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Opportunities in Advanced Wound Closure

  • September 2013
  • -
  • Espicom Business Intelligence
  • -
  • 74 pages

The global market for wound closure products was worth approximately US$6.3 billion in 2012 and rose by 4% compared with 2011 levels. The principal drivers of growth are the rising numbers of surgical procedures being performed globally and the increasing adoption of advanced biosurgery products such as surgical sealants and haemostats by clinicians. There is a geographical twist, with higher demand in emerging economies for lower-cost traditional wound closure products, while newer technologies are finding more favourable conditions in western markets, principally the US.

Despite these positives, the sector faces challenges. The weak global economy and health payer cost control policies have impacted healthcare spending. In such a market, healthcare providers are not always inclined to sanction advanced products over lower-cost treatments.


Advanced biosurgery products set to lead market growth

While traditional wound closure products will continue to dominate the market, it is the new sectors that will see the best growth. Wider adoption of surgical sealants and haemostat technologies outside of the US will see these new approaches maintain annual growth rates of up to 7% over the next 5 years. In 2012, new technologies accounted for 31.7% of the market and are forecast to rise to 36.8% by 2017. Of the older technologies, sutures will be most affected, falling from a market share of 48.8% in 2012 to 45% in 2017. These figures must been seen in the context of the whole wound closure market: from an annual growth of 3.1% in 2012 we forecast that growth will rise over 5 years to 4.5% in 2017.

Competitive Landscape

For some years, J&J’s Ethicon has been the market leader due its dominating position in the sutures market. However, the company is facing stiffer opposition in the biosurgery sector. For example, market-leading surgical sealants such as Baxter’s Coseal, CryoLife's BioGlue, Covidien's DuraSeal and CR Bard's NeoMend are competing with Ethicon's OMNEX. A number of new companies have entered the field attracted by the wound closure sector’s positive market attributes and growth potential.


Covering all major wound closure technologies

• Sutures
• Staples and Clips
• Topical Skin Adhesives
• Fibrin Sealants and Thrombin Products
• Internal Surgical Sealants
• Surgical Haemostats and Haemostatic Bandages


Use this report to...

• Understand the opportunities and challenges which are shaping the wound closure market’s operations
• Know the growth potential and market share over the next 5 years for sutures, staples, adhesives, haemostats and surgical sealants
• Assess the competitive landscape and evaluate the strengths and weaknesses of companies
• Know which Pharma companies have entered into the field and in what product areas


Extensive content and coverage of the issues, technologies, companies and trends which are driving this valuable medical device sector


EXECUTIVE SUMMARY
• Current Methods of Wound Closure
• Sutures
• Staples and Clips
• Topical Tissue Adhesives
• Internal Surgical Sealants
• Surgical Haemostats
• Summary: Methods of Wound Closure
• Haemostatic Dressings and Bandages

COMPETITIVE LANDSCAPE
• Recent Mergers and Acquisitions in the Wound Closure Market
• Entrants from the Pharmaceutical Industry
• Other Market Entrants
• Industry Consolidation and Collaboration
• Key Wound Closure Mergers and Acquisitions, 2011-2013 CURRENT MARKET DYNAMICS
• Product Segments
• Global Wound Closure Market by Product Type, 2008-2012
(US$ million)
• Growth in the Global Wound Closure Market by Product Type, 2009-2012 (%)
• Regulatory Environment
• Summary: US & EU Wound Closure Regulatory Environment
• European Medicines Agency Review of Fibrin Sealants
• Regional Perspective
• Summary: Market Drivers, Restraints and Opportunities

MARKET FORECASTS
• Global Wound Closure Market by Product Type, 2012-2017E
(US$ million)
• Wound Closure Market Growth by Product Type, 2012-2017E (%)

NEW WOUND CLOSURE PRODUCTS & TECHNOLOGIES
For each of the new sectors covered, the report examines the technology performance and competitive environment, drilling down into the detail of launches, events and performance at the product level. The sectors covered are:
• Surgical Sealants
• Fibrin Sealants
• Haemostatic Agents
• Haemostatic Bandages, Dressings and Devices
• Other Wound Closure Devices

COMPANY DIRECTORY
Contact information, areas of focus, product summary and financial status for over 50 companies active in the wound closure market.

