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Nanotechnology in Medical Applications: The Global Market

  • September 2015
  • -
  • BCC Research
  • -
  • 156 pages

This BCC Research report discusses the implications of technology and commercial trends in the context of current size and growth of the pharmaceutical market, both in global terms and as analyzed by selected national markets. Includes forecast through 2019.

REPORT HIGHLIGHTS

Global nanomedicine market was valued at $214.2 billion in 2013 and $248.3 billion in 2014. The total market is projected to grow at a compound annual growth rate (CAGR) of 16.3% from 2014 through 2019 and reach $528 billion by 2019.

This report provides:
• An overview of the global markets for nanotechnology used in medical applications.
• Analyses of global market trends, with data from 2012 to 2014, and projections of CAGRs through 2019.
• A review of technologies involved, in-depth analysis of applications in practice, and evaluation of future or potential applications.
• Information on a number of significant products in which the nano dimension has made a significant contribution to product effectiveness.
• A look at the regulatory environment, healthcare policies, demographics, and other factors that directly affect nanotechnology used in medicine.
• Analysis of the market's dynamics, specifically growth drivers, inhibitors, and opportunities.
• Coverage of strategies employed by companies specializing in nanomedicine to meet the challenges of this highly competitive market.

SCOPE OF REPORT

This report discusses the implications of technology and commercial trends in the context of the current size and growth of the pharmaceutical market, both in global terms and as analyzed by selected national markets. The important technologies supporting nanomedicine are reviewed, and the nature and structure of the nanomedicine industry is discussed with profiles of the leading companies, including recent M&A activity. Five-year sales forecasts are provided for the national markets and the major therapeutic categories of products involved.

