Cell and Tissue Analysis Products: The Global Market

• Publication date: September 2009

STUDY GOALS AND OBJECTIVES This report, Cell and Tissue Analysis Products: The Global Market, provides a detailed analysis of the products and technologies that define the market space and summarizes the composition and dynamics of individual companies in the competitive environment. The study also includes an overview of the relevant regulatory issues, patent landscapes, and strategic partnerships that will play a role in shaping t...

STUDY GOALS AND OBJECTIVES

This report, Cell and Tissue Analysis Products: The Global Market, provides a detailed analysis of the products and technologies that define the market space and summarizes the composition and dynamics of individual companies in the competitive environment. The study also includes an overview of the relevant regulatory issues, patent landscapes, and strategic partnerships that will play a role in shaping the market in the future.

THIS REPORT:
- Provides a comprehensive overview of the global market for cell and tissue analysis products
- Offers a breakdown of the market by application including those for diagnostics, basic research, drug screening and others
- Contains global market forecasts for cell and tissue analysis products, with trends and forecasts for growth through 2014
- Discusses industry structure including key vendors, mergers and acquisitions, distribution of products, government regulation and industry trends
- Describes the latest technological advances including those in flow cytometry, microscope based image analysis, high throughput screening (HTS) devices and reagents and supplies.


REASONS FOR DOING THE STUDY

The use of cells and tissue has been a mainstay of biomedical research since the isolation and propagation of the HeLa cell in the 1950s. Along with the recent emphasis on translational research in academia and demand for improved clinical models during drug development and screening, the current use of tissue and cells in the life sciences is at an all time high, creating intense demand for upstream isolation and downstream analytical products in industrial and academic markets.

Contemporary tissue repositories have vastly expanded their capacity and stock breadth. Technological advances in cellular engineering now have the ability to produce customized cell lines for specific research and industrial applications. In parallel, the cell remains at the center of experimental design in academia. All of these factors, as well as numerous others, have led to increased demand for products used to isolate and analyze cells and tissue.

The recent surge in NIH and NSF funding, $10.4 billion and $3 billion, respectively, stemming from President Obama’s stimulus package, will serve to drive novel and existing domestic research programs. As innovative projects get underway and new proposals are developed, the acute demand for products associated with life-science research will increase accordingly. As a corollary, due to the central role of cell and tissue analysis products in the life-science research flow, this market report will be particularly timely.

SCOPE OF REPORT

The study scope of this report includes commercialized products used in the isolation, purification, and analysis of cells, as well as novel products and technologies that may be commercially viable by 2014. Biospecimens, enzymatic, and mechanical tissue dissociation products, flow cytometry hardware and software, magnetic cell separation products, laser microdissection (LMD) systems, research antibodies, cell based assays and products used in high content screening (HCS) platforms are included. Market growth forecasts through 2014 are presented.

In addition to examining larger and more established producers in cell and tissue analysis product market segments, BCC Research profiled numerous smaller specialized market players in this report. Market segmentation within the areas of biospecimen vendors, cell separation products and cell and tissue analysis products are highlighted. Each technology is also analyzed by application type and in the context of relevant technological and regulatory forces to determine its current market status and forecast growth through 2014. Recent industrial alliances and acquisitions affecting producer market penetration and dominance are also discussed.

BCC examines the structure of both the academic research and industrial end-user markets predominantly in the U.S., but also in key international markets. Important intellectual property holdings of industrial producers of cell and tissue analysis products are also discussed.

INTENDED AUDIENCE

This report will be of general interest to business professionals in the field of biotechnology. Both life science reagent suppliers and research scientists will benefit from the comprehensive summary of relevant technologies and industrial profiles contained here. Consultants, strategic and market analysts, and investors working within the pharmaceutical, clinical and biotechnology industries will also find this report particularly useful. In addition, business development professionals, as well as those in sales, marketing, information sciences, and competitive intelligence fields of biotechnology will benefit from the information contained in this report.

