1. Market Research
  2. > Healthcare
  3. > Pathology Market Trends

Competitor Analysis: Janus Kinase (JAK) and spleen tyrosine kinase (syk) Inhibitors

  • November 2013
  • 69 pages
  • La Merie Publishing
Report ID: 1864718

Summary

Table of Contents

Search Inside

Develpment update for new JAK and syk Inhibitors

This Competitive Intelligence Report about new developments in the pipeline of inhibitors of the janus-associated kinase (JAK) and of spleen tyrosine kinase provides a competitor evaluation in the field of active R&D projects from preclinical stages up to marketed JAK and syk Inhibitors as of November 2013. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects. Credentials to access the database will be sent by e-mail and allow online work with the project data to print or export an individual report.


The Janus kinases (JAK) are made up of a family of four cytoplasmic tyrosine kinases—JAK1, JAK2, JAK3, and TYK2—that play pivotal roles in the signaling pathways of many cytokines, hormones, and growth factors. These signaling pathways regulate important physiological processes such as immune response to pathogens, erythropoiesis, and thrombopoiesis. Aberrant signaling of the JAK kinases are thought to lead to numerous diseases, including hematological malignancies, allergies, asthma, and rheumatoid arthritis. The discovery of activating mutations in JAK2 in a majority of patients with myeloproliferative disorders has led to the rapid clinical development of several JAK kinase inhibitors. JAK3 has attracted much attention as an anti-inflammatory drug target because of its restricted hematopoietic tissue expression and because of its specific association with the common gamma chain of the interleukin-2 (IL-2) receptor.


Spleen Tyrosine Kinase (SYK) is an intracellular, non-receptor cytoplasmic protein tyrosine kinase. It serves as a key mediator of Fc and B cell immunoreceptors that produce signals in inflammatory cells including macrophages, neutrophiles, master cells, NK cells and B cells. Immunoreceptors are important for both allergic and antibody-mediated immune diseases; therefore, interfering with SYK positioned upstream within the signaling pathway may be viable as an effective therapeutic target for treating a range of allergic inflammatory diseases that is differentiated from current therapies.


The report includes a compilation of current active projects in research and development of selective JAK and syk inhibitors and of dual- or multi-target JAK inhibitors for the treatment of myeloproliferative disorders such as primar myelofibrosis or polycythemia vera and of psoriasis, rheumatoid arthritis and other inflammatory diseases. In addition, the report lists company-specific pipelines of JAK and syk inhibitors. Competitor projects are listed in a tabular format providing information on:


-Drug Codes,
-Target / Mechanism of Action,
-Class of Compound,
-Company,
-Product Category,
-Indication,
-R&D Stage and
-additional comments with a hyperlink leading to the source of information.


About Competitor Analysis Series:

The Competitor Analysis Series delivers NO-FRILLS, but concise information about the pipeline of R&D projects for targets, diseases, technologies and companies at low prices. The information is provided in a tabular format and fully referenced.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 60 Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
  • Single User License — provides access to the report by one individual.
  • Department License — allows you to share the report with up to 5 users
  • Site License — allows the report to be shared amongst all employees in a defined country
  • Corporate License — allows for complete access, globally.

Veronica helps you find the right report:

Testimonials

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

We were impressed with the support that ReportLinker’s research specialists’ team provided. The report we purchased was useful and provided exactly what we want.

Category Manager at
Ikea

ReportLinker gave access to reliable and useful data while avoiding dispersing resources and spending too much time on unnecessary research.

Executive Director at
PwC Advisory

The customer service was fast, responsive, and 100% professional in all my dealings (...) If we have more research needs, I'll certainly prioritize working with ReportLinker!

Scott Griffith

Vice President Marketing at
Maurice Sporting Goods

The research specialist provided prompt, helpful instructions for accessing ReportLinker's product. He also followed up to make sure everything went smoothly and to ensure an easy transition to the next stage of my research

Jessica P Huffman

Research Associate at
American Transportation Research Institute

Excellent customer service. Very responsive and fast.

Director, Corporate Strategy at
Ingredion

I reached out to ReportLinker for a detailed market study on the Air Treatment industry. The quality of the report, the research specialist’s willingness to solve my queries exceeded my expectations. I would definitely recommend ReportLinker for in-depth industry information.

Mariana Mendoza

Global Platform Senior Manager at
Whirlpool Corporation

Thanks! I like what you've provided and will certainly come back if I need to do further research works.

Bee Hin Png

CEO at
LDR Pte Ltd

The research specialist advised us on the best content for our needs and provided a great report and follow-up, thanks very much we shall look at ReportLinker in the future.

Kate Merrick

Global Marketing Manager at
Eurotherm by Schneider Electric

Purchase Reports From Reputable Market Research Publishers

Infectious Disease Testing Market 2021: A 74-Country Analysis--Supplier Shares and Strategies, Test Volume and Sales Segment Forecasts, Technology and Instrumentation Review

  • $ 59500
  • Industry report
  • May 2017
  • by Venture Planning Group

This unique 68-country survey from VPGMarketResearch.com provides data and analysis not available from any other published source. The survey is designed to assist diagnostics industry executives, as well ...

Virology and Bacteriology Testing Market 2021: A 68-Country Analysis--Supplier Shares and Strategies, Test Volume and Sales Segment Forecasts, Technology and Instrumentation Review

  • $ 59500
  • Industry report
  • June 2017
  • by Venture Planning Group

This unique 68-country survey from VPGMarketResearch.com provides data and analysis not available from any other published source. The survey is designed to assist diagnostics industry executives, as well ...

Automated Microbiology Market 2021: A 68-Country Analysis--Supplier Shares and Strategies, Volume and Sales Segment Forecasts for 100 Molecular Diagnostic, Microbial Identification

  • $ 52500
  • Industry report
  • June 2017
  • by Venture Planning Group

This new 74-country survey from VPGMarketResearch.com provides granular data and analysis not available from any other published source. The survey is designed to help current suppliers and potential market ...


ref:plp2013

Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.