STUDY OBJECTIVE

BCC Research’s objective in conducting this study is to provide an overview of the current and future global pharmaceutical contract manufacturing, research and packaging markets. The study provides a global as well as a regionally specific market overview. The key objective is to present a comprehensive analysis of the current and future direction of contract manufacturing, research and packaging as an important tool for a company’s growth and financial stability and as a way to overcome various trade barriers. It also addresses the role of these organizations in reducing costs, meeting strict regulatory requirements globally, dealing with the effects of patent expiries on market share and in competing in a highly competitive and tough business environment.

A detailed analysis of the industry structure of contract manufacturing, contract research and contract packaging has been conducted. Revenues are broken down by type of industry. Sales figures are estimated for the five-year period from 2013 through 2018.

Applications and various formulations for which contract manufacturing, research and packaging are widely used are also discussed separately in the report. The report also takes into account various new developments and regulatory aspects in this industry. The report also covers significant patents in each category.

REASONS FOR DOING THIS STUDY

Comprehensive research in the fields of contract manufacturing, contract research and contract packaging has revealed their benefits in various industries. Contract manufacturing, research and packaging are advantageous to both parties to the contract as it provides the manufacturing company with financial stability for the duration of the contract and the hiring company the benefit of cost savings, time saved in operating and managing a production facility and research. Many industries have now begun to explore the advantages of contracting their research, production and packaging, leading to a steady market for these services.

Cost control, R&D spend, new technologies, increasing competition and patent expiries resulting in markets for generics are moving this industry in a new direction. New advancements, product launches and changing technologies will drive the growth of the market in the foreseeable future. This study looks at most of the systems affected by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each type of technology in light of the new technologies, growing competition and changing market needs.

CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE

This study contributes to the market growth of contract manufacturers, contract research and contract packaging and users. Pharmaceutical, biotechnical companies, research institutes and companies involved in the packaging of pharma and biotech products will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses contract manufacturers, contract research and contract packaging in the pharmaceutical and biotechnology markets. BCC analyzes each market and its applications, regulatory environment, technology, market projections and market shares. Technological issues include the latest trends and developments. The emerging markets for contract manufacturing research and packaging include countries such as India, China, Japan, Korea, Taiwan, Canada, Africa, Australia and New Zealand.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals and many other sources. Data were collected through interviews and correspondence with manufacturers of enzyme inhibitors and technical experts. Projections were based on estimates, including the current number of end users, potential end users, mergers and acquisitions and market trends.

INFORMATION SOURCES

Many companies were surveyed to obtain data for this study. Included were manufacturers and end users of kinase inhibitors in various therapeutic categories and disease segments. Data were gathered from various industry sources. BCC spoke with officials within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

A team of professionals in the biotechnology industry carried out this study. The project manager is Shalini S. Dewan, who holds a master’s degree in pharmaceutical chemistry and has more than 14 years of industry experience. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest such as ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and the U.S. Some of her other reports with BCC are: Reagents for Chromatography; Spectroscopy: An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit, including her thesis, which was given an award of excellence.

REPORT HIGHLIGHTS

This report provides:
• An overview of the global market for contract pharmaceutical manufacturing, research, and packaging, with emphasis on the current and future outlook of the market and a comprehensive analysis of the overall pharmaceutical and biotechnology outsourcing industry.
• Analyses of global market trends, with data from 2011 and 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018.
• Examination of the effects on market growth of state-of-the-art packaging facilities as well as expensive research facilities and the capabilities of research organizations.
• Coverage of the market's need for outsourcing, the regulatory environment, and technological issues, including the latest trends and developments.
• Comprehensive company profiles of major players.

Table Of Contents

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 3
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 4
BCC ONLINE SERVICES 4
DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE GLOBAL MARKET FOR PHARMACEUTICAL AND
BIOPHARMACEUTICAL CONTRACT MANUFACTURING, RESEARCH AND PACKAGING,
THROUGH 2018 ($ BILLIONS) 6
SUMMARY FIGURE GLOBAL MARKET FOR PHARMACEUTICAL AND
BIOPHARMACEUTICAL CONTRACT MANUFACTURING, RESEARCH AND PACKAGING,
2011-2018 ($ BILLIONS) 6

