Global Apheresis Equipment Industry

  • August 2013
  • -
  • Global Industry Analysts
  • -
  • 170 pages

This report analyzes the worldwide markets for Apheresis Equipment in US$ Million by the following type of Apheresis and Procedure: Equipment by Type of Apheresis (Equipment for Therapeutic Apheresis, and Equipment for Donor Apheresis) and Equipment by Type of Apheresis Procedure (Plasmapheresis, Erythrocytapheresis, Plateletpheresis, and Others).

The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2010 through 2018. Also, a six-year historic analysis is provided for these markets.

The report profiles 16 companies including many key and niche players such as Asahi Kasei Medical Co., Ltd., B Braun Melsungen AG, Cerus Corporation, Fenwal, Inc., Fresenius Medical Care North America, Haemonetics Corp., HemaCare Corp., Kaneka Corporation, Kawasumi Laboratories, Inc., Medica SpA, NIKKISO Europe GmbH, Terumo BCT, and Therakos, Inc.

Market data and analytics are derived from primary and secondary research.

Company profiles are primarily based on public domain information including company URLs.

Table Of Contents




I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation and Reporting Level I-2
Quantitative Techniques and Analytics I-2
Product Definitions and Scope of Study I-3


II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Apheresis Market: A Prelude II-1
Growth Drivers in a Nutshell II-2
Table 1: World Market for Apheresis Systems (2012):
Percentage Breakdown of Value Sales by Leading Players
(includes corresponding Graph/Chart) II-2
Donor Apheresis: The Largest Segment II-2
Therapeutic Apheresis to Witness Strong Growth II-3
Key Market Trends and Drivers II-3
Developing Nations to Lead the Charge in Future II-3
Developed Markets: Traditional Revenue Generators II-3
Rising Cancer Incidence to Drive Volume of Apheresis Procedures II-3
Table 2: Number of New Cancer Cases Worldwide by Affected
Site: 2012 (in Thousands) (includes corresponding
Graph/Chart) II-4

Table 3: Global Cancer Incidence by Income Group: 2012 (in
Thousands) (includes corresponding Graph/Chart) II-5
Photopheresis: A Popular Therapeutic Apheresis Procedure II-5
Plasmapheresis Continues to Lead the Apheresis Market II-6
Table 4: Plasma Collection Methods: Percentage Breakdown by
Fractionation and Extraction from Whole Blood (2013 Vs.
2010) (includes corresponding Graph/Chart) II-6
Plateletpheresis Emerges as the ‘Treatment of Choice’ II-6
Increase in Number of Platelet Donors Drives Apheresis
Procedures II-7
Technological Advancements and Novel Indications Augur Well
for Apheresis Market II-7
Pediatrics: An Unexplored Domain in Therapeutic Apheresis II-8
Automated Blood Processing Systems in Open Heart Surgeries II-8
CFA - An Effective Way to Pull Up Cold Hemagglutinin Disease II-8
Key Challenges and Issues II-8
Lack of Awareness among Patients Restrains Market Growth II-8
Vendors’ Attitude Hampers Growth Prospects of Therapeutic
Apheresis II-9
Development of Inexpensive Apheresis Therapies II-9
Scarcity of Qualified Donors II-9
Challenges for Therapeutic Apheresis in the Unexplored
Pediatrics Segment II-9
Market Outlook II-10

