCENCE
MICROSCOPES, 2011 (%) 100
TABLE 42 LEADING MANUFACTURERS OF THERMAL IMAGING SYSTEMS 101
TABLE 43 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011 (%) 103
TABLE 44 NUMBER OF PATENTS BY YEAR, 2008-2012 (NUMBER/%) 106
TABLE 45 NUMBER OF PATENTS BY TYPE, 2008-2012 107
TABLE 46 NUMBER OF PATENTS BY COUNTRY, 2008-2012 109
TABLE 47 NUMBER OF PATENTS BY COMPANY, 2008-2012 110
TABLE 48 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 112
TABLE 49 NUMBER OF PATENTS BY YEAR, 2008-2012 113
TABLE 50 NUMBER OF PATENTS BY TYPE, 2008-2012 114
TABLE 51 NUMBER OF PATENTS BY COUNTRY, 2008-2012 115
TABLE 52 NUMBER OF PATENTS BY COMPANY, 2008-2012 116
TABLE 53 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 116



LIST OF FIGURES

SUMMARY FIGURE GLOBAL REVENUE OF MOLECULAR, ATOMIC AND NANOSCALE
IMAGING, 2010-2017 ($ MILLIONS) 8
FIGURE 1 GLOBAL MARKET AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE AND
ATOMIC IMAGING BY TYPE, 2010-2017 ($ MILLIONS) 55
FIGURE 2 MARKET SHARES OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY TYPE, 2011 (%) 56
FIGURE 3 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2010-2017 ($ MILLIONS) 60
FIGURE 4 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY REGION, 2011 (%) 61
FIGURE 5 GLOBAL MARKET FOR ELECTRON AND ION MICROSCOPY BY REGION,
2010-2017 ($ MILLIONS) 64
FIGURE 6 MARKET SHARE OF ELECTRON AND ION MICROSCOPY BY REGION, 2011
(%) 65
FIGURE 7 GLOBAL MARKET FOR IMAGING PROBES BY REGION, 2010-2017 ($
MILLIONS) 67
FIGURE 8 MARKET SHARE OF IMAGING PROBES, BY REGION, 2011 (%) 68
FIGURE 9 GLOBAL MARKET FOR SCANNING PROBE MICROSCOPY BY REGION,
2010-2017 ($ MILLIONS) 70
FIGURE 10 MARKET SHARE OF SCANNING PROBE MICROSCOPY BY REGION, 2011 (%) 71
FIGURE 11 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
2010-2017 ($ MILLIONS) 72
FIGURE 12 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 73
FIGURE 13 GLOBAL MARKETS AND TECHNOLOGIES FOR MOLECULAR, NANOSCALE
AND ATOMIC IMAGING BY APPLICATIONS, 2010-2017 ($ MILLIONS) 76
FIGURE 14 MARKET SHARE OF GLOBAL MARKETS AND TECHNOLOGIES FOR
MOLECULAR, NANOSCALE AND ATOMIC IMAGING BY APPLICATIONS, 2011 (%) 77
FIGURE 15 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY TYPE,
2010-2017 ($ MILLIONS) 82
FIGURE 16 MARKET SHARE OF IMAGING SYSTEMS BY TYPE, 2011 (%) 83
FIGURE 17 GLOBAL MARKET FOR OPTICAL AND THERMAL IMAGING BY REGION,
2010-2017 ($ MILLIONS) 85
FIGURE 18 MARKET SHARE OF OPTICAL AND THERMAL IMAGING BY REGION, 2011
(%) 86
FIGURE 19 GLOBAL MARKET FOR OPTICAL IMAGING BY REGION, 2010-2017 ($
MILLIONS) 88
FIGURE 20 MARKET SHARE OF OPTICAL IMAGING BY REGION, 2011 (%) 88
FIGURE 21 GLOBAL MARKET FOR THERMAL IMAGING BY REGION, 2010-2017 ($
MILLIONS) 91
FIGURE 22 MARKET SHARE OF THERMAL IMAGING BY REGION, 2011 (%) 91
FIGURE 23 GLOBAL REVENUE FOR OPTICAL AND THERMAL IMAGING BY
APPLICATION, 2010-2017 ($ MILLIONS) 93
FIGURE 24 GLOBAL REVENUE FOR OPTICAL IMAGING BY APPLICATION, 2010-2017 ($
MILLIONS) 94
FIGURE 25 GLOBAL REVENUE FOR THERMAL IMAGING BY APPLICATION, 2010-2017
($ MILLIONS) 96
FIGURE 26 MARKET SHARES OF OPTICAL AND THERMAL IMAGING BY APPLICATION,
2011 (%) 97
FIGURE 27 GLOBAL MARKET SHARES OF FLUORESCENCE AND BIOLUMINESCENCE
MICROSCOPES, 2011 (%) 100
FIGURE 28 GLOBAL MARKET SHARES OF THERMAL IMAGING CAMERAS, 2011 (%) 103
FIGURE 29 NUMBER OF PATENTS, BY YEAR, 2008-2012 106
FIGURE 30 NUMBER OF PATENTS, BY YEAR, 2008-2012 (%) 106
FIGURE 31 NUMBER OF PATENTS BY TYPE, 2008-2012 (NUMBER) 107
FIGURE 32 NUMBER OF PATENTS BY COUNTRY, 2008-2012 109
FIGURE 33 NUMBER OF PATENTS BY ASSIGNEE, 2008-2012 112
FIGURE 34 NUMBER OF PATENTS BY YEAR, 2008-2012 113
FIGURE 35 NUMBER OF PATENTS BY YEAR, 2008-2012 (%) 113
FIGURE 36 NUMBER OF PATENTS BY TYPE, 2008-2012 114

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