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  4. > 2014 Analysis of the German Molecular Diagnostics Market Outlook: Innovations, Trends and Opportunities for Suppliers

This report presents a comprehensive analysis of the German molecular diagnostics market, including:
Major issues pertaining to the German molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
Ten-year test volume and reagent sales forecasts for the following categories:
- Infectious Diseases
- Genetic Diseases
- Cancer
- Paternity Testing/HLA Typing
- Forensic Testing

Review of testing methodologies an instrumentation technologies.
Feature comparison of automated and semiautomated analyzers.
Sales and market shares of leading suppliers.
Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
Alternative market penetration strategies.
Potential market entry barriers and risks.
Business planning issues and concerns.
Contains 850 pages and 36 tables

Table Of Contents

2014 Analysis of the German Molecular Diagnostics Market Outlook: Innovations, Trends and Opportunities for Suppliers
Introduction
Worldwide Market And Technology Overview
A. DNA Sequencing
1. Introduction
2. Sequencing Methods
3. Autoradiography
4. The Human Genome Project
5. Sequencing Automation
6. Image Scanners
7. Fluorescent Detection
8. Gene Profiling
9. Gene Expression
10. Polymorphism Screening
11. Protein Interaction Networks
B. DNA And RNA Probe Technology
1. Basic Principles
2. Probe Preparation
3. The DNA Probe Test
a. Sample Preparation
b. Hybridization
c. Separation
d. Detection/Measurement
4. Test Formats
a. Filter Hybridization
b. Southern Blot
c. Northern Blot
d. In Situ Hybridization
e. Others
5. Labeling Techniques
6. Amplification Methods
O Polymerase Chain Reaction
- Temperature Cyclers
- PCR Variations
* Immuno-PCR
* QC-PCR
* DAP-PCR
O Strand Displacement Activation
O TMA
O Ligase Chain Reaction
O Branched DNA
- Hybridization Protection Assay
O Nucleic-Acid Sequence-Based Amplification
O Self-Sustained Sequence Replicase
O Others
- Ampliprobe
- CAR
- CAS
- CPT
- Dendritic Polymer Technology
- ISO-CR
- LAT
- Probe Networks
- RAMP
- Repair Chain Reaction
- Rolling Circles
- Sequence Independent Gene Amplification
- Sequence Initiation Reaction
- SISPA
- Solid Phase Amplification
C. Detection Technologies
1. Radioactive Methods
a. Overview
b. Major Isotopes
O P-32
O S-35
O H-3
O I-125
2. Non-Isotopic Methods
a. Enzymatic Labels
b. Chemical Labeling
O Indirect Chemical Labeling
O Direct Chemical Labeling
c. Fluorescence
d. Chemiluminescence
e. Electrical Conductivity
D. Instrumentation Review
1. Abbott LCx
2. Beckman Coulter/Biomek FK
3. Becton Dickinson SDA
4. Bio-Rad GeneScope
5. Gen-Probe Tigris
6. Roche Cobas Amplicor
7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and
Labs-on-the-Chip
- Liquid Transportation and Mixing
- Separation
- Reaction
- Detection
F. Pharmacogenomics
G. Major Applications
1. Microbiology/Infectious Diseases
a. Overview
b. Major Infectious Diseases
* AIDS
O Structure and Composition
O Classification
O AIDS Origins
O Animal Lentivirus Systems
O Virus Receptors
O HIV Infections in Humans
- Pathogenesis and Pathology
O CD4T Lymphocytes and Memory Cells
O Monocytes and Macrophages
O Lymphoid Organs
O Neural Cells
O Viral Coinfections
- Clinical Findings
O Plasma Viral Load

