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RNAi Technologies and Global Markets

  • January 2016
  • -
  • BCC Research
  • -
  • 176 pages

This BCC Research report summarizes the global RNAi technologies market by category and by region. The RNAi market is analyzed based on RNAi research tools and reagents as well as on RNAi diagnostics. The report includes sales forecasts from 2015 to 2020.

Use this report to:

Analyze the market prospects of ribonucleic acid interference (RNAi) technology
Evaluate the product usage, research and development, collaborations, market trends
and future applications, prospects, challenges, etc. in the RNAi market Assess the progress of new RNAi techniques in the areas of research tools and products, therapeutics, diagnostics and agricultural segments
Gain information on the regulatory aspects, drivers and other factors of RNAi market

Highlights

The global market for RNA interference technologies is expected to grow from $262.1 million in 2015 to $392.6 million in 2020, registering a compound annual growth rate (CAGR) of 8.4%.
The RNAi research tools and reagents market is projected to reach $391.0 million in 2020 from $261.1 million in 2015, increasing at a CAGR of 8.4%.
The RNAi diagnostics market reached $1.0 million in 2015 and should reach $1.6 million by 2020 growing at a CAGR of 9.9%.

STUDY OBJECTIVES

BCC Research conducted this report to analyze the market prospects of ribonucleic acid interference (RNAi) technology. The report assesses the progress of new RNAi techniques in the areas of research tools and products, therapeutics, diagnostics andagricultural segments. Further, the report evaluates the product usage, research and development, collaborations, market trends and future applications, prospects, challenges, etc. in the RNAi market.

Global RNAi technology is in its nascent state. However, the market holds significant opportunities due to the promising application of RNAi therapeutics in often-fatal diseases like cancer, heart ailments, autoimmune diseases, neurodegenerative disease and others. The RNAi research tools and reagents market is growing well due to its major applications in RNAi therapeutics, diagnostics and agricultural areas. Secondly, various RNAi therapeutics candidates are showing success in advanced stages of their clinical investigations. Further, the availability of RNAi diagnostics tests offer great promises of successful application of RNAi therapeutics and diagnostics in medical settings.

The market projections are based on the commercialized research products and tools and trends in their applications, product development, applications in diagnostics, and investments for RNAi therapeutics, agricultural products and other areas. The report provides present market analysis as well as a projection for the next five years (until 2020). The report includes market analysis, market leaders, manufacturers and market shares, profiles of leading companies, current situations, new developments, patent analysis, regulatory aspects, drivers and other factors of RNAi market.

REASONS FOR DOING THIS STUDY

The RNAi market is burgeoning and is one of the most watched markets in the pharmaceuticals industry. The reason for this status is the encouraging application of RNAi mechanisms in therapeutics through gene silencing. There is no approved therapy so far; however, various candidates have shown successful results in their
clinical investigations. The report reflects the details of those candidates along with prospective applications of RNAi in diagnostics and agriculture. This market will grow through 2020 with the successful utilization of techniques in both therapeutics and agriculture.



