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US Excipients Market

  • March 2014
  • -
  • Freedonia
  • -
  • 284 pages

US demand to grow 4.3% annually through 2018

Demand for pharmaceutical excipients in the US is projected to rise 4.3 percent per year to $2.0 billion in 2018. In volume terms, demand is expected to grow 1.9 percent annually to 900 million pounds over the same period. While continued growth in pharmaceutical output will be the primary driver of increases in excipient demand, gains will accelerate as excipients play a larger role in bringing additional value to pharmaceutical products by improving properties such as the controlled release or improved
absorption of active ingredients.

Preservatives, suspension agents to see strong gains

Trends in pharmaceutical output by dosage formulation will have a strong influence on excipient demand by application. Output of parenteral preparations is expected to rise at an especially strong pace through 2018, supporting demand for suspension agents and preservatives. Solvents are also projected to benefit from increased shipments of parenteral drugs, although gains in dollar terms will be limited by the continued decline in glycerin prices due to oversupply.
Oral preparations are the largest category of pharmaceutical dosage formulations; thus, oral pharmaceuticals tend to require more excipients than other types of drugs and have a significant impact on excipient demand. Shipments of oral pharmaceuticals are forecast to rise at a faster pace than seen in the 2008-2013 period, supporting accelerated gains in demand for fillers, binders, coatings, flavoring agents, capsules, and disintegrants. In addition, oral formulations such as delayed- and extended-release tablets and capsules and dissolving tablets are expected to boost their market share, further raising demand for excipients such as binders and disintegrants.

Specialty excipient blends to add value to product mix

A major development in the excipient and pharmaceutical industries is the increased dependence on specialty excipient blends. Specialty excipient blends can add value to pharmaceutical products by differentiating them from competitive products, and by optimizing the production process. These value-added excipient blends are often formulated for usage in specific manufacturing processes such as direct compression or wet granulation, and are optimized for certain performance characteristics such as delayed- or extended-release oral tablets. Product differentiation will play an increasingly important role going forward as generic pharmaceutical products increase their market share and as consumers take a more active role in choosing their drugs from among a wide range of products with the same active pharmaceutical ingredients.

Polymers to benefit from specialty blend advances

Product versatility will be a key factor impacting product mix in excipient demand going forward, especially as specialty excipient blends play an increasingly important role in pharmaceutical formulation. Polymers -- including cellulose derivatives, povidone, starch, polyethylene glycol, acrylic polymers, and natural gums -- are expected to benefit from this trend as many of these products can function in multiple applications and are easily formulated with other excipients. These favorable characteristics will serve to offset the higher prices associated with some polymers.

Study coverage

Excipients, an upcoming industry study presents historical demand data (2003, 2008, 013) plus forecasts for 2018 and 2023 by product type and application. This study also analyzes market environment factors, evaluates company market share and profiles 47 US industry competitors.