METHODOLOGY AND INFORMATION SOURCES

The market assessments presented in this report were derived from publicly available information up to and including April 2009. Using 2008 as the base year, forecast data are provided through 2014. In cases where data for 2009 were incomplete or not readily available, figures were extrapolated from 2008 statistics, half-year figures for 2008, and historical trends between 2004 and 2008. Market figures are based on current U.S. dollars with no adjustments for inflation made in the projections.
The information contained in this report has been assembled from both primary and secondary data sources. Primary research was conducted via telephone interviews with industry professionals, research scientists, physician-researchers, and laboratory heads to discover the most recent developments in their fields of interest. Secondary data was collected via a comprehensive search of the scientific, peer-reviewed literature, clinical trial reports and databases, industry trade media, company websites, annual reports, intellectual property databases, and industry press releases.

ANALYST CREDENTIALS

Dr. Willem Westra brings more than a decade of experience as an analyst in diverse areas of biomedical science, including basic research, intellectual property and investor relations to BCC Research. He is the author of several peer-reviewed scientific articles and book chapters and is a co-inventor of a recently patented method for characterizing and using stem cells. In addition to his academic research experience, Dr. Westra has served as an intellectual property/patent consultant, held visiting faculty positions, worked in the pharmaceutical and software industries in Silicon Valley and was a professional ski instructor. Dr. Westra earned both a B.S. in Pharmacological Chemistry and a Ph.D. in Biomedical Science from the University of California at San Diego.

Global Biomaterial Industry

Chapter- 1: INTRODUCTION -- Complimentary

STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
METHODOLOGY AND INFORMATION SOURCES
ANALYST CREDENTIALS
RELATED BCC REPORTS
BCC ONLINE SERVICES
DISCLAIMER

Chapter-2: SUMMARY

SUMMARY TABLE GLOBAL MARKET FOR CELL AND TISSUE ANALYSIS PRODUCTS, BY SEGMENT, THROUGH 2014 ($ MILLIONS)
SUMMARY FIGURE GLOBAL MARKET FOR CELL AND TISSUE ANALYSIS PRODUCTS, BY SEGMENT, 2008–2014 ($ MILLIONS)
SUMMARY (CONTINUED)