Table Of Contents

RNAi Technologies and Global Markets
CHAPTER 1 INTRODUCTION 2
STUDY OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
CONTRIBUTIONS OF THE STUDY AND INTENDED AUDIENCE 2
SCOPE OF THE STUDY 3
METHODOLOGY 3
INFORMATION SOURCES 3
ANALYST CREDENTIALS 4
RELATED BCC RESEARCH REPORTS 4
BCC RESEARCH WEBSITE 5
DISCLAIMER 5
CHAPTER 2 EXECUTIVE SUMMARY 7
SUMMARY TABLE GLOBAL REVENUE FOR RNA INTERFERENCE TECHNOLOGIES BY
TYPE, THROUGH 2020 ($ MILLIONS) 8
SUMMARY FIGURE GLOBAL REVENUE FOR RNA INTERFERENCE TECHNOLOGIES BY
TYPE, 2013-2020 ($ MILLIONS) 8
CHAPTER 3 OVERVIEW 10
RIBONUCLEIC ACID (RNA) 10
EVOLUTION OF RNA 10
TABLE 1 EVOLUTION OF RNA 11
RNA INTERFERENCE (RNAI) 12
MECHANISM OF ACTION OF RNA INTERFERENCE 12
MicroRNA (miRNA) 13
TABLE 2 MICRORNA (MIRNA) DATABASES 14
Short Interfering RNA (siRNA) 14
TABLE 3 SHORT/SMALL INTERFERING RNA (SIRNA) DATABASES 15
Small Hairpin RNA (shRNA) 16
Piwi-Interacting RNA (piRNA) 16
TABLE 4 PIWI-INTERACTING RNA (PIRNA) DATABASES 17
RNA INTERFERENCE DRUG DELIVERY 17
SYSTEMIC ELIMINATION OF SIRNA 18
SIRNA STABILITY IN BLOODSTREAM 18
RETICULOENDOTHELIAL SYSTEM (RES) ENTRAPMENT 19
VASCULAR ENDOTHELIUM 19
DIFFUSION 19
PLASMA MEMBRANE 19
ENDOSOMAL ENTRAPMENT 19
NANO-CARRIER MEDIATED TOXICITY 20
METHODS OF RNA INTERFERENCE DRUG DELIVERY SYSTEMS 20
Physical RNAi Delivery Methods 20
Hydrodynamic Injection 20
Electroporation 21
Vector-Based RNAi Delivery Methods 21
Plasmid Vector RNAi Delivery 21
Virus Vector RNAi Delivery 21
Carrier-Based Nonviral RNAi Delivery 22
Cationic Cell-Penetrating Peptide (CPP) 22
Aptamer 23
Lipid-Based siRNA Delivery 23
TABLE 5 STABILIZATION METHODS FOR LIPID BASED SIRNA DELIVERY SYSTEM 24
Polymer- and Peptide-Based Vector 25
Lipid-Polymer Combination 26
Dendrimers 26
Phi29 Packaging RNA 26
Mesoporous Silica Nanoparticles 27
Antibodies 27
Stem Cell 27
Light-Controlled Delivery 28
Quaternized Starch Based Carrier 28
RNAI DRUG DISCOVERY AND DEVELOPMENT 28
RNA-BASED THERAPIES 28
Antisense RNA Therapy 29
Ribosome RNA Therapy 29
Aptamer RNA Therapy 30
Messenger RNA (mRNA) Therapeutics 31
RNAi Therapeutics 31
Drug Discovery 32
Targeting miRNA Processes 32
Delivering Designed siRNAs Into Cells 32
Drug Target Validation 32
Designing RNAi Therapeutics 33
Sequence Selection 33
Chemical and Structure Modification 33
Drug Development 34
RNAi Instability 34
Off-Target Effects 34
Innate/Intrinsic Immune Response 35
Delivery Material Toxicity 35
Saturation of RNAi Machinery 36
OTHER POTENTIAL APPLICATIONS OF RNA INTERFERENCE 36
DIAGNOSTICS 36
AGRICULTURE 36
CHAPTER 4 NEW DEVELOPMENTS AND REGULATORY ACTIVITY 39
