STUDY OBJECTIVES

BCC Research’s objective in carrying out this study is to provide an overview of the current and future characteristics of the global market for emerging insulin drugs and delivery technologies. The fundamental objective is to present a comprehensive analysis and identify the future direction of insulin drugs and delivery devices as important tools in treating diabetes with well-tolerated delivery devices.

This report explores present and future strategies within the insulin drug and delivery market, which includes syringes, pumps, pens and many newer methods. The market’s improvisation, setbacks and needs are also discussed. The classifications, comparisons and usage of different insulin types and devices are presented as well.

A detailed analysis of insulin drugs and delivery industry structure has been conducted. Revenues are broken down by type, as well as by region. Sales figures are estimated for the five-year period from 2013 through 2018.

Applications for insulin drugs and delivery are also discussed in a separate section, with emphasis on their usage in treating different types of diabetes. The report also covers significant patents and their allotments in each category.

REASONS FOR DOING THIS STUDY

The emerging technologies in the insulin drug and delivery field have potential in the diabetes market, with improved glucose control, along with improved and well-accepted newer delivery methods. Modern industries and research institutes have begun to explore newer method for diabetes control in adults and juveniles. , leading to a steady market for these technologies.

Research and development (R&D) spending, increasing competition, patent expiries and emerging technologies are guiding this to a new direction. The new advancements, new product launches, and increased awareness and early detection of the disease have influenced the market to grow in the foreseeable future. This study looks at many of the systems affected by these factors.

Companies’ acquisition strategies and collaborations are covered in this report. This study also discusses the strength and weaknesses of each technology type in light of the new technologies, growing competition and changing customer needs.

CONTRIBUTIONS OF THE STUDY AND FOR WHOM

This study contributes to the areas of market growth for insulin drug and delivery manufacturers and users. It will be of interest to pharmaceutical biotechnical companies, research institutes, hospitals and physicians.

SCOPE OF THE STUDY

The scope of this study encompasses insulin drugs and delivery in pharmaceutical and biotechnology markets with its classification and its usage in diabetes types. BCC analyzes each market and its applications, as well as its regulatory environment, technology and market share. The markets, such as type 1 diabetes, type 2 diabetes and gestational diabetes, are analyzed for the years 2011 and 2012. The markets are projected through the end of 2013 and for a five-year period until 2018.

The market is also segmented by insulin syringes and vials, insulin pens and insulin pumps. Technological issues include the latest trends and developments. The study also includes the patent identifications for insulin as a drug, along with its deliveries.

The emerging markets for insulin drug and delivery include India, China, Japan, Korea, Taiwan, Canada, Africa, Australia and New Zealand.

METHODOLOGY

Both primary and secondary research methodologies were used in the preparation of this study. BCC Research conducted a comprehensive literature search, which included technical newsletters and journals, as well as many other sources. Data were collected through interviews and correspondence with manufacturers of enzyme inhibitors technical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies were surveyed to obtain data for this study. including manufacturers of insulin drugs and delivery technologies and their users in hospitals and medical centers. Data were gathered from various industry sources. BCC Research spoke with officials within the industry and also consulted newsletters; company literature; product literature; and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

A team of professionals in the biotechnology industry carried out this study. The project manager is Shalini S. Dewan, who holds a master’s degree in pharmaceutical chemistry and has more than 14 years of industry experience. She has worked studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid, along others. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has also worked with top companies in India and in the U.S. Her reports BCC Research reports include Reagents for Chromatography; Spectroscopy: An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets.

The lead consultant for this project was Dr. Kapil A. Setia, who holds a doctoral degree in the life sciences. She has a number of research publications to her credit.

REPORT HIGHLIGHTS

This report provides:
• An overview of global insulin drugs and delivery in pharmaceutical and biotechnology markets with classification and usage in diabetes types.
• Analyses of global market trends, with data from 2011 and 2012, estimates for 2013 and 2018 and projections of compound annual growth rates (CAGRs) through 2018.
• Discussion of the market segmented by insulin syringes and vials, and insulin pens and insulin pumps.
• Evaluation of emerging technologies in the insulin drug and delivery field that have potential in the diabetes market, with improved glucose control, along with improved and well-accepted newer delivery methods.
• Patent identifications for insulin as a drug, along with its delivery methods.

