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Global qPCR and dPCR Instrumentation Industry

  • February 2015
  • -
  • Global Industry Analysts
  • -
  • 288 pages

This report analyzes the worldwide markets for qPCR and dPCR Instrumentation in US$ Thousands by the following Product Segments: qPCR (quantitative Polymerase Chain Reaction), and dPCR (digital Polymerase Chain Reaction). Also, the report analyzes the following End-Uses: Educational/Research, Testing Laboratories, Pharmaceuticals. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East & Africa, and Latin America. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a four-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 41 companies including many key and niche players such as -

Agilent Technologies, Inc.
Becton, Dickinson and Company
BioFire Diagnostics, Inc.
Bio-Rad Laboratories, Inc.
Cepheid

Table Of Contents

Global qPCR and dPCR Instrumentation Industry



I. INTRODUCTION, METHODOLOGY and PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation and Reporting Level I-2
Quantitative Techniques and Analytics I-3
Product Definitions and Scope of the Study I-3
qPCR I-4
dPCR I-4


II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Polymerase Chain Reaction (PCR): An Integral Part of Gene
Amplification and Quantification II-1
Striking the Right Balance between qPCR and dPCR in Research
Laboratories II-2
qPCR- A Suitable Tool for Gene Expression and Validation II-2
Select qPCR Systems Available in Marketplace II-3
Thermo Fisher Life Sciences Prism 7000 Series II-3
Thermo Fisher Life Sciences ViiA 7 II-3
Thermo Fisher Life Sciences QuantStudio II-3
Cepheid SmartCycler Platform II-3
Roche LightCycler Platform II-4
Roche FLOW II-4
As qPCR Technology Matures, Saturation is Imminent II-4
Table 1: Global qPCR Instrumentation Market by Category
(2014): Percentage Share Breakdown of Annual Revenues for
Reagents and Instruments (includes corresponding
Graph/Chart) II-5
Digital PCR Holds Potential to Take Quantification of Nucleic
Acids to the Next Level II-5
Despite Onslaught of Digital PCR, qPCR Maintains Relevance II-6
dPCR - A Valuable Tool in Virology Research II-6
High Sensitivity in Viral Detection II-6
Table 2: World PCR Market for Clinical Diagnosis of
Infectious Diseases by Type of Disease (2014): Percentage
Market Share Breakdown for Hepatitis B and Hepatitis C Test,
Tuberculosis Diagnosis, HIV Diagnosis, and Others (includes
corresponding Graph/Chart) II-7

Table 3: Worldwide PCR Market for Clinical Diagnosis of
Non-Infectious Diseases by Type of Disease (2014):
Percentage Market Share Breakdown for Hepatitis B and
Hepatitis C Test, Tuberculosis Diagnosis, HIV Diagnosis, and
Others (includes corresponding Graph/Chart) II-7
Creation and Validation of Viral Reference Standards II-7
High-Precision Quantification II-8
Digital PCR Sales to Skyrocket in the Near Term II-8
New dPCR Systems to Capture a Bigger Slice of the Overall PCR
Market II-8
Table 4: Leading dPCR Systems at a Glance II-9
QuantStudio 3D Digital PCR System II-9
QuantStudio 12K II-9
BioMark HD system II-10
QX100 droplet digital PCR System II-10
RainDrop Systems II-10
High Installation Cost Remains a Roadblock to Widespread
Adoption of dPCR II-10
Table 5: Price Range of Select PCR Equipment of Thermo Fisher
Life Sciences Solutions II-11

2. GROWTH DRIVERS, MARKET TRENDS and ISSUES II-12
Increasing Incidence and Prevalence of Cancer: A Grim Reality
Driving Demand for qPCR and dPCR II-12
Table 6: Worldwide Incidence of Cancer (2013, 2020 and 2030):
Number of New Cases Diagnosed (includes corresponding
Graph/Chart) II-12

Table 7: New Cancer Cases in the World by Affected Site: 2012
(in Thousands) (includes corresponding Graph/Chart) II-13

