The human immune system can go awry, either attacking an individual body or producing an exaggerated response to a foreign substance that is normally benign. In these situations, immunotherapies are needed to balance or suppress the unwarranted immune response. In this report:

  • Approximately 400 product candidates and development programs are identified.
  • Current and emerging therapies for selected autoimmune or inflammatory disorders and prevention of organ transplant rejection, directed against a wide range of putative targets, are summarized.
  • Specifically, more than 250 emerging autoimmune disease therapies, 80 asthma therapies in development, and 50+ therapy candidates for allergies are covered.
  • The strategic consequences of intense competition in a crowded product space are considered.
Inflammatory Disorders: Therapies That Suppress or Balance the Immune Response reviews the problems of insuf-ficient efficacy, side effects, and adverse events associated with the small-molecule and biological drugs available today to treat these disorders. These observations have led to an interest in identifying ways to balance the immune reaction, to suppress the part of the immune response that is causing the disease, while maintaining or enhancing other aspects of the immune system. This report identifies nearly 400 ongoing product candidates and development programs in these indication areas. The companies active in these areas range from multinational pharmaceutical companies with a number of active programs to small boutique start-ups working on a very defined topic.

 
 

Table Of Contents

CHAPTER 1: INTRODUCTION

1.1. The Immune System
1.2. Scope of the Report

CHAPTER 2: REVIEW OF MAJOR DISEASES/ CONDITIONS TARGETED BY NEW AND/OR EMERGING IMMUNOTHERAPIES AND VACCINES TO SUPPRESS OR BALANCE THE IMMUNE SYSTEM

2.1. Major Autoimmune Diseases
Rheumatoid Arthritis
Type 1 Diabetes Mellitus
Inflammatory Bowel Disease—Crohn’s Disease and Ulcerative Colitis
Multiple Sclerosis
Psoriasis
Psoriatic Arthritis
Systemic Lupus Erythematosus
2.2. Asthma
2.3. Allergies
2.4. Immune Suppression to Prevent
Rejection of Organ Transplants

CHAPTER 3: CURRENT PHARMACOLOGICAL TREATMENT OPTIONS

3.1. Major Autoimmune Diseases
Rheumatoid Arthritis
Nonsteroidal Anti-inflammatory Drugs
(NSAIDs)
Disease-Modifying Antirheumatic
Drugs (DMARDs)
Corticosteroids
Biological Response Modifiers
Type 1 Diabetes Mellitus
Inflammatory Bowel Disease—Crohn’s Disease and Ulcerative Colitis
Multiple Sclerosis
Interferon-beta
Copaxone (glatiramer acetate)
Novantrone (mitoxantrone)
Tysabri (natalizumab)
Psoriasis
Psoriatic Arthritis
Systemic Lupus Erythematosus
3.2. Asthma
3.3. Allergies
3.4. Immune Suppression to Prevent Rejection of Organ Transplants

CHAPTER 4: CURRENT AND EMERGING APPROACHES TO SUPPRESS OR BALANCE THE IMMUNE SYSTEM FOR PREVENTION AND TREATMENT OF DISEASE

CHAPTER 5: EMERGING THERAPIES IN DEVELOPMENT FOR TREATMENT OF MAJOR AUTOIMMUNE DISEASES

5.1. Introduction
5.2. Abbott Laboratories
5.3. Biogen Idec
5.4. AstraZeneca
5.5. Bristol-Myers Squibb
5.6. Centocor Ortho Biotech
5.7. Centocor Ortho Biotech and Schering-Plough
5.8. Diamyd Medical
5.9. Eli Lilly and BioMS Medical
5.10. Eli Lilly and MacroGenics
5.11. Genzyme and Bayer
5.12. GlaxoSmithKline and Genmab
5.13. GlaxoSmithKline and Human Genome Sciences
5.14. GlaxoSmithKline and Tolerx
5.15. GlaxoSmithKline (Selected Additional Product Candidates and Research)
5.16. Isotechnika
5.17. Merck Serono and ZymoGenetics
5.18. Merck Serono
5.19. Novartis
Multiple Sclerosis
Rheumatoid Arthritis
Psoriasis
5.20. Pfizer
5.21. Roche and Chugai Pharmaceutical
5.22. Roche and Genentech (A Wholly-Owned Member of the Roche Group)
5.23. Sanofi-Aventis
5.24. Takeda Pharmaceutical and Millennium Pharmaceuticals
5.25. Teva Pharmaceutical Industries and Active Biotech
5.26. UCB

CHAPTER 6: EMERGING THERAPIES FOR TREATMENT OF ASTHMA

6.1. Pipeline Overview
6.2. Abbott Laboratories and SkyePharma (Also Mundipharma and Kyorin)
6.3. Aerovance
6.4. Amgen
6.5. AstraZeneca
6.6. Ception Therapeutics
6.7. Genentech
6.8. GlaxoSmithKline
6.9. Icagen
6.10. MediciNova
6.11. Pfizer
6.12. Schering-Plough and Novartis
6.13. Topigen Pharmaceuticals
6.14. Wyeth

CHAPTER 7: SELECTED EXAMPLES OF EMERGING THERAPIES FOR TREATMENT OF ALLERGIES

7.1. Introduction
7.2. ALK-Abello and Schering-Plough
7.3. Allergy Therapeutics
7.4. Ception Therapeutics
7.5. Cytos Biotechnology
7.6. Greer Laboratories
7.7. Stallergenes

CHAPTER 8: IMMUNOTHERAPIES IN DEVELOPMENT FOR PREVENTING REJECTION OF ORGAN TRANSPLANTS

8.1. Introduction
8.2. APT Pharmaceuticals
8.3. Astellas Pharma
8.4. Bristol-Myers Squibb
8.5. Isotechnika
8.6. Novartis
8.7. Pfizer

CHAPTER 9: BUSINESS CONSIDERATIONS —THERAPIES THAT SUPPRESS OR BALANCE THE IMMUNE SYSTEM

9.1. Current Market and Market Potential
9.2. Competition
9.3. Strong Interest on the Part of Major Pharmaceutical Companies
9.4. Agreements and Mergers/Acquisitions
9.5. Other Major Challenges and Hurdles Being Faced by Companies
Competition
Potential Need for Personalized Medicine in at Least Certain Situations
Targeted Patient Populations

CHAPTER 10: THOUGHT LEADER INTERVIEWS

10.1. David W. Pritchard, President and Chief Executive Officer, KaloBios
10.2. Randall C. Schatzman, PhD, President and Chief Executive Officer, Alder Biopharmaceuticals
10.3. Louis Vaickus, MD, Chief Medical Officer, Tolerx
10.4. Eric H. Zanelli, PhD, Vice President, Research, Peptimmune

REFERENCES

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Allergy Therapeutics PLC

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