1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends

Multiple Sclerosis: KOL Insight

  • October 2015
  • Firstword Pharma
Report ID: 1202993


Table of Contents

Roche’s/Biogen’s novel ocrelizumab is set to radically alter the Multiple Sclerosis (MS) treatment paradigm. Which companies and products will lose market share as its use widens and what clinical benefits underpin KOL excitement? Could it challenge interferon therapy? Where will oral therapies such as Novartis’ Gilenya (fingolimond) fit in? Where will Biogen’s well regarded Tecfidera (dimethyl fumarate) find a role?

This report reveals the unique insights of 12 leading US and European KOLs – see who they are. How they view the clinical benefits of current and late-stage disease-modifying agents, safety concerns and the influence patients exert are fully explored. The report analyses 8 leading launched products and 8 significant late-stage therapies see full list.

View: US KOLS, EU KOLS, Market drugs, Pipeline drugs

“Ocrelizumab is the most exciting of all the MS drugs. This drug will take markets. This will be the most disruptive therapy of any therapy we’ve discussed.” EU KOLv

Answering key questions

Ocrelizuzimab: What safety and dosage benefits underpin KOLs positive opinions about ocrelizumab?
Copaxone/Glatopa: Will longer acting formulations help Teva defend Copaxone revenues against Sandoz/Momenta's Glatopa (generic glatiramer acetate)?
Gilenya/Tecfidera: Have safety concerns blunted the growth of Novartis'Gilenya (fingolimond) and Biogen's Tecfidera (dimethyl fumarate) - how do KOLs see their role in the treatment paradigm evolving?
Plegridy: How is the launch of Plegridy impacting other interferon products and what effect will this have on the interferon market as a whole?
Lemtrada: How might the CAM-THY, EMERALD and TOPAZ trials for Sanofi's/Genzyme's Lemtrada (alemtuzumab) influence KOLs views?
Ozanimod/siponimod: Can new sphingosine modulators such as Celgene's ozanimod, Novartis' siponimod and Actelion's ponesimod differentiate themselves against established therapies and find a market?
Biotin: MedDay's ultra-high dose biotin (MD 1003) is showing promise for progressive diease and could be an effective low-cost treatment – but what KOL concerns do MedDay have to address in clinical trials?

Top Takeaways

A changing treatment paradigm: While ocrelizumab will initially compete as a second line in RRMS it could move to first line therapy and get traction in PPMS. Understand its clinical benefits and why it is being seen as a really potent alternative to current products.
A question of safety: Many treatments are effective in treating MS but come with a range of adverse reactions. Assess the impact safety is having on prescribing habits and how new therapies will benefit.
Patient preferences: Appreciate how patient choice plays a key role in prescribing decisions. The route of administration and frequency of treatment are critical to patient buy-in and healthcare cost control.
The next generation: Understand why Anti-LINGO could be the next game changer in multiple sclerosis.
Underserved patient populations: While there are plenty of options for the treatment of RRMS , there remains an unmet need for progressive forms of the disease – how will new treatments play a role?
Combination Therapy: Most MS treatments are given as monotherapy, and cost is cited as the dampener of combination treatment. Could innovative pricing be an opportunity area and would the clinical benefits justify the increase?
Research points the way: Review KOL attitudes to recently completed or ongoing clinical trials such as BEST-MS, CAM-THY, ORATORIO, OPTIMUM, ARPEGGIO and EXPAND.

Key Issues Explored

Patients play a critical role in therapy choice. The frequency of treatment, additional monitoring and fear of adverse reactions are just some of the issues that clinicians take into account. It’s more than just efficacy and there are lessons for companies for their patient outreach programmes.
There is much promise in the new therapies coming to market but they are competing with established products whose profile and risks are known – it will take some time to build clinical confidence and start to fully realise their potential - medical and patient education will play a key role.
Product differentiation is critical in getting formulary placement. Knowing what product attributes and patient characteristics KOLs think are the most important in terms of prescribing decisions are “must-know” to ensure commercial success.
Unlike many treatment areas, combination therapy is not common in MS. KOLs cite cost as an issue, but could progressive pricing and combination therapy be considered as an end game for products superseded by new therapies?
How do KOLs view high-dose biotin (MD 1003) and what specific advantages would such a product have?