Table 8: Global Cancer Incidence by Income Group: 2012 (in
Thousands) (includes corresponding Graph/Chart) II-13

Table 9: Cancer Incidence in High Income Countries by Site:
2012 (in Thousands) (includes corresponding Graph/Chart) II-14

Table 10: Cancer Incidence in Upper Middle Income Countries
by Site: 2012 (in Thousands) (includes corresponding
Graph/Chart) II-15

Table 11: Cancer Incidence in Lower Middle Income Countries
by Site: 2012 (in Thousands) (includes corresponding
Graph/Chart) II-16

Table 12: Cancer Incidence in Low Income Countries by Site:
2012 (in Thousands) (includes corresponding Graph/Chart) II-17
Improving Healthcare Expenditure to Drive Demand for qPCR and
dPCR-based Tests II-17
Table 13: Per-Capita Healthcare Expenditure in Select
Regions: 2014E (includes corresponding Graph/Chart) II-18
Progress in Human Genome Project and Molecular Diagnostics
Spur Demand for the Gene Amplification Technologies II-18
Prospects for Predictive Genetic Diagnostics and Testing Grow
Brighter II-19
Expanding Scope of Applications in Applied Sciences Drive
Demand for qPCR Instruments and Supplies II-19
qPCR and NGS to Drive Single-Cell Genomics Market II-20
Advancements in Probe Technology Enhance qPCR Sensitivity II-21
qPCR Market to Witness increasing Affinity for Automated and
Robotic Equipment II-21
Factors influencing Selection of Lab Robots II-22
Lab on Chip/Microfluidic Real-time-PCR- A Game Changer in the
Offing II-23
Two Types of Microfluidic Designs II-23
Advantages of Lab on Chip PCR II-23
Roadblocks in the Path to Development II-24
New Developments in Lab-on-chip PCR II-24
Droplet digital PCR Finds Increasing Application in Life
Sciences Research II-24
ddPCR gains Traction in Cancer Diagnosis II-25
Monitoring Disease Progression in HIV Studies II-26
Analysis of Genetically Modified Organisms in Edible Products II-26
RT-ddPCR Techniques Applied for Quantitating RNA Viruses in
Water Samples II-26
Researchers Continue to Campaign for Adoption and Strict
Compliance with MIQE and SPIDIA Guidelines II-27
Alternate Technologies Pose Threat to Growth of PCR Market II-28
New Isothermal PCR Technology - A Potential Game Changer
Promising Faster PCR II-28

3. COMPETITION II-30
Table 14: Global qPCR Instruments Market by Leading Player
(2014): Percentage Market Share Breakdown of Value Sales for
Life Sciences Research for Thermo Fisher Life Sciences,
Bio-Rad, Roche, Agilent, Qiagen, and Others (includes
corresponding Graph/Chart) II-30
Select qPCR Products by Company II-30
Thermo Fisher Life Sciences Solutions - The Leading Player II-31
Table 15: PCR Systems Product Portfolio of Thermo Fisher Life
Sciences Solutions II-31
Patent Expiries Impact Royalty Revenues Inflow of Thermo
Fisher Life Sciences II-31
Table 16: Life Technologies' Royalty Roll-Off by Year:
2009-2013 (includes corresponding Graph/Chart) II-32
Cost of PCR instruments and Reagents to Decline II-32
Competition Heats Up in dPCR Market II-32
Intense Competition Triggers a Spate of MandA II-33
Manufacturers Step-Up Online Exposure II-33
Multiple Factors to Sustain Consolidation Trend in PCR Industry II-34
Accelerated Commercialization of Products II-34
Offering Integrated and Multi-technology Solutions II-34
Manufacturers Target Expansion of Distribution Reach and
Global Footprint II-35

