Advances in Ophthalmology: Markets in the Treatment of Eye Disorders and Corrective Vision, 2nd Ediiton

Advances in Ophthalmology: Markets in the Treatment of Eye Disorders and Corrective Vision, 2nd Ediiton

The information represented in this report is a comprehensive analysis of the eye care
market globally with a special focus on the United States and selected international sectors.
The year ending December 31, 2008 was used as the base year with forecasts to the year
2013. Market statistics are given in U.S. dollars and in units [where appropriate]. Basis for
the market analysis consists of key data, statistics; references, and information from a large
data base of primary and secondary research sources documented in the report consisting of
interviews, professional meetings; conferences; presentations; journals; consumer media
[radio, TV, magazines, newspapers]; and Internet content involving more than 40,000
sources. Data were collected for global populations and medical providers who represent the
key influences in the eye care market.


The market analysis is comprised of two major sectors:

• refractive vision correction

[addressing myopia, hyperopia, presbyopia, and astigmatism]
• and major eye diseases

[addressing cataracts, glaucoma, AMD, retinal disorders].

Within the primary sectors the
analysis includes the top RVC treatment modalities [traditional and advanced laser systems;
RVC lens implants, and alternative surgical implants] and surgical intervention for each of
the major diseases [retinal laser surgery, photo dynamic therapy, pneumatic thermoplasticy,
capsulectomy, and trabeculectomy]. Competitive market shares are given for the key
manufacturers of RVC treatment methodologies and for major devices and ophthalmic
therapeutics employed in the management of eye diseases.

New technologies and treatment modalities for both visual acuity and major eye diseases may dramatically change the composition and competitive dynamics of the ophthalmology market. This report explores these dynamics and discoveries along with their profound impact on clinical eye care and the competitive positions of the market supplier. Also examined are traditional [conventional] approaches, the role of medical skills and techniques developed and cultivated over past years, and the importance of supporting increasingly global demand to correct vision deficiencies.


Other competitive technologies presented herein under the heading of refractive vision correction [RVC] include:

• Integrated [diagnostic] laser surgery


• RF conductive keratoplasty


• Earlier versions of corrective laser systems.

This segment also includes RVC breakthrough technologies such as

• Imaging topography


• Accommodating implants


• Special vision lens


• Vision restoration systems and


• Other evolving technologies

Vision abnormalities [restoration of impaired vision] presented and investigated are confined to following four primary conditions:

• Myopia [nearsightedness]-leading eye disorder affecting all age groups


• Hyperopia [farsightedness]-second leading eye disorder affecting all age groups


• Presbyopia [near focus abnormality]-phenomenon of aging, mostly 40 + year olds


• Astigmatism [cornea irregularities, eye globe distortion]-affects all age groups

The range of therapeutic modalities mentioned above offers multiple options in treating one or more of the four primary diseases. While some modalities like ophthalmic pharmaceuticals are used to treat one disease, other medical devices like lasers and implants [Refocus Group’s PresView SRP-Scleral Lens Spacers] are more flexible and used in multiple applications for disease-specific procedures.


The market described herein is also positioning itself to resolve its most compelling
problems effecting older populations-the alarming increase in loss of vision worldwide
resulting from diseases, aging, and declining health conditions. The race is underway to
develop and exploit cutting-edge technologies [diagnostics, imaging, therapeutics, devices]
that will address the growing threat of deteriorating vision and blindness caused by the most
serious eye diseases, including:

• Cataracts-surgery & replacement intra ocular lens [IOL] and accommodating

lens,

• Glaucoma/Ocular Hypertension-chronic opened-angle and acute closedangle


• Age-Related Macular Degeneration [AMD]-both wet and dry, and


• Retinal Disorders-diabetic retinopathy, diabetic edema, detached retina.

While technological innovations continue to play a crucial role in slowing [or stopping]
the progress of vision loss through laser surgery and other medical and therapeutic
intervention, early diagnosis of these diseases and knowledge of available treatment options
is equally crucial to prevent the progression and further deterioration of vision. However, the
availability of technologies, medical disciplines, and skills to take advantage of the gains
made in managing eye diseases has yet to realize its full competitive and market potential. And many players entering this field will find this report a useful resource.

