For six editions, this authoritative resource has defined the market opportunity for companies assisting in the beginning phase of the drug development process.

This Kalorama Information Report, Outsourcing in Drug Discovery, t provides an in depth look into the trends that have shaped the drug discovery outsourcing market today, and details the current and future global market. As part of its coverage, the report provides markets and forecasts for the following segments.

Chemistry Services Market: Building Blocks, Compound
Synthesis, Libraries, Process Research, and Other Services,
Biology Market Revenue by Protein Expression, Structural
Analysis, Target Validation, Pathways Analysis, and Other Service
Screening Services Market: Assay Development, Primary
Screening, Secondary Screening
Lead Optimization Services Market: Early ADMET/Tox, Create Analogues, Computational Support, and Other Services

The drug discovery process consists of iterative cycles between chemistry and biology that begin with the target finding phase, or selecting a protein (a drug target) leading to the identification of a chemical compound with biological activity (a hit). After confirmation of biological activity and chemical feasibility, the hit becomes a lead structure, which is improved through chemical modifications until it fulfills the criteria for a clinical candidate. A drug candidate then moves into the next stage of drug development, the preclinical phase.

The drug discovery process is long, arduous and costly, which has driven outsourcing in this field. The first phase is discovery of a lead compound, a molecule that affects biological function by binding to a target protein or nucleic acid in a way that is useful for treatment of disease. The process by which molecules are identified for their therapeutic value involves synthesis and analysis of many derivatives of the original leads. There are several steps in the drug discovery process including hit confirmation, lead generation, lead optimization, and other studies. Drug discovery is a high-cost, risky business because only a fraction of the therapeutic targets selected for study will actually yield products that achieve regulatory approval by the Food & Drug Administration (FDA).Since the last edition of Kalorama's Report on the outsourcing of discovery, major trends that have led to an increase in demand for contract services in drug discovery include:The following companies are profiled in the report:

Albany Molecular Research, Inc.
Aptuit, LLC
Argenta Discovery, Ltd.
Asclepia MedChem Solutions
Asinex Ltd.
AsisChem, Inc.
Axxam SpA
BioDuro
BioFocus DPI
Caliper Life Sciences
Charles River Laboratories, Inc.
ChemBridge Corp.
Chemical Diversity Inc.
Covance, Inc.
CreaGen Biosciences, Inc.
Crown Bioscience
Cyprotex PLC
Domainex
Emerald Biostructures
Enamine Ltd.
Evotec AG
Exelgen Discovery
GVK Biosciences Private Limited
GenScript USA Inc.
Graffinity Pharmaceuticals GmbH
Hutchison MediPharma Ltd.
Jubilant Biosys Ltd
Nanosyn, Inc.
Pharmaron Inc.
Ricerca Biosciences, LLC
Scynexis, Inc.
Selcia Limited
Selvita S.A.
Shanghai ChemPartner Co., Ltd.
Shanghai Medicilon Inc.
Sundia Meditech Company, Ltd.
Sygnature Discovery Limited
TCG Lifesciences Limited
Viva Biotech, Ltd
WuXI AppTec Co. Ltd.

Table Of Contents


ONE: EXECUTIVE SUMMARY
Overview
Scope and Methodology
Introduction

Pharmaceutical Industry Challenges
Number of NMEs and BLAs Approved between 1993-2013
Reducing RandD Spending

The Drug Discovery Process

Accelerating the Drug Discovery Process
Bottlenecks Within the Drug Discovery Process

Outsourcing to Increase Efficiency
Outsourcing Drug Discovery

The Outsourcing Decision
Developing an Outsourcing Plan

Contract Research Organizations

Strategic Versus Tactical Outsourcing Model
Effective Communication Is Essential
Mitigating the Challenges of Protecting IP Rights

Offshoring Contract Drug Discovery

Factors to Consider in Offshore Outsourcing
Benefits of Global Outsourcing
Concerns about Global Outsourcing