NEW DEVELOPMENTS 39
TABLE 6 NEW DEVELOPMENTS IN THE RESEARCH PIPELINE OF RNAI THERAPEUTICS
AND TECHNOLOGIES AS OF SEPTEMBER 2015 40
REGULATORY ASPECTS 43
REGULATORY DEVELOPMENTS 43
COLLABORATIVE TRIALS AND FUTURE ACTIVITIES 44
CHAPTER 5 MARKET ANALYSIS 48
MARKET BY TECHNOLOGY 49
TABLE 7 GLOBAL REVENUE FOR RNAI TECHNOLOGIES BY TYPE, THROUGH 2020 ($
MILLIONS) 50
FIGURE 1 GLOBAL REVENUE FOR RNAI TECHNOLOGIES BY TYPE, 2013-2020 ($
MILLIONS) 50
MARKET SHARE 50
TABLE 8 MARKET SHARE OF RNAI TECHNOLOGIES BY TYPE, 2014 (%) 51
FIGURE 2 MARKET SHARE OF RNAI TECHNOLOGIES BY TYPE, 2014 (%) 51
RNA INTERFERENCE RESEARCH TOOLS AND REAGENTS 51
RNAi Research Tools and Constructs 52
TABLE 9 MODIFICATIONS OF SIRNA 52
TABLE 10 RNAI VECTORS 53
Reagents 54
Market Overview 54
Market Revenue 56
TABLE 11 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS,
THROUGH 2020 ($ MILLIONS) 56
FIGURE 3 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS,
2013-2020 ($ MILLIONS) 56
Market Share 57
TABLE 12 MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS, 2014 (%) 57
FIGURE 4 MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS, 2014 (%) 57
RNAI INTERFERENCE THERAPEUTICS 58
TABLE 13 DISEASE-SPECIFIC TARGET GENES/PROTEINS FOR RNAI THERAPEUTICS 59
GLOBAL PHARMACEUTICAL MARKET 60
TABLE 14 GLOBAL PHARMACEUTICAL MARKET, THROUGH 2020 ($ BILLIONS) 60
FIGURE 5 GLOBAL PHARMACEUTICAL SALES MARKET,2013-2020 ($ BILLIONS) 60
Market Share of Pharmaceutical Products by Region 61
TABLE 15 GLOBAL PHARMACEUTICAL MARKET SHARES BY REGION, 2014 (%) 61
FIGURE 6 GLOBAL PHARMACEUTICAL MARKET SHARES BY REGION, 2014 (%) 61
Sales of Top Pharmaceutical Companies 61
TABLE 16 TOP GLOBAL PHARMACEUTICAL COMPANIES BY SALES, 2014 ($
MILLIONS) 62
Diseases 62
Cardiovascular Disease 62
Pulmonary Disease 63
Central Nervous System (CNS) Disease 63
Alzheimer's Disease (AD) 63
Parkinson's Disease (PD) 64
Huntington's Disease (HD) 64
Oncology 64
Breast Cancer 65
Pancreatic Cancer 65
Ovarian Cancer 65
Liver Cancer 66
Renal Cancer 66
Colon Cancer 67
Lung Cancer 67
Brain Tumor 67
Prostate Cancer 68
Age-Related Macular Degeneration (AMD) 68
Global Outlook of Therapeutic Spending for Certain Diseases 69
TABLE 17 GLOBAL OUTLOOK OF THERAPEUTIC SPENDING BY DISEASE, THROUGH
2018 ($ BILLION/%) 69
Market Overview 70
RNAI DIAGNOSTICS 73
TABLE 18 NUMBER OF PUBLICATIONS ASSOCIATED WITH MIRNA AND DISEASES,
OCTOBER 2015 73
miRNA in Cancer Diagnostics 74
TABLE 19 MIRNA IN VARIOUS CANCER TYPES 75
TABLE 20 MIRNA AND TARGET GENE PAIRS IN VARIOUS CANCER TYPES 77
miRNAs as Diagnostic, Prognostic and Predictive Biomarkers 79
TABLE 21 BIOMARKERS IN VARIOUS CANCER TYPES 80