Table Of Contents

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND FOR WHOM 2
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 4
BCC ONLINE SERVICES 4
DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET,
THROUGH 2018 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET,
2011-2018 ($ MILLIONS) 8

CHAPTER 3 OVERVIEW 10

DIABETES OVERVIEW 10
DIABETES CLASSIFICATION 10
TABLE 1 DISTINGUISHING FEATURES OF TYPE 1 AND TYPE 2 DIABETES 11
EPIDEMIOLOGY 13
TABLE 2 ESTIMATED DIABETES CASES IN 2030 AND POPULATION CHANGES WITH
RESPECT TO 2000 13
TYPE 1 DIABETES MELLITUS MANAGEMENT 14
INSULIN 15
HISTORY OF INSULIN ISOLATION AND THE DEVELOPMENT OF ITS ANALOGS 15
TABLE 3 HISTORY OF INSULIN ISOLATION AND DEVELOPMENT 15
STRUCTURE OF INSULIN 16
INSULIN BIOSYNTHESIS 16
INSULIN TYPES 17
TABLE 4 CHARACTERISTIC PROPERTIES OF VARIOUS INSULIN FORMULATIONS 19
TREATMENT PROTOCOL 20
Multiple Daily Injections 20
TABLE 5 ADVANTAGES AND DISADVANTAGES OF SYRINGES 21
Continuous Subcutaneous Insulin Infusion and Insulin Pump Therapy 21
TABLE 6 INSULIN PUMPS CURRENTLY ON THE MARKET 22
TABLE 7 COMPARATIVE DEPICTION OF RISK VERSUS BENEFIT FEATURES FOR
VARIOUS INSULIN DELIVERY SYSTEMS 23
TABLE 8 INSULIN PENS CURRENTLY ON THE MARKET 25
ADMINISTRATION ROUTES 26
TABLE 9 INSULIN ADMINISTRATION ROUTES 26

CHAPTER 4 REGULATORY ASPECTS 29

APPROVALS FOR INSULIN DRUGS 29
TABLE 10 INSULIN DRUG APPROVALS, 2009-MARCH 2013 29
APPROVALS GRANTED FOR INSULIN DEVICES 30
TABLE 11 PREMARKET APPROVAL SUPPLEMENTAL APPROVALS FOR INSULIN
DEVICES, 2009-MARCH 2013 30
PREMARKET NOTIFICATION OR 510(K) CLEARANCE 32
TABLE 12 PREMARKET NOTIFICATION OR 510 (K) CLEARANCES FOR INSULIN
DEVICES, 2009-MARCH 2013 33
SAFETY ALERTS AND RECALLS 34
TABLE 13 SAFETY ALERTS FOR INSULIN DRUGS AND DEVICES, 2009-APRIL 2013 34
TABLE 14 DRUG RECALLS FOR INSULIN DRUGS AND DEVICES, 2009-APRIL 2013 35

CHAPTER 5 NEW DEVELOPMENTS 41

NEW TECHNOLOGIES FOR INSULIN DELIVERY 42
INSULIN INHALERS 42
INSULIN SPRAY 42
IMPLANTABLE INSULIN PUMPS 42
TRANSDERMAL PATCH 42
PRODUCT DEVELOPMENT 43
TABLE 15 NEW DEVELOPMENTS FOR INSULIN DRUGS AND DELIVERY DEVICES 43
MERGERS AND ACQUISITIONS 45
TABLE 16 INSULIN DRUG AND DELIVERY DEVICE COMPANY MERGERS AND
ACQUISITIONS 46
LICENSING, PARTNERSHIPS, AND AGREEMENTS 47
TABLE 17 LICENSING, PARTNERSHIPS, AND AGREEMENTS FOR INSULIN DRUGS
AND DELIVERY DEVICES 48
PIPELINE PRODUCTS 51
TABLE 18 INSULIN DRUG AND DELIVERY DEVICE PIPELINE PRODUCTS 51