Table Of Contents

Opportunities in Advanced Wound Closure
Table of Contents

MARKET OVERVIEW 1
EXECUTIVE SUMMARY 1
INTRODUCTION 2
Current Methods of Wound Closure 2
Sutures 2
Staples and Clips 3
Topical Tissue Adhesives 3
Internal Surgical Sealants 3
Surgical Haemostats 4
Haemostatic Dressings and Bandages 5
COMPETITIVE LANDSCAPE 6
Recent Mergers and Acquisitions in the Wound Closure Market 7
Entrants from the Pharmaceutical Industry 7
Other Market Entrants 8
Industry Consolidation and Collaboration 8
CURRENT MARKET DYNAMICS 10
Product Segments 10
Regulatory Environment 12
European Medicines Agency Review of Fibrin Sealants 12
Regional Perspective 13
NEW WOUND CLOSURE PRODUCTS and TECHNOLOGIES 15
SURGICAL SEALANTS 15
The Surgical Sealant Market 15
Competitive Environment 17
Key Synthetic Surgical Sealants 18
Baxter/Angiotech Pharmaceuticals' Coseal 18
C R Bard's (Neomend) Progel Pleural Air Leak Sealant 18
CryoLife's BioGlue Surgical Adhesive and BioFoam Surgical Matrix 19
Sales Performance 19
BioGlue Surgical Adhesive 21
BioFoam Surgical Matrix 22
Ethicon's OMNEX 23
New Products and Technologies 23
Cohera Medical TissuGlu Surgical Adhesive 23
Tenaxis Medical's ArterX Surgical Sealant 23
Tissuemed's TissuePatch 24
TissuePatch Clinical Study Results 24
Products in Development 25
Cohera Medical's Sylys Surgical Sealant 25
Dural Sealants 25
Covidien's DuraSeal 25
HyperBranch Medical Technology's Adherus AutoSpray Dural Sealant 26
Tissuemed's TissuePatchDural 26
TissuePatchDural Clinical Study Results 26
Dural Sealants in Development 27
Kuros Biosurgery's KUR-023 Synthetic Dural Sealant 27
FIBRIN SEALANTS 29
Availability and the Regulatory Environment 29
European Medicines Agency Review 29
Available Products 30
Baxter's TISSEEL 31
Baxter's ARTISS 31
CSL Behring's Beriplast P Combi Set 31
Ethicon's EVICEL 32
Ethicon's EVARREST Fibrin Sealant Patch 32
Ethicon's BIOSEAL 33
Takeda Pharmaceuticals' TachoSil 33
HAEMOSTATIC AGENTS 34
Market Dynamics 34
Competitive Environment 36
Active Haemostats 37
Thrombin Products 37
Ethicon's EVITHROM 38
Pfizer's Thrombin-JMI 38
The Medicines Company/Bristol-Myers Squibb's Recothrom 38
Leading Flowable Haemostats 39
Baxter's Floseal Matrix 39
Baxter's Gelfoam Plus 40
Ethicon's Surgiflo Hemostatic Matrix with FlexTip 40
Stryker/Angiotech Pharmaceutcals' Vitagel Surgical Hemostat 40
Leading Mechanical Haemostats 41
Collagen Haemostats 41
CR Bard's Avitene 41
Ethicon's Instat MCH Microfibrillar Collagen Hemostat 41
Integra LifeSciences' Helistat and Helitene 41
Gelatine-Based Haemostats 42
Pfizer's Gelfoam 42
Ethicon's Surgifoam 42
Polysaccharide and Plant-Based Haemostats 42
BioCer Entwicklungs-GmbH's HaemoCer 42
CryoLife/Starch Medical's PerClot 43
Ethicon's SURGICEL 44
Lifescience PLUS' BloodSTOP 45
Medafor's Microporous Polysaccharide Hemospheres 45
Other Non-Animal or Human-Derived Haemostats 47
Biolife's StatSeal Range 47
Z-Medica's QuikClot Hemostatic Dressings 47
Products in Development 48
Arch Therapeutics' AC5 Hemostatic Agent 48
Nano Labs' Haemostatic Mesh 48
ProFibrix' Fibrocaps 48
HAEMOSTATIC BANDAGES, DRESSINGS AND DEVICES 50
Currently-Available Products and Technologies 50
Mineral-Based Dressings 51
Z-Medica's QuikClot Hemostatic Dressings 51
Chitosan Dressings 51
HemCon Medical Technologies' Products 52
Medtrade Products' Celox Products 52
Acetylated Glucosamine Dressings 53
Marine Polymer Technologies' Products 53
New Haemostatic Devices 53
iTraumaCare's iTClamp Hemorrhage Control System 53
Products in Development 53
Arsenal Medical's Arsenal Foam System 53
STB Lifesaving Technologies' FAST Dressing 54
Remedium Technologies' Hemogrip 55
TOPICAL TISSUE ADHESIVES 56
Market Size and Trends 57
New and Key Products 58
Advanced Medical Solutions' Topical Skin Adhesives 58
B Braun's Histoacryl 59
BSN Medical's Leukosan Adhesive 59
Cardinal Health's SecureSeal Octyl Topical Skin Adhesive's 59
Henkel/Covidien's Indermil Tissue Adhesive 59
Ethicon's Dermabond Range 60
GluStitch's PeriAcryl 90 60
Meyer-Haake's EPIGLU 61
WOUND CLOSURE DEVICES 62
New Products 62
Ethicon/Angiotech Pharmaceuticals' Quill Knotless Tissue-Closure Device 62
Ethicon Transaction 62
Covidien's V-Loc 62
Covidien's Endo Stitch 63
Incisive Surgical's INSORB Absorbable Skin Stapling Technology 64
Products in Development 64
IonMed's BioWeld1 64
Mantra Medical's Wound Closure Device 65
MANUFACTURERS 66
COMPANY DIRECTORY 66
APPENDICES 73
APPENDIX 1 - LIST OF ABBREVIATIONS 73
APPENDIX 2 - REPORT METHODOLOGY 74