Market Overview 84
Market Revenue 85
TABLE 22 GLOBAL REVENUE MARKET FOR RNAI DIAGNOSTICS, THROUGH 2020 ($
MILLIONS) 86
FIGURE 7 GLOBAL REVENUE MARKET FOR RNAI DIAGNOSTICS, 2013-2020 ($
MILLIONS) 86
Revenue for Global mRNA Research Tools Market 86
TABLE 23 GLOBAL REVENUE FOR MIRNA RESEARCH TOOLS, THROUGH 2020 ($
MILLIONS) 87
FIGURE 8 GLOBAL REVENUE FOR MIRNA RESEARCH TOOLS,2013-2020 ($ MILLIONS) 87
RNA INTERFERENCE IN AGRICULTURE 87
Virus Control Through RNAi 88
Safety Concerns 89
TABLE 24 SAFETY ISSUES WITH RNAI CROP IMPROVEMENT 89
RNAi In Crops 91
TABLE 25 PLANT IMPROVEMENT AREAS THROUGH RNAI TECHNOLOGIES 92
TABLE 26 REGIONS, GENES AND APPLICATION OF RNAI-TARGETING ORGANISMS
FOR IMPROVEMENT OF CROPS 92
RNAi In Aquaculture 93
Market Overview 94
MARKET BY REGION 95
MARKET OVERVIEW 95
MARKET REVENUE 96
RNAi Research Tools and Reagents 96
TABLE 27 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, THROUGH 2020 ($ MILLIONS) 97
FIGURE 9 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2013-2020 ($ MILLIONS) 97
Market Share 97
TABLE 28 GLOBAL MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2014 (%) 97
FIGURE 10 GLOBAL MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2014 (%) 98
RNAi Diagnostics 98
TABLE 29 GLOBAL REVENUE FOR RNAI DIAGNOSTICS BY REGION, THROUGH 2020
($ MILLIONS) 99
FIGURE 11 GLOBAL REVENUE FOR RNAI DIAGNOSTICS BY REGION, 2013-2020 ($
MILLIONS) 99
Market Share 99
TABLE 30 GLOBAL MARKET SHARE OF RNAI DIAGNOSTICS BY REGION, 2014 (%) 100
FIGURE 12 GLOBAL MARKET SHARE OF RNAI DIAGNOSTICS BY REGION, 2014 (%) 100
CHAPTER 6 INDUSTRY STRUCTURE 102
RNAI RESEARCH TOOLS AND REAGENTS 102
MARKET LEADERS 102
TABLE 31 LEADING MANUFACTURERS/SUPPLIERS OF RNAI RESEARCH TOOLS AND
REAGENTS, 2014 102
MARKET SHARES 108
TABLE 32 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
RESEARCH TOOLS AND REAGENTS, 2014 (%) 108
FIGURE 13 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
RESEARCH TOOLS AND REAGENTS, 2014 (%) 109
RNAI DIAGNOSTICS 109
MARKET LEADERS 109
TABLE 33 LEADING MANUFACTURERS/SUPPLIERS OF RNAI DIAGNOSTICS, 2014 109
MARKET SHARES 110
TABLE 34 MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
DIAGNOSTICS, 2014 (%) 110
FIGURE 14 MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
DIAGNOSTICS, 2014 (%) 110
CHAPTER 7 PATENT ANALYSIS 112
PATENTS BY YEAR 113
TABLE 35 TOTAL NUMBER OF PATENTS BY YEAR, 2013-AUGUST 2015 113
FIGURE 15 TOTAL NUMBER OF PATENTS BY YEAR, 2013-AUGUST 2015 113
PATENTS BY COUNTRY FOR RNA INTERFERENCE TECHNOLOGIES 113
TABLE 36 NUMBER OF U.S. PATENTS FOR RNAI TECHNOLOGIES BY COUNTRY,