CHAPTER 3 OVERVIEW 10

DEFINITIONS 10
OUTSOURCING 10
CONTRACT MANUFACTURING 10
CONTRACT MANUFACTURER 10
CORE COMPETENCIES 11
VENDOR 11
CONTRACT RESEARCH ORGANIZATION (CRO) 11
REASONS FOR OUTSOURCING 12
REDUCE AND CONTROL OPERATING COSTS 12
IMPROVE FOCUS ON CORE COMPETENCIES 12
GAIN ACCESS TO WORLD-CLASS CAPABILITIES 12
SHARE RISKS WITH A PARTNER COMPANY 13
HISTORY OF OUTSOURCING 13
TABLE 1 KEY DEVELOPMENTS IN THE HISTORY OF OUTSOURCING 14
CONTRACT MANUFACTURING 16
TYPES OF CONTRACT MANUFACTURERS 16
Supply Manufacturers 16
Toll Manufacturers 17
Types of Toll Manufacturers 17
Vendors of Excess Capacity 17
Providers of Niche Services 17
Academic Institutions 17
SPECIFIC REASONS FOR OUTSOURCING 17
STRATEGIES FOR SUCCESSFUL OUTSOURCING 18
ADVANTAGES AND DISADVANTAGES OF CONTRACT MANUFACTURING 18
TABLE 2 KEY ADVANTAGES OF CONTRACT MANUFACTURING 18
TABLE 3 KEY DISADVANTAGES OF CONTRACT MANUFACTURING 19
SELECTING A CONTRACT MANUFACTURER 19
TABLE 4 KEY FACTORS IN SELECTING A CONTRACT MANUFACTURER 20
IMPORTANT FACTORS IN WORKING WITH A CONTRACT MANUFACTURER 21
Product Quality 21
Cost Competitiveness 21
Delivery Schedule 21
Client-CMO Relationship 21
CONTRACT RESEARCH 22
RESPONSIBILITIES OF CONTRACT RESEARCH ORGANIZATIONS 23
CRO-SPONSOR RELATIONSHIP: KEY TO SUCCESS 23
SERVICES OFFERED BY CONTRACT RESEARCH ORGANIZATIONS 24
TABLE 5 SERVICES OFFERED BY CONTRACT RESEARCH ORGANIZATIONS 24
SELECTION CRITERIA 25
TABLE 6 KEY FACTORS IN SELECTING A CONTRACT RESEARCH ORGANIZATION 25
RESEARCH PROVIDED BY CONTRACT RESEARCH ORGANIZATIONS 26
TABLE 7 TYPES OF SERVICES PROVIDED BY CONTRACT RESEARCH
ORGANIZATIONS 26
CONTRACT PACKAGING 27
NEED FOR CONTRACT PACKAGERS 27
TABLE 8 REASONS COMPANIES HIRE CONTRACT PACKAGERS 28
ETHICAL STANDARDS FOR CONTRACT PACKAGERS 28

CHAPTER 4 REGULATORY ASPECTS 31

WARNING LETTERS 31
TABLE 9 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2012 32
TABLE 10 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2011 33
TABLE 11 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2010 33
REGULATORY APPROVALS 33
TABLE 12 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, JAN. AND FEB. 2013 34
TABLE 13 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, 2012 35
TABLE 14 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, 2011 35
TABLE 15 REGULATORY APPROVALS OF CONTRACT MANUFACTURER ACTIVITIES
AND FACILITIES, 2010 36

CHAPTER 5 NEW DEVELOPMENTS 38

LONZA 38
BRISTOL-MYERS SQUIBB 39
ABBOTT 39
ALBANY MOLECULAR RESEARCH INC. (AMRI) 40
EVOTEC AG 40
HOSPIRA 41
COVIDIEN 41
DR. REDDY'S LABORATORIES 42
OTHER 42