4. END-USE MARKET ANALYSIS II-36
Application Areas of PCR II-36
Medical and Diagnostics II-36
PCR Plays a Vital Role in the Diagnosis of Infectious Diseases II-36
Detection of Antimicrobial Resistance II-37
PCR-Based Nucleic Acid Amplification for Detection of
Antimicrobial Agents II-37
Forensic and Paternity Testing II-38
Food Safety II-38
Detection and Quantification of Food Pathogens II-38
Detection of Beneficial and Non-Pathogenic Microbes II-39
Study of Microbial Responses to Environment II-39
Microbial Risk Assessment II-39
qPCR Application in Food Microbiology: Study of Select
Micro-Organisms by Target Gene and Food Substrate II-39
PCR Technique in Identification of GMOs II-40
Research and Academics II-40
SYBR Dye and TaqMan Techniques Popular in Research Publications II-41

5. PRODUCT OVERVIEW II-42
Introduction to Polymerase Chain Reaction (PCR) II-42
Reagents and Components Required for PCR II-42
Reaction Steps II-43
Denaturation II-43
Annealing II-43
Extension II-43
Real-Time PCR or Quantitative PCR (qPCR) II-44
qPCR Instrumentation II-44
Evolution II-44
Working of qPCR Instruments II-45
Thermal Control II-45
Fluorimetry II-45
DNA Detection Methods II-46
Fluorescence Measurement II-46
Asymmetrical dsDNA dyes II-46
Quantification II-46
High-Throughput qPCR II-47
Comparison of Working of Conventional PCR versus qPCR II-47
Drawbacks in Core PCR II-47
Advantages of qPCR II-48
Disadvantages of qPCR II-48
End-Use Applications of qPCR II-49
Factors Influencing Purchase Decisions of qPCR Systems II-50
qPCR Consumables, Accessories and Software II-50
DIGITAL PCR II-50
Development of dPCR II-51
Working Principle II-51
Droplet dPCR II-51
Applications of dPCR II-52
Advantages of dPCR II-52

6. INSIGHT INTO GLOBAL SPENDING ON LIFE SCIENCES RESEARCH II-53
Global Life Sciences Research and Development Landscape II-53
Table 17: Select Countries with RandD Spending as a % of GDP:
2014 (includes corresponding Graph/Chart) II-53
Sequestration Bites Deep into US Research Funds II-54
Table 18: NIH Annual Appropriations in US$ Billions, and RPG
Funding (2008-2014) (includes corresponding Graph/Chart) II-55

Table 19: NCI Research Spending in US$ Millions on Major
Types of Cancers Listed in Decreasing Order of Prevalence
(2010, 2011, 2012 and 2013) (includes corresponding
Graph/Chart) II-56
New MoPath Codes for Reimbursement for Medical Diagnostics Tests II-57
Government Takes Major Steps to Revive Japan Life Sciences Sector II-57
Table 20: Human Frontier Science Program Budget for 2014 by
Country: Contribution in US$ Million for Japan, United
States, European Union, and Others (includes corresponding
Graph/Chart) II-58

Table 21: Japanese Government Stimulus Package for Life
Sciences Sector: 2013 (includes corresponding Graph/Chart) II-58
Fiscal Prudence to Undermines Research Programs II-59
Table 22: European Research Council (ERC) Funding for Life
Sciences by Country (2008-2013): Breakdown of Number of
Starting Grants Allocated for United Kingdom, Germany,
France, Israel, Switzerland, Netherlands, Sweden, Spain,
Belgium, Austria, and Others (includes corresponding
Graph/Chart) II-60

Table 23: European Research Council (ERC) Funding for Life
Sciences by Country (2008-2013): Breakdown of Number of
Advance Grants Allocated for United Kingdom, Germany, France,
Switzerland, Netherlands, Italy, Israel, Spain, Sweden,
Belgium, and Others (includes corresponding Graph/Chart) II-61
Asia Pacific - The New Global Hub for Life Sciences Research II-62