2. TECHNOLOGY OVERVIEW II-11
Apheresis - The Definition II-11
Apheresis Vs Whole Blood Collection II-11
Comparison of Apheresis and Whole Blood Collection II-12
The Process of Apheresis - An Overview II-12
Blood Components II-12
Apheresis Procedure II-13
Duration, Frequency, and Efficiency of Apheresis II-13
Segregation of Blood Components II-13
Centrifugation II-13
Centrifugal Cell Separators II-14
Filtration II-14
Side Effects II-14
Types of Apheresis Procedures II-14
Plasmapheresis II-14
Plasma Exchange and Plasmapheresis: The Difference II-15
Therapeutic Plasma Exchange (TPE) or Plasma Exchange II-15
TPE: Abnormal Components Removed from Blood II-15
Plasmapheresis: Potential Uses Discovered in the Early Years II-16
Potential Use of Plasmapheresis in Select Diseases
Discovered in the Early Years II-16
Erythrocytapheresis II-16
Plateletpheresis II-16
Leukapheresis II-17
Photopheresis II-17
Functioning of THERAKOSâ„¢ - A Typical Photopheresis System II-17
Lipidpheresis II-17
Cytapheresis II-18
Stem Cell Collection II-18
Apheresis - A Review of Segmentation II-18
Donor Apheresis II-18
Process of Donor Apheresis II-18
Automated Blood Donation Procedures II-19
Safety of the Donor II-19
Blood Components Required by Different Patients II-19
Automated Apheresis II-20
Therapeutic Apheresis: An Introduction II-20
Therapeutic Apheresis Techniques II-21
Applications of Therapeutic Apheresis II-21
Categories of Indications for Therapeutic Apheresis II-24
Therapeutic Apheresis is Remedial for Various Diseases II-25
Indications for Therapeutic Apheresis II-25
Type of Therapeutic Apheresis Procedure Used in Different
Medication Conditions II-26
Emerging Applications of Therapeutic Apheresis II-27
Cost of Select Therapeutic Apheresis Procedures: An Overview II-27
1. Photopheresis in GVHD (Graft-Versus-Host Disease) II-27
2. Lipid Apheresis (LDL Apheresis) II-27
3. Plasmapheresis and Other Procedures II-28
Therapeutic Apheresis: What is the Risk Involved? II-28
Replacement Fluid in Therapeutic Apheresis II-29
Replacement Fluids Used in Therapeutic Apheresis II-29
Various Replacement Fluids in Use II-29
Select Replacement Fluids and their Limitations II-29
Table 5: Fluid Balance in Fluid Replacement II-30
Table 6: Volume Exchange of Plasma Constituents II-30
Table 7: Removal of IgM and IgG by Plasma Exchange Volume II-30
Table 8: Therapeutic Apheresis: Percentage Decrease and
Restoration of Blood Components II-30
Complications Involved and Suggested Treatment in the
Therapeutic Apheresis Procedure II-31
Therapeutic Plasmapheresis with Fresh Frozen Plasma (FFP)
Replacement II-31

3. BLOOD COMPONENTS and DERIVATIVES II-32
Red Blood Cells (RBCs) II-32
White Blood Cells (WBCs) II-32
Platelets II-32
Sources of Blood Plasma II-33
Facts About Plasma and its Donation II-33
Pre-requisites for Plasma Donors II-34
The Complex Process of Becoming a Donor II-34
Medical Screening II-35
The Process of Plasma Donation II-35
Select IQPP-authorized Plasma Collection Centers (US) II-35
Ionic Composition of Blood II-36
Types of Blood II-36
General Facts about Blood II-36
General Uses of Blood II-37
Blood - Global Facts II-37

4. PRODUCT AND TECHNOLOGICAL DEVELOPMENTS II-38
Terumo BCT Receives FDA Approval for Enhancement to MNC
Collection Protocol for Spectra Optia System II-38
Fenwal Unveils Auroraâ„¢ Plasmapheresis System II-38
Terumo BCT Introduces MNC Collection Protocol for Spectra
Optia System II-38
Terumo BCT Unveils New Therapeutic Apheresis Capabilities and
Procedures II-39
Terumo BCT Obtains FDA Approval for PF24 and PF24RT24 on
TrimaAccel System II-39
Fenwal Secures US FDA Approval for Therapeutic Plasma Exchange
Protocol on Amicus® Separator II-40
CaridianBCT Introduces MNC Collection Protocol for Spectra
Optia Apheresis System II-40
NxStage Medical Obtains FDA Approval for Therapeutic Plasma
Exchange Cartridge II-40
Health Canada Licenses CaridianBCT’s new Protocol for Spectra
Optia® Apheresis System II-40
CaridianBCT Releases Spectra Optia Apheresis System Version 5 II-41
CaridianBCT Introduces Trima Accel® Version 6 II-41
CaridianBCT Introduces RBCX Protocol in Canada II-41

