1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends

Vital Signs - The Global Market for Type 2 Diabetes Therapeutics

  • September 2013
  • 8 pages
  • Frost & Sullivan
Report ID: 1650896

Summary

Table of Contents

This issue of Vital Signs, released on September 30, 2013, provides a market overview and drug pipeline analysis of Type 2 diabetes therapeutics. Additionally, a company spotlight is provided for Trovagene in San Diego, CA. The company has a proprietary transrenal nucleic acid platform with the potential to deliver superior molecular diagnostics in urine.

Introduction

Type 2 diabetes is one of the most significant global health concerns of modern times. According to the International Diabetes Federation, more than 317 million people have been diagnosed with diabetes and an additional 187 million are living with undiagnosed diabetes. Type 2 diabetes is no longer a disease exclusive to developed countries; it is rapidly overwhelming developing countries such as China and India as more and more countries adopt the westernized lifestyle that contributes to disease prevalence. The global revenue earned from sales of drugs to treat type 2 diabetes was approximately $36.89 billion in 2012. The rapidly growing incidence and prevalence globally will help drive this figure to approximately $68.42 billion by 2017. The market for type 2 diabetes therapeutics in China is growing rapidly and is expected to outpace Europe to become the second-largest market by 2017. South Korea and Vietnam are also forecast to experience rapid growth.

The market for diabetes drugs has many barriers to entry, particularly for the insulin segment, which requires a great deal of specialization. Due to the chronic nature of the disease and the numerous co-morbidities that make this patient population particularly sensitive to long-term drug safety, the clinical and regulatory hurdles are considerable and the inherent risks involved, such as failure to receive marketing approval after a relatively large investment of time and money, limit this market to those organizations with the necessary expertise and capital. Despite the risk, the immense potential market has stimulated a vast and growing pipeline of new therapies aimed at more precise glucose control, improved safety profiles, and greater convenience to patients. This article will summarize some of the key findings from a recent analysis of the type 2 diabetes therapeutics market, which examines, in detail, the insulin and non-insulin segments of this market on a global level.

Non-insulin Therapeutics Segment

Non-insulin anti-diabetic drugs are mostly oral therapies and are typically prescribed as first-line therapy when diet and exercise alone are insufficient to control elevated blood glucose. Non-insulin therapeutics can be sub-segmented into Standard of Care (SOC) therapies and add-on to SOC. The main drug classes prescribed as SOC are all available as low-cost generics and are comprised of biguanides (metformin), sulfonylureas (glipizide, glyburide, gliclazide, glimepiride), and alpha glucosidase inhibitors (acarbose, voglibose, miglitol). In the United States and most of the world, metformin is the gold standard for first-line therapy. Add-on therapies, which are comprised of newer novel drug classes, are typically prescribed in combination with SOC when those treatments eventually fail to control elevated blood glucose on their own. Add-on therapies can also generally be prescribed as first-line or monotherapy when SOC therapies are contraindicated or not well tolerated.

The main drug classes used as add-on therapies are metiglinides, glitazones, incretin-based therapies comprised of glucagon-like peptide-1 (GLP-1) analogues or receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and the newest class, sodium-glucose co-transporter 2 (SGLT2) inhibitors. The metiglinides, of which there are two marketed drugs, Novartis’ Starlix (nateglinide) and Novo Nordisk’s Prandin (repaglinide), are post-meal glucose-lowering therapies and are a relatively minor portion of the market. Santarus’ new diabetes product Cycloset (bromocriptine) launched in 2010 is a novel first-in-class oral antidiabetic (OAD) based on the circadian rhythm of dopamine activity. Cycloset also has a minor share of the market, but is gaining ground as physicians become more familiar with its unique mechanism. The glitazones (also known as thiazoladinediones (TZDs) or PPAR gamma agonists), represented by Takeda’s Actos (pioglitazone) and GlaxoSmithKline’s Avandia (rosiglitazone), were former blockbusters until the recent emergence of serious safety issues and have since seen significant declines in sales, thereby restraining overall revenue growth for the segment. However, the segment was soon revived, stimulated by strong uptake of Novo Nordisk’s Victoza (liraglutide, a GLP-1 analogue) and the continued strong sales of Januvia along with the introduction of additional members of the DPP-4 class and the initial launches of a new class, the SGLT2 inhibitors. In 2012, the majority of global revenue generated for the non-insulin therapeutics segment was from sales of Januvia as well as metformin, the most widely prescribed diabetes therapeutic worldwide.

The recent implication of the incretin-based therapies such as Januvia and Victoza in increased risk of pancreatic cancer has drawn considerable media attention, but is not expected to have a significant impact on the market overall in light of the lack of compelling data in support of the theory. The European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA) each initiated an investigation of the matter in March 2013 and both agencies have recently announced in July 2013 that they have found no confirmed link between incretin therapies and increased risk for pancreatic cancer. This is good news for the manufacturers of the numerous GLP-1 therapies coming to market. While this class has been long dominated by Byetta (exenatide) and Victoza (liraglutide), several rivals are beginning to arrive to the market, the most advanced being Sanofi’s Lyxumia (lixisenatide), currently under review by the FDA with a decision expected in December 2013 or early 2014. Lyxumia, developed by Zealand Pharma and commercialized by Sanofi, is already approved in Mexico, Australia, Europe, and most recently Japan. GlaxoSmithKline is also awaiting FDA approval for its once-weekly GLP-1 albiglutide, with a decision expected in April 2014. Most anticipated, however, is Eli Lilly’s dulaglutide, a once-weekly GLP-1 with strong positive data that is poised to be a formidable competitor to all of the GLP-1s, including Victoza. Dulaglutide could launch as early as late 2014 or 2015.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 60 Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

Veronica helps you find the right report:

Testimonials

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at
Ikea

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at
Ingredion

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

Purchase Reports From Reputable Market Research Publishers

Global Needle-Free Diabetes Management Market Size, Share, Development, Growth and Demand Forecast to 2025 - Industry Insights by Device Type

  • $ 5100
  • Industry report
  • February 2017
  • by P&S Market Research

Market Overview Needle-free diabetes management refers to treatment, diagnosis and monitoring of diabetic patients without using needles. Needle-free diabetes management devices are used for injecting ...

Future of Diabetes Care Paradigms, Forecast to 2022

  • $ 4950
  • Industry report
  • March 2017
  • by Frost & Sullivan

Innovations to Disrupt Diabetes Wellness, Diagnosis, Monitoring, and Therapy Diabetes management is on the verge of being disrupted by innovative technologies such as artificial pancreas, non-invasive ...

Opportunity in the Indian Anti-Diabetic Pharmaceuticals Market - 2017

  • $ 4500
  • Industry report
  • March 2017
  • by Feedback Business Consulting

This report provides insight into the current market scenario, structure and practices. In depth market scenario includes: - Current market size estimate - Revenues by players - Top 5 Companies - Market ...


ref:plp2013

Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.