Table Of Contents

Nanotechnology in Medical Applications: The Global Market
CHAPTER 1 INTRODUCTION 2
STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
SCOPE OF REPORT 2
MARKET ANALYSES AND FORECASTS 2
METHODOLOGY 3
INTENDED AUDIENCE 3
INFORMATION SOURCES 3
ANALYST'S CREDENTIALS 3
RELATED BCC RESEARCH REPORTS 3
BCC RESEARCH WEBSITE 4
DISCLAIMER 4
CHAPTER 2 SUMMARY 6
DEFINITION OF NANOMEDICINE 6
RESEARCH AND COMMERCIALIZATION 6
APPLICATIONS 6
DRUG DELIVERY 6
DRUGS AND THERAPY 7
IN VIVO IMAGING 7
IN VITRO DIAGNOSTICS 7
BIOMATERIALS 7
ACTIVE IMPLANTS 7
MARKET 8
SUMMARY TABLE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA,
THROUGH 2019 ($ BILLIONS) 8
SUMMARY FIGURE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA,
2012-2019 ($ BILLIONS) 9
CHAPTER 3 OVERVIEW 11
ABOUT NANOTECHNOLOGY 11
THE MANY USES OF NANOTECHNOLOGY 12
MEDICAL APPLICATIONS 12
ENVIRONMENTAL APPLICATIONS 12
MILITARY APPLICATIONS 13
COSMETICS 13
APPLICATIONS IN DEVELOPMENT 13
THE TOOLS OF NANOTECHNOLOGY 14
C60/FULLERENES 14
CARBON NANOTUBES 14
NANOPARTICLES 14
NANOWIRES 14
MOLECULAR NANOTECHNOLOGY 15
RISKS OF NANOTECHNOLOGY 15
POISON/TOXICITY 15
NANOTECHNOLOGY IN THE MARKETPLACE 16
MEDICAL NANOTECHNOLOGY - NANOMEDICINE 17
FUTURE POSSIBILITIES 18
MARKET POTENTIAL 18
CHAPTER 4 NANOMEDICINE 20
DEVELOPMENT OF NANOMEDICAL TECHNOLOGIES 20
TABLE 1 NANOMEDICINE - ESTMIATED TIMESCALE BY DECADE 20
TABLE 2 MAIN NANOTECHNOLOGIES AND APPLICATIONS IN MEDICINE 21
LIPOSOMES 22
TABLE 3 MARKETED LIPOSOMAL NANOPHARMACEUTICAL PRODUCTS 22
DENDRIMERS 23
NANOCRYSTALS 23
TABLE 4 MARKETED NANOCRYSTAL PHARMACEUTICAL PRODUCTS 24
MICELLES 24
TABLE 5 MARKETED PRODUCTS IN MICELLE FORM 25
FULLERENES 25
POLYMERIC NANOPARTICLES 25
NANOPARTICLE-DRUG CONJUGATES 26
LIGAND-TARGETED NANOPARTICLES 26
CERAMIC NANOPARTICLES 26
VIROSOME NANOPARTICLES 27
CHAPTER 5 THERAPEUTIC USES OF NANOMEDICINE 29
CANCER DIAGNOSTICS AND THERAPY 29
SILICA NANOSPHERES 29
NANOSCALE HYDROGEL SHELLS 29
Carbon Nanoparticles 29
Photodynamic Therapy and Gold 30
Dendrimer Conjugates 30
Ligand-Targeted Emulsion Technologies 31
Linear Cyclodextrin-Containing Polymers 31
Smart Lipid-Based Nanocarriers 32
Thermotherapy Using Magnetic Nanoparticles 32
Targeted Cell Destruction 32
Nanoshells 33
DRUG DELIVERY 33
TABLE 6 MARKETED PRODUCTS WITH NANO-ENHANCED DRUG DELIVERY 34
AlphaRx 36
Aphios 36
Bind Biosciences 36
Biodelivery Sciences 37
Calando Pharmaceuticals Inc. 37
Capsulution NanoScience 37
Ceramisphere 38
CytImmune 38
Health Plus International 39
IGI Laboratories Inc. 39
Labopharm 39
MagnaMedics 40
Mebiopharm 40
Nanocopoeia 40
NanoCrystal 40
NanoMed 41
NanoCyte 41
NanoPharm 41
Nanotherapeutics 42
Nanotrope 42
pSivida 42
Selecta Biosciences 43
SoluBest 43
Transave/Insmed 44
INFECTION CONTROL 44
Silver Nanoparticles against Infection 44
Detecting Nanobacteria 45
Killing Viruses 46
CHAPTER 6 DIAGNOSTIC TOOLS 48
PRACTICAL APPLICATION OF TOOLS 48
COMPANIES THAT DEVELOP THE TOOLS 48
BioCrystal/InVitrogen 48
BioForce 48
Biophage 48
CombiMatrix 49
Farfield Sensors 49
GE Healthcare BioSciences 49
Immunicon 50
MagnaMedics 50
Nanogen 51
Nanosphere 51
Qiagen 51
Sphere 52
TransGenex 52
Veredus 53
VARIOUS THERAPEUTIC TARGETS TECHNOLOGIES 53
Anthrax 53
Cholesterol 54
Artificial Retina 54
Nerve Regeneration 54
Crossing the Blood-Brain Barrier 55
Protecting Against Radiation Damage 55
Antibody Therapeutics 56
Hemostasis 56
Bone Fracture Repair 57
Dental Implant and Tissue Regeneration 57
Vaccine Adjuvant 57
Treatment of Thrombosis 58
Coatings for Stents and Other Devices 58
CHAPTER 7 FUTURE TRENDS AND RESEARCH POSSIBILITIES 61
NON-INVASIVE NANODEVICES 62
EXTRACELLULAR DEVICES 62
INTRACELLULAR DEVICES 63
NANOMACHINES TO CONTROL TISSUE HEALING 63
ELIMINATING VIRUSES 64
CORRECTING CHEMISTRY 64
NEW ORGANS AND LIMBS 65
FUNDAMENTAL NANOTECHNOLOGY RESEARCH 65
UNITED STATES 66
University at Albany-SUNY 66
Cornell University 66
University of Michigan 67
Rice University 67
University of Pennsylvania 68
University of Virginia 68
University of North Carolina 68
Ohio State University 69
Northwestern University 69
University of Pittsburgh 69
Case Western Reserve University 70
University of California at Berkeley 70
EUROPE 70
TABLE 7 EUROPEAN NANOCENTRES 71
JAPAN 72
Development of Active Targeting DDS 72
Development of Novel Tissue Engineering 72
Development of New Biomaterials 72
THE RISK FACTOR 73
CHAPTER 8 MARKETS FOR NANOMEDICINE 76