CHAPTER 6 GLOBAL MARKETS 56

MARKET BY TYPE 57
MARKET OVERVIEW 57
MARKET REVENUE 58
TABLE 19 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY TYPE,
THROUGH 2018 ($ MILLIONS) 58
FIGURE 1 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY TYPE,
2011-2018 ($ MILLIONS) 59
MARKET SHARE 59
TABLE 20 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY TYPE, 2012
(%) 59
FIGURE 2 INSULIN DRUG AND DEVICE MARKET SHARES BY TYPE, 2012 (%) 60
MARKET BY REGION 60
MARKET OVERVIEW 61
MARKET REVENUE 62
TABLE 21 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 62
FIGURE 3 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY REGION,
2011-2018 ($ MILLIONS) 63
MARKET SHARE 63
TABLE 22 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARE BY REGION, 2012
(%) 63
FIGURE 4 INSULIN DRUG AND DEVICE MARKET SHARE BY REGION, 2012 (%) 63
INSULIN SYRINGES AND VIALS 64
Market Overview 64
Market Revenue 64
TABLE 23 GLOBAL INSULIN SYRINGE AND VIAL MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 65
FIGURE 5 GLOBAL INSULIN SYRINGE AND VIAL MARKET BY REGION, 2011-2018 ($
MILLIONS) 65
Market Share 65
TABLE 24 INSULIN SYRINGE AND VIAL MARKET SHARES BY REGION, 2012 (%) 66
FIGURE 6 INSULIN SYRINGE AND VIAL MARKET SHARES BY REGION, 2012 (%) 66
INSULIN PENS 66
Market Overview 67
Market Revenue 67
TABLE 25 GLOBAL INSULIN PEN MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 68
FIGURE 7 GLOBAL INSULIN PEN MARKET BY REGION, 2011-2018 ($ MILLIONS) 68
Market Share 68
TABLE 26 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 69
FIGURE 8 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 69
INSULIN PUMPS 69
Market Overview 70
Market Revenue 71
TABLE 27 GLOBAL INSULIN PUMP MARKET BY REGION, THROUGH 2018 ($
MILLIONS) 71
FIGURE 9 GLOBAL INSULIN PUMP MARKET BY REGION, THROUGH 2018 ($
MILLIONS) 72
Market Share 72
TABLE 28 INSULIN PUMP MARKET SHARES BY REGION, 2012 (%) 72
FIGURE 10 INSULIN PUMP MARKET SHARES BY REGION, 2012 (%) 72
MARKET BY APPLICATIONS 73
TYPE 1 DIABETES 73
TYPE 2 DIABETES 74
GESTATIONAL DIABETES 75
MARKET OVERVIEW 75
MARKET REVENUE 76
TABLE 29 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY APPLICATION,
THROUGH 2018 ($ MILLIONS) 76
FIGURE 11 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY
APPLICATION, 2011-2018 ($ MILLIONS) 76
MARKET SHARE 77
TABLE 30 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY APPLICATION,
2012 (%) 77
FIGURE 12 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY
APPLICATION, 2012 (%) 77

