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As blockbusters go off patent and the pool of marketed products supporting pharmaceutical Research & Development (R&D) decline, questions about the future of R&D in the pharmaceutical and biotech industry arise. Where will funding come from? Is spend decreasing? If spend is decreasing, what impact is this having on R&D? What can be done to encourage innovation in the biotech and pharmaceutical industry? Is the biotech model of R&D better for innovation than the traditional pharmaceutical model?

Gauging the overall growth of R&D in the pharmaceutical and biotech industry proves challenging in regards to stipulating the appropriate definition of variables by which this is measured. Public companies may release overall expenses, yet allocations to specific products or franchises may be more difficult to assess. On a related note, information may be available about specific research projects and molecules under development, yet tying those back to the overall R&D expenses can also be challenging. To that end, we are focused on general estimations in this report which address a high level analysis of the overall industry and a basic formulaic approach to understanding growth and productivity within R&D. The methods used for assessing these variables are supported by literature in the field.

Research & Development (R&D) in the Pharmaceutical and Biotech Industry has experienced a major shift from the blockbuster era of the last decade. Pharmaceutical manufacturers are operating with thinner margins and smaller pipelines, the success rates of early stage research projects have decreased, and overall the complexity of efficient and productive R&D in the pharmaceutical industry has increased. This report provides an overview of the current situation in pharmaceutical and biotech R&D.

Scope

- Current scenario of R&D
- Review of the pipeline and key issues affecting R&D efforts
- Approvals by year and by sponsor (established vs. new companies)
- Trends in R&D spending
- Analysis of R&D productivity
- Company snapshots

Key Reasons to Purchase

- Understand the current state of R&D in the biopharmaceutical industry and the key issues that are affecting companys’ efforts
- Assess the strategies being used to strengthen R&D productivity and relate them to what is taking place within your organization
- Evaluate how the top pharmaceutical and biotech companies have structured their pipeline
- Analyze the trends being seen in R&D spend and how different forms of collaboration could support a stronger R&D organization
- Examine the R&D landscape and identify the key disease areas seeing the greatest activity
- Benefit from CBR’s insights & case study analysis to support a better understanding of different influencers of R&D productivity and the strategies which can be used within your organization

Table Of Contents

RandD Productivity - The State of Research and Development in the BioPharmaceutical Industry
Executive Summary
Current Picture of Research and Development
Key issues affecting the industry's RandD efforts
A review of the industry pipeline
Near term and future outlook
Pipeline by phase of development
Is the industry pipeline addressing global needs?
Pipeline by therapeutic area and, more specifically, indication
The convergence of Biotechnology and Pharmaceuticals to Biopharmaceuticals
Pipeline's molecule mix
Do traditional pharmaceutical companies still exist?
Status of Top companies
Approvals by year and by sponsor (Established vs. Emerging companies)
Trends in RandD spend
Is RandD spend decreasing?
Review of Top companies RandD spend
RandD spend by phase of development
Probability of success rates on several levels: overall clinical approval, phase transition, and therapeutic area.
How have overall clinical approval rates changed over time?

RandD Productivity
Components of RandD productivity: efficiency and effectiveness
Variables that influence productivity

RandD Productivity (continued)
Industry efforts to improve productivity
Collaboration
Companies are going beyond their own four walls to cut costs, mitigate risk, and inspire innovation.
Outsourcing
CROs take on a greater role
Consideration of Key Stakeholders
What roles do Physicians, Payers, Patients, and Shareholders play in RandD?
Innovation
Featuring Biotech Incubators

Company Pipeline Snapshots
Pipeline views on a company by company basis.
Views may include core therapeutic areas, compound origination, molecule type, and new molecular entities.
Trends in RandD spend

References

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