A report based on expert knowledge


Dr Robert Naismith, MD, Associate Professor of Neurology and Neurology Clerkship Director at Washington University in St. Louis
Dr Benjamin M. Greenberg, MD, Associate Professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology and Neurotherapeutics at UT Southwestern Medical Center
Dr Daniel Harrison, MD, Assistant Professor of Neurology at Johns Hopkins University Medical Center and a faculty member of the Johns Hopkins MS Center
Dr Shiv Saidha, M.B.B.Ch, Assistant Professor of Neurology at Johns Hopkins University School of Medicine
Dr Darin T. Okuda, MD, Director of the Multiple Sclerosis and Neuroimmunology Imaging Program and the Deputy Director of the MS Program and Clinical Center for Multiple Sclerosis at the University of Texas Southwestern Medical Center in Dallas, Texas
Dr Anne Cross, MD, Professor of Neurology and Section Head of Neuroimmunology at Washington University School of Medicine, St. Louis


Prof Cris Constantinescu, Head of the Academic Division of Clinical Neurology at the University of Nottingham; senior consultant in charge of the MS Clinic, University Hospital Nottingham
Prof Nighoghossian, Chief Neurologist at CHU Lyon, France
clinic in a university hospital.
Dr Elio Scarpini, Chief of the Center for Neurodegenerative and Demyelinating Disorders, University of Milan, Fondazione IRCCS Cà Granda, Ospedale Policlinico, Milan, Italy
Dr Belen Caminero, is responsible for the Multiple Sclerosis Unit in the Healthcare Complex of Avila, Spain.
Anonymous, German KOL, is a Professor of Neurology. This expert is Managing Lead Consultant of a neurology
Anonymous, European KOL, Principal investigator on several multinational MS clinical trials

Get KOL insights on

Marketed MS Drugs

Interferons (Avonex, Rebif, Betaseron, Extavia)
Plegridy (peginterferon beta-1a/BIIB017; Biogen)
Copaxone (glatiramer acetate; Teva)
Tecfidera (dimethyl fumarate; Biogen)
Aubagio (teriflunomide; Sanofi/Genzyme)
Gilenya (fingolimod; Novartis/Mitsubishi Tanabe Pharma)
Tysabri (natalizumab; Biogen)
Lemtrada (alemtuzumab; Sanofi/Genzyme/Bayer HealthCare)

MS Pipeline

Zinbryta (daclizumab high-yield process, DAC-HYP; Biogen/AbbVie)
Nerventra (laquinimod; Active Biotech/Teva)
Ozanimod (RPC 1063; Celgene)
Siponimod (BAF 312; Novartis)
Ponesimod (ACT 128800; Actelion)
Ocrelizumab (Roche/Biogen)
Masitinib (AB 1010; AB Science)
Biotin (MD 1003; MedDay)

Ongoing Benefits

The world of pharma is ever changing and executives must always be up-to-date with new developments that could affect their own products, position and research. That is why FirstWord’s guarantee to keep Therapy Trends clients up to date with Update Bulletins offers a real commercial advantage.

Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update.

Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the report's publication date, October.
You will receive a copy of each Update Bulletin once available, which are issued each quarter after the publication date.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 60 Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

Ahmad helps you find the right report:


The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

Purchase Reports From Reputable Market Research Publishers

Crohn’s Disease Market and Forecast Analysis

  • $ 22000
  • Industry report
  • March 2017
  • by Datamonitor Healthcare

Disease Overview Crohn’s disease involves inflammation of the gastrointestinal (GI) tract and most commonly affects the terminal ileum or colon. Because Crohn’s disease can occur in various areas of ...

PharmaPoint: Rheumatoid Arthritis - Global Drug Forecast and Market Analysis to 2025

  • $ 10995
  • Industry report
  • February 2017
  • by GlobalData

PharmaPoint: Rheumatoid Arthritis - Global Drug Forecast and Market Analysis to 2025 Summary Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes inflammation and deformity of the joints. ...

PharmaFocus: Tauopathies - Global Market Analysis

  • $ 9495
  • Industry report
  • February 2017
  • by GlobalData

PharmaFocus: Tauopathies - Global Market Analysis Summary Tauopathies are a class of more than 20 neurodegenerative diseases characterized by tau protein aggregation in the brain. There are currently no ...

Hnscc: Kol Insight - 2017

March 2017 $ 8355

Download Unlimited Documents from Trusted Public Sources

Therapy Market in the US

  • May 2017
    2 pages
  • Therapy  

  • United States  

View report >

Therapy Market in the US

  • May 2017
    3 pages
  • Therapy  


  • United States  

View report >

Hormone and Therapy Market in Pakistan and the US

  • May 2017
    7 pages
  • Hormone  



  • Pakistan  

    United States  

View report >

Related Market Segments :



Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.