Chapter-3: OVERVIEW

GENERAL DESCRIPTION
DEFINITIONS
Antibody
Antigen
Apoptosis
Biomarker
Biospecimen
Cell
TABLE 1 CHARACTERISTICS OF PROKARYOTIC AND EUKARYOTIC CELLS
TABLE 2 CHARACTERISTICS OF PLANT AND ANIMAL CELLS
TABLE 2 (CONTINUED)
Cell-Based Assay
Epitope
Flow Cytometer
FIGURE 1   MAIN COMPONENTS OF A FLOW CYTOMETER
Fluorescence Activated Cell Sorting
High-Content Screening
Hybridoma
Immunohistochemistry
In vitro Culture
Isotype
Laser Microdissection
Monoclonal (Antibody)
Polyclonal (Antibody)
Primary Antibody
Primary Cells
Secondary Antibody
Tissue
TABLE 3 MAJOR TISSUE TYPES AND CONSTITUENT CELLS
Tissue Microarray
INDUSTRY DEFINITION
INDUSTRY BREAKDOWN
Biospecimens
TABLE 4 MAJOR BIOSPECIMENS USED IN RESEARCH AND DRUG DEVELOPMENT
TABLE 5 BIOSPECIMENS LIFECYCLE
Cell and Tissue Separation Products
TABLE 6 MAJOR TYPES OF CELL AND TISSUE SEPARATION PRODUCTS USED IN RESEARCH AND DRUG DEVELOPMENT
Cell and Tissue Characterization Products
TABLE 7 APPLICATIONS OF CELL AND TISSUE CHARACTERIZATION PRODUCTS IN RESEARCH AND DRUG DEVELOPMENT
PRODUCT BREAKDOWN
Biospecimens
History
Types of Biospecimens
Tissue Microarray
History
Frozen Arrays
FFPE Arrays
TMA Applications
Cell and Tissue Dissociation
Enzymatic Dissociators
TABLE 8 COMMON ENZYMES USED FOR CELL AND TISSUE DISSOCIATION
Mechanical Dissociators
Bead Method
Sonication
Pressure Homogenizing
Rotor-stator Homogenizing
Manual Grinding
Blade Homogenizing
Magnetic Cell Separation Technology
Technology
Laser Microdissection
History
LMD Applications
LMD Platforms
Laser Microdissection and Pressure Catapulting
Fusion Microdissection
Flow Cytometry
History
Cytometer Types
Analyzers
Sorters
Detection
Clinical Applications
Research Applications
Research Antibodies
History
Antibody Types
Primary Antibodies
Secondary Antibodies
Isotype Controls
Antibody Specifications
Host
TABLE 9 HOST SPECIES USED IN GENERATING RESEARCH ANTIBODIES (SPECIES)
Class/Isotype
Target Species (Reactivity)
Label
TABLE 10 COMMON ANTIBODY LABELS (TYPE)
Cell-Based Assays
History
Applications of Cell-Based Assays
Types of Cell-Based Assays
Signaling Assays
Cell Viability/Death Assays
Cell Proliferation Assays
Cell Migration Assays
High-Content Screening
History
HCS Applications
HCS Instrumentation
Confocal Machines
Non-confocal Machines
REGULATORY ISSUES
HISTORY
Biomedical Tissue Services
American Tissue
Willed Body Program
Body World
Bodies…the Exhibition
BIOSPECIMEN REGULATORY STRUCTURE
Federal Regulations
Current Good Tissue Practices
TABLE 11 INTERNATIONAL REGULATORY RULES & RULINGS GUIDING THE ACCESS/USE OF HUMAN TISSUE IN RESEARCH AND DRUG DISCOVERY, 2001–2009
State Regulations

Chapter-4: INDUSTRY STRUCTURE AND COMPETITIVE ANALYSIS

INDUSTRY PARTICIPANTS
TISSUE MICROARRAYS
TABLE 12 MAJOR COMPANIES IN THE TISSUE MICROARRAY MARKET
TABLE12 (CONTINUED)
CELL SEPARATION PRODUCTS
TABLE 13 MAJOR COMPANIES IN THE CELL SEPARATION PRODUCT MARKET
TABLE 13 (CONTINUED)
RESEARCH ANTIBODIES
TABLE 14 MAJOR COMPANIES IN THE RESEARCH ANTIBODIES MARKET
TABLE 15 COMPANIES IN THE GMP ANTIBODY PRODUCTION MARKET
TABLE 15 (CONTINUED)
TABLE 15 (CONTINUED)
TABLE 16 COMPANIES IN THE GMP ANTIBODY PRODUCTION MARKET, BY LOCATION, 2009
TABLE 16 (CONTINUED)
CELL-BASED ASSAYS
TABLE 17 COMPANIES IN THE CELL-BASED ASSAY PRODUCT MARKET
HIGH-CONTENT SCREENING PRODUCTS
TABLE 18 COMPANIES IN THE HIGH CONTENT SCREENING INSTRUMENTATION PRODUCT MARKET
MARKET SHARES
BIOSPECIMENS
TABLE 19 MARKET SHARE OF COMMERCIAL BIOSPECIMEN VENDORS 2008 ($ MILLION, %)
LASER MICRODISSECTION
TABLE 20 MARKET SHARE OF COMMERCIAL LASER MICRODISSECTION MARKET LEADERS 2009 ($ MILLION, %)
FLOW CYTOMETRY
TABLE 21 MARKET SHARE OF COMMERCIAL FLOW CYTOMETRY MARKET LEADERS, 2008 ($ MILLIONS)
RESEARCH ANTIBODIES
TABLE 22 MARKET SHARE OF COMMERCIAL RESEARCH ANTIBODY MARKET LEADERS, 2008 ($ MILLIONS)
HIGH CONTENT SCREENING/CELL-BASED ASSAYS
TABLE 23 MARKET SHARE OF COMMERCIAL HIGH CONTENT SCREENING AND CELL-BASED ASSAY INSTRUMENTATION MARKET LEADERS, 2009 ($ MILLIONS)
TABLE 24 MARKET SHARE OF COMMERCIAL HIGH CONTENT SCREENING AND CELL-BASED ASSAY REAGENT MARKET LEADERS, 2009 ($ MILLIONS)
MERGERS, ACQUISITIONS, STRATEGIC ALLIANCES & PARTNERSHIPS
BIOSPECIMENS
TABLE 25 MAJOR BIOSPECIMEN INDUSTRY EVENTS, 2005–2009
LASER MICRODISSECTION
TABLE 26 MAJOR LASER MICRODISSECTION INDUSTRY EVENTS, 2004–2009
FLOW CYTOMETRY
TABLE 27 MAJOR FLOW CYTOMETRY INDUSTRY EVENTS, 2005–2009
RESEARCH ANTIBODIES
TABLE 28 MAJOR RESEARCH ANTIBODY INDUSTRY EVENTS, 2005–2009
Notable Developments
HIGH CONTENT SCREENING
TABLE 29 MAJOR HIGH CONTENT SCREENING INDUSTRY EVENTS, 2004–2009
TABLE 29 (CONTINUED)