CHAPTER ONE: EXECUTIVE SUMMARY

Overview

Objectives, Scope, and Methodology

Summary Of Findings

Overview of Current Market Dynamics

Market Analysis and Forecasts

CHAPTER TWO: INTRODUCTION AND OVERVIEW

Overview

History in Treating Eye Diseases

World Demographics

Population by Gender

Aging Population

Staggering World Facts

CHAPTER THREE: ISSUES AND TRENDS IN THE OPHTHALMOLOGY INDUSTRY

Overview

Resistance to Change

The New Technological Revolution

Competition: Old vs New

Refractive Vision Correction [RVC]

Patient Reported Outcomes for Laser in situ Keratomileusis (LASIK) Surgery

World Economy and Refractive Surgery

Typical Refractive Demographic 2009

Major Eye Diseases

Regulation

Government’s Role as Overseer

Government Mandate: Safety & Effectiveness

Developed & Underdeveloped Countries Off-Label Use Ophthalmologists vs Optometrists Business Challenges in a Regulated Environment

Intellectual Property, Asset Ownership

International Trade [Export/Import] Governance in a Publicly-Owned Company

CHAPTER FOUR: RESTORATION OF IMPAIRED VISION

Treatment of Leading Vision Disorders

The Global Opportunity

Conventional Eye Glasses and Contact Lens

Conventional Eye Glasses

Traditional Contact Lenses

Other Corrective Modalities

LASIK/Laser Surgery Intervention

RF Conductive Keratoplasty [RFK]

Correctable Vision Implants—Spacers/Inserts

Other Investigational Treatments for Presbyopia

Temporary Correctable Vision Lenses

Lens Implants—Phakic & Implantable Lens Implants [ICL]

Challenges & Threats in the Global Marketplace

CHAPTER FIVE: DISEASES AFFECTING THE EYE

Overview

Cataracts

Glaucoma

Macular Degeneration

Vitreoretinal Disorders

Diabetic Retinopathy [DR]

Diabetic Macular Edema [DME]

Retinal Detachment [RD]

CHAPTER SIX: REFRACTIVE VISION CORRECTION: PRODUCTS AND TECHNOLOGIES

Overview

Competing Treatment Technologies

Competitive Products, Technology, Applications & Market Status

CHAPTER SEVEN: MAJOR EYE DISEASES: PRODUCTS AND TECHNOLOGIES

Overview

Summary of Competing Technologies

Cataract

Glaucoma

Age-Related Macular Degeneration

Vitreoretinal Conditions

CHAPTER EIGHT: MARKET SUMMARY

Description of the Market

Eye Care Challenges

The Aging Process and Complications of Chronic Conditions

Technology Overcomes Obsolete Methodologies

Older Treatment Modalities

Advanced Treatment Modalities

Pressures Influencing Structural Changes

Market Influences

CHAPTER NINE: REFRACTIVE VISION CORRECTION MARKET ANALYSIS & FORECAST

Background

Eye Glasses & Contact Lenses

Prevention & Wellness

Laser Surgery & Other Corrective Alternatives

Market and Competitive Analysis

Refractive Vision Correction Markets: Equipment, Supplies, and Devices

Refractive Vision Correction Markets: Services

CHAPTER TEN: MAJOR EYE DISEASES: MARKET ANALYSIS & FORECAST

Market Challenges

Market and Competitive Analysis

Eye Disease Markets: Equipment, Supplies, and Devices

Markets by Eye Disease

Cataracts—Surgical Intervention and Devices

Glaucoma Treatment and Management

Vitreoretinal—Conventional & Advanced Treatments

Other Treatments—Allergy, Dry Eye, Infection, Inflammation

Eye Disease Markets: Services

CHAPTER ELEVEN:COMPANY PROFILES

Overview

Abbott Medical Optics, Inc

Products/Technology/Intellectual Property

Financial Performance and Segment Analysis

Alcon, Inc

Products/Technology/Intellectual Property

Focus & Future Strategy

Allergan, Inc

Business Overview

Products and Strategy

Heidelberg Engineering, Inc

Business Overview

Products and Technology

Nidek Co. Ltd.