Table Of Contents

US Excipients Market
INTRODUCTION x
I. EXECUTIVE SUMMARY 1
II. MARKET ENVIRONMENT 4
General 4
Economic Factors 5
Demographic Patterns 9
Health Care Trends 13
National Health Expenditures 14
Medical Conditions 17
Chronic Conditions 18
Acute Conditions 20
Pharmaceuticals 22
Therapeutic Class 23
Dosage Formulations 24
Distribution Classifications 26
Commercial Status 28
Regulatory Overview 29
Historical Market Trends 31
Pricing Trends 32
Foreign Trade 34
International Markets 35
III. PRODUCTS 37
General 37
Polymers 43
Cellulose Derivatives 46
Microcrystalline Cellulose (MCC) 47
Hydroxypropyl Methylcellulose (HPMC) 50
Ethyl Cellulose 54
Methyl Cellulose 55
Carboxymethylcellulose (CMC) 57
Croscarmellose Sodium 59
Other Cellulose Excipients 61
Povidone 64
Starch Compounds 67
Pregelatinized Starch 69
Sodium Starch Glycolate 71
Other Starch Excipients 73
Polyethylene Glycol 77
Acrylic Polymers 80
Other Polymers 84
Natural Gums from Seaweeds 85
Other Natural Gums 88
All Other Polymers 90
Alcohols 91
Propylene Glycol 93
Glycerin 94
Sorbitol 96
Other Alcohols 98
Mannitol 99
Other Polyol Excipients 100
All Other Alcohols 104
Minerals 104
Calcium Phosphate 107
Calcium Carbonate 109
Clay 110
Mineral Hydrocarbons 112
Silicon Dioxide 115
Titanium Dioxide 117
Other Minerals 118
Gelatin 121
Sugars 125
Lactose 127
Sucrose 129
Other Sugar Excipients 131
Other Pharmaceutical Excipients 134
Dyes and Pigments 137
Flavors 138
Surfactants 139
Acidulants 142
Antioxidants and Antimicrobials 143
All Other Compounds 145
Stearate Compounds 145
Electrolytes and Related Compounds 146
Chemical Plasticizers 146
High Intensity Sweeteners 147
Natural Fats and Oils 149
Natural Waxes 150
IV. APPLICATIONS 152
General 152
Fillers and Diluents 155
Binders 157
Suspension and Viscosity Agents 160
Coatings 162
Solvents 164
Flavoring Agents 166
Capsules 168
Disintegrants 171
Colorants 173
Lubricants and Glidants 174
Preservatives 176
Other Applications 177
V. INDUSTRY STRUCTURE 179
General 179
Market Share 181
Competitive Strategies 184
Industry Restructuring 185
Cooperative Agreements 187
Marketing and Distribution 191
Research and Development 192
Manufacturing 193
Company Profiles 194
ABITEC, see Associated British Foods
Akzo Nobel NV 195
ANGUS Chemical, see Dow Chemical
Archer-Daniels-Midland Company 196
Ashland Incorporated 198
Associated British Foods plc 201
Avantor Performance Materials Incorporated 204
BASF SE 206
Berkshire Hathaway Incorporated 209
Berwind Corporation 211
Cabot Corporation 213
Cargill Incorporated 215
Celanese Corporation 218
Colorcon, see Berwind
Corn Products International, see Ingredion
CP Kelco US, see Huber (JM)
Croda International plc 220
CyDex Pharmaceuticals, see Ligand Pharmaceuticals
Dow Chemical Company 222
DuPont (EI) de Nemours 227
Eastman Chemical Company 229
EMD Millipore, see Merck
Evonik Industries AG 231
Ferro Corporation 234
FibroGen Incorporated 235
FLAVORx Incorporated 236
FMC Corporation 237
GELITA AG 239
Generichem Corporation 240
Huber (JM) Corporation 241
Huntsman Corporation 244
Ingredion Incorporated 245
Innophos Holdings Incorporated 247
JRS Pharma, see Rettenmaier (J.) and Söhne
Kraft Foods Group Incorporated 248
Kuraray Company Limited 249
Ligand Pharmaceuticals Incorporated 250
Lubrizol, see Berkshire Hathaway
LyondellBasell Industries NV 252
Merck KGaA 253
Mutchler Incorporated 255
Nitta Gelatin Incorporated 256
NutraSweet Company 257
Nutrinova, see Celanese
PandG Chemicals, see Procter and Gamble
PB Gelatins, see Tessenderlo Group
Pfanstiehl Incorporated 258
Procter and Gamble Company 259
Rettenmaier (J.) and Söhne GmbH and Company KG 260
Roquette Freres SA 262
Royal Dutch Shell plc 265
Sasol Limited 266
Shin-Etsu Chemical Company Limited 268
Solvay SA 270
SPI Pharma, see Associated British Foods
Stepan Company 271
Tate and Lyle plc 273
Tessenderlo Group NV 275
USG Corporation 276
Wacker Chemie AG 277
Other Companies Mentioned in Study 280