Chapter-5: CELL AND TISSUE ANALYSIS TECHNOLOGIES

INTRODUCTION
BIOSPECIMEN TECHNOLOGIES
TABLE 30 NEW PRODUCTS FROM BIOSPECIMEN MARKET COMPANIES
TABLE 30 (CONTINUED)
TABLE 30 (CONTINUED)
TISSUE MICROARRAYS
TABLE 31 PRODUCT SPECIFICATIONS OF TISSUE MICROARRAYS
FIGURE 2 FLOW DIAGRAM FOR TISSUE MICROARRAY PRODUCTION
Tissue Microarray Production
Types of Tissue Microarrays
Frozen Tissue Arrays
FFPE Arrays
TABLE 32 COMPARISON OF THE MAIN TYPES OF TISSUE MICROARRAY FORMATS
Multi-sample Arrays
Progression Arrays
Prognosis Arrays
Applications of TMA
TABLE 33 EXAMPLE APPLICATIONS OF DIFFERENT TISSUE MICROARRAY PREPARATIONS
TABLE 33 (CONTINUED)
TABLE 34 COMMMON DISEASED TISSUES AVAILABLE IN TISSUE MICROARRAY FORMAT
TABLE 34 (CONTINUED)
New Developments in Tissue Microarray Technology
TABLE 35 TISSUE MICROARRAY, TECHNOLOGY DEVELOPMENT
Matrix Assembly
TMA Content
TMA Analysis Software
TABLE 36 COMPARISON OF TISSUE MICROARRAY ANALYSIS SOFTWARE PACKAGES
TABLE 36 (CONTINUED)
CELL SEPARATION TECHNOLOGIES
MECHANICAL AND ENZYMATIC SEPARATION
Neural Stem Cells
Neural Tissue
Magnetic Separation
Positive Selection
Negative Selection
Multi-step Selection
TABLE 37 NEW MAGNETIC CELL SEPARATION PRODUCTS
TABLE 37 (CONTINUED)
Laser Microdissection
Platforms
LMPC
Fusion Microdissection
Microscopes, Objectives, Stages and Software
TABLE 38 CURRENT LASER MICRODISSECTION INSTRUMENTS
New Developments
Live Cell Microdissection
Remote Operation
Flow Cytometry
TABLE 39 COMMONLY USED FLUORESCENCE LABELS USED IN FLOW CYTOMETRY
TABLE 39 (CONTINUED)
Cytometer Types
TABLE 40 NEW INSTRUMENTATION PRODUCTS FROM FLOW CYTOMETRY COMPANIES
TABLE 40 (CONTINUED)
Alternative Technologies
Imaging Cytometers
Laser Scanning Cytometers
TABLE 41 NEW PRODUCTS FROM FLOW CYTOMETRY COMPANIES
New Developments
Benchtop Cytometers
Multi-parametric Analyses
CELL AND TISSUE ANALYSIS TECHNOLOGIES
RESEARCH ANTIBODIES
FIGURE 3   SCHEMATIC PRODUCTION OF MONOCLONAL AND POLYCLONAL ANTIBODIES
New Developments
Stem Cell Antibodies
Modification-state Specific Antibodies
New Fluorophores
High-Content Screening
FIGURE 4   BASIC SCHEMATIC OF A TYPICAL HIGH CONTENT SCREENING INSTRUMENT
HCS Instrumentation
Confocal Instruments
Image Sectioning
TABLE 42 FEATURES OF COMMON CONFOCAL HCS INSTRUMENTATION
Widefield Instruments
Illumination Sources
Autofocus
TABLE 43 FEATURES OF COMMON WIDEFIELD HCS INSTRUMENTATION
Software
HCS Applications
Profiling Studies
Screening Studies
New Developments
TABLE 44 NEW PRODUCTS FROM HCS COMPANIES

