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Bioactive Materials: Technologies and Global Markets

  • September 2013
  • -
  • BCC Research
  • -
  • 122 pages

STUDY GOALS AND OBJECTIVES

BCC began tracking the bioactive materials market in 2006. Since then, the market has been growing at a fairly rapid rate, primarily driven by increasing demand for synthetic materials for tissue replacement in medical applications.
With this study, BCC Research continues its commitment to monitoring the bioactive materials market by providing an updated review of the most important advances in bioactive material technology and fabrication methods and offering a detailed overview of the current market, including a quantitative and objective analysis of prospects for future growth.
Specifically, the major objectives of this study are to:
• Provide an updated review of bioactive material, focusing on materials and fabrication technologies.
• Highlight new technological developments during the past three years, while outlining current technical issues.
• Identify current and emerging applications for bioactive materials.
• Estimate current global markets for bioactive materials by type, product shape, application and region, with growth forecasts through 2018 for each market segment.
• Identify important technology and industry trends within each market segment.
• Offer an updated review of current industry players, including manufacturers of bioactive materials, technology developers and future market participants.
• Provide a description of the most relevant research and development activities.
• Determine trends in recently issued U.S. patents.

REASONS FOR DOING THIS STUDY

Bioactive materials represent a category of biomaterials materials that react with body tissues and fluids without adverse reactions in the body. They can be made from different types of materials, such as ceramics, glass, glass-ceramics and composites.
While the global biomaterials market is currently quite large, estimated to reach revenues of approximately $50 billion in 2013, the share represented by bioactive materials is a relatively small fraction of this market (less than 2%); however, it represents one of the fastest growing segments, with double-digit growth forecast through 2018.
The increased market penetration of these materials is attributed to different factors, including, for example, a rising demand for tissue replacement materials needed in surgical procedures used to treat a rapidly growing elderly population.
The principal objective of this report is to present a current assessment of the bioactive materials industry from both a technological and market point of view and to outline future trends and key developments.
There is also a need to evaluate the current status and future trends of this market from a global standpoint. As the use of these products expands and new fields of application emerge, information on the suppliers and developers of bioactive materials and their regional distribution becomes more valuable.
An equally important reason for undertaking this report is to provide technical insights into the manufacturing of bioactive materials by:
• Providing a review of materials, applications and production methods.
• Identifying current technical trends.
• Providing an overview of the main global R&D activities related to bioactive materials, resulting in the issuance of patents.
• Illustrating the latest technological developments.

This information can assist companies in identifying opportunities for process and productivity improvements and new product development, resulting in a positive impact on future market growth.

INTENDED AUDIENCE

This study will be of primary interest to all organizations that:
• Manufacture, sell and distribute bioactive materials and other biomaterials.
• Supply raw materials for the production of bioactive materials.
• Manufacture process equipment utilized during fabrication of bioactive materials.
• Utilize bioactive materials for dental and medical care, cosmetic and pharmaceutical products, food packaging, antibacterial items and other products.
• Provide technical and/or marketing services in conjunction with the above mentioned products.
• Are planning to enter the bioactive materials industry as a supplier, manufacturer or end user.

Overall, this report applies to industry segments such as medicine/surgery, dentistry/periodontics, bioengineering, pharmaceuticals, cosmetics/personal care and packaging.
The report is mainly directed toward executives, directors, surgeons, dentists, healthcare professionals, production managers, sales and marketing managers, and strategic planners working within the above industries. Universities and research facilities may also find this report to be a good source of technical information regarding bioactive materials, fabrication processes and applications, which can be used as a baseline for new or expanded R&D activities. Librarians of technical information and research centers can also use this report to provide critical data to healthcare personnel, product managers, market analysts, researchers and other professionals needing detailed and updated insights into the bioactive materials industry.

