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Bimmugen (Prophylactic Hepatitis B Virus Vaccines) - Forecast and Market Analysis to 2022

Summary

Hepatitis B, which is caused by the hepatitis B virus (HBV), is characterized by acute or chronic inflammation of the liver. Researchers and healthcare experts have estimated that roughly two billion people are infected with HBV worldwide, with roughly 600,000 people dying each year from HBV-related liver diseases. While the arrival of recombinant HBsAg vaccines has greatly reduced disease burden over the past two decades, questions surrounding vaccine uptake and effectiveness in adults, particularly in niche patient populations, still remain. GlobalData expects that the growing popularity of pediatric combination vaccines, along with the arrival of vaccines that achieve higher seroconversion rates in high-risk adults, will serve to stimulate growth in the marketplace over the forecast period. Country-specific immunization recommendations and policy implementation will be an essential metric for determining future vaccine uptake in the 7MM (US, France, Germany, Italy, Spain, UK, and Japan) and Canada.

Bimmugen [Recombinant adsorbed hepatitis B vaccine (yeast-derived)] is Kaketsuken’s monovalent vaccine that protects infants against acute and chronic infections caused by all known strains of HBV. In 1988, Bimmugen became the first HBV vaccine available in Japan. The antigen contained in Bimmugen, purified recombinant HBsAg, is obtained by culturing S. cerevisiae cells that have been genetically engineered to express the viral protein. All dosages and formulations of Bimmugen are administered by intramuscular injection.

Scope

- Overview of Hepatitis B disease, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Bimmugen including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Bimmugen for Japan from 2012 to 2022.
- Sales information covered for Japan

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Hepatitis B
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Bimmugen performance
- Obtain sales forecast for Bimmugen from 2012-2022 in Japan.

Table Of Contents

Bimmugen (Prophylactic Hepatitis B Virus Vaccines) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Related Reports 11
3 Disease Overview 12
3.1 Overview 12
3.2 Etiology and Pathophysiology 13
3.2.1 Etiology 13
3.2.2 Pathophysiology 16
3.3 Symptoms 18
3.4 Prognosis 20
4 Vaccination Recommendations and Coverage Rates 21
4.1 Overview 21
5 Competitive Assessment 25
5.1 Overview 25
5.2 Strategic Competitor Assessment 25
6 Bimmugen 28
6.1 Overview 28
6.2 SWOT Analysis 29
6.3 Forecast 29
7 Appendix 30
7.1 Bibliography 30
7.2 Abbreviations 44
7.3 Methodology 47
7.4 Forecasting Methodology 47
7.4.1 Patient Populations Targeted for Vaccination 48
7.4.2 Vaccination Coverage Rates 51
7.4.3 Vaccinated Patients 52
7.4.4 Regulatory Approval vs. Advisory Committee Recommendation 52
7.4.5 General Pricing Assumptions 53
7.4.6 Individual Vaccine Assumptions 54
7.5 Physicians and Specialists Included in this Study 55
7.5.1 Interviews of Key Opinion Leaders (KOLs) 55
7.5.2 Online Survey of High-Prescribing Physicians (non-KOLs) 57
7.6 About the Authors 58
7.6.1 Analyst 58
7.6.2 Therapy Area Director 58
7.6.3 Global Head of Healthcare 59
7.7 About GlobalData 60
7.8 Disclaimer 60

1.1 List of Tables

Table 1: Modes of HBV Transmission 17
Table 2: HBV Serological Markers and Test Interpretations 18
Table 3: Symptoms of HBV Infection 19
Table 4: HBV Vaccination Advisory Committees by Country 22
Table 5: HBV Immunization Recommendations by Country 23
Table 6: Targeted Age Group(s) for Routine Immunization and Most Administered HBV Vaccines by Country in the Global Markets, 2014 24
Table 7: Leading Vaccines for HBV, 2014 27
Table 8: Product Profile - Bimmugen 28
Table 9: Bimmugen SWOT Analysis, 2014 29
Table 10: Global Sales Forecasts ($m) for Bimmugen, 2012-2022 29
Table 11: Patient Population(s) Targeted for HBV Vaccination in the Pediatric Market, by Country 49
Table 12: Patient Population(s) Targeted for HBV Vaccination in the Adult Market, by Country 50
Table 13: High-Prescribing Physicians (non-KOLs) Surveyed, by Country 57

1.2 List of Figures

Figure 1: HBV Structure and the Recombinant Vaccine Development Process 14

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