LIST OF TABLES

SECTION I -- EXECUTIVE SUMMARY
Summary Table 3
SECTION II -- MARKET ENVIRONMENT
1 Macroeconomic Indicators 9
2 Population and Households 13
3 National Health Expenditures 17
4 Chronic Conditions by Type 20
5 Acute Conditions by Type 21
6 Pharmaceutical Supply and Demand 22
7 Pharmaceutical Shipments by Therapeutic Class 24
8 Pharmaceutical Shipments by Dosage Formulation 26
9 Pharmaceutical Shipments by Distribution Classification 28
10 Pharmaceutical Shipments by Commercial Status 29
11 Excipient Market, 2003-2013 32
12 Pharmaceutical Excipient Pricing 34
SECTION III -- PRODUCTS
1 Pharmaceutical Excipient Demand by Product Group 41
2 Polymer Excipient Demand by Type and Application 44
3 Cellulose Excipient Demand by Type and Application 47
4 Microcrystalline Cellulose Excipient Demand by Application 50
5 Hydroxypropyl Methylcellulose Excipient Demand
by Application 53
6 Ethyl Cellulose Excipient Demand by Application 55
7 Methyl Cellulose Excipient Demand by Application 57
8 Carboxymethylcellulose Excipient Demand by Application 59
9 Croscarmellose Sodium Excipient Demand 61
10 Other Cellulose Excipient Demand by Application 64
11 Povidone Excipient Demand by Application 67
12 Starch Excipient Demand by Type and Application 69
13 Pregelatinized Starch Excipient Demand by Application 71
14 Sodium Starch Glycolate Excipient Demand 73
15 Other Starch Excipient Demand by Application 74
16 Polyethylene Glycol Excipient Demand by Application 80
17 Acrylic Polymer Excipient Demand by Application 84
18 Other Polymer Excipient Demand by Type and Application 85
19 Alcohol Excipient Demand by Type and Application 92
20 Propylene Glycol Excipient Demand by Application 94
21 Glycerin Excipient Demand by Application 96
22 Sorbitol Excipient Demand by Application 98
23 Other Alcohol Excipient Demand by Type and Application 99
24 Mineral Excipient Demand by Type and Application 106
25 Calcium Phosphate Excipient Demand 108
26 Calcium Carbonate Excipient Demand 110
27 Clay Excipient Demand by Application 112
28 Mineral Hydrocarbon Excipient Demand by Application 115
29 Silicon Dioxide Excipient Demand by Application 117
30 Titanium Dioxide Excipient Demand 118
31 Other Mineral Excipient Demand by Application 121
32 Gelatin Excipient Demand by Application 125
33 Sugar Excipient Demand by Type and Application 126
34 Lactose Excipient Demand by Application 129
35 Sucrose Excipient Demand by Application 131
36 Other Sugar Excipient Demand by Application 134
37 Other Pharmaceutical Excipient Demand by Type and Application 136
SECTION IV -- APPLICATIONS
1 Pharmaceutical Excipient Demand by Application 154
2 Filler and Diluent Excipient Demand by Type 157
3 Binder Excipient Demand by Type 160
4 Suspension and Viscosity Excipient Demand by Type 162
5 Coating Excipient Demand by Type 164
6 Solvent Excipient Demand by Type 166
7 Flavoring Agent Excipient Demand by Type 168
8 Capsule Excipient Demand by Type 171
9 Disintegrant Excipient Demand by Type 172
10 Colorant Excipient Demand by Type 174
11 Lubricant and Glidant Excipient Demand by Type 175
12 Preservative Excipient Demand by Type 177
13 Other Applications for Excipients by Type 178
1 US Excipient Sales by Company, 2013 180
2 Selected Acquisitions and Divestitures 187
3 Selected Cooperative Agreements 189

LIST OF CHARTS

SECTION III -- PRODUCTS
1 Excipient Demand by Product: Value and Volume, 2013 42
2 Polymer Excipient Demand: Value and Volume, 2013 45
SECTION IV -- APPLICATIONS
1 Pharmaceutical Excipient Demand by Application, 2013 155
SECTION V -- INDUSTRY STRUCTURE
1 US Excipient Market Share, 2013 182

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