CHAPTER 7 INSULIN PEN MARKET ANALYSIS 80

MARKET BY TYPE 80
MARKET OVERVIEW 81
MARKET REVENUE 81
TABLE 31 GLOBAL INSULIN PEN MARKET BY TYPE, THROUGH 2018 ($ MILLIONS) 81
FIGURE 13 GLOBAL INSULIN PEN MARKET BY TYPE, THROUGH 2018 ($ MILLIONS) 81
MARKET SHARE 82
TABLE 32 INSULIN PEN MARKET SHARES BY TYPE, 2012 (%) 82
FIGURE 14 INSULIN PEN MARKET SHARES BY TYPE, 2012 (%) 82
MARKET BY REGION 83
MARKET OVERVIEW 83
MARKET REVENUE 84
TABLE 33 GLOBAL INSULIN PEN MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 84
FIGURE 15 GLOBAL INSULIN PEN MARKET BY REGION, 2011-2018 ($ MILLIONS) 85
DURABLE OR REUSABLE INSULIN PENS 85
Market Overview 85
Market Revenue 86
TABLE 34 GLOBAL DURABLE OR REUSABLE INSULIN PEN MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 86
FIGURE 16 GLOBAL DURABLE OR REUSABLE INSULIN PEN MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 86
DISPOSABLE INSULIN PENS 87
Market Overview 87
Market Revenue 88
TABLE 35 GLOBAL DISPOSABLE INSULIN PEN MARKET BY REGION, THROUGH 2018
($ MILLIONS) 88
FIGURE 17 GLOBAL DISPOSABLE INSULIN PEN MARKET BY REGION, THROUGH
2018 ($ MILLIONS) 89
MARKET SHARE 89
TABLE 36 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 89
FIGURE 18 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 89
MARKET BY APPLICATIONS 90
TYPE 1 DIABETES 90
TYPE 2 DIABETES 91
GESTATIONAL DIABETES 91
MARKET OVERVIEW 91
MARKET REVENUE 92
TABLE 37 INSULIN PEN MARKET BY APPLICATION, THROUGH 2018 ($ MILLIONS) 92
FIGURE 19 INSULIN PEN MARKET BY APPLICATION, THROUGH 2018 ($ MILLIONS) 92
MARKET SHARE 93
TABLE 38 INSULIN PEN MARKET SHARES BY APPLICATION, 2012 (%) 93
FIGURE 20 INSULIN PEN MARKET SHARES BY APPLICATION, 2012 (%) 93
INDUSTRY STRUCTURE 93
MARKET LEADERS 94
TABLE 39 LEADING INSULIN PEN MANUFACTURERS AND SUPPLIERS 94
MARKET SHARES 95
TABLE 40 INSULIN PEN MANUFACTURER MARKET SHARES, 2012 (%) 95
FIGURE 21 INSULIN PEN MANUFACTURER MARKET SHARES, 2012 (%) 96

CHAPTER 8 PATENT ANALYSIS 98

PATENTS BY YEAR 98
TABLE 41 U.S. PATENTS, JANUARY 2009-MARCH 2013 (%) 98
FIGURE 22 U.S. PATENTS, JANUARY 2009-MARCH 2013 (%) 98
PATENTS BY TYPE 99
TABLE 42 U.S. INSULIN PATENTS BY TYPE, JANUARY 2009-MARCH 2013 99
FIGURE 23 U.S. INSULIN PATENTS BY TYPE, JANUARY 2009-MARCH 2013 99
PATENTS BY COMPANY 100
TABLE 43 U.S. PATENTS BY COMPANY, JANUARY 2009-MARCH 2013 100
PATENTS BY COUNTRY 102
TABLE 44 U.S. PATENTS BY COUNTRY, JANUARY 2009-MARCH 2013 102
FIGURE 24 U.S. PATENTS BY COUNTRY, JANUARY 2009-MARCH 2013 103
PATENTS BY ASSIGNEE 103
TABLE 45 U.S. PATENTS BY ASSIGNEE, JANUARY 2009-MARCH 2013 103
FIGURE 25 U.S. PATENTS BY ASSIGNEE, JANUARY 2009-MARCH 2013 103

CHAPTER 9 CURRENT SITUATION 106

MARKET TRENDS 107
INSULIN PUMPS 107
Artificial Pancreas 107
Closed-Loop Insulin Pump 107
INSULIN PENS 108
INSULIN SYRINGES 108
MODERN INSULIN AND ALTERNATIVE DELIVERY METHODS 108
ORAL INSULIN 108
NASAL INSULIN SPRAY 109
BIOSIMILAR INSULIN 109
OVERALL MARKET DRIVERS FOR INSULIN DELIVERY DEVICE MARKET 109
FACTORS GOVERNING THE INSULIN DELIVERY DEVICE MARKET 110
COLLABORATIONS, MERGERS AND AQUISITIONS 110

CHAPTER 10 COMPANY PROFILES 114

ADOCIA 114
ANIMAS CORPORATION 114
ANTRIABIO 115
BECTON, DICKINSON AND COMPANY 116
BIOCON LIMITED 116
BIODEL INC. 117
DEBIOTECH 118
ELI LILLY 118
ETERNITY HEALTHCARE 119
F. HOFFMANN-LA ROCHE LTD. (DISETRONIC MEDICAL SYSTEMS AG) 120
GENEREX BIOTECHNOLOGY CORPORATION 120
HALOZYME THERAPEUTICS INC. 121
INSULINE MEDICAL 121
INSULUTION ABM 122
LIFESCAN 122
MANNKIND 123