O Pediatric AIDS
- Neurologic Disease
- Opportunistic Infections
- Cancer
O Immunity
- Virus Isolation
- Serology
- Viral Nucleic Acid/Antigen Detection
O Epidemiology
- Worldwide Spread of AIDS
- United States
- Routes of Transmission
O DNA Probes
- Overview
- Quantitative PCR
- In Situ PCR
- Needed Improvements
O Viral Load/Drug Resistance Testing
O Genotype and Phenotype Testing
O Blood Banking Considerations
* Adenovirus
O Background
O Diagnostic Tests
O Vaccines and Drugs
O Adeno-Associated Viruses (AAV)
* Anthrax/Bacillus Anthracis
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Babesiosis
O Background
* BEA and Other Bartonella Diseases
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Chagas Disease
O Background
* Campylobacter
O Background
O Diagnostic Tests
- Culture Identification
O Vaccines and Drugs
* Chlamydia
O Background
- Chlamydia psittaci
- Chlmaydia pneumoniae
- Chlamydia trachomatis
O Diagnostic Tests
O Vaccines and Drugs
* Creutzfeldt-Jakob's Disease
O Background
O Blood Transmission
O Diagnostic Tests
O Major Commercial and Academic Players
- Bayer
- Disease Sciences/Bio Tec Global
- Imperial College School of Medicine
- Ortho-Clinical Diagnostics
- Pall
- ProMetic Life Sciences
- Proteome Sciences/Idexx
- Q-One Biotech
- Serono
- U.S. Agricultural Research Service
O Drugs
O Vaccines
* Cytomegalovirus
O Background
- Chorioretinitis
- Gastrointestinal
- Central Nervous System Disease
O Diagnostic Tests
O Vaccines and Drugs
* Ebola Virus
O Background
- Epidemiology
- Clinical Syndromes
O Diagnostic Tests
O Vaccines and Drugs
* EchoVirus
O Background
- Acute Aseptic Meningitisis
- Encephalitis
- Exanthems
- Respiratory Disease
- Myopericarditis
- Neonatal Infections
O Diagnostic Tests
O Vaccines and Drugs
* Encephalitis
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Enteroviruses
O Background
O Diagnostic Tests
- Viral Isolation and Identification
- Antibody Tests
O Vaccines and Drugs
* Epstein-Barr Virus
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Gonorrhea
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Hepatitis
O Hepatitis A
O Hepatitis B
- Structure and Composition
- Replication
O Hepatitis C
O Hepatitis D (Delta)
O Hepatitis E
O Hepatitis G
O Hepatitis Infections Pathology
O Clinical Findings
O Laboratory Tests
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
O Virus-Host Immune Reactions
O Epidemiology
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D (Delta)
O Vaccines and Drugs
* Herpes Simplex Virus
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Legionella
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Lyme Disease
O Background
- Clinical Description
- Clinical Case Definition
- Laboratory Criteria for Diagnosis
- Case Classification
O Diagnostic Tests
O Vaccines and Drugs
* Malaria
* Mycoplasma
O Background
- Ureaplasma Urealyticum and Mycoplasma
Hominis
O Diagnostic Tests
O Vaccines and Drugs
* Papillomaviruses/HPV
O Background
- HPV in Cancer
- Cervical Neoplasm
O Diagnostic Tests
O Vaccines and Drugs
- Prevention
* Parvovirus B19
O Background
- Microbiology
- Epidemiology
- Clinical Syndromes
- Erythema Infectiosum (Slapped Cheek)
- Adult Polyarthropathy
- Transient Aplastic Crisis
- Transient Pancytopenia
- Red Cell Aplasia in Immunocompromised
- Perinatal Infections
O Diagnostic Test
O Vaccines and Drugs
* Pneumonia
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Polyomaviruses
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Salmonellosis
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Shigellosis
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Streptococci
O Background
O Diagnostic Tests
O Vaccines and Drugs
- Group A Streptococci
- Group B Streptococci
* Toxoplasmosis
O Background
O Diagnostic Tests
O Vaccines and Drugs
* Tuberculosis
O Background
O Diagnostic Tests
- Microscopic Characteristics
- Cultural Characteristics
- Skin Tests
- MDRTB
O Vaccines and Drugs
* West Nile Virus
O Background
- Clinical Syndromes
O Diagnostic Tests
O Vaccines and Drugs
* Yersinia
O Background
O Diagnostic Tests
O Vaccines and Drugs
c. Antibiotic Susceptibility
2. Cancer Testing
a. Overview
b. Major Cancer Types
* Prostate
* Lung
* Colon and Rectum
* Breast
* Skin
* Uterine
* Leukemia
* Oral
c. Oncogenes
O Abl/abl-bcr
O AIB1
O BCL-2
O BRCA1
O CD44
O C-fos
O C-myb
O C-myc
O CYP17
O Erb-B
O HPC1
O N-myc
O P40
O P51
O P53
O PIK3CA
O PTI-1
O Ras
O Reg
O Sis
O Src
3. Genetic Diseases
a. Overview
b. Nucleic Acid Amplification
c. Chromosome Imaging
d. Genomics Technologies
e. Proteomics Technologies
f. Current Pharmacogenomic Tests
g. Future Pharmacogenomic Testing
h. Major Diseases
* Achondroplasia
* Autosomal Dominant Polycystic Kidney
Disease
* Cancer
* Cosmetogenomics
* Cystic Fibrosis
* Down's Syndrome
* Duchenne and Becker Muscular Dystrophy
* Factor V (Leiden)
* Factor IX Deficiency
* Fragile X Syndrome
* Heart Disease
* Hemochomatosis
* Hemophilia
* Huntington's Disease
* Maternal-Fetal Incompatibility
* Multiple Endocrine Neoplasia
* Phenylketonuria (PKU)
* Polycystic Kidney Disease (PKD)
* Prenatal Screening
* Retinitis Pigmentosa
* Retinoblastoma
* Sickle Cell Anemia
* Spinal Muscular Atrophy
* Vitamin B12 Metabolism
i. Social Issues and Concerns
4. Forensic Testing
a. Overview
b. Multilocus and Single Locus Probes
* Multilocus Probes
* Single Locus Probes
* PCR and RFLP
c. The FBI
d. DNA Profile Data Banks
* U.S.A.
* U.K.
e. Judicial Implementation
f. Major Crime Categories
g. Factors Contributing to the DNA Probe
Market Expansion
* Technology Availability
* Use of Hair as Evidence
h. Wildlife Forensics
5. Paternity Testing/HLA Typing
6. Other Applications
a. Disease Susceptibility Testing
b. Cardiovascular Diseases
c. Diabetes
d. Alzheimer's Disease
e. Periodontal Disease
f. Plasma Purification
g. Organ Transplantation
h. Water Contamination
i. Other
H. Competing/complementing Technologies
1. Monoclonal Antibodies/Immunoassays
2. RNA Probes
3. Two-Dimensional Electrophoresis
4. Flow Cytometry