CHAPTER 6 GLOBAL MARKETS FOR CONTRACT MANUFACTURING, RESEARCH AND

PACKAGING 47
MARKETS BY TYPE 47
CONTRACT MANUFACTURE OF VARIOUS DOSAGE FORMS AND BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS 48
Market Overview 49
Market Revenue 49
TABLE 16 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
THROUGH 2018 ($ BILLIONS)
50
FIGURE 1 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
2011-2018 ($ BILLIONS)
50
Market Shares 50
TABLE 17 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
2012 (%)
51
FIGURE 2 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
2012 (%)
51
MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONALS 51
Market Overview 52
Market Revenues 52
TABLE 18 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 53
FIGURE 3 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2011-2018 ($ BILLIONS) 53
Market Share 53
TABLE 19 MARKET SHARES OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 54
FIGURE 4 MARKET SHARES OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 54
MARKET FOR VARIOUS DOSAGE FORMS, BULK DRUGS/ACTIVE
PHARMACEUTICAL INGREDIENTS AND OTC DRUGS/NUTRITIONALS 54
Market Revenue 54
TABLE 20 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, THROUGH 2018 ($ BILLIONS)
55
FIGURE 5 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, 2011-2018 ($ BILLIONS)
55
Market Share 56
TABLE 21 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, 2012 (%)
56
FIGURE 6 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, 2012 (%)
56
CONTRACT RESEARCH MARKET 57
Market Overview 57
Market Revenue 57
TABLE 22 GLOBAL MARKET FOR CONTRACT RESEARCH BY SEGMENT, THROUGH
2018 ($ BILLIONS) 57
FIGURE 7 GLOBAL MARKET FOR CONTRACT RESEARCH BY SEGMENT, 2011-2018 ($
BILLIONS) 58
Market Shares 58
TABLE 23 CONTRACT RESEARCH MARKET SHARES BY SEGMENT, 2012 (%) 59
FIGURE 8 CONTRACT RESEARCH MARKET SHARES BY SEGMENT, 2012 (%) 59
CONTRACT PACKAGING MARKET 59
Market Overview 60
Market Revenue 61
TABLE 24 GLOBAL MARKET FOR CONTRACT PACKAGING BY TYPE, THROUGH 2018
($ BILLIONS) 61
FIGURE 9 GLOBAL MARKET FOR CONTRACT PACKAGING BY TYPE, 2011-2018 ($
BILLIONS) 61
Market Share 62
TABLE 25 MARKET SHARES OF CONTRACT PACKAGING BY TYPE, 2012 (%) 62
FIGURE 10 MARKET SHARES OF CONTRACT PACKAGING BY TYPE, 2012 (%) 62
MARKET BY REGION 62
MARKET FOR CONTRACT MANUFACTURE OF VARIOUS DOSAGE FORMS,
BULK DRUGS AND ACTIVE PHARMACEUTICAL INGREDIENTS 63
Market Overview 64
Market Revenue 66
TABLE 26 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS
DOSAGE FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY
REGION, THROUGH 2018 ($ BILLIONS)
66
FIGURE 11 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS
DOSAGE FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY
REGION, 2011-2018 ($ BILLIONS)
67
Market Share 67
TABLE 27 REGIONAL MARKETS SHARES OF CONTRACT MANUFACTURING OF
VARIOUS DOSAGE FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL
INGREDIENTS, 2012 (%)
68
FIGURE 12 REGIONAL MARKETS SHARES OF CONTRACT MANUFACTURING OF
VARIOUS DOSAGE FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL
INGREDIENTS, 2012 (%)
68
MARKET FOR CONTRACT MANUFACTURING, RESEARCH AND PACKAGING 68
Market Overview 69
Market Revenue 72
TABLE 28 GLOBAL MARKET FOR CONTRACT MANUFACTURING, RESEARCH AND
PACKAGING BY REGION, THROUGH 2018 ($ BILLIONS) 73
FIGURE 13 GLOBAL MARKET FOR CONTRACT MANUFACTURING, RESEARCH AND
PACKAGING BY REGION, 2011-2018 ($ BILLIONS) 73
Market Share 73
TABLE 29 REGIONAL MARKET SHARES OF CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING, 2012 (%) 74
FIGURE 14 REGIONAL MARKET SHARES OF CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING, 2012 (%) 74
MARKET BY THERAPEUTIC USE 74
CARDIOVASCULAR DRUGS 75
ONCOLOGY 75
ANTIBIOTICS 75
ANALGESICS 76
ANTIVIRALS 76
REPRODUCTIVE DRUG PRODUCTS 77
INFLAMMATION AND IMMUNOLOGY 78
NEUROSCIENCE 78
VACCINES 78
OTHERS 79
MARKET REVENUE 79
TABLE 30 GLOBAL MARKET FOR CONTRACT MANUFACTURING AND RESEARCH OF
DRUGS BY THERAPEUTIC AREA, THROUGH 2018 ($ MILLIONS) 80
FIGURE 15 GLOBAL MARKET FOR CONTRACT MANUFACTURING AND RESEARCH OF
DRUGS BY THERAPEUTIC AREA, 2011-2018 ($ MILLIONS) 80
MARKET SHARES 81
TABLE 31 CONTRACT MANUFACTURING AND RESEARCH MARKET SHARES BY
THERAPEUTIC AREA, 2012 (%) 81
FIGURE 16 CONTRACT MANUFACTURING AND RESEARCH MARKET SHARES BY
THERAPEUTIC AREA, 2012 (%) 82

