1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends
  4. > Physician Views: What is reaction among urologists, oncologists to the Xtandi PREVAIL data – can it displace Zytiga in the pre-chemotherapy prostate cancer setting?

Scope of the Report

The prostate cancer market looks poised to enter its next stage of evolution in 2014, with Medivation and Astellas expected to seek approval for their androgen receptor antagonist Xtandi (enzalutamide) for the treatment of castrate-resistant prostate cancer (CRPC) patients in the pre-chemotherapy setting.

Johnson & Johnson's Zytiga (abiraterone) – which was approved for pre-chemotherapy usage in December last year – has demonstrated that a notable commercial opportunity exists for treatment of prostate cancer at this stage. Indeed, some analysts believe that the pre-chemotherapy market could be worth up to $5 billion in the US alone.

Furthermore, initial key opinion leader (KOL) feedback in response to top-line data from Medivation's PREVAIL study – which was released last week – would appear to suggest that Xtandi may emerge as the therapy of choice in pre-chemotherapy patients. See In Focus – Will PREVAIL data allow Medivation's Xtandi to overtake Johnson & Johnson's Zytiga in the pre-chemotherapy prostate cancer market?

Approval for the treatment of pre-chemotherapy patients is expected to significantly increase the use of Xtandi among urologists (in addition to oncologists). This population of physicians will be keen to use Xtandi, not only given its impressive overall survival (OS) and disease progression data, note KOLs, but its greater convenience; such as the lack of requirement to dose with steroids.

In addition, Xtandi's status as an androgen receptor antagonist (a familiar drug class among urologists) may prove to be useful in driving longer-term use in even earlier lines of therapy – a strategy that Johnson & Johnson is also pursuing for their next-generation prostate cancer treatment ARN-509, which was acquired from Aragon Pharmaceuticals earlier this year for a cost of up to $1 billion.

Reasons to Buy this Report

This week's Physician Views poll will look to assess whether initial KOL and analyst reaction to the top-line PREVAIL data is shared by the broader urologist and oncologist populations. FirstWord is polling urologists and oncologists based in both the US and EU5 with the following questions:
• What percentage of castrate-resistant prostate cancer patients do you currently treat in the pre-chemotherapy setting with abiraterone (Zytiga)?
• Based on top-line data from the PREVAIL study, and assuming enzalutamide (Xtandi) is approved for the treatment of castrate-resistant prostate cancer in the pre-chemotherapy setting, to what percentage of new pre-chemotherapy patients would you prescribe the drug once approved?
• Based on data from the PREVAIL study, to what percentage of new pre-chemotherapy patients do you expect to prescribe enzalutamide (Xtandi) to on an off-label basis prior to approval?
• What characteristic would most influence you to prescribe enzalutamide (Xtandi) in favour of abiraterone (Zytiga) in the pre-chemotherapy setting?
• Based on enzalutamide's mechanism of action (androgen receptor antagonist), how comfortable would you be in prescribing the drug on an off-label basis in the hormone ablation setting?


Table Of Contents

Physician Views: What is reaction among urologists, oncologists to the Xtandi PREVAIL data - can it displace Zytiga in the pre-chemotherapy prostate cancer setting?

View This Report »

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 24 Million searchable statistics with tables, figures & datasets
  • More than 10,000 trusted sources
24/7 Customer Support

Talk to Amrita

+1 718 303 2019

Purchase Reports From Reputable Market Research Publishers
PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025

PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025

  • $ 10995
  • Industry report
  • August 2016
  • by Global Data

PharmaPoint: Acute Coronary Syndrome - Global Drug Forecast and Market Analysis to 2025 Summary Cardiovascular diseases (CVD), including ischemic heart disease and stroke, are the leading causes of mortality ...

PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024

PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024

  • $ 10995
  • Industry report
  • September 2016
  • by Global Data

PharmaPoint: Attention Deficit Hyperactivity Disorder (ADHD) - Global Drug Forecast and Market Analysis to 2024 Summary Attention deficit hyperactivity disorder (ADHD) is characterized by excessive levels ...

Ulcerative Colitis: KOL Insight

Ulcerative Colitis: KOL Insight

  • $ 8085
  • Industry report
  • September 2016
  • by Firstword Pharma

Are UC biosimilars a real or perceived threat to branded drugs? Ulcerative colitis (UC) treatment is on the brink. Patents are ending on various branded drugs and clearing the way for an influx of biosimilars; ...

Hepatitis C: Kol Insight

September 2016 $ 8085

Download Unlimited Documents from Trusted Public Sources

Anti-Infective Market in Tanzania

  • December 2016
    9 pages
  • Anti-Infective  

  • Tanzania  

    Africa  

View report >

Opioid Market in Iran

  • December 2016
    8 pages
  • Opioid  

  • Iran  

View report >

Therapy and Hormone Market in South Korea

  • December 2016
    4 pages
  • Therapy  

    Hormone  

    Cancer  

  • South Korea  

View report >

Related Market Segments :

Therapy
Hormone
Chemotherapy
Prostate Cancer

ref:plp2013

Reportlinker.com © Copyright 2016. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.