Chapter-6: PATENT LANDSCAPE

INTRODUCTION
CTA INDUSTRY
IMPORTANT CONCEPTS
Priority Dates
Patent Cooperation Treaty
IPC Codes
METHODOLOGY
PATENTS FOR BIOSPECIMEN VENDORS
TABLE 45 NUMBER OF U.S. PATENTS FOR MAJOR BIOSPECIMEN VENDORS, 2009 (NO. OF PATENTS, % OF PATENTS)
TABLE 46 NUMBER OF INTERNATIONAL PATENTS FOR MAJOR BIOSPECIMEN VENDORS, THROUGH 2009 (NO. OF PATENTS, % OF PATENTS)
TISSUE MICROARRAY PATENTS
TABLE 47 PATENT PUBLICATIONS FOR TISSUE MICROARRAY TECHNOLOGIES, BY YEAR, 2001–2009 (NO. OF PATENTS)
TABLE 48 MAJOR PATENT ASSIGNEES FOR TISSUE MICROARRAY TECHNOLOGIES, 2001–2009 (AS OF JUNE 2009)
TABLE 48 (CONTINUED)
TABLE 49 MAJOR IPC CLASSES FOR TISSUE MICROARRAY PATENTS, 2001–2009 (NO. OF PATENTS)
SUMMARY
PATENTS FOR CELL SEPARATION PRODUCT COMPANIES
TABLE 50 NUMBER OF U.S. PATENTS FOR MAJOR CELL SEPARATION PRODUCT COMPANIES, AS OF JUNE 1, 2009 (NO. OF PATENTS, PERCENT OF PATENTS)
TABLE 51 NUMBER OF INTERNATIONAL PATENTS FOR MAJOR CELL SEPARATION PRODUCT COMPANIES, AS OF JUNE 1, 2009 (NO. OF PATENTS, PERCENT OF PATENTS)
LASER MICRODISSECTION PATENTS
TABLE 52 PATENT PUBLICATIONS FOR LASER MICRODISSECTION TECHNOLOGIES, BY YEAR, 1999–2009 (NO. OF PATENTS)
TABLE 53 MAJOR PATENT ASSIGNEES FOR LASER MICRODISSECTION TECHNOLOGIES, 1999–2009 (NO. OF PATENTS)
TABLE 54 MAJOR IPC CLASSES FOR LASER MICRODISSECTION PATENTS, 1999–2009 (NO. OF PATENTS)
FLOW CYTOMETRY PATENTS
TABLE 55 PATENT PUBLICATIONS FOR FLOW CYTOMETRY TECHNOLOGIES, BY YEAR, 1999–2009 (NO. OF PATENTS)
TABLE 56 MAJOR PATENT ASSIGNEES FOR FLOW CYTOMETRY TECHNOLOGIES, 2001–2009 (NO. OF PATENTS)
TABLE 57 NUMBER OF U.S. PATENTS FOR MAJOR FLOW CYTOMETRY COMPANIES, 1971–2009 (NO. OF PATENTS, PERCENT OF PATENTS)
TABLE 58 MAJOR IPC CLASSES FOR FLOW CYTOMETRY PATENTS, 2001–2009 (NO. OF PATENTS)
SUMMARY
PATENTS FOR CELL AND TISSUE ANALYSIS COMPANIES
RESEARCH ANTIBODY PATENTS
TABLE 59 NUMBER OF ANTIBODY-RELATED PATENTS FOR MAJOR RESEARCH ANTIBODY COMPANIES, AS OF JUNE 1 2009 (NO. OF PATENTS)
Licensing
HIGH CONTENT SCREENING PATENTS
TABLE 60 CELLOMICS PATENTS IN THE HIGH CONTENT SCREENING INDUSTRY
TABLE 61 PATENT PUBLICATIONS RELATING TO HIGH CONTENT SCREENING, BY YEAR, 2004–2009 (NO. OF PATENTS)
TABLE 62 MAIN INDUSTRY SEGMENT OF HIGH CONTENT SCREENING PATENT ASSIGNEES, 2004–2009
CELL-BASED ASSAY PATENTS
TABLE 63 PATENT PUBLICATIONS RELATING TO CELL-BASED ASSAYS, BY YEAR, 2001–2009 (NO. OF PATENTS)
TABLE 64 MAIN INDUSTRY SEGMENT OF CELL-BASED ASSAY PATENT ASSIGNEES, 2001–2009 (%)

