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Global Ion Channel Modulators Industry

  • April 2015
  • -
  • Global Industry Analysts
  • -
  • 161 pages

This report analyzes the worldwide markets for Ion Channel Modulators in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2014 through 2018. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 47 companies including many key and niche players such as -

AstraZeneca
Bayer HealthCare
CalciMedica, Inc.
Convergence Pharmaceuticals Limited
Evotec AG

Table Of Contents

Global Ion Channel Modulators Industry



I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation and Reporting Level I-2
Quantitative Techniques and Analytics I-3
Product Definitions and Scope of Study I-3


II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Ion Channel Modulators - A Receding Market II-1
Current and Future Analysis II-1
Impending Patent Expiries of Select Ion Channel Modulators II-2
Currently Available Ion Channel Modulating Drugs in the Market II-2
Select Ion Channel Modulator Drugs by Mode of Action II-3
Competitive Scenario II-6
Table 1: Global Ion Channel Modulators Market by Top Ten
Drugs (2013): Percentage Share Breakdown of Revenues
(includes corresponding Graph/Chart) II-6

2. ION CHANNEL MODULATORS BY THERAPEUTIC INDICATION II-7
Cardiovascular Diseases/ Hypertension II-7
Select Major Anti-Hypertensive Drugs Targeting Ion Channels:
2014 II-7
Table 2: Global Annual Medical Cost of CVD in US$ Billion
(2010-2030) (includes corresponding Graph/Chart) II-8

Table 3: Fatalities by Heart Conditions - Estimated
Percentage Breakdown for Cardiovascular Disease, Ischemic
Heart Disease, Stroke, and Others (includes corresponding
Graph/Chart) II-8

Table 4: Fatalities in High Income Countries by Health
Disorder (2015 and 2030): Projected Percentage Breakdown of
Number of Deaths for CVD, Cancer, Injury, and Others
(includes corresponding Graph/Chart) II-9

Table 5: Fatalities in Mid Income Countries by Health
Disorder (2015 and 2030): Projected Percentage Breakdown of
Number of Deaths for CVD; Cancer; Injury; HIV, TB and Malaria;
Malnutrition; and Others (includes corresponding Graph/Chart) II-10

Table 6: Fatalities in Low Income Countries by Health
Disorder (2015 and 2030): Projected Percentage Breakdown of
Number of Deaths for CVD; Cancer; Injury; HIV, TB and Malaria;
Malnutrition; and Others (includes corresponding Graph/Chart) II-11
Ion Channel Modulation in Arrhythmia Treatment II-11
Select Anti-Arrhythmic Drugs Targeting Ion Channels: 2014 II-11
Ion Channel Modulation in Convulsions II-12
Select Anti-Convulsant Drugs Targeting Ion Channels: 2014 II-12
Ion Channel Modulation in Pain Management II-13
Pain Management/Analgesic Drugs Targeting Ion Channels: 2014 II-14
Ion Channel Modulation in Oncology II-14
Ion Channel Modulation of Antidiabetic Agents II-14
Ion Channel Modulation of Antiemetics II-15
Ion Channel Modulators Find Extensive Use in Neglected
Tropical Diseases II-15
Ion Channel Modulation in Other Therapeutic Areas II-15
Select Ion Channel Modulators for Other Therapeutic
Indications: 2014 II-16

3. MARKET DYNAMICS II-17
Aging Population: Sustaining the Market II-17
Table 7: Global Population Worldwide: Percentage Share
Breakdown by Age Group for the year 2025 (includes
corresponding Graph/Chart) II-17

Table 8: Global Population of People Aged 65+ Years (In
Million) for the Years 2012, 2020 and 2050 (includes
corresponding Graph/Chart) II-17
Ion Channel Screening Aided by APC II-18
Increased Interest Witnessed in Outsourcing of Ion Channel
Services II-18
Limitations and Challenges II-18
Ion Channels - Difficult Drug Targets II-18
The Threat Posed by the Influx of Generic Drugs II-19

4. PRODUCT OVERVIEW II-20
Ion Channel Modulators: An Introduction II-20
Biological Significance of Ion Channels II-20
Ion Channel Modulators as an Option for Treating Diseases II-20
Types of Ion Channels II-21
Voltage-Gated Ion Channels II-21
Extracellular Ligand-gated Ion Channels II-22
Intracellular Ligand-gated Ion Channels II-24