7. PRODUCT INNOVATIONS/INTRODUCTIONS II-63
Agilent Technologies Launches AriaMx System II-63
Life Technologies Launches QuantStudio 3D Digital PCR System II-63
LGC Introduces Updated 1536-Well PCR Plate for Genomics
Applications II-63
Exiqon Unveils Toxicology Focus microRNA PCR Panel II-63
Exiqon Introduces LNAâ„¢ LongRNA GapmeR Products II-63
Life Technologies and Quidel Secure US FDA Approval for
Marketing qPCR Instruments II-63
Life Technologies Obtains US FDA Approval for 3500 Dx Genetic
Analyzers and SeCore® HLA Typing Kit II-63
Bio-Rad Laboratories Unveils QX200 ddPCR System II-64
Exiqon Introduces Customized qPCR Arrays II-64
Life Technologies Provides QuantStudio 3D Digital PCR System
to Five Research Labs II-64
Bio-Rad Unveils iTaq Universal Supermixes II-64
Nextreme Thermal Solutions Introduces New-Generation Reference
Design for Compact PCR Thermal Cycler II-64
Sigma Life Science Introduces KiCqStart Primers II-64
Bio-Rad Rolls Out CFX96 Touch Deep Well PCR Detection System II-64
Roche Introduces Light Cycler 96 System II-65
Fluidigm Rolls Out New Integrated Fluidic Circuits II-65
Promega Unveils GoTaq Master Mixes Range II-65
Illumina Unveils Real-Time PCR Reagent Portfolio II-65
Integromics® Introduces OmicsOffice® Platform II-65
Ingenuity Systems and Life Technologies Unveil Ingenuity
iReport for Real-Time PCR II-65
Life Technologies Introduces QuantStudioâ„¢ Dx Real-Time PCR
Instrument II-65
RainDance Technologies Introduces RainDropâ„¢ Digital PCR Platform II-66
Life Technologies Unveils QuantStudio 3D Digital PCR System
Chip-Based Instrument II-66
Integromics® Unveils RealTime StatMiner® 4.3 on TIBCO® Spotfire® II-66
Bio-Rad Laboratories Unveils CFX Qualification Plate II-66
Exiqon Unveils miRCURYâ„¢ RNA Isolation Kit-Biofluids II-66
Bio-Rad Laboratories Launches One-Step RT-ddPCR Kit II-66
Accelero® Bioanalytics Announces Addition of RT-qPCR System of
Applied Biosystems II-66

8. RECENT INDUSTRY ACTIVITY II-67
Thermo Fisher Scientific Completes Take Over of Life Technologies II-67
Quotient Bioresearch Divests Bioanalytical Sciences Business
to LGC II-67
Thermo Fisher Scientific Inks Definitive Agreement to Take
Over Life Technologies II-67
QIAGEN and WaferGen Bio-systems Ink Co-Marketing Agreement II-67
Biodesign Institute® Enters into Partnership with Life
Technologies II-67
WaferGen Bio-systems Enters into Partnership with Salk
Institute to Establish nano-qPCR Core Laboratory II-67
TATAA Biocenter Extends Product Line II-67
Integrated DNA Technologies to Showcase Novel Multiplex qPCR
Assays II-68
Illumina and VWR International Sign Agreement II-68
Integrated DNA Technologies Collaborates with RainDance
Technologies II-68
Life Technologies Takes Over Compendia Bioscience II-68
Luminex Takes Over GenturaDx II-68
Life Technologies Takes Over Pinpoint Genomics II-68
Idaho Technology Announces Corporate Rebranding to BioFire
Diagnostics II-68
Exosome Diagnostics and Life Technologies Ink Agreement II-68
Abbott Inks Partnership Agreement with Astellas Pharma Global
Development for Executing Clinical Trial on TransVaxâ„¢ Vaccine II-69
Accelero Bioanalytics and Synlab Clinical Trial Enter into
Collaboration II-69
Immunexpress Group, Biocartis and Debiopharm Ink Agreement to
Develop and Commercialze SeptiCyte® Triage Assay II-69
Accelero Bioanalytics Collaborates with LPT Laboratory II-69