Germany
A. Executive Summary
B. Business Environment
C. Market Structure
D. Market Size, Growth And Major Suppliers'
Sales And Market Shares
Major Product Development Opportunities
A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products
Design Criteria For Decentralized Testing Products
Alternative Market Penetration Strategies
A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing
Markets
1. Marketing Approaches
2. Product Complexity
3. Customer Preference
4. Established Suppliers
5. Emerging Suppliers
6. Major Types Of Distributors
7. Market Segmentation
Potential Market Entry Barriers And Risks
A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

Competitive Profiles

- Abbott
- Affymetrix
- Agilent
- Applied Gene Technologies
- Arca
- Beckman Coulter/Danaher
- Becton Dickinson
- Biokit
- BioMerieux
- Bio-Rad
- Biotest
- Caliper
- Cepheid
- Decode
- Diadexus
- Eiken
- Enzo
- Exact Sciences
- Fujirebio
- Gen-Probe
- Hologic
- Illumina
- Innogenetics/Solvay
- Kreatech
- Li-Cor Biosciences
- Life Technologies
- Monogram Biosciences
- Myriad Genetics
- Nanogen/Elitech
- Novartis
- Orchid CellMark
- Ortho-Clinical Diagnostics
- Proteome Sciences
- Qiagen
- Roche
- Scienion
- Sequenom
- Shimadzu
- Siemens
- Sierra Molecular
- Takara Bio
- Tecan Group
Appendixes
Appendix I: Major Universities and Research Centers
Developing Molecular Diagnostic
Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

List of Tables

Major Companies Developing or Marketing AIDS Molecular
Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Campylobacter
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Chlamydia
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing CMV Molecular
Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular
Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Hepatitis
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Herpes
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Legionella
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Lyme
Disease Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Mycoplasma
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Papilloma
Virus Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Pneumonia
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Salmonella
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Shigella
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Streptococci
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Toxoplasmosis
Molecular Diagnostic And Other Direct
Identification Tests
Major Companies Developing or Marketing Tuberculosis
Molecular Diagnostic And Other Direct
Identification Tests
Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer
Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular
Diagnostic Test For Genetic Diseases
Summary Table Germany, Molecular Diagnostics Test Volume
And Sales Forecast by Major Application
Germany, Laboratories Performing
DNA Sequencing by Market Segment
Germany, Molecular Diagnostics Market
Potential Laboratory Universe by Market Segment
Germany, Molecular Diagnostics Test Volume Forecast
By Major Application
Germany, Major Infectious Disease Molecular
Diagnostics Test Volume Forecast
Germany, Infectious Disease Screening
NAT Volume Forecast
Germany, Molecular Diagnostics Market Forecast
By Major Application
Germany, Infectious Disease Screening
NAT Reagent Market Forecast by Test
Germany, Molecular Diagnostics
Market by Major Supplier
Germany, HIV/Hepatitis NAT Market Reagent
Sales by Major Supplier

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