TABLE 8 MARKETED NANOPHARMACEUTICALS 76
TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS AND BIOMATERIALS 77
MARKET DRIVERS 78
MARKET ESTIMATES AND FORECASTS 79
TABLE 10 GLOBAL MARKET SHARE FOR NANOTECHNOLOGY BY INDUSTRY SECTOR,
2010 (%) 79
GLOBAL NANOMEDICINE MARKET 79
TABLE 11 GLOBAL NANOMEDICINE, NANOPHARMACEUTICAL AND
NANODIAGNOSTIC MARKET, THROUGH 2019 ($ BILLIONS/%) 80
MAIN PRODUCT CATEGORIES 80
DRUG DELIVERY 80
MOLECULAR DIAGNOSTICS 81
MARKET ANALYSIS BY CLINICAL APPLICATION 82
Cancer 82
TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICAL PRODUCTS BY
COMPONENT, MANUFACTURER AND SALES ($ MILLIONS) 82
TABLE 13 GLOBAL MARKET FOR CANCER NANOTHERAPEUTICS AND
NANODIAGNOSTICS ($ BILLIONS) 82
CNS Disorders 83
TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICAL PRODUCTS BY
COMPONENT, MANUFATURER AND SALES ($ MILLIONS) 83
TABLE 15 GLOBAL MARKET FOR CNS NANOMEDICINES 83
Infection 83
TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICAL PRODUCTS
BY COMPONENT, MANUFACTURER AND SALE ($ MILLIONS) 84
TABLE 17 GLOBAL MARKET FOR ANTI-INFECTIVE NANOMEDICINE,
NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) 84
Cardiovascular and Autoimmune Disorders 84
TABLE 18 MAJOR MARKETED NANOMEDICINE PRODUCTS FOR CARDIOVASCULAR
AND INFLAMMATORY DISEASES BY COMPONENT, MANUFACTURER AND SALE ($
BILLIONS)85
TABLE 19 GLOBAL MARKET FOR CARDIOVASCULAR AND ANTI-INFLAMMATORY
NANOPRODUCTS ($ BILLIONS) 85
REGIONAL MARKET ANALYSIS 85
U.S. 85
TABLE 20 U.S. NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86
Japan 86
TABLE 21 JAPANESE NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86
Europe 87
TABLE 22 GERMAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 23 FRENCH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 24 UNITED KINGDOM NANOMEDICINE MARKET, THROUGH 2019 ($
BILLIONS/%) 87
TABLE 25 ITALIAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 26 BELGIUM AND NETHERLANDS NANOMEDICINE MARKET, THROUGH 2019
($ BILLIONS/%) 88
TABLE 27 SPANISH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 88
CHAPTER 9 COMPANY PROFILES 91
COMPANIES THAT COMPRISE THE GLOBALNANOMEDICINE INDUSTRY 91
ABLYNX NV 91
ABRAXIS BIOSCIENCE INC. 92
ACRYMED INC. 93
ACUSPHERE INC. 94
AMAG PHARMACEUTICALS INC. 95
ALLTRACELL 96
ANSON NANO-BIOTECHNOLOGY 97
APHIOS CORP. 97
Protein Nanoparticles 98
Polymer Nanospheres 98
Phospholipid Nanosomes 98
BIND THERAPEUTICS INC. 99
BIOCRYSTAL LTD. 100
BIOFORCE NANOSCIENCES INC. 101
The ViriChip Virus Detection Platform 101
BIO-GATE AG 101
Medical Applications 102
BIOPHAGE PHARMA INC. 103
BioPhage Products 103
Development through Collaborations: 103
Phages 104
BIOPHAN TECHNOLOGIES INC. 104
CALANDO PHARMACEUTICALS INC. 105
About CALAA-01 106
C SIXTY INC. 107
COMBIMATRIX CORP. 108
Drug Development 108
ELAN DRUG TECHNOLOGIES 109
FARFIELD SCIENTIFIC 111
GE HEALTHCARE 112
IGI LABORATORIES INC. 113
KEREOS INC. 114
KER-1001 115
KER-1002 115
KER-1003 115
KEYSTONE NANO INC. 115
NanoJackets 115
KLEINDIEK NANOTECHNIK GMBH 116
NanoWorkstation 117
LABOPHARM INC. 117
LIPLASOME PHARMA A/S 118
LUMERA CORP. 119
Product Portfolio 120
Nanocapture Microarrays 120
MAGFORCE NANOTECHNOLOGIES AG 120
MAGNAMEDICS GMBH 122
Diagnostics: 122
Efficient and Low-Cost Diagnostics 123
Multifunctional Drug Carrier 123
MICROFLUIDICS INTERNATIONAL CORP. 123
MIDATECH PHARMA PLC 124
MIV THERAPEUTICS INC. 126
Cardiovascular Heart Stents 126
MOLECULAR PROFILES (NOW JUNIPER PHARMACEUTICALS ) 127
NANOBAC PHARMACEUTICALS INC. 128
NANOBIO CORP. 129
NANOBIOTIX 131
NANOCARRIER CO. LTD. 133
NANOCOPOEIA INC. 134
NANOCYTE INC. 135
NANOGEN INC. 136
Electronic Microarray 136
Instrumentation 137
Molecular Biology Workstation 137
Molecular Biology Workstation Cartridge 137
NanoChip 400 System 137
NANOLOGIX INC. 138
NANOMED PHARMACEUTICALS INC. 139
NANOMIX INC. 140
NANOSPECTRA BIOSCIENCES INC. 141
NANOSPHERE INC. 142
NANOSTRUCTURES INC. 143
NANOSYN INC. 144
NANOTHERAPEUTICS INC. 145
NANOTROPE INC. 148
Technology 149
NANOVIRICIDES INC. 149
Pipeline 150
NUCRYST PHARMACEUTICALS 151
NUTRALEASE LTD. 152
ORION INTEGRATED BIOSCIENCES INC. 152
Genomic Signatures 153
Rational Antiviral Development 153
Discovery of Malaria Invasion Pathways 154
ORTHOVITA INC. 154
PIONEER SURGICAL TECHNOLOGY 155
PSIVIDA LTD. 155
QIAGEN NV 157
SOLUBEST LTD. 158
STARPHARMA 159
Dendrimer Nanotechnology 160
TECAN GROUP LTD. 160
TRANSGENEX NANOBIOTECH INC. 161
Therapy 161
CHAPTER 10 APPENDIX 164
GLOSSARY 164