9. FOCUS ON SELECT GLOBAL PLAYERS II-70
Agilent Technologies, Inc. (US) II-70
Becton, Dickinson and Company (US) II-70
BioFire Diagnostics, Inc. (US) II-71
Bio-Rad Laboratories, Inc. (US) II-72
Cepheid (US) II-72
Eppendorf AG (Germany) II-73
Exiqon A/S (Denmark) II-73
F. Hoffmann-La Roche Ltd. (Switzerland) II-74
Fluidigm Corporation (US) II-74
Illumina, Inc. (US) II-75
Promega Corporation (US) II-75
RainDance Technologies, Inc. (US) II-76
QIAGEN N.V. (Netherlands) II-76
Takara Bio, Inc. (Japan) II-77
Thermo Fisher Scientific Inc. (US) II-78

10. GLOBAL MARKET PERSPECTIVE II-79
Table 24: World Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation and Reagents by Geographic
Region - US, Canada, Japan, Europe, Asia-Pacific, Middle East and
Africa and Latin America Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) II-79

Table 25: World Historic Review for qPCR and dPCR
Instrumentation and Reagents by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific, Middle East and Africa and
Latin America Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2009 through
2012 (includes corresponding Graph/Chart) II-80

Table 26: World 12-Year Perspective for qPCR and dPCR
Instrumentation and Reagents by Geographic Region - Percentage
Breakdown of Revenues for US, Canada, Japan, Europe,
Asia-Pacific, Middle East and Africa and Latin America Markets
for the Years 2009, 2014 and 2020 (includes corresponding
Graph/Chart) II-81

Table 27: World Recent Past, Current and Future Analysis for
qPCR and dPCR Reagents by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific, Middle East and Africa and Latin
America Markets Independently Analyzed with Annual Revenue
Figures in US$ Thousand for the Years 2013 through 2020
(includes corresponding Graph/Chart) II-82

Table 28: World Historic Review for qPCR and dPCR Reagents by
Geographic Region - US, Canada, Japan, Europe, Asia-Pacific,
Middle East and Africa and Latin America Markets Independently
Analyzed with Annual Revenue Figures in US$ Thousand for the
Years 2009 through 2012 (includes corresponding Graph/Chart) II-83

Table 29: World 12-Year Perspective for qPCR and dPCR Reagents
by Geographic Region - Percentage Breakdown of Revenues for
US, Canada, Japan, Europe, Asia-Pacific, Middle East and Africa
and Latin America Markets for the Years 2009, 2014 and 2020
(includes corresponding Graph/Chart) II-84

Table 30: World Recent Past, Current and Future Analysis for
qPCR and dPCR Instruments by Geographic Region - US, Canada,
Japan, Europe, Asia-Pacific, Middle East and Africa and Latin
America Markets Independently Analyzed with Annual Revenue
Figures in US$ Thousand for the Years 2013 through 2020
(includes corresponding Graph/Chart) II-85

Table 31: World Historic Review for qPCR and dPCR
Instrumentation by Geographic Region - US, Canada, Japan,
Europe, Asia-Pacific, Middle East and Africa and Latin America
Markets Independently Analyzed with Annual Revenue Figures in
US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) II-86

Table 32: World 12-Year Perspective for qPCR and dPCR
Instruments by Geographic Region - Percentage Breakdown of
Revenues for US, Canada, Japan, Europe, Asia-Pacific, Middle
East and Africa and Latin America Markets for the Years 2009,
2014 and 2020 (includes corresponding Graph/Chart) II-87

Table 33: World Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation and Reagents by Product Segment -
qPCR and dPCR Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) II-88

Table 34: World Historic Review for qPCR and dPCR
Instrumentation and Reagents by Product Segment - qPCR and
dPCR Markets Independently Analyzed with Annual Revenue
Figures in US$ Thousand for the Years 2009 through 2012
(includes corresponding Graph/Chart) II-89

Table 35: World 12-Year Perspective for qPCR and dPCR
Instrumentation and Reagents by Product Segment - Percentage
Breakdown of Revenues for qPCR and dPCR Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) II-90