5. RECENT INDUSTRY ACTIVITY II-26
Pfizer Wins Court Ruling to Block Generic Versions of Lyrica
Upto 2018 II-26
Forest Labs Discontinues Namenda 5/10 mg Tablets, Launches
Namenda XR II-26
Forest Files Lawsuit against Namenda Generic Manufacturers II-26
Cytocentrics Bioscience Selects Drug Safety Testing Center as
its Distributor in Japanese Market II-26
Zalicus Licenses Its Entire Sodium Channel Modulator Program
to AnaBios Corporation II-26
EPIRUS Merges with Zalicus II-26
XENTION Collaborates with SERVIER for Kv1.5 Modulator Project II-27
Aurora Biomed Inks Agreement with Specs and Alion Pharmaceuticals II-27
Hydra and Zalicus Enter into Partnership II-27
Hydra Biosciences and Cubist Pharmaceuticals to Commence Phase
1 Clinical Trial for TRPA1 Antagonist CB-625 II-27
Vertex Pharmaceuticals Receives USFDA Approval for KALYDECOâ„¢ II-27

6. FOCUS ON SELECT GLOBAL PLAYERS II-28
AstraZeneca (UK) II-28
Bayer HealthCare (Germany) II-28
CalciMedica, Inc. (US) II-29
Convergence Pharmaceuticals Limited (UK) II-29
Evotec AG (Germany) II-29
Forest Laboratories, LLC (US) II-30
GlaxoSmithKline Plc. (UK) II-30
Johnson and Johnson (US) II-31
Lundbeck (Denmark) II-31
Novartis AG (Switzerland) II-32
Parion Sciences, Inc. (US) II-32
Pfizer, Inc. (US) II-32
Neusentis, Inc. (US) II-33
Sanofi S.A. (France) II-33
Targacept, Inc. (US) II-34
Xention Limited (UK) II-35

7. GLOBAL MARKET PERSPECTIVE II-36
Table 9: World Recent Past, Current and Future Analysis for
Ion Channel Modulators by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), Latin America,
and Rest of World Markets Independently Analyzed with Annual
Sales in US$ Million for Years 2014 through 2018 (includes
corresponding Graph/Chart) II-36

Table 10: World Historic Review for Ion Channel Modulators by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), Latin America, and Rest of World Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2007 through 2013 (includes corresponding Graph/Chart) II-37

Table 11: World 12-Year Perspective for Ion Channel Modulators
by Geographic Region - Percentage Breakdown of Dollar Sales
for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan),
Latin America, and Rest of World Markets for Years 2007, 2015 and
2018 (includes corresponding Graph/Chart) II-38


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Overview III-1
Strategic Corporate Developments III-1
Select Key Players III-2
B.Market Analytics III-6
Table 12: The US Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-6

Table 13: The US Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-7

2. CANADA III-8
A.Market Analysis III-8
Strategic Corporate Development III-8
B.Market Analytics III-8
Table 14: Canadian Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-8

Table 15: Canadian Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-9

3. JAPAN III-10
A.Market Analysis III-10
Strategic Corporate Development III-10
B.Market Analytics III-11
Table 16: Japanese Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-11

Table 17: Japanese Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-12

4. EUROPE III-13
A.Market Analysis III-13
Overview III-13
B.Market Analytics III-14
Table 18: European Recent Past, Current and Future Analysis
for Ion Channel Modulators by Geographic Region - France,
Germany, Italy, UK, Spain, Russia and Rest of Europe Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2014 through 2018 (includes corresponding Graph/Chart) III-14

Table 19: European Historic Review for Ion Channel
Modulators by Geographic Region - France, Germany, Italy,
UK, Spain, Russia and Rest of Europe Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-15

Table 20: European 12-Year Perspective for Ion Channel
Modulators by Geographic Region - Percentage Breakdown of
Dollar Sales for France, Germany, Italy, UK, Spain, Russia
and Rest of Europe Markets for Years 2007, 2015 and 2018
(includes corresponding Graph/Chart) III-16

4a. FRANCE III-17
A.Market Analysis III-17
Sanofi S.A. - A Key Player III-17
B.Market Analytics III-18
Table 21: French Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-18

Table 22: French Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-19

4b. GERMANY III-20
A.Market Analysis III-20
Key Players III-20
B.Market Analytics III-22
Table 23: German Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-22

Table 24: German Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-23

4c. ITALY III-24
Market Analysis III-24
Table 25: Italian Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-24

Table 26: Italian Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-25

4d. THE UNITED KINGDOM III-26
A.Market Analysis III-26
Strategic Corporate Development III-26
Select Key Players III-26
B.Market Analytics III-29
Table 27: The UK Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-29