SCOPE OF REPORT

This report provides an updated review of bioactive materials and their production processes and identifies current and emerging applications for this technology.
BCC Research delineates the current market status for bioactive materials, defines trends and presents growth forecasts for the next five years. Market analysis is based on the following segments: material type, product shape, application and region. In addition, technological issues, including key events and the latest process developments, are also discussed.
More specifically, BCC’s market analysis is divided into five sections.
In the first section, an introduction to the topic and a historical review of bioactive materials are provided, including an outline of recent events. In this section, current and emerging applications for bioactive materials are also identified and described.
The second section provides a technological review of the various types of bioactive materials and their fabrication methods, with a focus on materials of recent development and innovative production processes. The most important technological developments since 2010 are described, including examples of significant patents recently issued and patent applications recently filed. This section concludes by highlighting the most active research organizations operating in this field.
The third section presents a global market analysis of bioactive materials. Global revenues (sales data in millions of dollars) are presented for each segment (material type, product shape, application and region) with actual data for the years 2011 and 2012 and estimated revenues for 2013. The analysis of current revenues for bioactive materials is followed by a detailed presentation of market growth trends, based on industry growth, technological trends and regional trends. The third section concludes by providing projected revenues for bioactive materials within each segment, together with forecast compound annual growth rates (CAGRs) for 2013 through 2018.
In the fourth section of the study, which covers the global industry structure, the report offers a list of the leading manufacturers of bioactive materials, together with a description of their products. The analysis includes a description of the geographical distribution of these suppliers and an evaluation of other key industry players. Detailed company profiles of the top players are also provided.
The fifth and final section includes an extensive U.S. patent analysis, with a summary of patents related to bioactive materials and their fabrication methods and applications. The patents examined in this study were issued from 2011 through 2013. Patent analysis is performed by region, country, assignee, patent category, application and material type.

METHODOLOGY AND INFORMATION SOURCES

To analyze the overall market and market segments, both primary and secondary research methodologies were used to obtain market data.
The technology section of this report is based on information derived from technical literature, related BCC reports, professional journals, the author’s field experience and online sources.
Global market analysis was performed by a thorough investigation of manufacturers of bioactive materials, raw material suppliers, producers of equipment used in manufacturing and testing these materials, and developers of new technologies, accounting for at least 90% of the global market. Data were obtained from the direct contribution of primary sources, including company executives, managers, engineers and other technical personnel representing manufacturers, developers and users of bioactive materials and related technologies; representatives of academia and trade associations; and industry market analysts.
Additional data for each company were obtained by thoroughly analyzing Security and Exchange Commission (SEC) filings, websites, annual reports, industry directories, industry magazines and catalogs, government sources and other public sources.
Secondary sources of information include but are not limited to:
• U.S. Securities and Exchange Commission filings.
• U.S. Patent and Trademark Office.
• European Patent Office.
• Company websites.
• Company annual reports.
• Thomas Register.
• Moody’s Directory.
• S&P Industry Survey.
• Dun & Bradstreet Business Directory.
• Foreign Chamber of Commerce Directories.
• Foreign stock exchange listings.
• American Ceramic Society Publications.
• American Chemical Society Publications.

In addition to utilizing the above primary and secondary sources, market growth trends and forecasts were compiled by gaining additional insights from relevant financial and market information, relevant BCC reports and the author’s own in-depth and comprehensive analysis of the collected information.

REPORT HIGHLIGHTS

This report provides:
• Descriptions of various types of bioactive materials (i.e., glasses, glass-ceramics, ceramics, and composites), including biological materials such as proteins and enzymes; their fabrication methods (including variants and upgrades); and identification of current and potential applications for each type
• Analyses of the industry on a worldwide basis from the standpoint of both manufacturing and consumption, with data for 2011 and 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018
• Examinations of commercial and public research activities in major regions of the world
• Comprehensive profiles of the top companies in the industry
• An in-depth patent analysis.

Table Of Contents

Bioactive Materials: Technologies and Global Markets
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
INTENDED AUDIENCE 3
SCOPE OF REPORT 4
METHODOLOGY AND INFORMATION SOURCES 4
ANALYST CREDENTIALS 5
RELATED BCC RESEARCH STUDIES 6
BCC ONLINE SERVICES 7
DISCLAIMER 7

CHAPTER 2 EXECUTIVE SUMMARY 9

SUMMARY TABLE GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($
MILLIONS) 10
SUMMARY FIGURE GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($
MILLIONS) 10

