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Geodon (Schizophrenia) - Forecast and Market Analysis to 2022

Summary

Schizophrenia is a persistent long-term brain disorder that causes severe, debilitating psychotic episodes. Its core symptoms, auditory or visual hallucinations, are often accompanied by fixed, false, and often paranoid beliefs, called delusions. These two features are often combined with learning and cognitive deficits. WHO experts have estimated that roughly 24 million people are affected by schizophrenia worldwide. While the arrival of atypical antipsychotics has greatly expanded pharmacologic treatment options over the past two decades, the current drug market does not treat the negative and cognitive symptoms that are associated with the disease. GlobalData expects that the growing popularity of long-acting injectable (LAI) antipsychotics, along with the arrival of novel treatments that achieve higher efficacy in negative- and cognitive-predominant patients, will serve to stimulate growth in the marketplace over the forecast period. Country-specific treatment recommendations and policy implementation will be an essential metric for determining future mental health services in the 7MM.

Geodon (ziprasidone; Pfizer/Meiji Seika) is a 5-HT2A/D2 antagonist, with greater affinity for 5-HT2A than D2. With agonism at the 5-HT1A receptor, Geodon has questionable effects on improving the negative and cognitive symptoms. The drug has no appreciable affinity for M1 or M3 muscarinic receptors, and is associated with low overall effects to weight and metabolic functions. With oral and IM formulations available, Geodon can be used in acute and maintenance treatment settings.

Scope

- Overview of Schizophrenia, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Geodon including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Geodon for the top five countries from 2012 to 2022.
- Sales information covered for the US, Germany, Italy, Spain and Japan

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Schizophrenia
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Geodon performance
- Obtain sales forecast for Geodon from 2012-2022 in the top five countries (the US, Germany, Italy, Spain and Japan)

Table Of Contents

Geodon (Schizophrenia) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Reports 10
3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 12
3.2 Symptoms 13
4 Disease Management 14
4.1 Diagnosis 14
4.1.1 Subjective Assessments 15
4.1.2 Disease Subtypes 16
4.2 Treatment Overview 19
4.2.1 Treatment of Acute Agitation Associated with Schizophrenia 21
4.2.2 Maintenance Treatment of Schizophrenia 22
5 Competitive Assessment 23
5.1 Overview 23
5.2 Strategic Competitor Assessment 24
6 Geodon (ziprasidone hydrochloride) 26
6.1 Overview 26
6.2 Efficacy 27
6.3 Safety 27
6.4 SWOT Analysis 28
6.5 Forecast 28
7 Appendix 29
7.1 Bibliography 29
7.2 Abbreviations 31
7.3 Methodology 32
7.4 Forecasting Methodology 32
7.4.1 Diagnosis and Treatment Rates 32
7.4.2 Adherence Rates 33
7.4.3 General Pricing Assumptions 33
7.4.4 Drug Assumptions 34
7.4.5 Generic Erosion 35
7.5 Key Opinion Leaders 36
7.6 About the Authors 37
7.6.1 Author 37
7.6.2 Reviewers 37
7.6.3 Global Head of Healthcare 38
7.7 About GlobalData 39
7.8 Disclaimer 39

1.1 List of Tables

Table 1: Symptom Clusters of Schizophrenia 13
Table 2: Common Subjective Rating Scales Employed in Schizophrenia Diagnosis 16
Table 3: Development-Based Classification of Antipsychotic Drugs 19
Table 4: Receptor Binding Profiles of Atypical Antipsychotics 20
Table 5: Guidelines for the Treatment of Schizophrenia 21
Table 6: Leading Branded Treatments for Schizophrenia, 2013 25
Table 7: Strategic Competitor Assessment of the Marketed Products in Schizophrenia, 2014 25
Table 8: Product Profile - Geodon 26
Table 9: Geodon SWOT Analysis, 2013 28
Table 10: Global Sales Forecasts ($m) for Geodon, 2012-2022 28

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