2013-AUGUST 2015 114
TABLE 37 PATENT SHARES FOR RNAI TECHNOLOGIES BY COUNTRY, 2013-AUGUST
2015 (%) 115
FIGURE 16 PATENT SHARES FOR RNAI TECHNOLOGIES BY COUNTRY, 2013-AUGUST
2015 (%) 115
PATENTS BY COMPANY FOR RNA INTERFERENCE TECHNOLOGIES 116
TABLE 38 NUMBER OF U.S. PATENTS FOR RNAI TECHNOLOGIES BY COMPANY,
2013-AUGUST 2015 117
PATENTS BY ASSIGNEE FOR RNA INTERFERENCE TECHNOLOGIES 119
TABLE 39 NUMBER OF PATENTS FOR RNAI TECHNOLOGIES BY TYPE OF ASSIGNEE,
2013-AUGUST 2015 120
FIGURE 17 NUMBER OF PATENTS FOR RNAI TECHNOLOGIES BY TYPE OF ASSIGNEE,
2013-AUGUST, 2015 120
CHAPTER 8 CURRENT STATUS 122
INNOVATIVE TECHNOLOGIES AND PLATFORMS FOR RNA INTERFERENCE 123
DYNAMIC POLYCONJUGATE (DPC) PLATFORM-ARROWHEAD RESEARCH
CORP.) 123
CONJUGATE DELIVERY PLATFORMS - ESC-GALNAC-CONJUGATE (ALNYLAM
PHARMACEUTICALS INC.) 124
LIPID NANOPARTICLE (LNP) TECHNOLOGY (ARBUTUS BIOPHARMA CORP) 124
SIRNA TECHNOLOGY PLATFORM (QUARK PHARMACEUTICALS INC.) 124
MODIFIED MESSENGER RNA THERAPEUTICS PLATFORM (MODERNA
THERAPEUTICS) 124
RNAI TECHNOLOGY PLATFORMS (GE DHARMACON) 125
On-TARGETplus siRNAs 125
Reverse Transfection Format (RTF) siRNA Libraries 125
Cherry-Pick RNAi Libraries 125
Human siRNA Libraries 125
Custom siRNA Synthesis 126
Accell siRNA 126
Mouse Accell siRNA Library - Protein Kinases 126
siGENOME siRNAs 126
Lincode siRNAs 126
Lincode siRNA Libraries 127
SMARTvector Lentiviral shRNA 127
SMARTvector Inducible Lentiviral shRNA 127
SMARTvector Lentiviral shRNA Pooled Libraries 127
GIPZ Lentiviral shRNA 127
TRIPZ Inducible Lentiviral shRNA 128
The RNAi Consortium (TRC) Lentiviral shRNA Library 128
Decode Pooled Lentiviral shRNA Screening Libraries and Reagents 128
Viral Packaging Kits 128
siRNA and microRNA Transfection Reagents 129
DharmaFECT Duo Transfection Reagent 129
RNAI TECHNOLOGIES (THERMO FISHER SCIENTIFIC) 129
Silencer Select siRNA 129
Silencer Select siRNA Libraries 129
Stealth RNAi siRNAs 129
BLOCK-iT siRNAs 130
Controls for RNAi Mechanism 130
RNAI TOOLS FROM SIGMA-ALDRICH 130
MISSION siRNA 130
Pre-arrayed siRNA Libraries 130
MISSION In Vivo Quality and iScale Oligos siRNA 130
N-TER Nanoparticle siRNA Transfection System 131
siRNA Controls (Positive and Negative) 131
MISSION shRNA Library 131
MISSION Lentiviral Controls 131
MISSION esiRNA 131
MISSION Human miRNA Mimics 132
LOCKED NUCLEIC ACID (LNA) PLATFORM (ROCHE [SANTARIS PHARMA]) 132
TRIFECTA RNAI KIT (INTEGRATED DNA TECHNOLOGIES) 132
PSITEST SYSTEM (INVIVOGEN) 132
SELF-DELIVERABLE RNAI TECHNOLOGY (ADVIRNA) 133
RNAI TECHNOLOGIES (BIONEER CORP) 133
AccuTarget Libraries 133
AccuTarget Control siRNAs from Bioneer 133