Business Overview

Products/Technology/Intellectual Property

STAAR Surgical Company

Business Overview

Products/Technology/Intellectual Property

Strategy

Novartis

Business Overview

Products & Strategy

Carl Zeiss Meditec AG

Products, Strategy and Focus

APPENDIX A: GLOSSARY AND ABBREVIATIONS

APPENDIX B: PROFESSIONAL/SCIENTIFIC SOURCES

APPENDIX C: NEWS/RESEARCH SOURCES

APPENDIX D: U.S. REGULATORY AUTHORITIES AND STATUTES

APPENDIX E: INTERNATIONAL REGULATORY AUTHORITIES AND STATUTES

APPENDIX F: ASSOCIATIONS, SOCIETIES, FOUNDATIONS FOR EYE HEALTH

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Ophthalmology Market: Product and Service Revenues [combined eye diseases and refractive], 2006-2013

CHAPTER TWO: INTRODUCTION AND OVERVIEW

Table 2-1: Estimated and Projected World Population by Selected Geographical Region, 2008-2050 (in millions)

Figure 2-1: Estimated and Projected World Population by Selected Geographical Region, 2008-2050

Table 2-2: Number and Percent Population by Sex and Region, 2008

Table 2-3: Estimated World Population by Age and Geographical Region, 2008 (in millions)

Figure 2-2: Estimated World Population by Age and Geographical Region, 2008

Figure 2-3: Estimated World Population by Age Group

CHAPTER FOUR: RESTORATION OF IMPAIRED VISION

Table 4-1: Primary Visual Acuity Conditions and Refractive Vision Correction Treatment Options

CHAPTER FIVE: DISEASES AFFECTING THE EYE

Table 5-1: Diagnostics & Treatment Modalities for the Management of Eye Diseases

CHAPTER SIX: REFRACTIVE VISION CORRECTION: PRODUCTS AND TECHNOLOGIES

Table 6-1: Refractive Vision Correction Competitive Products, Technology, Application, Market Status

CHAPTER SEVEN: MAJOR EYE DISEASES: PRODUCTS AND TECHNOLOGIES

Table 7-1: Major Eye Diseases Competitors, Competitive Products, Technology, Application, and Market Status

CHAPTER EIGHT: MARKET SUMMARY

Table 8-1: Ophthalmology Market: Product and Service Revenues [combined eye diseases and refractive], 2006-2013

CHAPTER NINE: REFRACTIVE VISION CORRECTION MARKET ANALYSIS & FORECAST

Table 9-1: Refractive Vision Correction Market: Equipment and Product Revenues and Annual Growth by Geography (U.S. and Non-U.S.), 2006-2013

Table 9-2: Refractive Vision Correction Market: Equipment and Product Supplier Revenues and Market Share by Geography, 2008

Table 9-3: Refractive Vision Correction Market: Service Revenues and Annual Growth by Geography (U.S. and Non-U.S.), 2006-2013

Table 9-4: Refractive Vision Correction Market: Service Revenues and Market Share by Provider Type and Geography, 2008

Table 9-5: Refractive Vision Correction Market: Service Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Condition Treated (Myopia, Hyperopia, Presbyopia, Astigmatism), 2008

CHAPTER TEN: MAJOR EYE DISEASES: MARKET ANALYSIS & FORECAST

Table 10-1: Eye Disease Market: Product Revenues and Annual Growth by Geography (U.S. and Non-U.S.), 2006-2013

Table 10-2: Eye Disease Market: Supplier Revenues and Market Share by Geography, 2008

Table 10-3: Major Eye Disease Market: Supplier Revenues and Market Share by Condition (Cataract, Glaucoma, Vitreoretinal, Others), 2008

Table 10-4: Eye Disease Treatment Market: Service Revenues and Annual Growth by Geography (U.S. and Non-U.S.), 2006-2013

Table 10-5: Eye Disease Treatment Market: Service Revenues and Market Share by Provider Type and Geography, 2008

Table 10-6: Eye Disease Treatment Market: Provider Service Revenues and Market Share by Geography (U.S. vs Non-U.S.) and Condition Treated (Cataract, Glaucoma, Vitreoretinal, Other), 2008