5. RECENT INDUSTRY ACTIVITY II-42
The Gores Group Acquires Therakos from Ortho-Clinical Diagnostics II-42
Terumo BCT to Acquire Medservice II-42
Fresenius Kabi Acquires Fenwal Holdings II-42
CaridianBCT Collaborates with Terumo Transfusion to Form
Terumo BCT II-42
Fenwal’s Aurora Plasmapheresis System Obtains FDA Clearance II-43
Cerus to Enter into Partnership with BSI and American Red
Cross to Commercialize INTERCEPT Plasma II-43
Fenwal’s Amicus System Obtains CE Mark Certification for a
Therapeutic Plasma Exchange Protocol II-43
Terumo Corp. Completes Acquisition of CaridianBCT II-44
Fenwal Obtains FDA Approval for Collection of InterSol®
Preserved Platelets using Amicus® Cell Separator II-44
FDA Clears Fenwal’s Software for Autopheresis-C® System II-44
HemaCare Inks Commercial Cell Therapy Collection Agreement
with Dendreon II-45
HemaCare Inks Partnership Agreement with Dendreon II-45

6. FOCUS ON SELECT GLOBAL PLAYERS II-46
Asahi Kasei Medical Co., Ltd. (Japan) II-46
B Braun Melsungen AG (Germany) II-46
Cerus Corporation (US) II-46
Fenwal, Inc. (US) II-47
Fresenius Medical Care North America (FMCNA) (US) II-47
Haemonetics Corp. (US) II-48
HemaCare Corp. (US) II-48
Kaneka Corporation (Japan) II-49
Kawasumi Laboratories, Inc. (Japan) II-50
Medica SpA (Italy) II-50
NIKKISO Europe GmbH (Germany) II-50
Terumo BCT (US) II-50
Therakos, Inc. (US) II-51

7. GLOBAL MARKET PERSPECTIVE II-52
Table 9: World Recent Past, Current and Future Analysis for
Apheresis Equipment Market by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific (excluding Japan), and Rest of
World Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) II-52

Table 10: World Historic Review for Apheresis Equipment Market
by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Rest of World Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) II-53

Table 11: World 15-Year Perspective for Apheresis Equipment
Market by Geographic Region - Percentage Breakdown of Dollar
Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding
Japan), and Rest of World Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) II-54

Table 12: World Recent Past, Current and Future Analysis for
Equipment for Therapeutic Apheresis by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific (excluding Japan), and
Rest of World Markets Independently Analyzed with Annual Sales
in US$ Million for Years 2010 through 2018 (includes
corresponding Graph/Chart) II-55

Table 13: World Historic Review for Equipment for Therapeutic
Apheresis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Rest of World Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2004 through 2009 (includes corresponding Graph/Chart) II-56

Table 14: World 15-Year Perspective for Equipment for
Therapeutic Apheresis by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Rest of World Markets for
Years 2004, 2013 and 2018 (includes corresponding Graph/Chart) II-57

Table 15: World Recent Past, Current and Future Analysis for
Equipment for Donor Apheresis by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific (excluding Japan), and
Rest of World Markets Independently Analyzed with Annual Sales
in US$ Million for Years 2010 through 2018 (includes
corresponding Graph/Chart) II-58

Table 16: World Historic Review for Equipment for Donor
Apheresis by Geographic Region - US, Canada, Japan, Europe,
Asia-Pacific (excluding Japan), and Rest of World Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2004 through 2009 (includes corresponding Graph/Chart) II-59

Table 17: World 15-Year Perspective for Equipment for Donor
Apheresis by Geographic Region - Percentage Breakdown of
Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific
(excluding Japan), and Rest of World Markets for Years 2004,
2013 and 2018 (includes corresponding Graph/Chart) II-60

Table 18: World Recent Past, Current and Future Analysis for
Apheresis Equipment by Procedure Type - Erythrocytapheresis,
Plasmapheresis, Plateletpheresis, and Others Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) II-61