AccuTarget Human miRNA Mimic and Inhibitor Library 133
Self-Assembled Micelle Inhibitory RNA (SAMiRNA) 134
POOLED LENTIVIRAL LIBRARIES (CELLECTA INC.) 134
NANOPARTICLE-DRUG CONJUGATES (NDCS) (CERULEAN PHARMA INC.) 134
ALLSTARS RNAI CONTROLS (QIAGEN N.V.) 134
RNAI TECHNOLOGIES (APPLIED BIOLOGICAL MATERIALS) 135
siRNA Adeno-Associated Virus (AAV) 135
iLenti RNAi Expression System 135
LIPID-ENABLED AND UNLOCKED NUCLEIC ACID MODIFIED RNA DELIVERY
TECHNOLOGY (ARCTURUS THERAPEUTICS, INC.) 135
ELASTIN-LIKE POLYPEPTIDE (ELP) NANOPARTICLES (PEPTIMED INC.) 135
MICRORNA-BASED DIAGNOSTIC TESTS (ROSETTA GENOMICS) 136
The Rosetta Cancer Origin Test 136
The Rosetta Lung Cancer Test 136
The Rosetta Kidney Cancer Test 136
The Rosetta Mesothelioma Test 136
ATURNAI (SILENCE THERAPEUTICS) 136
DSIRNA-EX-CONJUGATES (DICERNA PHARMACEUTICALS INC.) 137
LODER (SILENSEED LTD.) 137
FACTORS AFFECTING THE RNA INTERFERENCE MARKET 137
CURRENT DRIVERS FOR THE RNA INTERFERENCE TECHNOLOGY MARKET 138
MERGER AND ACQUISITION ACTIVITIES 138
FUNDING FOR DEVELOPMENT OF RNA INTERFERENCE THERAPEUTICS AND
TECHNOLOGIES 139
TABLE 40 FUNDING FOR DEVELOPMENT OF RNAI-BASED PRODUCTS AND
PLATFORMS, 2013-SEPTEMBER 2015 140
TABLE 41 INVESTMENTS FOR DEVELOPMENT OF RNAI-BASED PRODUCTS AND
PLATFORMS, 2013-SEPTEMBER 2015 142
CHAPTER 9 COMPANY PROFILES 145
ADVIRNA 145
ALNYLAM PHARMACEUTICALS, INC. 145
APEIRON BIOLOGICS AG 148
APPLIED BIOLOGICAL MATERIALS, INC. 148
ARBUTUS BIOPHARMA CORP. (PREVIOUSLY TEKMIRA PHARMACEUTICALS
CORP.) 148
ARCTURUS THERAPEUTICS, INC. 150
ARROWHEAD RESEARCH CORP. 151
ASCLETIS INC. 152
BENITEC BIOPHARMA LTD. 152
BIOGEN IDEC, INC. 153
BIOMICS BIOTECHNOLOGIES CO. LTD. 153
BIONEER CORP. 154
CELLECTA, INC. 154
CERULEAN PHARMA, INC. 155
DICERNA PHARMACEUTICALS, INC. 156
EXIQON A/S 157
F. HOFFMANN-LA ROCHE AG (ROCHE) 158
GENERAL ELECTRIC CO. 158
INTEGRATED DNA TECHNOLOGIES, INC. 160
INVIVOGEN 160
ISIS PHARMACEUTICALS, INC. 161
MARINA BIOTECH, INC. 161
MODERNA THERAPEUTICS 162
MONSANTO CO. 164
NITTO DENKO CORP. 164
PEPTIMED INC. 165
QIAGEN N.V. 166
QUARK PHARMACEUTICALS, INC. 166
REGULUS THERAPEUTICS 167
ROSETTA GENOMICS LTD. 168
RXI PHARMACEUTICALS CORP. 170
SANOFI 171
SIGMA-ALDRICH 172
SILENCE THERAPEUTICS PLC. 173
SILENSEED LTD. 174
SOLSTICE BIOLOGICS 174
SOMAGENICS, INC. 174
SUMITOMO DAINIPPON PHARMA CO. LTD. 175
SYNGENTA INTERNATIONAL AG 175
THE NATIONAL INSTITUTES OF HEALTH (NIH) 176
THE RNAI CONSORTIUM AT BROAD INSTITUTE OF MIT AND HARVARD 177
THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER 178
THERMO FISHER SCIENTIFIC, INC. 178
ZELTIA GROUP 179
CHAPTER 10 APPENDIX 182
GLOSSARY AND ABBREVIATIONS 182