List of tabLes

Summary: Methods of Wound Closure 4
Key Wound Closure Mergers and Acquisitions, 2011-2013 9
Global Wound Closure Market by Product Type, 2008-2012 (US$ million) 11
Growth in the Global Wound Closure Market by Product Type, 2009-2012 (%) 11
Summary: US and EU Wound Closure Regulatory Environment 12
Summary: Market Drivers, Restraints and Opportunities 14
Synthetic Surgical Sealants Currently on the Market 18
CryoLife's Surgical Sealant Sales by Region, 2011-2012 (US$ thousands) 20
Fibrin Sealants Currently on the Market 30
Haemostatic Agents Currently on the Market 36
Products Currently on the Market 51
Topical Tissue Adhesives: Benefits and Disadvantages 56



List of Charts

Fig.1: Wound Closure Market Shares by Competitor, 2012 6
Fig.2: Sutures Market Shares by Competitor, 2012 6
Fig.3: Wound Closure Market by Product Type, 2012 11
Fig.4: Wound Closure Market by Geographic Region, 2012 13
Fig.6: Surgical Sealants Market, 2008-2017E (US$ million) 16
Fig.7: Surgical Sealants Market Growth, 2009-2017E (%) 16
Fig.8: Surgical Sealants Market by Geographic Region, 2012 17
Fig.9: CryoLife's Surgical Sealant Sales, 2008-2012 (US$ thousands) 20
Fig.10: CryoLife's Surgical Sealant Sales by Product, 2012 21
Fig.11: CryoLife's Surgical Sealant Sales by Geographic Region, 2012 21
Fig.12: Haemostatic Agents Market, 2008-2017E (US$ million) 35
Fig.13: Haemostatic Agents Market Growth, 2009-2017E (%) 35
Fig.14: Haemostatic Agents Market by Geographic Region, 2012 36
Fig.15: CryoLife's PerClot Revenue, 2010-2012 (US$ thousands) 44
Fig.16: Topical Tissue Adhesive Market, 2008-2017E (US$ millions) 57
Fig.17: Topical Tissue Adhesive Market, 2009-2017E (%) 58
Fig.18: Topical Tissue Adhesive Market by Geographic Region, 2012 58

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