Table 36: World Recent Past, Current and Future Analysis for
qPCR Instrumentation and Reagents by Product Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) II-91

Table 37: World Historic Review for qPCR Instrumentation and
Reagents by Product Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures in
US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) II-92

Table 38: World 12-Year Perspective for qPCR Instrumentation
and Reagents by Product Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) II-93

Table 39: World Recent Past, Current and Future Analysis for
dPCR Instrumentation and Reagents by Product Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) II-94

Table 40: World Historic Review for dPCR Instrumentation and
Reagents by Product Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures in
US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) II-95

Table 41: World 12-Year Perspective for dPCR Instrumentation
and Reagents by Product Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) II-96

Table 42: World Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation and Reagents by End-Use Segment -
Educational/ Research, Testing Laboratories and Pharma
Markets Independently Analyzed with Annual Revenue Figures in
US$ Thousand for the Years 2013 through 2020 (includes
corresponding Graph/Chart) II-97

Table 43: World Historic Review for qPCR and dPCR
Instrumentation and Reagents by End-Use Segment -
Educational/Research, Testing Laboratories and Pharma Markets
Independently Analyzed with Annual Revenue Figures in US$
Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) II-98

Table 44: World 12-Year Perspective for qPCR and dPCR
Instrumentation by End-Use Segment - Percentage Breakdown of
Revenues for Educational/ Research, Testing Laboratories and
Pharma Markets for the Years 2009, 2014 and 2020 (includes
corresponding Graph/Chart) II-99


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
Current and Future Analysis III-1
qPCR Vs. dPCR Instrumentation is the US III-1
Cancer Stats III-2
Table 45: New Cancer Cases in the US by Gender and Affected
Site: 2014 III-2

Table 46: New Cancer Cases in Males in US by Leading Site:
2014 (includes corresponding Graph/Chart) III-4

Table 47: New Cancer Cases in Females in US by Leading
Site: 2014 (includes corresponding Graph/Chart) III-5

Table 48: New Cancer Cases in US by State: 2014 III-6

Table 49: The US Cancer Incidence for All Body Sites by
Gender and Age Group (2013): New Cancer Cases for Males and
Females for the Age groups Under 45 years; 45 years and
Above; Under 65 years; and 65 years and Above (includes
corresponding Graph/Chart) III-7
Cancer Mortality Statistics III-8
Table 50: Cancer Related Deaths in the US by Gender and
Body Site: 2014 III-8
Table 51: Cancer Related Deaths in Males in US by Leading
Site: 2014 (includes corresponding Graph/Chart) III-10

Table 52: Cancer Related Deaths in Females in US by Leading
Site: 2014 (includes corresponding Graph/Chart) III-11

Table 53: Number of Deaths Related to Major Types of Cancer
in US by State: 2014 III-12
Competition III-13
Product Introductions III-13
Strategic Corporate Developments III-16
Select Key Players III-18
B.Market Analytics III-25
Table 54: The US Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-25

Table 55: The US Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-26

Table 56: The US 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2013 and 2018 (includes corresponding Graph/Chart) III-27

2. CANADA III-28
A.Market Analysis III-28
Current and Future Analysis III-28
Cancer Statistics in Canada III-29
Table 57: New Cancer Cases in Canada by Gender and Affected
Site: 2014 (includes corresponding Graph/Chart) III-29

Table 58: New Cancer Cases in Canada by Province: 2014
(includes corresponding Graph/Chart) III-30

Table 59: New Cancer Cases in Canada by Age Group: 2014
(includes corresponding Graph/Chart) III-31

Table 60: Cancer Related Deaths in Canada by Gender and
Affected Site: 2014 (includes corresponding Graph/Chart) III-32

Table 61: Cancer Related Deaths in Canada by Province: 2014
(includes corresponding Graph/Chart) III-33

Table 62: Cancer Related Deaths in Canada by Age Group:
2014 (includes corresponding Graph/Chart) III-34
Funglyn Biotech, Inc. - A Key Player III-34
B.Market Analytics III-35
Table 63: Canadian Recent Past, Current and Future Analysis
for qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-35