MARINA BIOTECH INC. 124
MEDTRONIC INC. 125
MICROPORT SCIENTIFIC CORPORATION 125
MIDASOL THERAPEUTICS (JOINT VENTURE OF MIDATECH LTD. AND MONOSOL
RX) 126
NOVO NORDISK 126
ORAMED PHARMACEUTICALS INC. 127
PHOSPHAGENICS LIMITED 128
SANOFI 128
SENSILE MEDICAL AG 129
THERMALIN DIABETES INC. 130
XERIS PHARMACEUTICALS 131
YPSOMED HOLDING AG 131



LIST OF TABLES

SUMMARY TABLE GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET,
THROUGH 2018 ($ MILLIONS) 7
TABLE 1 DISTINGUISHING FEATURES OF TYPE 1 AND TYPE 2 DIABETES 11
TABLE 2 ESTIMATED DIABETES CASES IN 2030 AND POPULATION CHANGES WITH
RESPECT TO 2000 13
TABLE 3 HISTORY OF INSULIN ISOLATION AND DEVELOPMENT 15
TABLE 4 CHARACTERISTIC PROPERTIES OF VARIOUS INSULIN FORMULATIONS 19
TABLE 5 ADVANTAGES AND DISADVANTAGES OF SYRINGES 21
TABLE 6 INSULIN PUMPS CURRENTLY ON THE MARKET 22
TABLE 7 COMPARATIVE DEPICTION OF RISK VERSUS BENEFIT FEATURES FOR
VARIOUS INSULIN DELIVERY SYSTEMS 23
TABLE 8 INSULIN PENS CURRENTLY ON THE MARKET 25
TABLE 9 INSULIN ADMINISTRATION ROUTES 26
TABLE 10 INSULIN DRUG APPROVALS, 2009-MARCH 2013 29
TABLE 11 PREMARKET APPROVAL SUPPLEMENTAL APPROVALS FOR INSULIN
DEVICES, 2009-MARCH 2013 30
TABLE 12 PREMARKET NOTIFICATION OR 510 (K) CLEARANCES FOR INSULIN
DEVICES, 2009-MARCH 2013 33
TABLE 13 SAFETY ALERTS FOR INSULIN DRUGS AND DEVICES, 2009-APRIL 2013 34
TABLE 14 DRUG RECALLS FOR INSULIN DRUGS AND DEVICES, 2009-APRIL 2013 35
TABLE 15 NEW DEVELOPMENTS FOR INSULIN DRUGS AND DELIVERY DEVICES 43
TABLE 16 INSULIN DRUG AND DELIVERY DEVICE COMPANY MERGERS AND
ACQUISITIONS 46
TABLE 17 LICENSING, PARTNERSHIPS, AND AGREEMENTS FOR INSULIN DRUGS AND
DELIVERY DEVICES 48
TABLE 18 INSULIN DRUG AND DELIVERY DEVICE PIPELINE PRODUCTS 51
TABLE 19 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY TYPE,
THROUGH 2018 ($ MILLIONS) 58
TABLE 20 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY TYPE, 2012 (%) 59
TABLE 21 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 62
TABLE 22 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARE BY REGION, 2012
(%) 63
TABLE 23 GLOBAL INSULIN SYRINGE AND VIAL MARKET BY REGION, THROUGH 2018
($ MILLIONS) 65
TABLE 24 INSULIN SYRINGE AND VIAL MARKET SHARES BY REGION, 2012 (%) 66
TABLE 25 GLOBAL INSULIN PEN MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 68
TABLE 26 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 69
TABLE 27 GLOBAL INSULIN PUMP MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 71
TABLE 28 INSULIN PUMP MARKET SHARES BY REGION, 2012 (%) 72
TABLE 29 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY APPLICATION,
THROUGH 2018 ($ MILLIONS) 76
TABLE 30 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY APPLICATION,
2012 (%) 77
TABLE 31 GLOBAL INSULIN PEN MARKET BY TYPE, THROUGH 2018 ($ MILLIONS) 81
TABLE 32 INSULIN PEN MARKET SHARES BY TYPE, 2012 (%) 82
TABLE 33 GLOBAL INSULIN PEN MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 84
TABLE 34 GLOBAL DURABLE OR REUSABLE INSULIN PEN MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 86
TABLE 35 GLOBAL DISPOSABLE INSULIN PEN MARKET BY REGION, THROUGH 2018
($ MILLIONS) 88
TABLE 36 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 89
TABLE 37 INSULIN PEN MARKET BY APPLICATION, THROUGH 2018 ($ MILLIONS) 92
TABLE 38 INSULIN PEN MARKET SHARES BY APPLICATION, 2012 (%) 93
TABLE 39 LEADING INSULIN PEN MANUFACTURERS AND SUPPLIERS 94
TABLE 40 INSULIN PEN MANUFACTURER MARKET SHARES, 2012 (%) 95
TABLE 41 U.S. PATENTS, JANUARY 2009-MARCH 2013 (%) 98
TABLE 42 U.S. INSULIN PATENTS BY TYPE, JANUARY 2009-MARCH 2013 99
TABLE 43 U.S. PATENTS BY COMPANY, JANUARY 2009-MARCH 2013 100
TABLE 44 U.S. PATENTS BY COUNTRY, JANUARY 2009-MARCH 2013 102
TABLE 45 U.S. PATENTS BY ASSIGNEE, JANUARY 2009-MARCH 2013 103