Outsourcing to China

Chinese Contract Research Organizations
FDA Offices in China

Outsourcing to India

Drug Discovery Services in India

Outsourcing to Eastern Europe
Drug Discovery Outsourcing Market

Global Economic Downturn Has Minimal Affect on Drug Discovery
Current Market and Forecast
Market Analysis by Segment

TWO: INTRODUCTION TO OUTSOURCING DRUG DISCOVERY
Background

Number of NMEs and BLAs Approved between 1993-2013
Reducing RandD Spending
Ramping up the Pipelines

Outsourcing Drug Discovery
The Outsourcing Decision

Developing an Outsourcing Plan
Decision Criteria

Factors to Consider in Offshore Outsourcing

Benefits of Global Outsourcing

Cost advantage
Access to talent and technologies
Compress Timeline

Concerns about Global Outsourcing

Intellectual Property Protection (IP)
Confidential Information and Trade Secrets
Fraud and Corruption
Meeting Regulatory Compliance Demands
Long Distance

Selecting a Contract Research Organization

Introduction
Choosing the Right CRO
Contract Pharma’s Outsourcing Survey

Global Outsourcing
THREE: THE DRUG DISCOVERY PROCESS
Introduction

Drug Discovery Stages

Accelerating the Drug Discovery Process

Technologies Utilized in Drug Discovery
Bottlenecks Within the Drug Discovery Process

Outsourcing to Increase Efficiency
Outsourcing to Access Novel Technologies

Bioinformatics
Lab-on-a-Chip: Microfluidics in Drug Discovery

FOUR: OUTSOURCING DRUG DISCOVERY
Overview

Is the Traditional Drug Discovery Model Changing?
Outsourcing Drug Discovery Useful Core Management Tool

Contract Research Organizations

Introduction
Role of a CRO
Outsourcing Models
Effective Communication Is Essential for a Successful Partnership
Mitigating the Challenges of Protecting IP Rights

Offshoring Contract Drug Discovery

Introduction
Robust Growth of Outsourcing Drug Discovery in Asia

Outsourcing to China

Introduction
Multi-National Pharmaceutical Companies Establish Research and
Development Facilities in China
Chinese Contract Research Organizations
First Chinese CRO Alliance
FDA Offices in China
China's Management of Counterfeit Pharmaceuticals, IP Rights and Laws

Outsourcing to India

Introduction
Drug Discovery Services in India
India’s Handling of IP Rights and Laws
FDA Offices in India
Outsourcing to Eastern Europe
Introduction
Russian and Ukraine CROs

FIVE: DRUG DISCOVERY OUTSOURCING MARKET
Overview
Drug Discovery Outsourcing Market

Global Economic Downturn Has Minimal Affect on Drug Discovery
Current Market and Forecast

Market Analysis by Segment

Chemistry Services Market
Market Estimate
Forecast
Biology Services Market
Market Estimate
Forecast
High Throughput Screening Services Market
Market Estimate
Forecast
Lead Optimization Services Market
Market Estimate
Forecast

Contract Drug Discovery Competitors
The Evolving Open-Innovation Model Gaining Traction in Drug Discovery

Alliances between Academic Organizations and CROs
Academic CROs
Alliances between CROs

Market Growth Expanding Global Reach and Scale of Drug Discovery Services
SIX: COMPETITOR PROFILES
Albany Molecular Research, Inc.

History and Lines of Business
Drug Discovery Services
Financial Information

Aptuit, LLC

History and Lines of Business
Drug Discovery Services

Argenta Discovery, Ltd

History and Lines Business
Drug Discovery Services

Asclepia MedChem Solutions

History and Lines of Business
Drug Discovery Services

Asinex Ltd.

History and Lines of Business
Drug Discovery Services

AsisChem, Inc.