CHAPTER 3 OVERVIEW 12

BIOMATERIALS, BIOACTIVE MATERIALS AND THE BIOMATERIALS INDUSTRY 12
BIOMATERIALS AND BIOACTIVE MATERIALS 12
TABLE 1 CLASSIFICATION OF BIOMATERIALS 13
THE BIOMATERIALS INDUSTRY 13
TABLE 2 THE BIOMATERIAL MARKET BY REGION, 2013 ($ BILLIONS/%) 14
MILESTONES IN THE HISTORY OF BIOMATERIALS AND BIOACTIVE MATERIALS
AND RECENT EVENTS 14
TABLE 3 BIOMATERIALS AND BIOACTIVE MATERIALS-TECHNOLOGICAL MILESTONES 14
FIGURE 1 BIOACTIVE MATERIALS-WORLDWIDE PATENT APPLICATIONS AND
PATENTS ISSUED SINCE 1970 (NO.) 15
APPLICATIONS OF BIOACTIVE MATERIALS 17
TABLE 4 APPLICATIONS OF BIOACTIVE MATERIALS, 2013 17
TISSUE REPLACEMENT AND REPAIR 18
Autografts 18
Allografts 18
Xenografts 18
Synthetic Materials 19
IMPLANTS 19
OTHER EMERGING APPLICATIONS IN THE MEDICAL SECTOR 19
DENTISTRY AND PERIODONTICS 19
BIOENGINEERING 20
PHARMACEUTICALS AND OTHERS 20

CHAPTER 4 TECHNOLOGY 22

INTRODUCTION 22
BIOACTIVE MATERIALS 22
MATERIAL TYPES 22
TABLE 5 BIOACTIVE MATERIALS, 2013 22
BIOACTIVE GLASS 25
45S5 Bioglass 25
TABLE 6 COMPOSITION OF 45S5 BIOGLASS VERSUS COMMERCIAL GLASS (% BY
WEIGHT) 25
Reaction Mechanism of Bioglass 26
Other Bioactive Glasses 27
TABLE 7 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS (% BY WEIGHT) 27
BIOACTIVE GLASS-CERAMICS 28
A-W Glass-Ceramic 28
Bioverit 29
Ceravital 29
New-Generation Glass-ceramics 29
BIOACTIVE CERAMICS 30
Hydroxyapatite 30
Tricalcium Phosphate 30
Beta-Tricalcium Phosphate 30
Alpha-Tricalcium Phosphate 31
Tetracalcium Phosphate 31
Other Bioactive Ceramics 31
Biphasic Bioactive Ceramics 31
BIOACTIVE COMPOSITES 31
Polymer Matrix Composites 32
High-Density Polyethylene/Hydroxyapatite 32
High-Density Polyethylene/A-W glass-ceramic 32
High-Density Polyethylene/Bioglass 32
Polysulfone/Ceramic 33
Biodegradable Polymer/Ceramic 33
Acrylic Polymer/Ceramic 33
Polylactic Acid/Ceramic 34
Ceramic Matrix Composites 34
Metal Matrix Composites 34
LATEST TECHNOLOGICAL DEVELOPMENTS, 2010 TO PRESENT 34
PEEK/Bioactive Glass-ceramic Composite 34
Borate-Base Bioactive Glass for Wound Healing 35
Bioactive Glass with Fluoride 36
Bioactive Gelatin/Graphene Oxide Nanocomposite 36
Bioactive Ceramic Nanocomposite based on Zirconia and Alumina 37
Clay-Based Bioactive Materials 37
Other Relevant Bioactive Materials of Recent Development 38
PRODUCTION METHODS 39
TABLE 8 BIOACTIVE MATERIALS: TRADITIONAL FABRICATION METHODS, 2013 39
MELTING 39
SOL-GEL 40
TABLE 9 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS MADE BY THE SOL-GEL
METHOD (% BY WEIGHT) 41
SPECIALTY PROCESSES FOR GLASS AND GLASS-CERAMICS 41
MILLING AND SINTERING 42
SPRAY-DRYING 42
PLASTIC PROCESSING 43
IMPREGNATION 43
LATEST TECHNOLOGICAL DEVELOPMENTS, 2010 TO PRESENT 43
Bioactive Glass Scaffold Manufactured by Robocasting 43
Bioactive Ceramic/Polymer Composite by Electrospinning 44
Polymer/Bioactive Ceramic Composite by Spray Drying or
Precipitation 44
Three-Dimensional Printing of Bioactive Glass/Hydroxyapatite
Scaffolds 45
Fabrication of Hydroxyapatite/Zirconia Composite by Microwave
Sintering 45
Bioactive Glass-Ceramic Manufactured By Melt-Quench Process 46
OTHER RELEVANT RandD ACTIVITIES 46
TABLE 10 OTHER RELEVANT R andD ACTIVITIES, 2013 47