CHAPTER 7 CONTRACT MANUFACTURING MARKET 84

CONTRACT MANUFACTURE OF BULK DRUGS/ACTIVE PHARMACEUTICAL
INGREDIENTS 84
MARKET OVERVIEW 84
MARKET REVENUE 86
TABLE 32 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY REGION, THROUGH 2018 ($
BILLIONS)
87
FIGURE 17 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY REGION, 2011-2018 ($
BILLIONS)
87
CONTRACT MANUFACTURE OF DOSAGE FORMS 87
MARKET BY TYPE 88
Market Overview 89
Market Revenue 89
TABLE 33 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS
DOSAGE FORMS, THROUGH 2018 ($ BILLIONS) 89
FIGURE 18 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS
DOSAGE FORMS, 2011-2018 ($ BILLIONS) 89
MARKET BY REGION 90
Solid Dosage Form 90
Market Overview 90
Market Revenue 91
TABLE 34 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY REGION, THROUGH 2018 ($ BILLIONS) 92
FIGURE 19 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY REGION, 2011-2018 ($ BILLIONS) 92
Liquid Dosage Forms 92
Market Overview 93
Market Revenue from Non-sterile Formulations 94
TABLE 35 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY REGION, THROUGH 2018 ($ MILLIONS) 94
FIGURE 20 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON STERILE) BY REGION, 2011-2018 ($ MILLIONS) 94
Market Revenues from Sterile Formulations 95
TABLE 36 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORM (STERILE) DRUGS BY REGION, THROUGH 2018 ($ MILLIONS) 96
FIGURE 21 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORM (STERILE) DRUGS BY REGION, 2011-2018 ($ MILLIONS) 96
Semisolid Dosage Forms 97
Market Overview 97
Market Revenue 98
TABLE 37 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY REGION, THROUGH 2018 ($ MILLIONS) 98
FIGURE 22 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY REGION, 2011-2018 ($ MILLIONS) 99
MARKET BY FORMULATION 99
Solid Dosage Forms 99
Market Revenue 100
TABLE 38 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 100
FIGURE 23 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, 2011-2018 ($ BILLIONS) 100
Market Share 101
TABLE 39 MARKET SHARES OF CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, 2012 (%) 101
FIGURE 24 MARKET SHARES OF CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, 2012 (%) 101
Liquid Dosage Forms 102
Market Revenue from Non-sterile Forms 102
TABLE 40 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, THROUGH 2018 ($ MILLIONS) 103
FIGURE 25 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, 2011-2018 ($ MILLIONS) 103
Market Share of Non-sterile Formulations 104
TABLE 41 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, 2012 (%) 104
FIGURE 26 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, 2012 (%) 104
Market for Sterile Formulations 105
TABLE 42 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, THROUGH 2018 ($ MILLIONS) 105
FIGURE 27 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, 2011-2018 ($ MILLIONS) 105
Market Shares of Sterile Formulations 106
TABLE 43 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, 2012 (%) 106
FIGURE 28 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, 2012 (%) 106
Semisolid Dosage Forms 107
Market Revenue 107
TABLE 44 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY FORMULATION, THROUGH 2018 ($ MILLIONS) 108
FIGURE 29 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY FORMULATION, 2011-2018 ($ MILLIONS) 108
Market Shares 108
TABLE 45 MARKET SHARES OF CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY FORMULATION, 2012 (%) 109
FIGURE 30 MARKET SHARES OF CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY FORMULATION, 2012 (%) 109
CONTRACT MANUFACTURE OF ADVANCED DRUG DELIVERY PRODUCTS 109
MARKET OVERVIEW 110
TABLE 46 EXAMPLES OF CONTRACTING COMPANIES PROVIDING DRUG-DELIVERY
SYSTEMS 111
MARKET BY REGION 112
TABLE 47 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED
DRUG DELIVERY SYSTEMS BY REGION, THROUGH 2018 ($ BILLIONS) 112
FIGURE 31 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED
DRUG DELIVERY SYSTEMS BY REGION, 2011-2018 ($ BILLIONS) 112
MARKET BY FORMULATIONS 113
TABLE 48 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED
DRUG DELIVERY SYSTEMS BY TYPE, THROUGH 2018 ($ MILLIONS) 114
FIGURE 32 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED
DRUG DELIVERY SYSTEMS BY TYPE, 2011-2018 ($ MILLIONS) 114
MARKET SHARE 115
TABLE 49 MARKET SHARES OF CONTRACT MANUFACTURING OF ADVANCED DRUG
DELIVERY SYSTEMS BY TYPE, 2012 (%) 116
FIGURE 33 MARKET SHARES OF CONTRACT MANUFACTURING OF ADVANCED DRUG
DELIVERY SYSTEMS BY TYPE, 2012 (%) 116
CONTRACT MANUFACTURE OF OTC DRUGS AND NUTRITIONAL PRODUCTS 116
MARKET BY REGION 117
Market Revenue 118
TABLE 50 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY REGION, THROUGH 2018 ($ BILLIONS) 118
FIGURE 34 GLOBAL MARKET FOR CONTRACT MANUFACTURING OTC DRUGS AND
NUTRITIONAL PRODUCTS BY REGION, 2011-2018 ($ BILLIONS) 118
MARKET BY FORMULATION TYPE 119
TABLE 51 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 120
FIGURE 35 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS
AND NUTRITIONAL PRODUCTS BY FORMULATION, 2011-2018 ($ BILLIONS) 120
Market Share 120
TABLE 52 MARKET SHARES OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 121
FIGURE 36 MARKET SHARE S OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 121
CONTRACT MANUFACTURING OF BULK DRUGS AND DOSAGE FORMS BY
APPLICATION/THERAPEUTIC AREA 121
CARDIOVASCULAR 122
ANTIBIOTICS 122
ANALGESICS 123
ONCOLOGY 123
ANTIVIRALS 124
REPRODUCTIVE DRUG PRODUCTS 125
OTHER DRUGS 125
MARKET REVENUE 126
TABLE 53 GLOBAL MARKET FOR PHARMACEUTICAL CONTRACT MANUFACTURING
BY THERAPEUTIC AREA, THROUGH 2018 ($ MILLIONS) 127
FIGURE 37 GLOBAL MARKET FOR PHARMACEUTICAL CONTRACT MANUFACTURING
BY THERAPEUTIC AREA, 2011-2018 ($ MILLIONS) 127
MARKET SHARE 127
TABLE 54 MARKET SHARES OF VARIOUS THERAPEUTIC CATEGORIES OF CONTRACT
MANUFACTURING, 2012 (%) 127
FIGURE 38 MARKET SHARES OF VARIOUS THERAPEUTIC CATEGORIES OF
CONTRACT MANUFACTURING, 2012 (%) 128
INDUSTRY STRUCTURE 128
MARKET LEADERS 128
TABLE 55 SERVICES PROVIDED BY CONTRACT MANUFACTURING FIRMS 129
MARKET SHARES 130
Bulk Drugs and APIs 130
TABLE 56 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING BULK DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, 2012 (%) 131
FIGURE 39 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING BULK DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, 2012 (%) 131
Solid Dosage Forms 131
TABLE 57 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING SOLID DOSAGE FORMS, 2012 (%) 132
FIGURE 40 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING SOLID DOSAGE FORMS, 2012 (%) 132
Liquid Dosage Forms 133
Non-sterile 133
TABLE 58 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING NON-STERILE LIQUID DOSAGE FORMS, 2012 (%) 134
FIGURE 41 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING NON-STERILE LIQUID DOSAGE FORMS, 2012 (%) 134
Sterile 135
TABLE 59 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING STERILE LIQUID DOSAGE FORMS, 2012 (%) 135
FIGURE 42 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING STERILE LIQUID DOSAGE FORMS, 2012 (%) 135
Semisolid Dosage Forms 136
TABLE 60 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING SEMISOLID DOSAGE FORMS, 2012 (%) 136
FIGURE 43 MARKET SHARES OF CONTRACT MANUFACTURING COMPANIES
PROVIDING SEMISOLID DOSAGE FORMS, 2012 (%) 137

