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New to Insight Pharma Reports is: Ocular Disorders: Rising Therapeutics, Technologies, and Devices. This report covers a handful of companies and their approach to targeting ocular diseases including wet and dry age-related macular degeneration (AMD) while alsoproviding alternative therapeutic options for various ocular complications. In an interview with several companies including Oraya Therapeutics, VisionCare Ophthalmic Technologies, Omeros, and Kala Pharmaceuticals, representatives mentioned several technologies and devices in development to improve the current line of therapeutics.
Both invasive and noninvasive procedures are discussed, along with current treatment options and how they relate to rising therapies. Specific highlights of this report include extensive research, company backgrounds, challenges, and validation techniques for therapeutic applications offered by the participating companies. These techniques include:
• Radiation therapy
• Implantable telescope technology
• PharmacoSurgery
• Mucosal penetrating products

Also available are complementary interviews with company representatives at the end of each section. The interviewees include:
• President and CEO of Oraya Therapeutics
• Marketing Director of VisionCare Ophthalmic Technologies
• Chairman and CEO of Omeros
• CMO of Kala Pharmaceuticals

Also included in this report is a demographic survey of researchers working in ocular disorders. Some of the concepts include ocular areas of research, promising therapeutic options, targets of interest, and challenges encountered.

Table Of Contents

Ocular Disorders: Rising Therapeutics, Technologies, and Devices
Executive Summary

CHAPTER 1:Age-Related Macular Degeneration
Wet AMD
Dry AMD

CHAPTER 2:Therapeutic Efficacy
Anti-VEGF therapies
• Pegaptanib
• Bevacizumab
• Ranibizumab
• VEGF Trap-EYE

CHAPTER 3:Oraya Therapeutics
Radiotherapy platform
• Automatic Positioning System (APS)
• I-Guide
• System software

Radiation dosing
Potential complications and risk factors
Competitive advantage
Challenges and areas of improvement
Future expectations
Interview with Jim Taylor
• Radiation therapy
• Competitive advantage
• Challenges encountered
• Areas of improvement
• Future expectations

CHAPTER 4:VisionCare Ophthalmic Technologies
Company background
Telescope technology
Complications and challenges
Interview with Reena Mishra
• Company background
• Telescope technology
• Competitive advantage
• Complications and challenges

CHAPTER 5:Omeros
Company background
PharmacoSurgery platform
Pipeline
Competitive advantage
Challenges encountered
Validation
Future expectations
Interview with Greg Demopulos
• Company background
• PharmacoSurgery platform
• OMS302
• Competitive advantage
• Challenges encountered
• Validation procedure
• Future expectations

CHAPTER 6:Kala Pharmaceuticals
Company background
Mucosal penetrating products (MPP)
Competitive advantage
Future endeavors
Interview with Kim Brazzell
• Company background
• Mucosal penetrating products (MPP)
• Challenges encountered
• Competitive advantage
• Future endeavor

CHAPTER 7:Platforms and Products

CHAPTER 8:Survey of Ocular Industry
Areas of development
Promising targets and therapies
Challenges encountered

References



TABLES

Table 2.1: Clinical status for common therapies for wet AMD
Table 3.1 Platform specifications
Table 4.1: Platform specifications
Table 5.1: Targets and their clinical status
Figure 6.1: Targets and their clinical status
Table 7.1: Targets in clinical stages
Table 7.2: Therapeutic platform specifications



FIGURES

Figure 8.1: Areas of research
Figure 8.2: Ocular disorders of interest
Figure 8.3: Promising therapies for ocular diseases
Figure 8.4: Promising targets for ocular therapies
Figure 8.5: Challenges encountered

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