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Cell-based Assays: Technologies and Global Markets

  • April 2014
  • -
  • BCC Research
  • -
  • 199 pages

REPORT HIGHLIGHTS

BCC Research estimates that the global market for cell-based assays will increase at a compound annual growth rate (CAGR) of 12.4% over the next five years to reach $15.2 billion in 2015 and $21.6 billion by 2018 from $12.1 billion in 2013.

This report provides:

An overview of the global market for cell-based assays available and currently used.
Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018.
Examinations of major issues involved in the research and development (R&D) of more effective cell-based approaches, for drug discovery, and absorption, distribution, metabolism, and excretion (ADME)/ toxicity assays in development and in use.
Discussion of current issues and trends affecting the industry, and costs and other factors influencing demand.
Coverage of new technologies, trends, alliances, and mergers.

STUDY GOALS AND OBJECTIVES

This BCC Research market report, Cell-Based Assays: Technologies and Global Markets, provides a detailed overview and thorough analysis of the present and future global market for cell-based techniques. This report analyzes in detail the cell-based assays available and currently used and their markets. This report includes current products in this market and detailed analyses of markets and competitive environments; market for cell assays in newly emerging regions, and instrumentation and robotics and their impact on the market.

The report includes information about significant products and assays, key players, issues and trends, current market status of cell-based assays, strengths, weaknesses, opportunities and threats facing various assays and developments already on the market, major issues involved in the research and development (R&D) of more effective cell-based approaches, for drug discovery, and absorption, distribution, metabolism and excretion (ADME)/toxicity assays in development and in use.

REASONS FOR DOING THE STUDY

Cell-based assays have emerged as a more relevant alternative to biochemical assays involving the use of purified proteins especially in the field of drug discovery. There has been growth in demand for cell-based assays. A number of cell culture and liquid-handling instruments are available on the market that allows cell-based screening. The majority of compound screening programs performed by the biopharmaceutical industry are dependent on cell-based assays for functional measures of target activation. Label-free cellular assays are also driving this market forward, with their sensitivity, robustness, ease of use and flexibility. These assays are now used routinely throughout early drug discovery from target identification and validation to primary screening, lead identification, lead optimization and into safety and toxicology. There is a need to understand the trends in this market, currently available assays and latest developments for drug discovery.

SCOPE AND FORMAT

This report is an update on Cell-Based Assays: Technologies and Global Markets. It will review global markets for cell-based assays and new developments and will forecast trends for use of these assays for drug discovery and safety and toxicology through 2018. Important assays, technologies and the latest developments, market share by assay type, products on the market and market share by company, and statistical information for types of cancers prevalent worldwide, with a special emphasis on the U.S. market.
The report also includes current issues and trends affecting the industry and costs, and factors influencing demand will be discussed. The report covers products in development, new technologies, trends, alliances and mergers. The report offers market data with respect to segments and geography. It also provides market trends with respect to drivers, restraints and opportunities.

INTENDED AUDIENCE

This report is an exhaustive study on the global market for cell-based assays, giving crucial statistics and analysis on existing technologies, latest trends, market structure, market size, key drug segments, important trends in technology development, major opportunities and market shares of key players and drugs. This report may prove crucial for the firms or investors seeking investments in the concerned sector. This report shows cell-based assays currently being used, new developments, spending trends and revenue prospects for cell-based assays in pharma. The report provides market data for 2012 to 2018 and also covers commercial prospects for cell assays in drug research and ADME/toxicity assays.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this report. Secondary sources include books, newspapers, trade journals, white papers, industry portals, government agencies, trade associations, monitoring industry news and developments and through access to paid databases. The base year of the report is 2012, with forecast data provided through 2018. Historical, base year and forecast data are provided for each market segment of this report. Growth rates are determined through a compilation of data, including past trends, future trends, demographics, incidence, mortality, products in R&D and current product growth.