CHAPTER 8 CONTRACT RESEARCH MARKET 139

MARKET BY DISCIPLINE 139
MARKET OVERVIEW 139
MARKET REVENUE 140
TABLE 61 GLOBAL MARKET FOR CONTRACT RESEARCH BY DISCIPLINE, THROUGH
2018 ($ BILLIONS) 141
FIGURE 44 GLOBAL MARKET FOR CONTRACT RESEARCH BY DISCIPLINE, 2011-2018
($ BILLIONS) 141
MARKET SHARES 141
TABLE 62 MARKET SHARES OF CONTRACT RESEARCH BY DISCIPLINE, 2012 (%) 142
FIGURE 45 MARKET SHARES OF CONTRACT RESEARCH BY DISCIPLINE, 2012 (%) 142
MARKET BY REGION 142
MARKET OVERVIEW 143
MARKET REVENUE 143
TABLE 63 GLOBAL MARKET FOR CONTRACT RESEARCH BY REGION, THROUGH
2018 ($ BILLIONS) 144
FIGURE 46 GLOBAL MARKET FOR CONTRACT RESEARCH BY REGION, 2011-2018 ($
BILLIONS) 144
MARKET SHARES 145
TABLE 64 CONTRACT RESEARCH MARKET SHARES BY REGION, 2012 (%) 145
FIGURE 47 CONTRACT RESEARCH MARKET SHARES BY REGION, 2012 (%) 145
Contract Clinical Research Market by Region 145
TABLE 65 GLOBAL MARKET FOR CONTRACT CLINICAL RESEARCH BY REGION,
THROUGH 2018 ($ MILLIONS) 146
FIGURE 48 GLOBAL MARKET FOR CONTRACT CLINICAL RESEARCH BY REGION,
2011-2018 ($ MILLIONS) 146
Contract Drug Discovery Market by Region 147
TABLE 66 GLOBAL MARKET FOR CONTRACT DRUG DISCOVERY BY REGION,
THROUGH 2018 ($ MILLIONS) 147
FIGURE 49 GLOBAL MARKET FOR CONTRACT DRUG DISCOVERY BY REGION,
2011-2018 ($ MILLIONS) 147
Contract Analytical Research Market by Region 148
TABLE 67 GLOBAL MARKET FOR CONTRACT ANALYTICAL RESEARCH BY REGION,
THROUGH 2018 ($ MILLIONS) 149
FIGURE 50 GLOBAL MARKET FOR CONTRACT ANALYTICAL RESEARCH BY REGION,
2011-2018 ($ MILLIONS) 149
Other Contract Research Activities Market by Region 149
TABLE 68 GLOBAL MARKET FOR OTHER CONTRACT RESEARCH SERVICES BY
REGION, THROUGH 2018 ($ MILLIONS) 150
FIGURE 51 GLOBAL MARKET FOR OTHER CONTRACT RESEARCH SERVICES BY
REGION, 2011-2018 ($ MILLIONS) 150
MARKET BY THERAPEUTIC AREA 150
CARDIOLOGY 151
ONCOLOGY 151
INFLAMMATION AND IMMUNOLOGY 151
NEUROSCIENCE 152
VACCINES 152
OTHERS 153
MARKET REVENUE 154
TABLE 69 GLOBAL MARKET FOR CONTRACT RESEARCH BY THERAPEUTIC AREA,
THROUGH 2018 ($ MILLIONS) 154
FIGURE 52 GLOBAL MARKET FOR CONTRACT RESEARCH BY THERAPEUTIC AREA,
2011-2018 ($ MILLIONS) 154
MARKET SHARE 155
TABLE 70 MARKET SHARES OF CONTRACT RESEARCH BY THERAPEUTIC AREA,
2012 (%) 155
FIGURE 53 MARKET SHARES OF CONTRACT RESEARCH BY THERAPEUTIC AREA,
2012 (%) 156
INDUSTRY STRUCTURE 156
MARKET LEADERS 156
TABLE 71 SERVICES PROVIDED BY RESEARCH FIRMS 156
MARKET SHARES 157
TABLE 72 MARKET SHARES OF CONTRACT RESEARCH COMPANIES, 2012 (%) 158
FIGURE 54 MARKET SHARES OF CONTRACT RESEARCH COMPANIES, 2012 (%) 158

