1. Market Research
  2. > Pharmaceutical
  3. > Therapy Market Trends
  4. > Influence of Antibody Attributes on Clinical Success – A Technology and Coporate Benchmark Analysis

Influence of Antibody Attributes on Clinical Success – A Technology and Coporate Benchmark Analysis

  • March 2013
  • -
  • La Merie Publishing
  • -
  • 88 pages

Summary

Table of Contents

Search Inside

How do antibody characteristics impact clinical success?

The analytical report „Influence of Antibody Attributes on Clinical Success – A Technology and Coporate Benchmark Analysis“ evaluates the impact of a number of antibody attributes on the success rate of antibodies in clinical development. Among the antibody attributes studied  in this investigation are antibody generation technology, animal species of the parental antibody, antibody format, immunoglobulin class and isotype, target, and therapeutic area. Information from more than 500 naked recombinant monoclonal antibodies was used for this research. Antibodies which failed in clinical development were further analyzed for the reason of failure and phase in which they were discontinued. Biotech and pharmaceutical companies with a significant R&D portfolio of therapeutic antibodies were benchmarked for their antibody success rate in development and the underlying antibody attributes contributing to success.

Specific antibody attributes evaluated for their influence on success in clinical development in this research study are:

- In vitro antibody generation technologies: display technologies from CAT, Dyax, Morphosys, BioInvent, Domantis, Genentech, others;
- In vivo antibody generation technologies: chimeric, primatized, nanobodies, deimmunized, human engineered, humaneered, humanized, XenoMouse, HuMab mouse, KM mouse, VelocImmune mouse, human B-cell derived;
- Animal species of parental wild-type antibody: mouse, rat, rabbit, hamster, cynomolgus monkey, camelid;
- Target;
- Immunoglobulin (Ig) class;
- IgG isotype;
- Therapeutic area of lead indication.

When discovering a new monoclonal antibody, researchers have a number of choices to make regarding antibody generation technologies as well as antibody format and immunoglobulin isotpye among other attributes. One of the basic controversies in selecting the antibody generation technolgoy is the question whether antibodies generated in vitro by display technologies are really equivalent to those generated in vivo by a competent immune system.

Typical questions in antibody R&D are:

- When selecting an in vivo system for antibody generation, are conventional in vivo systems with an animal immune system and subsequent chimerization or humanization creating the same as „modern“ transgenic animals? 
- Are full length antibodies more successful than modern engineered nanobodies, scFv molecules or even domain antibodies?
- Do companies have different success rates in their antibody development portfolio?
- And, if yes, are they using different technologies than their peers which could explain the difference?
- Is there a different success rate of antibodies against the same target based on generation technologies or other attributes?
- Are there therapeutic areas with higher likelihood of successful development of antibodies than others?
- What are the main reasons for antibody failure in clinical development?
- In which phase do antibodies typically fail?

This analytical report will give you answers for many of these questions. The results of the analysis show

- whether and how antibody generation technologies differently impact clinical success;
- why and when antibodies fail;
- how target selection influences clinical success;
- if antibody format, class and isotype is relevant for development success;
- the antibody success rate of therapeutic areas;
- which companies are the most successful and which antibody attributes they prefer.

Get Industry Insights. Simply.

  • Latest reports & slideshows with insights from top research analysts
  • 60 Million searchable statistics with tables, figures & datasets
  • More than 25,000 trusted sources
Get This Report
24/7 Customer Support

Talk to Veronica

+1 718 514 2762

Purchase Reports From Reputable Market Research Publishers
Infectious Disease Drugs: The Chinese Market

Infectious Disease Drugs: The Chinese Market

  • $ 6650
  • Industry report
  • March 2017
  • by BCC Research

Use this report to: - Assess market dynamics of Chinese market for both communicable and - non-communicable infectious disease drugs, their opportunities and restraints. - Evaluate Chinese drug market ...

Global Antibacterial Drugs Market to 2022 - Vaccines Retain Market Prominence While Pipeline Offers Innovative Approaches to Tackling Antimicrobial Resistance

Global Antibacterial Drugs Market to 2022 - Vaccines Retain Market Prominence While Pipeline Offers Innovative Approaches to Tackling Antimicrobial Resistance

  • $ 4995
  • Industry report
  • January 2017
  • by GBI Research

Global Antibacterial Drugs Market to 2022 - Vaccines Retain Market Prominence While Pipeline Offers Innovative Approaches to Tackling Antimicrobial Resistance Summary The antibacterial drug market covers ...

Global Respiratory Complications Therapeutics Market to 2022 - Innovative Pneumonia and Pulmonary Arterial Hypertension Therapies Dominate Varied Disease Market

Global Respiratory Complications Therapeutics Market to 2022 - Innovative Pneumonia and Pulmonary Arterial Hypertension Therapies Dominate Varied Disease Market

  • $ 4995
  • Industry report
  • March 2017
  • by GBI Research

Global Respiratory Complications Therapeutics Market to 2022 - Innovative Pneumonia and Pulmonary Arterial Hypertension Therapies Dominate Varied Disease Market Summary Respiratory complications are a ...


Download Unlimited Documents from Trusted Public Sources

Anti-Infective Market in the Netherlands and Germany

  • April 2017
    10 pages
  • Anti-Infective  

  • Netherlands  

    Germany  

    Europe  

View report >

Anti-Infective Market in the UK

  • April 2017
    11 pages
  • Anti-Infective  

    Point Of Care T...  

    Hospital  

  • United Kingdom  

View report >

Anti-Infective Market in the US - Forecast

  • April 2017
    4 pages
  • Anti-Infective  

  • United States  

View report >

Related Market Segments :

Anti-Infective

ref:plp2013

Reportlinker.com © Copyright 2017. All rights reserved.

ReportLinker simplifies how Analysts and Decision Makers get industry data for their business.