LIST OF FIGURES

SUMMARY FIGURE GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET,
2011-2018 ($ MILLIONS) 8
FIGURE 1 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY TYPE,
2011-2018 ($ MILLIONS) 59
FIGURE 2 INSULIN DRUG AND DEVICE MARKET SHARES BY TYPE, 2012 (%) 60
FIGURE 3 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY REGION,
2011-2018 ($ MILLIONS) 63
FIGURE 4 INSULIN DRUG AND DEVICE MARKET SHARE BY REGION, 2012 (%) 63
FIGURE 5 GLOBAL INSULIN SYRINGE AND VIAL MARKET BY REGION, 2011-2018 ($
MILLIONS) 65
FIGURE 6 INSULIN SYRINGE AND VIAL MARKET SHARES BY REGION, 2012 (%) 66
FIGURE 7 GLOBAL INSULIN PEN MARKET BY REGION, 2011-2018 ($ MILLIONS) 68
FIGURE 8 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 69
FIGURE 9 GLOBAL INSULIN PUMP MARKET BY REGION, THROUGH 2018 ($ MILLIONS) 72
FIGURE 10 INSULIN PUMP MARKET SHARES BY REGION, 2012 (%) 72
FIGURE 11 GLOBAL INSULIN DRUG AND DELIVERY DEVICE MARKET BY APPLICATION,
2011-2018 ($ MILLIONS) 76
FIGURE 12 INSULIN DRUG AND DELIVERY DEVICE MARKET SHARES BY APPLICATION,
2012 (%) 77
FIGURE 13 GLOBAL INSULIN PEN MARKET BY TYPE, THROUGH 2018 ($ MILLIONS) 81
FIGURE 14 INSULIN PEN MARKET SHARES BY TYPE, 2012 (%) 82
FIGURE 15 GLOBAL INSULIN PEN MARKET BY REGION, 2011-2018 ($ MILLIONS) 85
FIGURE 16 GLOBAL DURABLE OR REUSABLE INSULIN PEN MARKET BY REGION,
THROUGH 2018 ($ MILLIONS) 86
FIGURE 17 GLOBAL DISPOSABLE INSULIN PEN MARKET BY REGION, THROUGH 2018
($ MILLIONS) 89
FIGURE 18 INSULIN PEN MARKET SHARES BY REGION, 2012 (%) 89
FIGURE 19 INSULIN PEN MARKET BY APPLICATION, THROUGH 2018 ($ MILLIONS) 92
FIGURE 20 INSULIN PEN MARKET SHARES BY APPLICATION, 2012 (%) 93
FIGURE 21 INSULIN PEN MANUFACTURER MARKET SHARES, 2012 (%) 96
FIGURE 22 U.S. PATENTS, JANUARY 2009-MARCH 2013 (%) 98
FIGURE 23 U.S. INSULIN PATENTS BY TYPE, JANUARY 2009-MARCH 2013 99
FIGURE 24 U.S. PATENTS BY COUNTRY, JANUARY 2009-MARCH 2013 103
FIGURE 25 U.S. PATENTS BY ASSIGNEE, JANUARY 2009-MARCH 2013 103

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