CHAPTER 9 CONTRACT PACKAGING MARKETS 160

MARKET BY TYPE 160
MARKET OVERVIEW 161
MARKET REVENUE 161
TABLE 73 GLOBAL MARKET FOR CONTRACT PACKAGING BY TYPE, THROUGH 2018
($ MILLIONS) 162
FIGURE 55 GLOBAL MARKET FOR CONTRACT PACKAGING BY TYPE, 2011-2018 ($
MILLIONS) 162
TABLE 74 GLOBAL MARKET FOR PRIMARY PACKAGING, THROUGH 2018 ($
MILLIONS) 163
FIGURE 56 GLOBAL MARKET FOR PRIMARY PACKAGING, 2011-2018 ($ MILLIONS) 163
MARKET SHARE 163
TABLE 75 MARKET SHARES OF CONTRACT PACKAGING BY TYPE, 2012 (%) 164
FIGURE 57 MARKET SHARES OF CONTRACT PACKAGING BY TYPE, 2012 (%) 164
MARKET BY REGION 164
MARKET OVERVIEW 165
MARKET REVENUE 166
TABLE 76 GLOBAL MARKET FOR CONTRACT PACKAGING BY REGION, THROUGH
2018 ($ MILLIONS) 166
FIGURE 58 GLOBAL MARKET FOR CONTRACT PACKAGING BY REGION, 2011-2018
($ MILLIONS) 166
MARKET SHARE 167
TABLE 77 MARKET SHARES OF CONTRACT PACKAGING BY REGION, 2012 (%) 167
FIGURE 59 MARKET SHARES OF CONTRACT PACKAGING BY REGION, 2012 (%) 167
Primary Packaging by Region 168
TABLE 78 GLOBAL MARKET FOR PRIMARY PACKAGING BY REGION, THROUGH 2018
($ MILLIONS) 168
FIGURE 60 GLOBAL MARKET FOR PRIMARY PACKAGING BY REGION, 2011-2018 ($
MILLIONS) 168
Secondary Packaging by Region 169
TABLE 79 GLOBAL MARKET FOR SECONDARY PACKAGING BY REGION, THROUGH
2018 ($ MILLIONS) 170
FIGURE 61 GLOBAL MARKET FOR SECONDARY PACKAGING BY REGION, 2011-2018
($ MILLIONS) 170
Other Types of Packaging by Region 170
TABLE 80 GLOBAL MARKET FOR OTHER PACKAGING BY REGION, THROUGH 2018
($ MILLIONS) 171
INDUSTRY STRUCTURE 171
MARKET LEADERS 171
TABLE 81 SERVICES PROVIDED BY CONTRACT PACKAGING FIRMS BY PACKAGING
TYPE, 2012 172
MARKET SHARE 173
TABLE 82 MARKET SHARES OF CONTRACT PACKAGING COMPANIES, 2012 (%) 173
FIGURE 63 MARKET SHARES OF CONTRACT PACKAGING COMPANIES, 2012 (%) 173

CHAPTER 10 PATENT ANALYSIS 176

PATENTS BY YEAR 176
TABLE 83 SIGNIFICANT U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING COMPANIES BY YEAR, 2010-FEB. 2013 (NO.) 176
FIGURE 64 SIGNIFICANT U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING COMPANIES BY YEAR, 2010-FEB. 2013 (NO.) 176
PATENTS BY EMPHASIS 177
TABLE 84 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY EMPHASIS, 2010-FEB. 2013 (NO.) 177
FIGURE 65 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY EMPHASIS, 2010-FEB. 2013 (NO.) 177
PATENTS BY COMPANY 178
TABLE 85 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES, 2010-FEB. 2013 (NO.) 179
PATENTS BY THE PATENT HOLDER'S COUNTRY 180
TABLE 86 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY THE PATENT HOLDER’S COUNTRY, 2010-FEB.
2013 (NO.)
181
FIGURE 66 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY PATENT HOLDER'S COUNTRY, 2010-FEB. 2013
(NO.)
182
TABLE 87 SHARES OF U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING COMPANIES BY PATENT HOLDER’S COUNTRY,
2010-FEB. 2013 (%)
182
FIGURE 67 SHARES OF U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING,
RESEARCH AND PACKAGING COMPANIES BY PATENT HOLDER'S COUNTRY,
2010-FEB. 2013 (%)
183
PATENTS BY PATENT HOLDER TYPE 183
TABLE 88 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY TYPE OF PATENT HOLDER, 2010-FEB. 2013 (NO.) 184
FIGURE 68 U.S. PATENTS GRANTED TO CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING COMPANIES BY TYPE OF PATENT HOLDER, 2010-FEB. 2013 (NO.) 184