CHAPTER 5 GLOBAL MARKETS 50

ANALYSIS OUTLINE 50
GLOBAL MARKET SUMMARY 50
TABLE 11 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($
MILLIONS) 51
FIGURE 2 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($ MILLIONS) 51
CURRENT MARKET STATUS 52
CURRENT MARKET SUMMARY 52
TABLE 12 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2013 ($
MILLIONS) 53
FIGURE 3 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2013 ($ MILLIONS) 53
REVENUES BY MATERIAL TYPE 53
TABLE 13 BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE,
THROUGH 2013 ($ MILLIONS) 54
FIGURE 4 BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE, 2013 (%) 55
TABLE 14 BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE, 2013 ($
MILLIONS/%) 55
TABLE 15 BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE TYPE, 2013
($ MILLIONS/%) 56
REVENUES BY PRODUCT SHAPE 56
TABLE 16 BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT SHAPE,
THROUGH 2013 ($ MILLIONS) 57
FIGURE 5 BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE, 2013 (%) 57
REVENUES BY APPLICATION 58
TABLE 17 BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION, THROUGH
2013 ($ MILLIONS) 58
FIGURE 6 BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION, 2013 (%) 58
REVENUES BY REGION 59
TABLE 18 BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH 2013 ($
MILLIONS) 60
FIGURE 7 BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2013 (%) 60
MARKET GROWTH TRENDS 61
INDUSTRY GROWTH AND TECHNOLOGICAL TRENDS 61
Cranio-maxillofacial Surgery 61
Spinal and Orthopedic Bone Grafting Procedures 61
TABLE 19 FORECAST—VERTEBRAL AND ORTHOPEDIC BONE GRAFTS AND BONE
GRAFTS REPLACEMENTS: REVENUES BY REGION, THROUGH 2018 ($ MILLIONS) 62
Orthopedic Implants 62
TABLE 20 FORECAST-ORTHOPEDIC IMPLANTS: REVENUES BY REGION, THROUGH
2018 ($ BILLIONS) 63
Dentistry/Periodontics 63
Cosmetics and Personal Care 63
Others 64
Tissue Engineering Scaffolds 64
Wound Treatment Products 65
Specialty Materials for Food Packaging 65
TECHNOLOGICAL TRENDS 65
Orthobiologics and Biologics 65
Materials with Enhanced Bioactivity 66
Nanotechnology 66
TABLE 21 THE NANOTECHNOLOGY INDUSTRY, 2013 67
TABLE 22 NANOTECHNOLOGY: GLOBAL REVENUES BY SEGMENT, THROUGH 2018
($ BILLIONS) 68
FIGURE 8 NANOTECHNOLOGY: GLOBAL MARKET SHARE BY SEGMENT, 2013 (%) 69
REGIONAL TRENDS 69
MARKET FORECAST 70
REVENUES BY MATERIAL TYPE 70
TABLE 23 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL
TYPE, THROUGH 2018 ($ MILLIONS) 71
FIGURE 9 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE,
2018 (%) 71
TABLE 24 FORECAST-BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE,
THROUGH 2018 ($ MILLIONS) 72
TABLE 25 FORECAST-BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE
TYPE, THROUGH 2018 ($ MILLIONS) 72
REVENUES BY PRODUCT SHAPE 72
TABLE 26 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT
SHAPE, THROUGH 2018 ($ MILLIONS) 73
FIGURE 10 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE,
2018 (%) 73
REVENUES BY APPLICATION 74
TABLE 27 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION,
THROUGH 2018 ($ MILLIONS) 75
FIGURE 11 FORECAST—BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION,
2018 (%) 75
REVENUES BY REGION 76
TABLE 28 FORECAST-BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH
2018 ($ MILLIONS) 76
FIGURE 12 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2018
(%) 77