Table 64: Canadian Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-36

Table 65: Canadian 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-37

3. JAPAN III-38
A.Market Analysis III-38
Current and Future Analysis III-38
Table 66: Cancer Related Deaths by Age Group: 2013
(includes corresponding Graph/Chart) III-38
Takara Bio, Inc. - A Key Player III-39
B.Market Analytics III-40
Table 67: Japanese Recent Past, Current and Future Analysis
for qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-40

Table 68: Japanese Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-41

Table 69: Japanese 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-42

4. EUROPE III-43
A.Market Analysis III-43
Current and Future Analysis III-43
PCR Reagents in Europe: An Overview III-43
Cancer Stats III-43
Table 70: Cancer Incidence in Europe by Site: 2012 (in
Thousands) (includes corresponding Graph/Chart) III-44

Table 71: Number of New Cancer Cases in Europe (2012-2030)
(in Million) (includes corresponding Graph/Chart) III-45
B.Market Analytics III-45
Table 72: European Recent Past, Current and Future Analysis
for qPCR and dPCR Instrumentation by Geographic Region -
France, Germany, Italy, UK, and Rest of Europe Markets
Independently Analyzed with Annual Revenue Figures in US$
Thousand for the Years 2013 through 2020 (includes
corresponding Graph/Chart) III-45

Table 73: European Historic Review for qPCR and dPCR
Instrumentation by Geographic Region - France, Germany,
Italy, UK, and Rest of Europe Markets Independently Analyzed
with Annual Revenue Figures in US$ Thousand for the Years
2009 through 2012 (includes corresponding Graph/Chart) III-46

Table 74: European 12-Year Perspective for qPCR and dPCR
Instrumentation by Geographic Region - Percentage Breakdown
of Revenues for France, Germany, Italy, UK, and Rest of
Europe Markets for the Years 2009, 2014 and 2020 (includes
corresponding Graph/Chart) III-47

Table 75: European Recent Past, Current and Future Analysis
for qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-48

Table 76: European Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-49

Table 77: European 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-50

4a. FRANCE III-51
A.Market Analysis III-51
Current and Future Analysis III-51
B.Market Analytics III-51
Table 78: French Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-51

Table 79: French Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-52

Table 80: French 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-53

4b. GERMANY III-54
A.Market Analysis III-54
Current and Future Analysis III-54
Product Introduction III-54
Strategic Corporate Developments III-54
Eppendorf AG - A Key German Player III-54
B.Market Analytics III-55
Table 81: German Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-55

Table 82: German Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-56

Table 83: German 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-57

4c. ITALY III-58
A.Market Analysis III-58
Current and Future Analysis III-58
B.Market Analytics III-58
Table 84: Italian Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-58

Table 85: Italian Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-59

Table 86: Italian 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-60

4d. THE UNITED KINGDOM III-61
A.Market Analysis III-61
Current and Future Analysis III-61
Product Introductions III-61
Strategic Corporate Development III-61
B.Market Analytics III-62
Table 87: The UK Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-62

Table 88: The UK Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-63

Table 89: The UK 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-64

4e. REST OF EUROPE III-65
A.Market Analysis III-65
Current And Future Analysis III-65
Product Introductions III-65
Strategic Corporate Developments III-66
Key Players III-66
B.Market Analytics III-69
Table 90: Rest of European Recent Past, Current and Future
Analysis for qPCR and dPCR Instrumentation by Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) III-69

Table 91: Rest of European Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-70

Table 92: Rest of European 12-Year Perspective for qPCR and
dPCR Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-71

5. ASIA-PACIFIC III-72
A.Market Analysis III-72
Current and Future Analysis III-72
B.Market Analytics III-73
Table 93: Asia-Pacific Recent Past, Current and Future
Analysis for qPCR and dPCR Instrumentation by Geographic
Region - China and Rest of Asia-Pacific Markets
Independently Analyzed with Annual Revenue Figures in US$
Thousand for the Years 2013 through 2020 (includes
corresponding Graph/Chart) III-73