LIST OF TABLES

SUMMARY TABLE GLOBAL NANOMEDICINE MARKET BY THERAPEUTIC AREA,
THROUGH 2019 ($ BILLIONS) 8
TABLE 1 NANOMEDICINE - ESTMIATED TIMESCALE BY DECADE 20
TABLE 2 MAIN NANOTECHNOLOGIES AND APPLICATIONS IN MEDICINE 21
TABLE 3 MARKETED LIPOSOMAL NANOPHARMACEUTICAL PRODUCTS 22
TABLE 4 MARKETED NANOCRYSTAL PHARMACEUTICAL PRODUCTS 24
TABLE 5 MARKETED PRODUCTS IN MICELLE FORM 25
TABLE 6 MARKETED PRODUCTS WITH NANO-ENHANCED DRUG DELIVERY 34
TABLE 7 EUROPEAN NANOCENTRES 71
TABLE 8 MARKETED NANOPHARMACEUTICALS 76
TABLE 9 MARKETED NANO-IMAGING, DIAGNOSTICS AND BIOMATERIALS 77
TABLE 10 GLOBAL MARKET SHARE FOR NANOTECHNOLOGY BY INDUSTRY SECTOR,
2010 (%) 79
TABLE 11 GLOBAL NANOMEDICINE, NANOPHARMACEUTICAL AND NANODIAGNOSTIC
MARKET, THROUGH 2019 ($ BILLIONS/%) 80
TABLE 12 MAJOR MARKETED ANTICANCER NANOPHARMACEUTICAL PRODUCTS BY
COMPONENT, MANUFACTURER AND SALES ($ MILLIONS) 82
TABLE 13 GLOBAL MARKET FOR CANCER NANOTHERAPEUTICS AND
NANODIAGNOSTICS ($ BILLIONS) 82
TABLE 14 MAJOR MARKETED CNS NANOPHARMACEUTICAL PRODUCTS BY
COMPONENT, MANUFATURER AND SALES ($ MILLIONS) 83
TABLE 15 GLOBAL MARKET FOR CNS NANOMEDICINES 83
TABLE 16 MAJOR MARKETED ANTI-INFECTIVE NANOPHARMACEUTICAL PRODUCTS BY
COMPONENT, MANUFACTURER AND SALE ($ MILLIONS) 84
TABLE 17 GLOBAL MARKET FOR ANTI-INFECTIVE NANOMEDICINE,
NANOTHERAPEUTICS AND NANODIAGNOSTICS ($ BILLIONS) 84
TABLE 18 MAJOR MARKETED NANOMEDICINE PRODUCTS FOR CARDIOVASCULAR
AND INFLAMMATORY DISEASES BY COMPONENT, MANUFACTURER AND SALE ($
BILLIONS) 85
TABLE 19 GLOBAL MARKET FOR CARDIOVASCULAR AND ANTI-INFLAMMATORY
NANOPRODUCTS ($ BILLIONS) 85
TABLE 20 U.S. NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86
TABLE 21 JAPANESE NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 86
TABLE 22 GERMAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 23 FRENCH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 24 UNITED KINGDOM NANOMEDICINE MARKET, THROUGH 2019 ($
BILLIONS/%) 87
TABLE 25 ITALIAN NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 87
TABLE 26 BELGIUM AND NETHERLANDS NANOMEDICINE MARKET, THROUGH 2019
($ BILLIONS/%) 88
TABLE 27 SPANISH NANOMEDICINE MARKET, THROUGH 2019 ($ BILLIONS/%) 88
HLC069C - Nanotechnology in Medical Applications: The Global Market

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