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Stem Cell Research Products: Opportunities, Tools & Technologies

  • June 2014
  • -
  • BioInformant Worldwide, L.L.C.
  • -
  • 155 pages

EXECUTIVE SUMMARY

Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity to differentiate into any mature cell type.

Stem cells are still a relatively new discovery, as the first mouse embryonic stem cells were derived from embryos in 1981, but it was not until 1995 that the first successful culturing of embryonic stem cells from non-human primates occurred and not until November 1998 that a technique was developed to isolate and grow embryonic stem cells from human blastocysts. In 2006, induced pluripotent stem cells were produced for the first time from mouse cells and in 2007 they were produced from human cells. Furthermore, it was not until 2008 that the first full transplant of a human organ grown from adult stem cells was performed when a section of trachea was successfully transplanted into an adult woman in Spain.

This overview report provides global strategies for the stem cell industry, and importantly, identifies unique market opportunities by stem cell type, including:

Embryonic stem cells, derived from blastocysts
Fetal stem cells, obtained from fetuses
Post-natal stem cells, derived from newborn tissues
Adult stem cells, found in adult tissues – including hematopoietic stem cells, mesenchymal stem cells, and neural stem cells
Cord blood stem cells, isolated from umbilical tissue
Dental stem cells, derived from deciduous teeth
Induced pluripotent stem cells, reprogrammed from adult cells
Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
Animal stem cells, derived from non-human sources

Table Of Contents

Stem Cell Research Products: Opportunities, Tools and Technologies
TABLE OF CONTENTS

I. ABSTRACT

II. BACKGROUND: TYPES OF STEM CELLS
A. Human Embryonic Stem Cells (hESCs)
1. Early, 5-7 days (totipotent)
2. Gonadal Ridge, 6 months (multipotent)
B. Fetal Stem Cells (pluripotent)
C. Umbilical Cord Stem Cells (multipotent)
1. Cord Blood
2. Cord Matrix (“Wharton's Jelly”)
D. Adult Stem Cells (multipotent)
1. Hematopoietic Stem Cells
2. Mesenchymal Stem Cells
3. Neural Stem Cells
4. Dental Stem Cells (multipotent)
E. Cancer Stem Cells (multipotent)
F. Induced Pluripotent Stem Cells (iPSCs)
G. Novel (recently discovered and uncharacterized) Stem Cell Types
1. Neural Rosette Cells (R-NSCs)
2. Very Small Embryonic Like (VSEL) Stem Cells
H. Stimulus-Triggered Acquisition of Pluipotency (STAP) Cells [Unverified]

III. TIMELINE OF KEY STEM CELL EVENTS

IV. STEM CELL RESEARCH APPLICATIONS
A. Regenerative Medicine (Cell-Based Therapies)
1. Diabetes Mellitus
2. Cardiovascular Disease
3. Neurological Disease
4. Autoimmune Disease
5. Hematopoietic Disease and Transplantation Research
6. Orthopedic Repair
7. Cancer Research
8. Birth Defect Research
B. Drug Development and Discovery
1. Assays to Aid Early Stage Discovery
2. Improved Prediction of Human Responses
3. Drug Development with Humanized Mouse Models
4. Genetically-Engineered Stem Cell Lines for Screening
5. Pluripotent Stem Cell Lines for Target Validation and Drug Screening
6. Summary - Use of Stem Cells in Drug Development and Discovery

V. KEY MARKET COMPETITORS: PROVIDERS OF DIVERSE STEM CELL PRODUCT LINES
A. Thermo Fisher Scientific (Recently Merged with Life Technologies / Includes Invitrogen Brand)
1. Stem Cell Products
a. Isolation and Characterization Products
b. Expansion and Differentiation Products
2. Collaborations
a. Invitrogen and Cellartis AB
b. Invitrogen and Novocell
c. Invitrogen and the Buck Institute
d. Life Technologies and Cellular Dynamics International
e. Life Technologies and iPS Academia Japan
f. Life Technologies and Harvard University
g. Life Technologies and DNAVEC Corporation
B. BD Biosciences
1. Stem Cell Products
a. Isolation
b. Culturing
c. Analysis
2. Collaborations: BD Biosciences and STEMCELL Technologies