Table 94: Asia-Pacific Historic Review for qPCR and dPCR
Instrumentation by Geographic Region - China and Rest of
Asia-Pacific Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2009 through
2012 (includes corresponding Graph/Chart) III-74

Table 95: Asia-Pacific 12-Year Perspective for qPCR and dPCR
Instrumentation by Geographic Region - Percentage Breakdown
of Revenues for China and Rest of Asia-Pacific Markets for
the Years 2009, 2014 and 2020 (includes corresponding
Graph/Chart) III-75

Table 96: Asia-Pacific Recent Past, Current and Future
Analysis for qPCR and dPCR Instrumentation by Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2009
through 2018 (includes corresponding Graph/Chart) III-76

Table 97: Asia-Pacific Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-77

Table 98: Asia-Pacific 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-78

5a. CHINA III-79
A.Market Analysis III-79
Current and Future Analysis III-79
B.Market Analytics III-79
Table 99: Chinese Recent Past, Current and Future Analysis for
qPCR and dPCR Instrumentation by Category - Reagents and
Instruments Markets Independently Analyzed with Annual
Revenue Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-79

Table 100: Chinese Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-80

Table 101: Chinese 12-Year Perspective for qPCR and dPCR
Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-81

5b. REST OF ASIA-PACIFIC III-82
A.Market Analysis III-82
Current And Future Analysis III-82
Strategic Corporate Development III-82
Professional Biotech Pvt. Ltd. - A Key Real Time PCR
Manufacturer In India III-82
B.Market Analytics III-83
Table 102: Rest of Asia-Pacific Recent Past, Current and
Future Analysis for qPCR and dPCR Instrumentation by
Category - Reagents and Instruments Markets Independently
Analyzed with Annual Revenue Figures in US$ Thousand for the
Years 2013 through 2020 (includes corresponding Graph/Chart) III-83

Table 103: Rest of Asia-Pacific Historic Review for qPCR and
dPCR Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-84

Table 104: Rest of Asia-Pacific US 12-Year Perspective for
qPCR and dPCR Instrumentation by Category - Percentage
Breakdown of Revenues for Reagents and Instruments Markets
for the Years 2009, 2014 and 2020 (includes corresponding
Graph/Chart) III-85

6. MIDDLE EAST and AFRICA III-86
A.Market Analysis III-86
Current and Future Analysis III-86
B.Market Analytics III-86
Table 105: The Middle East Recent Past, Current and Future
Analysis for qPCR and dPCR Instrumentation by Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) III-86

Table 106: The Middle East Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-87

Table 107: The Middle East 12-Year Perspective for qPCR and
dPCR Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-88

7. LATIN AMERICA III-89
A.Market Analysis III-89
Current and Future Analysis III-89
B.Market Analytics III-89
Table 108: Latin American Recent Past, Current and Future
Analysis for qPCR and dPCR Instrumentation by Category -
Reagents and Instruments Markets Independently Analyzed with
Annual Revenue Figures in US$ Thousand for the Years 2013
through 2020 (includes corresponding Graph/Chart) III-89

Table 109: Latin American Historic Review for qPCR and dPCR
Instrumentation by Category - Reagents and Instruments
Markets Independently Analyzed with Annual Revenue Figures
in US$ Thousand for the Years 2009 through 2012 (includes
corresponding Graph/Chart) III-90

Table 110: Latin American 12-Year Perspective for qPCR and
dPCR Instrumentation by Category - Percentage Breakdown of
Revenues for Reagents and Instruments Markets for the Years
2009, 2014 and 2020 (includes corresponding Graph/Chart) III-91


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 41 (including Divisions/Subsidiaries - 44)

The United States (26)
Canada (1)
Japan (1)
Europe (15)
- Germany (5)
- The United Kingdom (2)
- Spain (1)
- Rest of Europe (7)
Asia-Pacific (Excluding Japan) (1)

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