Table 19: World Historic Review for Apheresis Equipment by
Procedure Type - Erythrocytapheresis, Plasmapheresis,
Plateletpheresis, and Others Markets Independently Analyzed
with Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) II-62

Table 20: World 15-Year Perspective for Apheresis Equipment by
Procedure Type - Percentage Breakdown of Dollar Sales for
Erythrocytapheresis, Plasmapheresis, Plateletpheresis, and
Others Markets for Years 2004, 2013 and 2018 (includes
corresponding Graph/Chart) II-63


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Current and Future Analysis III-1
Apheresis Market - An Overview III-1
Market Trends at a Glance III-1
Opportunity Indicator: III-2
Table 21: US Market for Blood Collection by Type:
Percentage Breakdown by Blood Component for 2012 (includes
corresponding Graph/Chart) III-2
Blood Donations III-2
Criteria for Platelet Donation III-2
Criteria for Double Red Cell Donation III-3
Plasma Donations III-3
Table 22: Number of Plasma Donations Required Annually by
Disease Type in the US: 2012 (includes corresponding
Graph/Chart) III-4
Therapeutic Apheresis Registers Strong Growth III-4
Table 23: US Market for Therapeutic Apheresis (2013):
Percentage Breakdown of Revenues Generated Through
Procedures by Therapeutic Area (includes corresponding
Graph/Chart) III-4
An Overview of Regulatory Environment and Reimbursement
Scenario III-5
New Reimbursement Policies to Create Growth Opportunities
for Therapeutic Apheresis III-5
Medicaid Coverage for Therapeutic Apheresis by Various
Conditions III-6
Medicaid Coverage for Therapeutic Plasma Exchange III-6
Medicaid covers therapeutic Cytapheresis for the following
conditions: III-7
Medicaid covers Extracorporeal Photopheresis (ECP) for the
following conditions III-7
Table 24: APC Payment Rates for Different Therapeutic
Apheresis Procedures in 2012 and 2013 (In US$) III-7
Competitive Scenario III-7
Trima Accel, the Most Widely Used Platelet Collection
Equipment in the US III-8
Key Statistical Findings: III-9
Table 25: US Market for Therapeutic Apheresis in
Neurological Disorders (2012): Market Share Breakdown of
Revenues by Company (includes corresponding Graph/Chart) III-9

Table 26: US Market for Therapeutic Apheresis in
Neurological Disorders (2012): Market Share Breakdown of
Number of Procedures by Company (includes corresponding
Graph/Chart) III-9

Table 27: US Market for Therapeutic Apheresis in Hematology
and Oncology Disorders (2012): Market Share Breakdown of
Revenues by Company (includes corresponding Graph/Chart) III-9

Table 28: US Market for Therapeutic Apheresis in Hematology
and Oncology Disorders (2012): Market Share Breakdown of
Number of Procedures by Company (includes corresponding
Graph/Chart) III-10
Product Launches III-10
Strategic Corporate Developments III-14
Select Players III-18
B.Market Analytics III-22
Table 29: US Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-22

Table 30: US Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-23

Table 31: US 15-Year Perspective for Apheresis Equipment by
Segment - Percentage Breakdown of Dollar Sales for Equipment
for Therapeutic Apheresis and Equipment for Donor Apheresis
Markets for Years 2004, 2013 and 2018 (includes corresponding
Graph/Chart) III-24

2. CANADA III-25
A.Market Analysis III-25
Current and Future Analysis III-25
B.Market Analytics III-25
Table 32: Canadian Recent Past, Current and Future Analysis
for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-25

Table 33: Canadian Historic Review for Apheresis Equipment
by Segment - Equipment for Therapeutic Apheresis and
Equipment for Donor Apheresis Markets Independently Analyzed
with Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-26

Table 34: Canadian 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-27

3. JAPAN III-28
A.Market Analysis III-28
Current and Future Analysis III-28
Therapeutic Apheresis Market - An Overview III-28
Key Finding III-28
Table 35: Japanese Apheresis Market (2012): Market Share
Breakdown by Leading Players (includes corresponding
Graph/Chart) III-28
Growing Demand for Cancer Treatments Drives Plateletpheresis
Market III-28
Select Players III-29
B.Market Analytics III-30
Table 36: Japanese Recent Past, Current and Future Analysis
for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-30