Table 28: The UK Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-30

4e. SPAIN III-31
Market Analysis III-31
Table 29: Spanish Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-31

Table 30: Spanish Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-32

4f. RUSSIA III-33
Market Analysis III-33
Table 31: Russian Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-33

Table 32: Russian Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-34

4g. REST OF EUROPE III-35
A.Market Analysis III-35
Key Players III-35
B.Market Analytics III-36
Table 33: Rest of Europe Recent Past, Current and Future
Analysis for Ion Channel Modulators with Annual Sales in US$
Million for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-36

Table 34: Rest of Europe Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-37

5. ASIA-PACIFIC III-38
Market Analysis III-38
Table 35: Asia-Pacific Recent Past, Current and Future
Analysis for Ion Channel Modulators by Geographic Region -
China, India and Rest of Asia-Pacific Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2014
through 2018 (includes corresponding Graph/Chart) III-38

Table 36: Asia-Pacific Historic Review for Ion Channel
Modulators by Geographic Region - China, India and Rest of
Asia-Pacific Markets Independently Analyzed with Annual
Sales in US$ Million for Years 2007 through 2013 (includes
corresponding Graph/Chart) III-39

Table 37: Asia-Pacific 12-Year Perspective for Ion Channel
Modulators by Geographic Region - Percentage Breakdown of
Dollar Sales for China, India and Rest of Asia-Pacific
Markets for Years 2007, 2015 and 2018 (includes corresponding
Graph/Chart) III-40

5a. CHINA III-41
Market Analysis III-41
Table 38: Chinese Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-41

Table 39: Chinese Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-42

5b. INDIA III-43
Market Analysis III-43
Table 40: Indian Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-43

Table 41: Indian Historic Review for Ion Channel Modulators
with Annual Sales in US$ Million for Years 2007 through 2013
(includes corresponding Graph/Chart) III-44

5c. REST OF ASIA-PACIFIC III-45
Market Analysis III-45
Table 42: Rest of Asia-Pacific Recent Past, Current and
Future Analysis for Ion Channel Modulators with Annual Sales
in US$ Million for Years 2014 through 2018 (includes
corresponding Graph/Chart) III-45

Table 43: Rest of Asia-Pacific Historic Review for Ion
Channel Modulators with Annual Sales in US$ Million for
Years 2007 through 2013 (includes corresponding Graph/Chart) III-46

6. LATIN AMERICA III-47
Market Analysis III-47
Table 44: Latin American Recent Past, Current and Future
Analysis for Ion Channel Modulators by Geographic Region -
Brazil and Rest of Latin America Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2014
through 2018 (includes corresponding Graph/Chart) III-47

Table 45: Latin American Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million by Geographic
Region - Brazil and Rest of Latin America Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2007 through 2013 (includes corresponding Graph/Chart) III-48

Table 46: Latin American 12-Year Perspective for Ion Channel
Modulators by Geographic Region - Percentage Breakdown of
Dollar Sales for Brazil and Rest of Latin America Markets
for Years 2007, 2015 and 2018 (includes corresponding
Graph/Chart) III-49

6a. BRAZIL III-50
Market Analysis III-50
Table 47: Brazilian Recent Past, Current and Future Analysis
for Ion Channel Modulators with Annual Sales in US$ Million
for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-50

Table 48: Brazilian Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-51

6b. REST OF LATIN AMERICA III-52
Market Analysis III-52
Table 49: Rest of Latin America Recent Past, Current and
Future Analysis for Ion Channel Modulators with Annual Sales
in US$ Million for Years 2014 through 2018 (includes
corresponding Graph/Chart) III-52

Table 50: Rest of Latin America Historic Review for Ion
Channel Modulators with Annual Sales in US$ Million for
Years 2007 through 2013 (includes corresponding Graph/Chart) III-53

7. REST OF WORLD III-54
Market Analysis III-54
Table 51: Rest of World Recent Past, Current and Future
Analysis for Ion Channel Modulators with Annual Sales in US$
Million for Years 2014 through 2018 (includes corresponding
Graph/Chart) III-54

Table 52: Rest of World Historic Review for Ion Channel
Modulators with Annual Sales in US$ Million for Years 2007
through 2013 (includes corresponding Graph/Chart) III-55


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 47 (including Divisions/Subsidiaries - 50)

The United States (20)
Canada (1)
Japan (2)
Europe (26)
- France (2)
- Germany (6)
- The United Kingdom (6)
- Italy (2)
- Rest of Europe (10)
Asia-Pacific (Excluding Japan) (1)

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