VI. PRODUCT AREAS
A. Primary Antibodies
B. Bead-based Cell Separations Systems
C. Fluorescent-based Labeling and Detection
D. Protein Purification and Analysis Tools
1. Protein Purification
2. Stem Cell Protein Analysis
3. Quantitative Proteomics
E. DNA/RNA Based Characterization
1. Tools for DNA- and RNA-based Characterization
2. Stem Cell HLA Typing
3. Stem Cell Nucleic Acid Extraction and Purification, PCR/qRT-PCR Reagents
F. Isolation / Characterization Services
1. Stem Cell HLA Typing Services
2. Stem Cell Custom Services
3. Stem Cell Custom Antibodies
G. Stem Cell Culture Media and Reagents
H. Growth Factors and Cytokines
I. Stem Cell Gene Regulation
J. In vivo / In vitro Stem Cell Tracking
K. Expansion / Differentiation Services
1. Stem Cell Media Services
2. RNAi Services
L. Stem Cell Lines
M. Summary of Product Categories

VII. MARKET SIZE
A. Definition: Stem Cell Research Products
B. Experimental Approach
C. Stem Cell Research Products, Market Size Determination
D. Stem Cell Antibodies, Market Size Determination
E. Stem Cell Therapies, Market Size Determination

VIII. CURRENT MARKET ASSESSMENT
A. Breakdown of Research Segments by End-user Application
1. Basic Research
2. Applied Research
a. Autologous and Allogeneic Cell Therapy
b. Toxicology Screening for Drug Discovery and Development
B. Breakdown of Stem Cell Research by Cell Type
C. Emerging Areas for Stem Cell Products
1. Cord Blood Stem Cells
2. Dental Stem Cells
3. Induced Pluripotent Stem Cells (iPSCs)
D. Top 10 Most Influential People within Stem Cell Industry

IX. MARKET TRENDS ANALYSIS
A. Clinical Trial Data
B. Grant Analysis
C. Patent Analysis
D. Scientific Publication Rate Analysis
1. Historical Data
2. Future 5-Year Projections
3. Comparison of Stem Cell Research Frequency, by Cell Type
E. Sources of Stem Cell Funding
1. Federal
2. State
3. Private

X. MARKET FORECASTS AND FUTURE CONSIDERATIONS
A. 5-Year Market Forecasts
B. Future Considerations
1. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery
2. Short-term (3-5yrs): Therapies Involving Cord Blood and Adult Stem Cells
3. Long-Term (10yrs): Therapies involving hESCs

XI. SCIENTIST PANEL - DETAILED END-USER SURVEY
A. Survey Overview
B. Characterization of Market Survey Respondents
1. Geographic Distribution of Respondents
2. Respondent Breakdown by Industry Affiliation
3. Breakdown of Respondents by Duration of Stem Cell Research Activity
C. Survey Findings - General Scope
D. Survey Findings - Applied Stem Cell Research
E. Survey Findings - Comparison of Providers (Brand Preferences)

XII. STRATEGIES FOR ACCESSING THE MARKETPLACE
A. Top Research Institutions Performing Stem Cell Research
1. University of Wisconsin, including WARF, WiCell, and the WISC Bank
2. Johns Hopkins University
3. US National Institutes of Health (NIH)
4. California Institute for Regenerative Medicine
B. Events of Interest

XIII. CONCLUSIONS

APPENDICES

APPENDIX A - Full List of Conditions Being Explored within Stem Cell Clinical Grants Trials (2014)
APPENDIX B - Full List of Stem Cell Conferences (2014)

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