Table Of Contents

Cell-based Assays: Technologies and Global Markets
Chapter- 1: INTRODUCTION

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE AND FORMAT
INTENDED AUDIENCE
METHODOLOGY
ANALYST CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER

Chapter- 2: SUMMARY

Table Summary : GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018
Figure Summary : GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018

Chapter- 3: OVERVIEW 28 $1404

INTRODUCTION
DRUG DISCOVERY
OVERVIEW: CELL-BASED ASSAYS
TOOLS FOR DRUG DISCOVERY

Chapter- 4: ASSAYS FOR DRUG DISCOVERY

CELL-BASED APPROACHES FOR ADME/TOX SCREENING
CONCLUSIONS

Chapter- 5: CELL BASED ASSAYS: CURRENT TECHNOLOGIES

FACTORS IN CELL-BASED ASSAY DEVELOPMENT
REPORTER GENE TECHNOLOGY
CELL-BASED ASSAYS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
CELL-BASED PROTEIN-FRAGMENT COMPLEMENTATION ASSAYS
MEASURING CALCIUM SIGNALING
CELL-BASED LABEL-FREE APPROACHES
AUTOMATION AND MINIATURIZATION
CELL PATTERNING
CELL-BASED ASSAYS AND PHYSIOLOGICAL RELEVANCE
CELL-BASED ASSAYS AND MULTIPLEXING
ULTRAHIGH-THROUGHPUT SCREENING
DEVELOPMENT OF PATHHUNTER ASSAY
HIGH-CONTENT SCREENING TECHNOLOGY
INVESTIGATIONAL NEW DRUG (IND) STUDIES IN DRUG DEVELOPMENT
PRODRUG STRATEGIES
MOLECULAR MODELING
SUMMARY
NEW TECHNOLOGIES
CONCLUSION

Chapter- 6: COMMERCIALIZATION OF CELL-BASED ASSAYS

ROLE OF CELL-BASED ASSAYS
DRUG DISCOVERY AND CELL-BASED ASSAYS
OPPORTUNITIES FOR MARKET ADOPTION
MEASURING CELL PROLIFERATION
MOVE TOWARD THERAPIES WITH STEM AND IMMUNE CELLS
CELL-BASED SCREENING ASSAYS
ORPHAN RECEPTORS
SUMMARY

Chapter- 7: GLOBAL CELL-BASED ASSAY AND INSTRUMENTATION MARKET

CURRENT MARKET OVERVIEW
ROLE OF CELL-BASED ASSAYS
CELL-BASED ASSAY MARKET
DRUG DISCOVERY TECHNOLOGY MARKET
CELL-BASED ASSAYS MARKET GROWTH
ADME AND TOXICOLOGY MARKET
ADME-TOXICOLOGY TESTING MARKET
CELL-BASED ASSAYS FOR DRUG DISCOVERY: GLOBAL MARKET
HIGH-CONTENT SCREENING MARKET
HIGH-CONTENT SCREENING INSTRUMENTATION MARKET
CELL-BASED ASSAYS FOR RESEARCH PURPOSES
CELL-BASED ASSAYS: SCREENING ION CHANNELS
CONCLUSION

Chapter- 8: GLOBAL REGIONAL MARKETS

GLOBAL MARKET FOR CELL-BASED ASSAYS
DRUG DISCOVERY IN THE EMERGING ECONOMIES

Chapter- 9: KEY COMPANIES

ACEA BIOSCIENCES
BD BIOSCIENCES
BECKMAN COULTER
CELLULAR DYNAMICS INTERNATIONAL
CALIPER LIFE SCIENCES
CELSIS IVT
CISBIO BIOASSAYS
DISCOVERX CORP.
EMD MILLIPORE
ENZO LIFE SCIENCES
EVOTEC AG
GE HEALTHCARE
HEMOGENIX
LIFE TECHNOLOGIES
LONZA
MOLECULAR DEVICES (DANAHER)
ONCOIMMUNIN
ORIGENE TECHNOLOGIES
PERKINELMER
PROMEGA CORP.
ROCHE
STEMCELLS INC.
THERMO FISHER SCIENTIFIC
TTP LABTECH
VIVO BIOSCIENCES
VITRO BIOPHARMA