History and Lines of Business
Drug Discovery Services

Axxam SpA

History and Lines of Business
Drug Discovery Services

BioDuro

History and Lines of Business
Drug Discovery Services

BioFocus DPI

History and Lines of Business
Drug Discovery Services

Caliper Life Sciences

History and Lines of Business
Drug Discovery Services

Charles River Laboratories, Inc.

History and Lines of Business
Drug Discovery Services
Financial Information

ChemBridge Corp.

History and Background
Drug Discovery Services

Chemical Diversity Inc.

History and Lines of Business
Drug Discovery Services

Covance, Inc.

History and Lines of Business
Drug Discovery Services
Financial Information

CreaGen Biosciences, Inc.

History and Lines of Business
Drug Discovery Services

Crown Bioscience

History and Lines of Business
Drug Discovery Services

Cyprotex PLC

History and Lines of Business
Drug Discovery Services

Domainex

History and Lines of Business
Drug Discovery Services

Emerald Biostructures

History and Lines of Business
Drug Discovery Services

Enamine Ltd.

History and Lines of Business
Drug Discovery Services

Evotec AG

History and Lines of Business
Drug Discovery Services
Financial Information

Exelgen Discovery

History and Lines of Business
Drug Discovery Services

GVK Biosciences Private Limited

History and Lines of Business
Drug Discovery Services

GenScript USA Inc.

History and Lines of Business
Drug Delivery Services

Graffinity Pharmaceuticals GmbH

History and Lines of Business
Drug Discovery Services

Hutchison MediPharma Ltd.

History and Lines of Business
Drug Discovery Services

Jubilant Biosys Ltd

History and Lines of Business
Drug Discovery Services

Nanosyn, Inc.

History and Lines of Business
Drug Delivery Services

Pharmaron Inc.

History and Lines of Business
Drug Discovery Services

Ricerca Biosciences, LLC

History and Lines of Business
Drug Discovery Services

Scynexis, Inc.

History and Lines Business
Drug Discovery Services

Selcia Limited

History and Lines of Business
Drug Delivery Services

Selvita S.A.

History and Lines of Business
Drug Discovery Services

Shanghai ChemPartner Co., Ltd.

History and Lines of Business
Drug Discovery Services

Shanghai Medicilon Inc.

History and Lines of Business
Drug Discovery Services

Sundia Meditech Company, Ltd.

History and Lines of Business
Drug Discovery Services

Sygnature Discovery Limited

History and Lines of Business
Drug Discovery Services

TCG Lifesciences Limited

History and Lines of Business
Drug Discovery Services

Viva Biotech, Ltd

History and Lines of Business
Drug Delivery Services

WuXI AppTec Co. Ltd.