Chapter-7: END USERS

INTRODUCTION
TABLE 65 CELL AND TISSUE ANALYSIS PRODUCT END-USER INDUSTRIES
TABLE 65 (CONTINUED)
ACADEMIC RESEARCH
TABLE 66 NATIONAL INSTITUTES OF HEALTH BUDGET, THROUGH 2009 ($ BILLIONS)
TABLE 67 NATIONAL SCIENCE FOUNDATION BUDGET, THROUGH 2009 ($ BILLIONS)
RESEARCH UNIVERSITIES
TABLE 68 TOP 20 U.S. RESEARCH UNIVERSITIES RECEIVING FEDERAL SUPPORT, 2006 ($ MILLIONS)
TABLE 69 FEDERAL RESEARCH SUPPORT GROWTH RATES FOR THE TOP 20 FEDERALLY FUNDED U.S. RESEARCH UNIVERSITIES, THROUGH 2006 ($ MILLIONS, % CAGR)
TABLE 70 HIGHEST ANNUAL LIFE SCIENCES EXPENDITURES FOR THE TOP 20 FEDERALLY FUNDED U.S. RESEARCH UNIVERSITIES, 2006 ($ MILLIONS)
Translational Research
TABLE 71 MAJOR U.S. CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) CENTERS, BY LOCATION, 2009
TABLE 71 (CONTINUED)
TABLE 71 (CONTINUED)
TABLE 71 (CONTINUED)
Government Laboratories
TABLE 72 LIST OF NIH RESEARCH LABS
TABLE 73 NIH INTRAMURAL RESEARCH BUDGET, THROUGH 2009 ($ MILLIONS)
Nonprofit Research Institutes
TABLE 74 LIST OF THE LARGEST U.S. NONPROFIT RESEARCH INSTITUTES, 2008 ($ MILLION)
TABLE 74 (CONTINUED)
BIOPHARMACEUTICAL
Drug Development Process
Biotechnology Industry
TABLE 75 ANNUAL BIOTECHNOLOGY R&D EXPENDITURES OF SELECT INTERNATIONAL COUNTRIES ($ BILLIONS)
TABLE 76 LIST OF NOTABLE BIOTECHNOLOGY INDUSTRY COMPANIES
Pharmaceutical Industry
TABLE 77 LIST OF NOTABLE PHARMACEUTICAL INDUSTRY COMPANIES
TABLE 78 BIOPHARMACEUTICAL R&D SPENDING, THROUGH 2009 ($ BILLIONS)
HEALTHCARE/CLINICAL
Research Hospitals
INTERNATIONAL ASPECTS
Europe
TABLE 79 TOTAL RESEARCHERS IN EUROPEAN COUNTRIES BY PERFORMANCE SECTOR, 2008 (#, X1,000)
GLOBAL MARKET
Trends in U.S. Research and Development
TABLE 80 U.S. EXPENDITURES ON R&D FINANCING BY SECTOR, THROUGH 2014 ($ BILLIONS)
TABLE 81 U.S. GROSS DOMESTIC EXPENDITURE ON R&D (GERD) FINANCING BY SECTOR, THROUGH 2014 (%)
Trends in International Research and Development
TABLE 82 GROSS DOMESTIC EXPENDITURE ON R&D (GERD) BY THE PRIVATE BUSINESS SECTOR IN EUROPEAN COUNTRIES, 2000-2008 (%)
TABLE 83 GROSS DOMESTIC EXPENDITURE ON R&D (GERD) BY THE GOVERNMENT SECTOR IN EUROPEAN COUNTRIES, 2000-2008 (%)
MARKETS BY PRODUCTS
Biospecimens
Tissue Microarray Use
TABLE 84 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING TISSUE MICROARRAY, 1998–2009
TABLE 85 CLINICAL TRIALS USING TISSUE MICROARRAY, 2001–2009
TABLE 85 (CONTINUED)
TABLE 86 PROJECTED GLOBAL SALES OF BIOSPECIMENS, THROUGH 2014 (% MILLIONS)
Cell Separation Products
TABLE 87   PROJECTED GLOBAL SALES OF CSP, THROUGH 2014 ($ MILLIONS)
Laser Microdissection