LIST OF TABLES

SUMMARY TABLE GLOBAL REVENUE FOR RNA INTERFERENCE TECHNOLOGIES BY
TYPE, THROUGH 2020 ($ MILLIONS) 8
TABLE 1 EVOLUTION OF RNA 11
TABLE 2 MICRORNA (MIRNA) DATABASES 14
TABLE 3 SHORT/SMALL INTERFERING RNA (SIRNA) DATABASES 15
TABLE 4 PIWI-INTERACTING RNA (PIRNA) DATABASES 17
TABLE 5 STABILIZATION METHODS FOR LIPID BASED SIRNA DELIVERY SYSTEM 24
TABLE 6 NEW DEVELOPMENTS IN THE RESEARCH PIPELINE OF RNAI THERAPEUTICS
AND TECHNOLOGIES AS OF SEPTEMBER 2015 40
TABLE 7 GLOBAL REVENUE FOR RNAI TECHNOLOGIES BY TYPE, THROUGH 2020 ($
MILLIONS) 50
TABLE 8 MARKET SHARE OF RNAI TECHNOLOGIES BY TYPE, 2014 (%) 51
TABLE 9 MODIFICATIONS OF SIRNA 52
TABLE 10 RNAI VECTORS 53
TABLE 11 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS,
THROUGH 2020 ($ MILLIONS) 56
TABLE 12 MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS, 2014 (%) 57
TABLE 13 DISEASE-SPECIFIC TARGET GENES/PROTEINS FOR RNAI THERAPEUTICS 59
TABLE 14 GLOBAL PHARMACEUTICAL MARKET, THROUGH 2020 ($ BILLIONS) 60
TABLE 15 GLOBAL PHARMACEUTICAL MARKET SHARES BY REGION, 2014 (%) 61
TABLE 16 TOP GLOBAL PHARMACEUTICAL COMPANIES BY SALES, 2014 ($ MILLIONS) 62
TABLE 17 GLOBAL OUTLOOK OF THERAPEUTIC SPENDING BY DISEASE, THROUGH
2018 ($ BILLION/%) 69
TABLE 18 NUMBER OF PUBLICATIONS ASSOCIATED WITH MIRNA AND DISEASES,
OCTOBER 2015 73
TABLE 19 MIRNA IN VARIOUS CANCER TYPES 75
TABLE 20 MIRNA AND TARGET GENE PAIRS IN VARIOUS CANCER TYPES 77
TABLE 21 BIOMARKERS IN VARIOUS CANCER TYPES 80
TABLE 22 GLOBAL REVENUE MARKET FOR RNAI DIAGNOSTICS, THROUGH 2020 ($
MILLIONS) 86
TABLE 23 GLOBAL REVENUE FOR MIRNA RESEARCH TOOLS, THROUGH 2020 ($
MILLIONS) 87
TABLE 24 SAFETY ISSUES WITH RNAI CROP IMPROVEMENT 89
TABLE 25 PLANT IMPROVEMENT AREAS THROUGH RNAI TECHNOLOGIES 92
TABLE 26 REGIONS, GENES AND APPLICATION OF RNAI-TARGETING ORGANISMS
FOR IMPROVEMENT OF CROPS 92
TABLE 27 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, THROUGH 2020 ($ MILLIONS) 97
TABLE 28 GLOBAL MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2014 (%) 97
TABLE 29 GLOBAL REVENUE FOR RNAI DIAGNOSTICS BY REGION, THROUGH 2020 ($
MILLIONS) 99
TABLE 30 GLOBAL MARKET SHARE OF RNAI DIAGNOSTICS BY REGION, 2014 (%) 100
TABLE 31 LEADING MANUFACTURERS/SUPPLIERS OF RNAI RESEARCH TOOLS AND
REAGENTS, 2014 102
TABLE 32 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
RESEARCH TOOLS AND REAGENTS, 2014 (%) 108
TABLE 33 LEADING MANUFACTURERS/SUPPLIERS OF RNAI DIAGNOSTICS, 2014 109
TABLE 34 MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
DIAGNOSTICS, 2014 (%) 110
TABLE 35 TOTAL NUMBER OF PATENTS BY YEAR, 2013-AUGUST 2015 113
TABLE 36 NUMBER OF U.S. PATENTS FOR RNAI TECHNOLOGIES BY COUNTRY,
2013-AUGUST 2015 114
TABLE 37 PATENT SHARES FOR RNAI TECHNOLOGIES BY COUNTRY, 2013-AUGUST
2015 (%) 115
TABLE 38 NUMBER OF U.S. PATENTS FOR RNAI TECHNOLOGIES BY COMPANY,
2013-AUGUST 2015 117
TABLE 39 NUMBER OF PATENTS FOR RNAI TECHNOLOGIES BY TYPE OF ASSIGNEE,
2013-AUGUST 2015 120
TABLE 40 FUNDING FOR DEVELOPMENT OF RNAI-BASED PRODUCTS AND
PLATFORMS, 2013-SEPTEMBER 2015 140
TABLE 41 INVESTMENTS FOR DEVELOPMENT OF RNAI-BASED PRODUCTS AND
PLATFORMS, 2013-SEPTEMBER 2015 142