CHAPTER 11 CURRENT MARKET ENVIRONMENT 186

FACTORS AFFECTING THE OUTSOURCING MARKET 186
COST SAVINGS 186
STRINGENT REGULATIONS 186
PATENT EXPIRIES 187
DECREASING RESEARCH AND DEVELOPMENT SUCCESS RATES 187
INCREASING DEMAND FOR BIOSIMILARS 187
PHARMACEUTICAL OUTSOURCING TRENDS 188

CHAPTER 12 COMPANY PROFILES 191

3M CO. 191
AAI PHARMA INC. 191
ABBOTT LABORATORIES 192
AEROGEN LTD. 193
ALBANY MOLECULAR RESEARCH INC. (AMRI) 193
ALKERMES PLC 194
ALTHEA TECHNOLOGIES 194
AMCOR 195
AMERISOURCEBERGEN CORP. 195
AMPAC FINE CHEMICALS 196
A.P. PHARMA INC. 196
APTIV SOLUTIONS 197
APTUIT INC. 197
ARADIGM CORP. 198
BASF SE 198
BAXTER HEALTHCARE 199
BCM/BOOTS MANUFACTURING 200
BOEHRINGER INGELHEIM 200
CAMBREX CORP. 201
CANGENE BIOPHARMA INC. 202
CATALENT PHARMA SOLUTIONS 202
CEDARBURG HAUSER PHARMACEUTICALS INC. 202
CENEXI 203
CHARLES RIVER LABORATORIES 203
CHEMBRIDGE CORP. 204
CONFAB LABORATORIES 204
COVANCE INC. 205
COVIDIEN 206
CONTRACT PHARMACEUTICALS LTD. 206
CORDENPHARMA SWITZERLAND LLC 207
DECODE GENETICS 208
DISHMAN PHARMACEUTICALS AND CHEMICALS LTD. 208
DOW PHARMACEUTICAL SCIENCES 209
DPT LABORATORIES INC. 209
DR. REDDY'S LABORATORIES 210
DSM PHARMACEUTICAL PRODUCTS 210
FUJIFILM DIOSYNTH BIOTECHNOLOGY 211
ELAN DRUG TECHNOLOGIES 211
EVOTEC AG 212
GIRINDUS AG 212
GLAXOSMITHKLINE 213
GRIFOLS INTERNATIONAL SA 214
HOSPIRA 214
HAUPT PHARMA AG 215
HOVIONE SA 216
ICON PLC 216
INC RESEARCH LLC 217
JUBILANT LIFESCIENCES 217
KENDLE INTERNATIONAL INC. 218
KP PHARMACEUTICAL TECHNOLOGIES INC. 218
LIGAND PHARMACEUTICALS INC. 219
LONZA GROUP 219
LYNE LABORATORIES 220
MEADWESTVACO CORP. 221
MIKART INC. 221
NEXTPHARMA TECHNOLOGIES 222
NORWICH PHARMACEUTICALS 222
NOVAVAX INC. 223
PAREXEL INTERNATIONAL CORP. 224
PATHEON INC. 224
PERRIGO CO. 225
PFIZER CENTRESOURCE 225
PIRAMAL HEALTHCARE LTD. 226
PPD 227
PRA INTERNATIONAL 227
QUINTILES 228
RANBAXY LABORATORIES LTD. 228
RECIPHARM AB 229
REGIS TECHNOLOGIES INC. 230
SCHOTT PHARMACEUTICAL PACKAGING 230
SKYEPHARMA PLC 231
TAKEDA PHARMACEUTICALS 231
THEOREM CLINICAL RESEARCH 232
VETTER PHARMA INTERNATIONAL GMBH 232
WOCKHARDT LTD. 233
WUXI APP TEC 233
XCELLEREX LLC 234
ZACH SYSTEM SPA 234