CHAPTER 6 GLOBAL INDUSTRY STRUCTURE 79

LEADING MANUFACTURERS OF BIOACTIVE MATERIALS 79
TABLE 29 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS, 2013 79
TABLE 30 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS BY TYPE, 2013 82
TABLE 31 LEADING SUPPLIERS OF BIOACTIVE MATERIALS, BY TYPE AND REGION,
2013 85
OTHER PLAYERS IN THE BIOACTIVE MATERIAL INDUSTRY 85
TABLE 32 OTHER RELEVANT INDUSTRY PLAYERS, 2013 85
COMPANY PROFILES 86
3DI 86
AAP IMPLANTATE 87
ARTHREX 88
BAXTER/APATECH 88
BERKELEY ADVANCED BIOMATERIALS 89
BIOCOMPOSITES 90
BIOMATLANTE 90
BIOMET 91
CAM BIOCERAMICS 93
CERAVER 93
CURASAN 94
DENTSPLY INTERNATIONAL 95
DEPUY SYNTHES 96
DOT 97
HERAEUS KULZER 98
HOYA/PENTAX NEW CERAMICS 98
INTEGRA LIFE SCIENCES 99
KYOCERA 100
MEDTRONIC 101
NOVABONE PRODUCTS 102
SCHOTT 103
STRYKER 103
TAKIRON 105
WRIGHT MEDICAL TECHNOLOGY 105
ZIMMER 106

CHAPTER 7 U.S. PATENT ANALYSIS 109

INTRODUCTION 109
SUMMARY OF PATENTS AWARDED FROM 2011 THROUGH 2013 109
TABLE 33 BIOACTIVE MATERIALS-U.S. PATENTS, 2013 109
TABLE 34 BIOACTIVE MATERIALS-U.S. PATENTS, 2012 112
TABLE 35 BIOACTIVE MATERIALS—U.S. PATENTS, 2011 115
GENERAL TRENDS 117
TABLE 36 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 VS. 2004-2006
(NUMBER OF PATENTS) 118
FIGURE 13 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 (NUMBER OF
PATENTS) 118
TRENDS BY COUNTRY AND REGION 119
FIGURE 14 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY REGION,
2011-2013 (%) 120
FIGURE 15 BIOACTIVE MATERIALS: U.S. PATENTS BY COUNTRY, 2011-2013 (NO. OF
PATENTS) 121
TRENDS BY ASSIGNEE 121
TABLE 37 BIOACTIVE MATERIALS: ASSIGNEES OF U.S. PATENTS, 2011-2013 122
FIGURE 16 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY ORGANIZATION
TYPE, 2011-2013 (%) 124
TRENDS BY PATENT CATEGORY 125
FIGURE 17 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY CATEGORY,
2011-2013 (%) 126
TRENDS BY APPLICATION 126
FIGURE 18 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY APPLICATION,
2011-2013 (%) 127
TRENDS BY MATERIAL TYPE 128
FIGURE 19 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY MATERIAL TYPE,
2011-2013 (%) 128



LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($
MILLIONS) 10
TABLE 1 CLASSIFICATION OF BIOMATERIALS 13
TABLE 2 THE BIOMATERIAL MARKET BY REGION, 2013 ($ BILLIONS/%) 14
TABLE 3 BIOMATERIALS AND BIOACTIVE MATERIALS-TECHNOLOGICAL MILESTONES 14
TABLE 4 APPLICATIONS OF BIOACTIVE MATERIALS, 2013 17
TABLE 5 BIOACTIVE MATERIALS, 2013 22
TABLE 6 COMPOSITION OF 45S5 BIOGLASS VERSUS COMMERCIAL GLASS (% BY
WEIGHT) 25
TABLE 7 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS (% BY WEIGHT) 27
TABLE 8 BIOACTIVE MATERIALS: TRADITIONAL FABRICATION METHODS, 2013 39
TABLE 9 TYPICAL COMPOSITIONS OF BIOACTIVE GLASS MADE BY THE SOL-GEL
METHOD (% BY WEIGHT) 41
TABLE 10 OTHER RELEVANT R andD ACTIVITIES, 2013 47
TABLE 11 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2018 ($
MILLIONS) 51
TABLE 12 GLOBAL MARKET FOR BIOACTIVE MATERIALS, THROUGH 2013 ($
MILLIONS) 53
TABLE 13 BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE, THROUGH
2013 ($ MILLIONS) 54
TABLE 14 BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE, 2013 ($
MILLIONS/%) 55
TABLE 15 BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE TYPE, 2013
($ MILLIONS/%) 56
TABLE 16 BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT SHAPE,
THROUGH 2013 ($ MILLIONS) 57
TABLE 17 BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION, THROUGH
2013 ($ MILLIONS) 58
TABLE 18 BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH 2013 ($
MILLIONS) 60
TABLE 19 FORECAST—VERTEBRAL AND ORTHOPEDIC BONE GRAFTS AND BONE
GRAFTS REPLACEMENTS: REVENUES BY REGION, THROUGH 2018 ($ MILLIONS) 62
TABLE 20 FORECAST-ORTHOPEDIC IMPLANTS: REVENUES BY REGION, THROUGH
2018 ($ BILLIONS) 63
TABLE 21 THE NANOTECHNOLOGY INDUSTRY, 2013 67
TABLE 22 NANOTECHNOLOGY: GLOBAL REVENUES BY SEGMENT, THROUGH 2018 ($
BILLIONS) 68
TABLE 23 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY MATERIAL TYPE,
THROUGH 2018 ($ MILLIONS) 71
TABLE 24 FORECAST-BIOACTIVE CERAMICS: GLOBAL REVENUES BY CERAMIC TYPE,
THROUGH 2018 ($ MILLIONS) 72
TABLE 25 FORECAST-BIOACTIVE COMPOSITES: GLOBAL REVENUES BY COMPOSITE
TYPE, THROUGH 2018 ($ MILLIONS) 72
TABLE 26 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY PRODUCT
SHAPE, THROUGH 2018 ($ MILLIONS) 73
TABLE 27 FORECAST-BIOACTIVE MATERIALS: GLOBAL REVENUES BY APPLICATION,
THROUGH 2018 ($ MILLIONS) 75
TABLE 28 FORECAST-BIOACTIVE MATERIALS: REVENUES BY REGION, THROUGH
2018 ($ MILLIONS) 76
TABLE 29 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS, 2013 79
TABLE 30 LEADING MANUFACTURERS OF BIOACTIVE MATERIALS BY TYPE, 2013 82
TABLE 31 LEADING SUPPLIERS OF BIOACTIVE MATERIALS, BY TYPE AND REGION,
2013 85
TABLE 32 OTHER RELEVANT INDUSTRY PLAYERS, 2013 85
TABLE 33 BIOACTIVE MATERIALS-U.S. PATENTS, 2013 109
TABLE 34 BIOACTIVE MATERIALS-U.S. PATENTS, 2012 112
TABLE 35 BIOACTIVE MATERIALS—U.S. PATENTS, 2011 115
TABLE 36 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 VS. 2004-2006
(NUMBER OF PATENTS) 118
TABLE 37 BIOACTIVE MATERIALS: ASSIGNEES OF U.S. PATENTS, 2011-2013 122



LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($
MILLIONS) 10
FIGURE 1 BIOACTIVE MATERIALS-WORLDWIDE PATENT APPLICATIONS AND PATENTS
ISSUED SINCE 1970 (NO.) 15
FIGURE 2 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2018 ($ MILLIONS) 51
FIGURE 3 GLOBAL MARKET FOR BIOACTIVE MATERIALS, 2011-2013 ($ MILLIONS) 53
FIGURE 4 BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE, 2013 (%) 55
FIGURE 5 BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE, 2013 (%) 57
FIGURE 6 BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION, 2013 (%) 58
FIGURE 7 BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2013 (%) 60
FIGURE 8 NANOTECHNOLOGY: GLOBAL MARKET SHARE BY SEGMENT, 2013 (%) 69
FIGURE 9 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY MATERIAL TYPE,
2018 (%) 71
FIGURE 10 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY PRODUCT SHAPE,
2018 (%) 73
FIGURE 11 FORECAST—BIOACTIVE MATERIALS: MARKET SHARE BY APPLICATION,
2018 (%) 75
FIGURE 12 FORECAST-BIOACTIVE MATERIALS: MARKET SHARE BY REGION, 2018 (%) 77
FIGURE 13 BIOACTIVE MATERIALS: U.S. PATENT TRENDS, 2011-2013 (NUMBER OF
PATENTS) 118
FIGURE 14 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY REGION, 2011-2013
(%) 120
FIGURE 15 BIOACTIVE MATERIALS: U.S. PATENTS BY COUNTRY, 2011-2013 (NO. OF
PATENTS) 121
FIGURE 16 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY ORGANIZATION
TYPE, 2011-2013 (%) 124
FIGURE 17 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY CATEGORY,
2011-2013 (%) 126
FIGURE 18 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY APPLICATION,
2011-2013 (%) 127
FIGURE 19 BIOACTIVE MATERIALS: SHARES OF U.S. PATENTS BY MATERIAL TYPE,
2011-2013 (%) 128

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