Chapter- 10: LEGAL ASPECTS OF CELL-BASED ASSAYS

INTELLECTUAL PROPERTY LANDSCAPE OF CELL-BASED ASSAYS

Chapter- 11: BIBLIOGRAPHY



List of Tables

GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018
Table 1 : CELL-BASED ASSAYS AND USES
Table 2 : TYPES OF CELL-BASED ASSAYS
Table 3 : APOPTOTIC MARKERS
Table 4 : PROOF OF CONCEPT FOR CELL-BASED ASSAYS
Table 5 : GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, THROUGH 2018
Table 6 : BIOLOGICAL ASSAY SYSTEMS FOR THE EVALUATION OF CYTOCHROME P450 ENZYME ISOFORMS
Table 7 : HEPATOCYTE ASSAY SYSTEMS
Table 8 : ADME ASSAYS
Table 9 : COMMON TOXICITY ASSAYS
Table 10 : TRADITIONAL METHODS OF ADME/TOX TESTING
Table 11 : CONVENTIONAL IN VITRO ADME/TOX SCREENING METHODS
Table 12 : LABEL-FREE ASSAYS AND APPLICATIONS
Table 13 : FACTORS FOR CELL-BASED ASSAY DEVELOPMENT
Table 14 : DIFFERENT APPROACHES TO CELL-BASED SYSTEMS FOR DRUG SCREENING
Table 15 : CURRENT CONFOCAL HCS PLATFORMS
Table 16 : WIDEFIELD HCS PLATFORMS
Table 17 : STUDIES FOR FILING AN IND
Table 18 : STUDIES FOR CLINICAL FILINGS
Table 19 : BIOLOGICAL APPLICATIONS FOR HCA
Table 20 : GLOBAL HTS MARKET, THROUGH 2018
Table 21 : HTS TECHNOLOGIES: KEY COMPANIES
Table 22 : GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES, THROUGH 2018
Table 23 : GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, THROUGH 2018
Table 24 : GLOBAL MARKET FOR LIFE SCIENCE TOOLS, THROUGH 2018
Table 25 : GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, THROUGH 2018
Table 26 : GLOBAL MARKET FOR CELL CULTURE TOOLS, THROUGH 2018
Table 27 : GLOBAL MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018
Table 28 : U.S. MARKET FOR CELL CULTURE REAGENTS, THROUGH 2018
Table 29 : GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, THROUGH 2018
Table 30 : CELL-BASED ASSAY COMPANIES
Table 31 : GLOBAL MARKET FOR CELL-BASED ASSAYS, THROUGH 2018
Table 32 : LIMITATIONS OF CELL-BASED ASSAYS
Table 33 : GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, THROUGH 2018
Table 34 : GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, THROUGH 2017
Table 35 : GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, THROUGH 2018
Table 36 : IN VITRO PREDICTIVE TOXICOLOGY ASSAYS
Table 37 : GLOBAL MARKET FOR ADME ASSAYS, THROUGH 2018
Table 38 : GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, THROUGH 2018
Table 39 : KEY COMPANIES
Table 40 : GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, THROUGH 2018
Table 41 : HCS MARKET: MAJOR COMPANIES
Table 42 : MOLECULAR DEVICES: PRODUCTS
Table 43 : HCS SYSTEM PLATFORMS
Table 44 : MILLIPORE PRODUCTS: APPLICATIONS
Table 45 : GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, THROUGH 2018
Table 46 : KEY COMPANIES
Table 47 : GPCR-TARGETING KEY DRUGS
Table 48 : KEY COMPANIES WITH GPCR PRODUCTS
Table 49 : OMEROS: GPCRS AND INDICATIONS
Table 50 : ASSAY METHODS TO STUDY GPCRS
Table 51 : GPCR PRIMARY SCREENING ASSAYS
Table 52 : GLOBAL MARKET FOR GPCR SCREENING AND PROFILING, 2010
Table 53 : LIFE TECHNOLOGIES PRODUCTS
Table 54 : INVITROGEN'S CELL-BASED TECHNOLOGIES
Table 55 : COMPARISON OF YEARS ENDED DEC. 31, 2011 AND 2010
Table 56 : THERMO FISHER SCIENTIFIC'S ANALYTICAL TECHNOLOGIES SEGMENT REVENUE, 2012 AND 2013
Table 57 : GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, THROUGH 2018
Table 58 : U.S. MARKET FOR CELL-BASED ASSAYS, THROUGH 2018
Table 59 : KEY GROWTH DRIVERS OF THE MARKET FOR CELL-BASED ASSAYS
Table 60 : EUROPEAN CELL-BASED ASSAY MARKET, THROUGH 2018
Table 61 : CHINA'S DRUG DISCOVERY OUTSOURCING MARKET, THROUGH 2018
Table 62 : INDIAN DRUG DISCOVERY MARKET, 2009 AND 2010

