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Seroquel (Schizophrenia) - Forecast and Market Analysis to 2022

Summary

Schizophrenia is a persistent long-term brain disorder that causes severe, debilitating psychotic episodes. Its core symptoms, auditory or visual hallucinations, are often accompanied by fixed, false, and often paranoid beliefs, called delusions. These two features are often combined with learning and cognitive deficits. WHO experts have estimated that roughly 24 million people are affected by schizophrenia worldwide. While the arrival of atypical antipsychotics has greatly expanded pharmacologic treatment options over the past two decades, the current drug market does not treat the negative and cognitive symptoms that are associated with the disease. GlobalData expects that the growing popularity of long-acting injectable (LAI) antipsychotics, along with the arrival of novel treatments that achieve higher efficacy in negative- and cognitive-predominant patients, will serve to stimulate growth in the marketplace over the forecast period. Country-specific treatment recommendations and policy implementation will be an essential metric for determining future mental health services in the 7MM.

Seroquel (quetiapine; AstraZeneca) is a dibenzothiazepine derivative that has broad receptor activity and a relatively high affinity for serotonin 5-HT2A receptors over D1 and D2. Quetiapine also has affinity at H1, M1, a1 and a2 adrenergic receptor sites. Although the drug was originally developed in 1985, Seroquel did not receive FDA marketing approval until 1997. After later launching in Germany in 2000, Seroquel became a widely used atypical antipsychotic for severe acute manic episodes and schizophrenia.

Scope

- Overview of Schizophrenia, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Seroquel including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Seroquel for the top seven countries from 2012 to 2022.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Schizophrenia
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Seroquel performance
- Obtain sales forecast for Seroquel from 2012-2022 in the top seven countries (the US, France, Germany, Italy, Spain, the UK and Japan)

Table Of Contents

Seroquel (Schizophrenia) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Reports 10
3 Disease Overview 11
3.1 Etiology and Pathophysiology 12
3.1.1 Etiology 12
3.1.2 Pathophysiology 12
3.2 Symptoms 13
4 Disease Management 15
4.1 Diagnosis 15
4.1.1 Subjective Assessments 16
4.1.2 Disease Subtypes 17
4.2 Treatment Overview 20
4.2.1 Treatment of Acute Agitation Associated with Schizophrenia 22
4.2.2 Maintenance Treatment of Schizophrenia 23
5 Competitive Assessment 25
5.1 Overview 25
5.2 Strategic Competitor Assessment 26
6 Seroquel (quetiapine) 28
6.1 Overview 29
6.2 Efficacy 30
6.3 Safety 30
6.4 SWOT Analysis 30
6.5 Forecast 31
7 Appendix 32
7.1 Bibliography 32
7.2 Abbreviations 34
7.3 Methodology 35
7.4 Forecasting Methodology 35
7.4.1 Diagnosis and Treatment Rates 35
7.4.2 Adherence Rates 36
7.4.3 General Pricing Assumptions 36
7.4.4 Drug Assumptions 38
7.4.5 Generic Erosion 38
7.5 Key Opinion Leaders 39
7.6 About the Authors 40
7.6.1 Author 40
7.6.2 Reviewers 40
7.6.3 Global Head of Healthcare 41
7.7 About GlobalData 42
7.8 Disclaimer 42

1.1 List of Tables

Table 1: Symptom Clusters of Schizophrenia 14
Table 2: Common Subjective Rating Scales Employed in Schizophrenia Diagnosis 17
Table 3: Development-Based Classification of Antipsychotic Drugs 20
Table 4: Receptor Binding Profiles of Atypical Antipsychotics 21
Table 5: Guidelines for the Treatment of Schizophrenia 22
Table 6: Leading Branded Treatments for Schizophrenia, 2013 27
Table 7: Strategic Competitor Assessment of the Marketed Products in Schizophrenia, 2014 27
Table 8: Product Profile - Seroquel 29
Table 9: Seroquel SWOT Analysis, 2013 30
Table 10: Global Sales Forecast ($m) for Seroquel, 2012-2022 31

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