EpiCast Report: Bladder Cancer - Epidemiology Forecast to 2022

Summary

With more than 12 million new cases occurring worldwide each year, bladder cancer is estimated to be the ninth most common cancer, and the thirteenth most numerous cause of death from cancer (Parkin, 2008; Ploeg et al., 2009). The major risk factors for bladder cancer are exposure to smoking and occupational risk factors such as exposure to aromatic amines. These risk factors are more prevalent among men, which makes the disease the seventh most common cancer in men, whereas it is the seventeenth most common cancer in women (Ploeg et al., 2009). The majority of bladder cancer cases are among older individuals with the median age at diagnosis being 73 years; because of this, the comorbidities associated with bladder cancer are similar to conditions typically occurring in older age and therefore, are not specific to bladder cancer (Prout et al., 2005).


By 2022, GlobalData epidemiologists forecast that the 6MM are expected to have 199,691 incident cases of bladder cancer, representing a 22.2% increase from the number of incident cases in 2012 (163,380 incident cases). In 2012, the 6MM had 575,251 five-year prevalent cases of bladder cancer and GlobalData epidemiologists forecast that by 2022, this number will grow to 703,227 five-year prevalent cases at an Annual Growth Rate (AGR) of 2.22%.

This forecast is supported by at least 10 years of historical data obtained from country-specific studies published by the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC), the National Cancer Institute’s (NCI) Surveillance, Epidemiology, and End Results (SEER) Program, and the European Cancer Registry’s fourth database registry (EUROCARE-4). The IARC’s Cancer Incidence in Five Continents (CI-5) Plus data are the gold standard for country-level comparative analysis and was used to provide detailed case segmentation for each country by age and sex. Another major strength of this analysis is that GlobalData epidemiologists were able to forecast incident cases of bladder cancer in the 6MM by age, sex, and stage at diagnosis. Furthermore, the forecast methodology was also consistent across all markets, thereby allowing for a meaningful global comparison.

Scope

- The Bladder Cancer EpiCast Report provides an overview of the risk factors and global trends of bladder cancer in the 6MM (US, France, Germany, Italy, Spain, and UK). It includes a 10-year epidemiological forecast for the incident cases of bladder cancer segmented by sex, age (in five-year age groups beginning at 15 years and ending at 75 years and older), and cancer stage at diagnosis (in situ, local, regional, distant, and unstaged), in addition to five-year prevalent cases in these markets.
- The bladder cancer epidemiology report is written and developed by Masters- and PhD-level epidemiologists.
- The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 7MM.

Reasons to buy

- Develop business strategies by understanding the trends shaping and driving the global bladder cancer market.
- Quantify patient populations in the global bladder cancer market to improve product design, pricing, and launch plans.
- Organize sales and marketing efforts by identifying the sex and age groups that present the best opportunities for bladder cancer therapeutics in each of the markets covered.

Table Of Contents

Table of Contents

1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 6
2 Introduction 7
2.1 Catalyst 7
2.2 Upcoming Reports 7
3 Epidemiology 8
3.1 Disease Background 8
3.2 Risk Factors and Comorbidities 8
3.2.1 Smoking is the most significant risk factor for bladder cancer 9
3.2.2 Up to 25% of male bladder cancer cases are due to occupational exposure to aromatic amines 10
3.3 Global Trends 10
3.3.1 Incidence, Mortality, and Five-Year Prevalence 11
3.3.2 Relative Survival 13
3.3.3 Disability-Adjusted Life Years (DALYs) and Years of Life Lost (YLLs) 13
3.4 Forecast Methodology 14
3.4.1 Sources Used 14
3.4.2 Sources Not Used 16
3.4.3 Forecast Assumptions and Methods 17
3.5 Epidemiological Forecast for Bladder Cancer (2012-2022) 19
3.5.1 Incident Cases of Bladder Cancer 19
3.5.2 Age-Specific Incident Cases of Bladder Cancer 20
3.5.3 Sex-Specific Incident Cases of Bladder Cancer 22
3.5.4 Age-Standardized Incidence Rates of Bladder Cancer 23
3.5.5 Incident Cases of Bladder Cancer by Stage at Diagnosis 24
3.5.6 Five-Year Prevalent Cases of Bladder Cancer 26
3.6 Discussion 27
3.6.1 Epidemiological Forecast Insight 27
3.6.2 Limitations of the Analysis 28
3.6.3 Strengths of the Analysis 29
4 Appendix 30
4.1 Bibliography 30
4.2 About the Authors 32
4.2.1 Epidemiologists 32
4.2.2 Reviewers 32
4.2.3 Global Director of Epidemiology and Health Policy 33
4.2.4 Global Head of Healthcare 34
4.3 About GlobalData 35
4.4 About EpiCast 35
4.5 Disclaimer 36



List of Tables

Table 1: Bladder Cancer Risk Factors 9
Table 2: 6MM, GLOBOCAN Incidence, Five-Year Prevalence, and Mortality of Bladder Cancer, Ages ?15 Years, Men and Women, 2008 12
Table 3: 6MM, Relative Survival of Bladder Cancer (%), Men and Women 13
Table 4: 6MM, GLOBOCAN Disability-Adjusted Life Years (DALYs) and Years of Life Lost (YLLs) Due to Bladder Cancer, Men and Women, N, 2008 13
Table 5: 6MM, Sources of Bladder Cancer Incidence Data 14
Table 6: 6MM, Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, Select Years 2012-2022 19
Table 7: 6MM, Age-Specific Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N (Row %), 2012 21
Table 8: 6MM, Sex-Specific Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N (Row %), 2012 22
Table 9: 6MM, Incident Cases of Bladder Cancer by Stage at Diagnosis, Ages ?15 Years, Men and Women, N (Row %), 2012 25
Table 10: 6MM, Five-Year Prevalent Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, Select Years 2012-2022 26



List of Figures

Figure 1: 6MM, Incidence Rates of Bladder Cancer, Ages ?15 Years, Men, Rate per 100,000 Population, 1993-2002 11
Figure 2: 6MM, Incidence Rates of Bladder Cancer, Ages ?15 Years, Women, Rate per 100,000 Population, 1993-2002 12
Figure 3: 6MM, Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, Select Years 2012-2022 20
Figure 4: 6MM, Age-Specific Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, 2012 21
Figure 5: 6MM, Sex-Specific Incident Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, 2012 23
Figure 6: 6MM, Age-Standardized Bladder Cancer Incidence, Ages ?15 Years, Men and Women, Cases per 100,000 Population, 2012 24
Figure 7: 6MM, Incident Cases of Bladder Cancer by Stage at Diagnosis, Ages ?15 Years, Men and Women, N, 2012 25
Figure 8: 6MM, Five-Year Prevalent Cases of Bladder Cancer, Ages ?15 Years, Men and Women, N, 2012-2022 27

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