History and Lines of Buisness
Drug Discovery Services
Financial Information


LIST OF EXHIBITS

ONE: EXECUTIVE SUMMARY
Exhibit 1-1: Drug Discovery Timeline: Research to Viable Product to Commercialization
Exhibit 1-2: Number of NME and BLA License Applications Approved between 1993-2013
Exhibit 1-3: PhRMA Members RandD Spending, 1995 through 2012
Exhibit 1-4: The Drug Discovery Process
Exhibit 1-5: Drug Discovery Processes Frequently Outsourced
Exhibit 1-6: Global Drug Discovery Outsourcing Market, 2008-2018
Exhibit 1-7: Market Share of Segments of Drug Discovery Market, 2014
TWO: INTRODUCTION TO OUTSOURCING DRUG DISCOVERY
Exhibit 2-1: Number of NME and BLA License Applications Approved between 1993-2013
Exhibit 2-2: PhRMA Members RandD Spending, 1995 through 2012
Exhibit 2-3: Selection of Global Drug Discovery Outsourcing Collaborations
THREE: THE DRUG DISCOVERY PROCESS
Exhibit 3-1: The Drug Discovery Process
Exhibit 3-2: Drug Discovery Timeline: Research to Viable Product to Commercialization
Exhibit 3-3: Bioinformatics/Pharmacogenomics
Exhibit 3-4: Causes of New Drug Attrition
Exhibit 3-5: Drug Discovery Processes Frequently Outsourced
Exhibit 3-6: Bioinformatics as a Central Hub
FOUR: OUTSOURCING DRUG DISCOVERY
Exhibit 4-1: A Selection of RandD Facilities Closed or Reduced in Size between 2010 and 2014
Exhibit 4-2: A Selection of Chinese Drug Discovery CROs
Exhibit 4-3: A Selection Indian Drug Discovery CROs
Exhibit 4-4: A Selection of Major CROs Operating in Eastern Europe
FIVE: DRUG DISCOVERY OUTSOURCING MARKET
Exhibit 5-1: Global Drug Discovery Outsourcing Market, 2008-2018
Exhibit 5-2:Contract Drug Discovery Services, by Market Segment, 2008-2018
Exhibit 5-3: Market Share Drug Discovery Market Segments, 2014
Exhibit 5-4: Chemistry Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018
Exhibit 5-5: Chemistry Market Revenue by: Building Blocks, Compound Synthesis, Libraries, Process Research, and Other Services, 2014
Exhibit 5-6: Biology Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018
Exhibit 5-7: Biology Market Revenue by: Protein Expression, Structural Analysis, Target Validation, Pathways Analysis, and Other Service, 2014
Exhibit 5-8: Screening Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018
Exhibit 5-9: Screening Services Market: Assay Development, Primary Screening, Secondary Screening, 2014
Exhibit 5-10: Lead Optimization Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018
Exhibit 5-11: Lead Optimization Services Market: Early ADMET/Tox, Create Analogues, Computational Support, and Other Services, 2014
Exhibit 5-12: A Selection of Drug Discovery Contractors, by Market Segment
Exhibit 5-13: A Selection of Collaborations between Academic Organizations and CROs
Exhibit 5-14: Partnerships between Pharma and Academia
Exhibit 5-15: A Selection of Alliances between CROs
Exhibit 5-15: Global Expansion of Contract Drug Discovery Services, East and West

View This Report »

Find all the market research you need - instantly, in one place.

+1.2 Million Research Documents & Statistics +200,000 Trusted Public Sources 350 Industries With Global Coverage

24/7 Customer Support

Talk to Louis

+1 718 618 4302

Purchase Reports From Reputable Market Research Publishers

Enabling Technological Platforms for Lab-on-Chip Applications  (Technical Insights)

Enabling Technological Platforms for Lab-on-Chip Applications (Technical Insights)

  • $ 6 500
  • Industry report
  • June 2014
  • by Frost & Sullivan

6 Dimensional Assessment of Lab on a Chip Innovation Landscape A growing trend towards miniaturizing laboratory practices has been a major driving force behind the steady increase of innovations in the ...

Global Proteomics Market

Global Proteomics Market

  • $ 4 950
  • Industry report
  • May 2014
  • by Global Industry Analysts

This report analyzes the worldwide markets for Proteomics in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of ...

Label-Free Detection Market by Technology (Bio-layer interferometry, Optical waveguide grating technology, Surface Plasmon resonance), Consumables & Instruments, Applications (Lead Generation, Binding Kinetics), End user - Global Forecasts & Trends to 201

Label-Free Detection Market by Technology (Bio-layer interferometry, Optical waveguide grating technology, Surface Plasmon resonance), Consumables & Instruments, Applications (Lead Generation, Binding Kinetics), End user - Global Forecasts & Trends to 201

  • $ 4 650
  • Industry report
  • April 2014
  • by MarketsandMarkets

Label-free technology is rapidly gaining widespread acceptance as a drug discovery and life science research tool. Currently, the drug discovery process is based on target identification and screening ...


ReportLinker is an award-winning market research solution that finds, filters and organizes the latest industry data so you get all the market research you need - quickly, in one place.