TABLE 88 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING LASER CAPTURE MICRODISSECTION, 1998–2009
TABLE 89 CLINICAL TRIALS USING LASER MICRODISSECTON, 1999–2009
TABLE 90   PROJECTED GLOBAL SALES OF LMD, THROUGH 2014 ($ MILLIONS)
Flow Cytometry
TABLE 91 PUBMED INDEXED SCIENTIFIC PUBLICATIONS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, 1998–2009
TABLE 92 CLINICAL TRIALS USING FLOW CYTOMETRY FLUORESCENCE ACTIVATED CELL SORTING, BY LOCATION, 2009 (NO. OF TRIALS)
TABLE 93 CLINICAL TRIALS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, BY FUNDING SOURCE, 2002–2009
TABLE 94 CLINICAL TRIALS USING FLOW CYTOMETRY OR FLUORESCENCE ACTIVATED CELL SORTING, BY CONDITION CATEGORY, 2009
TABLE 95   PROJECTED GLOBAL SALES OF THE FLOW CYTOMETRY INDUSTRY THROUGH 2014 ($ MILLIONS)
Cell and Tissue Characterization Products
TABLE 96   PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS)
Research Antibodies
TABLE 97   PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS)
HCS/CBA
TABLE 98   PROJECTED GLOBAL SALES OF CTC PRODUCTS, THROUGH 2014 ($ MILLIONS)
TABLE 99   HCS/CBA PRODUCT SEGMENTS, 2009 (%)
MARKETS BY END-USER SEGMENTS
TABLE 100   GLOBAL END-USER MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS)
Academic Research
TABLE 101 ACADEMIC RESEARCH END-USER SEGMENTS, 2009 (%)
TABLE 102   GLOBAL MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS IN ACADEMIC RESEARCH, THROUGH 2014 ($ MILLIONS)
Biopharmaceutical
TABLE 103 BIOPHARMACEUTICAL END-USER SEGMENTS, 2009 (%)
TABLE 104   MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS IN BIOPHARMACEUTICAL RESEARCH, THROUGH 2014 ($ MILLIONS)
TABLE 105   OTHER MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS)
GEOGRAPHIC MARKETS
General Trends
TABLE 106 REAL GDP GROWTH RATES IN THE UNITED STATES, 2005–2010 (PERCENT CHANGE OVER PREVIOUS YEAR)
TABLE 107 REAL GDP GROWTH RATES IN EUROPEAN COUNTRIES, 2005–2010 (PERCENT CHANGE OVER PREVIOUS YEAR)
Global Market Trends
TABLE 108   GEOGRAPHIC MARKETS FOR CELL AND TISSUE ANALYSIS PRODUCTS, THROUGH 2014 ($ MILLIONS)
Biospecimens
TABLE 109 BIOSPECIMEN GEOGRAPHIC MARKET SHARES, 2009 AND 2014 (PERCENT OF GLOBAL SALES)
TABLE 110   GEOGRAPHIC MARKETS FOR BIOSPECIMENS, THROUGH 2014 ($ MILLIONS)
CSP
TABLE 111 CELL SEPARATION PRODUCT GEOGRAPHIC MARKET SHARES, 2009 AND 2014 (PERCENT OF GLOBAL SALES)
TABLE 112   GEOGRAPHIC MARKETS FOR CELL SEPARATION PRODUCTS, THROUGH 2014 ($ MILLIONS)
CTC Products
TABLE 113 CTC PRODUCT GEOGRAPHIC MARKET SHARES, 2009, AND 2014 (PERCENT OF GLOBAL SALES)
TABLE 114   GEOGRAPHIC MARKETS FOR CELL AND TISSUE CHARACTERIZATION PRODUCTS, THROUGH 2014 ($ MILLIONS)