Table 37: Japanese Historic Review for Apheresis Equipment
by Segment - Equipment for Therapeutic Apheresis and
Equipment for Donor Apheresis Markets Independently Analyzed
with Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-31

Table 38: Japanese 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-32

4. EUROPE III-33
A.Market Analysis III-33
Current and Future Analysis III-33
B.Market Analytics III-33
Table 39: European Recent Past, Current and Future Analysis
for Apheresis Equipment by Geographic Region - France,
Germany, Italy, UK, Spain, and Rest of Europe Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-33

Table 40: European Historic Review for Apheresis Equipment
by Geographic Region - France, Germany, Italy, UK, Spain,
and Rest of Europe Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-34

Table 41: European Recent Past, Current and Future Analysis
for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-35

Table 42: European Historic Review for Apheresis Equipment
by Segment - Equipment for Therapeutic Apheresis and
Equipment for Donor Apheresis Markets Independently Analyzed
with Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-36

Table 43: European 15-Year Perspective for Apheresis
Equipment by Geographic Region - Percentage Breakdown of
Dollar Sales for France, Germany, Italy, UK, Spain, and Rest
of Europe Markets for Years 2004, 2013 and 2018 (includes
corresponding Graph/Chart) III-37

Table 44: European 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-38

4a. FRANCE III-39
A.Market Analysis III-39
Current and Future Analysis III-39
B.Market Analytics III-39
Table 45: French Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-39

Table 46: French Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-40

Table 47: French 15-Year Perspective for Apheresis Equipment
by Segment - Percentage Breakdown of Dollar Sales for
Equipment for Therapeutic Apheresis and Equipment for Donor
Apheresis Markets for Years 2004, 2013 and 2018 (includes
corresponding Graph/Chart) III-41

4b. GERMANY III-42
A.Market Analysis III-42
Current and Future Analysis III-42
Select Players III-42
B.Market Analytics III-43
Table 48: German Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-43

Table 49: German Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-44

Table 50: German 15-Year Perspective for Apheresis Equipment
by Segment - Percentage Breakdown of Dollar Sales for
Equipment for Therapeutic Apheresis and Equipment for Donor
Apheresis Markets for Years 2004, 2013 and 2018 (includes
corresponding Graph/Chart) III-45

4c. ITALY III-46
A.Market Analysis III-46
Current and Future Analysis III-46
Medica SpA - A Select Player III-46
B.Market Analytics III-47
Table 51: Italian Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-47

Table 52: Italian Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-48

Table 53: Italian 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-49

4d. THE UNITED KINGDOM III-50
A.Market Analysis III-50
Current and Future Analysis III-50
B.Market Analytics III-50
Table 54: UK Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-50

Table 55: UK Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-51

Table 56: UK 15-Year Perspective for Apheresis Equipment by
Segment - Percentage Breakdown of Dollar Sales for Equipment
for Therapeutic Apheresis and Equipment for Donor Apheresis
Markets for Years 2004, 2013 and 2018 (includes corresponding
Graph/Chart) III-52

4e. SPAIN III-53
A.Market Analysis III-53
Current and Future Analysis III-53
B.Market Analytics III-53
Table 57: Spanish Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-53

Table 58: Spanish Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-54

Table 59: Spanish 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-55

4f. REST OF EUROPE III-56
A.Market Analysis III-56
Current and Future Analysis III-56
B.Market Analytics III-56
Table 60: Rest of Europe Recent Past, Current and Future
Analysis for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-56

Table 61: Rest of Europe Historic Review for Apheresis
Equipment by Segment - Equipment for Therapeutic Apheresis
and Equipment for Donor Apheresis Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) III-57

Table 62: Rest of Europe 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-58

5. ASIA-PACIFIC III-59
A.Market Analysis III-59
Current and Future Analysis III-59
B.Market Analytics III-59
Table 63: Asia-Pacific Recent Past, Current and Future
Analysis for Apheresis Equipment by Geographic Region -
Australia, China and Rest of Asia-Pacific Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-59