LIST OF FIGURES

SUMMARY FIGURE GLOBAL REVENUE FOR RNA INTERFERENCE TECHNOLOGIES BY
TYPE, 2013-2020 ($ MILLIONS) 8
FIGURE 1 GLOBAL REVENUE FOR RNAI TECHNOLOGIES BY TYPE, 2013-2020 ($
MILLIONS) 50
FIGURE 2 MARKET SHARE OF RNAI TECHNOLOGIES BY TYPE, 2014 (%) 51
FIGURE 3 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS,
2013-2020 ($ MILLIONS) 56
FIGURE 4 MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS, 2014 (%) 57
FIGURE 5 GLOBAL PHARMACEUTICAL SALES MARKET,2013-2020 ($ BILLIONS) 60
FIGURE 6 GLOBAL PHARMACEUTICAL MARKET SHARES BY REGION, 2014 (%) 61
FIGURE 7 GLOBAL REVENUE MARKET FOR RNAI DIAGNOSTICS, 2013-2020 ($
MILLIONS) 86
FIGURE 8 GLOBAL REVENUE FOR MIRNA RESEARCH TOOLS,2013-2020 ($ MILLIONS) 87
FIGURE 9 GLOBAL REVENUE FOR RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2013-2020 ($ MILLIONS) 97
FIGURE 10 GLOBAL MARKET SHARE OF RNAI RESEARCH TOOLS AND REAGENTS BY
REGION, 2014 (%) 98
FIGURE 11 GLOBAL REVENUE FOR RNAI DIAGNOSTICS BY REGION, 2013-2020 ($
MILLIONS) 99
FIGURE 12 GLOBAL MARKET SHARE OF RNAI DIAGNOSTICS BY REGION, 2014 (%) 100
FIGURE 13 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
RESEARCH TOOLS AND REAGENTS, 2014 (%) 109
FIGURE 14 MARKET SHARES OF MANUFACTURERS/SUPPLIERS FOR RNAI
DIAGNOSTICS, 2014 (%) 110
FIGURE 15 TOTAL NUMBER OF PATENTS BY YEAR, 2013-AUGUST 2015 113
FIGURE 16 PATENT SHARES FOR RNAI TECHNOLOGIES BY COUNTRY, 2013-AUGUST
2015 (%) 115
FIGURE 17 NUMBER OF PATENTS FOR RNAI TECHNOLOGIES BY TYPE OF ASSIGNEE,
2013-AUGUST, 2015 120

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