Chapter-8: COMPANY PROFILES

BIOSPECIMEN VENDORS (BSV)
TABLE 115 PRODUCTS AND SERVICES OFFERED BY BIOSPECIMEN VENDORS (BSV), 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED)
AMERICAN TYPE CULTURE COLLECTION (ATCC)
ANALYTICAL BIOLOGICAL SERVICES, INC.
ASTERAND PLC.
BIOCHAIN INSTITUTE, INC.
BIOSERVE BIOTECHNOLOGIES LTD.
CAPITAL BIOSCIENCES, INC.
CELLECTA, INC.
CURELINE, INC.
CYBRDI, INC.
FOLIO BIOSCIENCES
ILSBIO, LLC.
LIFESPAN BIOSCIENCES, INC.
PROMEDDX, LLC
U.S. BIOMAX, INC.
CELL SEPARATION PRODUCT (CSP) COMPANIES
TABLE 116 PRODUCTS AND SERVICES OFFERED BY CELL SEPARATION PRODUCT (CSP) COMPANIES, 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED)
ACCURI CYTOMETERS, INC.
BECKMAN COULTER, INC.
BD BIOSCIENCES
CARL ZEISS MICROIMAGING, GMBH
LEICA MICROSYSTMES, GMBH
MILLIPORE
MILTENYI BIOTEC
MDS ANALYTICAL TECHNOLOGIES
MOLECULAR MACHINES & INDUSTRIES, GMBH
PARTEC, GMBH
STEM CELL TECHNOLOGIES
WORTHINGTON BIOCHEMCIAL CORPORATION
CELL AND TISSUE CHARACTERIZATION COMPANIES
TABLE 117 PRODUCTS AND SERVICES OFFERED BY CELL & TISSUE CHARACTERIZATION COMPANIES, 2009 (X REPRESENTS PRODUCT OR SERVICE PROVIDED)
ABCAM, PLC.
CELL SIGNALING TECHNOLOGY, INC.
CELLUMEN, INC.
EBIOSCIENCE, INC.
GE HEALTHCARE BIOSCIENCES
INVITROGEN CORPORATION
MBL INTERNATIONAL
PERKINELMER, INC.
PLATYPUS TECHNOLOGIES, LLC
PROMEGA CORPORATION
ROCHE APPLIED SCIENCE
SIGMA-ALDRICH, INC.
THERMO FISHER SCIENTIFIC, INC.
APPENDIX: GLOSSARY