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  3. > Drug Discovery and Development Market Trends
  4. > Drug Solubility Technology: Spray Drying, Extrusion and SCF: Processes, Products, and Prospects

As drug suppliers re-examine their business models to adjust to the rapidly evolving competitive landscape, the importance and impact of drug solubility on drug design and development is increasing in importance, extending beyond potential future drug therapeutics, and affecting current reformulation strategies as well. As large-molecule therapeutics increase in number and as a percentage of all drug discoveries, the economic scales will tip in favor of those drug developers possessing the ability to engineer water-soluble formulations of inherently hydrophobic compounds. The importance of solubilization technologies is also underscored by the capability they bestow on formulators attempting to re-formulate approved drugs approaching the end of their patent life. The survey examines established physical processes for improving and enhancing drug solubility, including spray dry dispersion, hot melt extrusion and supercritical fluid processing.

Highlights

• Analyzes and evaluates drug formulation process technology improving the properties of insoluble poorly soluble and/or poorly absorbed drug candidates
• Examines evolving market factors
• Provides detailed assessments and status of commercial technologies designed to improve drug solubility
• Profiles drug solubility technology market participants, their research activity, proprietary technology, and business strategies

Table Of Contents

Drug Solubility Technology: Spray Drying, Extrusion and SCF: Processes, Products, and Prospects
Summary of Contents

Executive Summary

Drug Solubility Technology

Spray Dry Dispersion
Technology Market Drivers
Physicochemical Properties
Hot Melt Extrusion
Supercritical Fluid Processing

Approved Drug Products Formulated with SDD/HME/SFP

Acetaminophen
Nifedipine
Everolimus
Nabilone
Diethylpropion
Emend
Vildagliptin/Metformin
Clozapine
Fenofibrate
Griseofulvin
Ibuprofen
Etonogestrel
Etravirine
Verapamil
Liponavir+Ritonavir
Lacrisert
Tacrolimus
Rizatriptan
Naproxen
Norvir
Tapentadol
Etonogestrel, Ethinyl Estradiol
Itraconazole
Dexamethasone
Hydromorphone
Rapamune
Tricor, Triglide
Zoladex

Development/Pipeline Analysis and Assessment

Company Profiles


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