List of Figures

GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018
Figure 1 : DRUG DISCOVERY PROCESS AND STEPS
Figure 2 : GLOBAL MARKET AND FORECAST FOR CELL-BASED ASSAYS, 2012-2018
Figure 3 : GLOBAL MARKET FOR DRUG DISCOVERY TECHNOLOGIES 2012-2018
Figure 4 : GLOBAL MARKET FOR REAGENTS AND TOOLS USED IN DNA AND RNA RESEARCH, 2012-2018
Figure 5 : GLOBAL MARKET FOR LIFE SCIENCE TOOLS, 2012-2018
Figure 6 : GLOBAL MARKET FOR CELL BIOLOGY REAGENTS AND TOOLS, 2012-2018
Figure 7 : GLOBAL MARKET FOR CELL CULTURE TOOLS, 2012-2018
Figure 8 : GLOBAL MARKET FOR CELL CULTURE REAGENTS, 2012-2018
Figure 9 : U.S. MARKET FOR CELL CULTURE REAGENTS, 2012-2018
Figure 10 : GLOBAL MARKET FOR 3D CELL CULTURE REAGENTS, 2012-2018
Figure 11 : GLOBAL MARKET FOR CELL-BASED ASSAYS, 2012-2018
Figure 12 : GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN BASIC RESEARCH, 2012-2018
Figure 13 : GLOBAL MARKET FOR IN VITRO TOXICITY TESTS, 2012-2017
Figure 14 : GLOBAL MARKET FOR SPECIALIZED CELL-BASED ASSAYS USED IN DRUG DISCOVERY, 2012-2018
Figure 15 : GLOBAL MARKET FOR ADME ASSAYS, 2012-2018
Figure 16 : GLOBAL MARKET FOR CELL-BASED ASSAYS USED IN DRUG DISCOVERY BY SEGMENT, 2012-2018
Figure 17 : GLOBAL MARKET FOR HIGH-CONTENT SCREENING ASSAYS AND INSTRUMENTATION, 2012-2018
Figure 18 : GLOBAL MARKET FOR HIGH-CONTENT SCREENING INSTRUMENTS, 2012-2018
Figure 19 : GLOBAL MARKET FOR CELL-BASED ASSAYS BY REGION, 2012-2018
Figure 20 : U.S. MARKET FOR CELL-BASED ASSAYS, 2012-2018
Figure 21 : EUROPEAN CELL-BASED ASSAY MARKET, 2012-2018
Figure 22 : CHINA DRUG DISCOVERY OUTSOURCING MARKET, 2012-2018
Figure 23 : INDIAN DRUG DISCOVERY MARKET, 2009-2010

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