CHAPTER 13 APPENDIX: ACRONYMS 236



LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR PHARMACEUTICAL AND
BIOPHARMACEUTICAL CONTRACT MANUFACTURING, RESEARCH AND PACKAGING,
THROUGH 2018 ($ BILLIONS)
6
TABLE 1 KEY DEVELOPMENTS IN THE HISTORY OF OUTSOURCING 14
TABLE 2 KEY ADVANTAGES OF CONTRACT MANUFACTURING 18
TABLE 3 KEY DISADVANTAGES OF CONTRACT MANUFACTURING 19
TABLE 4 KEY FACTORS IN SELECTING A CONTRACT MANUFACTURER 20
TABLE 5 SERVICES OFFERED BY CONTRACT RESEARCH ORGANIZATIONS 24
TABLE 6 KEY FACTORS IN SELECTING A CONTRACT RESEARCH ORGANIZATION 25
TABLE 7 TYPES OF SERVICES PROVIDED BY CONTRACT RESEARCH ORGANIZATIONS 26
TABLE 8 REASONS COMPANIES HIRE CONTRACT PACKAGERS 28
TABLE 9 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2012 32
TABLE 10 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2011 33
TABLE 11 WARNING LETTERS ISSUED TO PHARMACEUTICAL CONTRACT
MANUFACTURERS, 2010 33
TABLE 12 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, JAN. AND FEB. 2013 34
TABLE 13 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, 2012 35
TABLE 14 REGULATORY APPROVALS OF PHARMACEUTICAL CONTRACT
MANUFACTURER ACTIVITIES AND FACILITIES, 2011 35
TABLE 15 REGULATORY APPROVALS OF CONTRACT MANUFACTURER ACTIVITIES
AND FACILITIES, 2010 36
TABLE 16 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
THROUGH 2018 ($ BILLIONS)
50
TABLE 17 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS AND VARIOUS DOSAGE FORMS,
2012 (%)
51
TABLE 18 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 53
TABLE 19 MARKET SHARES OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 54
TABLE 20 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, THROUGH 2018 ($ BILLIONS)
55
TABLE 21 MARKET SHARES OF CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS, VARIOUS DOSAGE FORMS AND
OTC DRUGS/NUTRITIONAL PRODUCTS, 2012 (%)
56
TABLE 22 GLOBAL MARKET FOR CONTRACT RESEARCH BY SEGMENT, THROUGH
2018 ($ BILLIONS) 57
TABLE 23 CONTRACT RESEARCH MARKET SHARES BY SEGMENT, 2012 (%) 59
TABLE 24 GLOBAL MARKET FOR CONTRACT PACKAGING BY TYPE, THROUGH 2018 ($
BILLIONS) 61
TABLE 25 MARKET SHARES OF CONTRACT PACKAGING BY TYPE, 2012 (%) 62
TABLE 26 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS DOSAGE
FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY REGION,
THROUGH 2018 ($ BILLIONS)
66
TABLE 27 REGIONAL MARKETS SHARES OF CONTRACT MANUFACTURING OF
VARIOUS DOSAGE FORMS AND BULK DRUGS/ACTIVE PHARMACEUTICAL
INGREDIENTS, 2012 (%)
68
TABLE 28 GLOBAL MARKET FOR CONTRACT MANUFACTURING, RESEARCH AND
PACKAGING BY REGION, THROUGH 2018 ($ BILLIONS) 73
TABLE 29 REGIONAL MARKET SHARES OF CONTRACT MANUFACTURING, RESEARCH
AND PACKAGING, 2012 (%) 74
TABLE 30 GLOBAL MARKET FOR CONTRACT MANUFACTURING AND RESEARCH OF
DRUGS BY THERAPEUTIC AREA, THROUGH 2018 ($ MILLIONS) 80
TABLE 31 CONTRACT MANUFACTURING AND RESEARCH MARKET SHARES BY
THERAPEUTIC AREA, 2012 (%) 81
TABLE 32 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF BULK
DRUGS/ACTIVE PHARMACEUTICAL INGREDIENTS BY REGION, THROUGH 2018 ($
BILLIONS)
87
TABLE 33 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF VARIOUS DOSAGE
FORMS, THROUGH 2018 ($ BILLIONS) 89
TABLE 34 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY REGION, THROUGH 2018 ($ BILLIONS) 92
TABLE 35 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY REGION, THROUGH 2018 ($ MILLIONS) 94
TABLE 36 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORM (STERILE) DRUGS BY REGION, THROUGH 2018 ($ MILLIONS) 96
TABLE 37 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY REGION, THROUGH 2018 ($ MILLIONS) 98
TABLE 38 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 100
TABLE 39 MARKET SHARES OF CONTRACT MANUFACTURING OF SOLID DOSAGE
FORMS BY FORMULATION, 2012 (%) 101
TABLE 40 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, THROUGH 2018 ($ MILLIONS) 103
TABLE 41 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (NON-STERILE) BY FORMULATION, 2012 (%) 104
TABLE 42 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, THROUGH 2018 ($ MILLIONS) 105
TABLE 43 MARKET SHARES OF CONTRACT MANUFACTURING OF LIQUID DOSAGE
FORMS (STERILE) BY FORMULATION, 2012 (%) 106
TABLE 44 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF SEMISOLID
DOSAGE FORMS BY FORMULATION, THROUGH 2018 ($ MILLIONS) 108
TABLE 45 MARKET SHARES OF CONTRACT MANUFACTURING OF SEMISOLID DOSAGE
FORMS BY FORMULATION, 2012 (%) 109
TABLE 46 EXAMPLES OF CONTRACTING COMPANIES PROVIDING DRUG-DELIVERY
SYSTEMS 111
TABLE 47 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED DRUG
DELIVERY SYSTEMS BY REGION, THROUGH 2018 ($ BILLIONS) 112
TABLE 48 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF ADVANCED DRUG
DELIVERY SYSTEMS BY TYPE, THROUGH 2018 ($ MILLIONS) 114
TABLE 49 MARKET SHARES OF CONTRACT MANUFACTURING OF ADVANCED DRUG
DELIVERY SYSTEMS BY TYPE, 2012 (%) 116
TABLE 50 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY REGION, THROUGH 2018 ($ BILLIONS) 118
TABLE 51 GLOBAL MARKET FOR CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, THROUGH 2018 ($ BILLIONS) 120
TABLE 52 MARKET SHARES OF CONTRACT MANUFACTURING OF OTC DRUGS AND
NUTRITIONAL PRODUCTS BY FORMULATION, 2012 (%) 121
TABLE 53 GLOBAL MARKET FOR PHARMACEUTICAL CONTRACT MA

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