Table 64: Asia-Pacific Historic Review for Apheresis
Equipment by Geographic Region - Australia, China and Rest
of Asia-Pacific Markets Independently Analyzed with Annual
Sales in US$ Million for Years 2004 through 2009 (includes
corresponding Graph/Chart) III-60

Table 65: Asia-Pacific Recent Past, Current and Future
Analysis for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-61

Table 66: Asia-Pacific Historic Review for Apheresis
Equipment by Segment - Equipment for Therapeutic Apheresis
and Equipment for Donor Apheresis Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) III-62

Table 67: Asia-Pacific 15-Year Perspective for Apheresis
Equipment by Geographic Region - Percentage Breakdown of
Dollar Sales for Australia, China and Rest of Asia-Pacific
Markets for Years 2004, 2013 and 2018 (includes corresponding
Graph/Chart) III-63

Table 68: Asia-Pacific 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-64

5a. AUSTRALIA III-65
A.Market Analysis III-65
Current and Future Analysis III-65
B.Market Analytics III-65
Table 69: Australian Recent Past, Current and Future Analysis
for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-65

Table 70: Australian Historic Review for Apheresis Equipment
by Segment - Equipment for Therapeutic Apheresis and
Equipment for Donor Apheresis Markets Independently Analyzed
with Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-66

Table 71: Australian 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-67

5b. CHINA III-68
A.Market Analysis III-68
Current and Future Analysis III-68
B.Market Analytics III-68
Table 72: Chinese Recent Past, Current and Future Analysis for
Apheresis Equipment by Segment - Equipment for Therapeutic
Apheresis and Equipment for Donor Apheresis Markets
Independently Analyzed with Annual Sales in US$ Million for
Years 2010 through 2018 (includes corresponding Graph/Chart) III-68

Table 73: Chinese Historic Review for Apheresis Equipment by
Segment - Equipment for Therapeutic Apheresis and Equipment
for Donor Apheresis Markets Independently Analyzed with
Annual Sales in US$ Million for Years 2004 through 2009
(includes corresponding Graph/Chart) III-69

Table 74: Chinese 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-70

5c. REST OF ASIA-PACIFIC III-71
A.Market Analysis III-71
Current and Future Analysis III-71
B.Market Analytics III-71
Table 75: Rest of Asia-Pacific Recent Past, Current and Future
Analysis for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-71

Table 76: Rest of Asia-Pacific Historic Review for Apheresis
Equipment by Segment - Equipment for Therapeutic Apheresis
and Equipment for Donor Apheresis Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) III-72

Table 77: Rest of Asia-Pacific 15-Year Perspective for
Apheresis Equipment by Segment - Percentage Breakdown of
Dollar Sales for Equipment for Therapeutic Apheresis and
Equipment for Donor Apheresis Markets for Years 2004, 2013 and
2018 (includes corresponding Graph/Chart) III-73

6. REST OF WORLD III-74
A.Market Analysis III-74
Current and Future Analysis III-74
B.Market Analytics III-74
Table 78: Rest of World Recent Past, Current and Future
Analysis for Apheresis Equipment by Segment - Equipment for
Therapeutic Apheresis and Equipment for Donor Apheresis
Markets Independently Analyzed with Annual Sales in US$
Million for Years 2010 through 2018 (includes corresponding
Graph/Chart) III-74

Table 79: Rest of World Historic Review for Apheresis
Equipment by Segment - Equipment for Therapeutic Apheresis
and Equipment for Donor Apheresis Markets Independently
Analyzed with Annual Sales in US$ Million for Years 2004
through 2009 (includes corresponding Graph/Chart) III-75

Table 80: Rest of World 15-Year Perspective for Apheresis
Equipment by Segment - Percentage Breakdown of Dollar Sales
for Equipment for Therapeutic Apheresis and Equipment for
Donor Apheresis Markets for Years 2004, 2013 and 2018
(includes corresponding Graph/Chart) III-76


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 16 (including Divisions/Subsidiaries - 23)

The United States (11)
Japan (4)
Europe (8)
- Germany (6)
- Italy (2)

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