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Humira (Ulcerative Colitis) - Forecast and Market Analysis to 2022

Summary

During the forecast period from 2012-2022, the growth of the UC market will be driven largely by the entry of Johnson & Johnson’s (J&J’s) Simponi and Takeda’s Entyvio, which will lead to an increase in the overall number of patients being treated with biologics in the US, 5EU, Japan, and Canada. Another key event affecting the UC market is the anticipated launch of biosimilars, given that the patent expiry of the UC blockbusters, Remicade and Humira are set to expire in the US in 2018 and 2016, respectively.

Humira is considered a first-generation, first-line biologic therapy for the treatment of moderate to severe psoriasis. It is injected subcutaneously and is administered every two weeks (Humira package insert, 2011). Despite being the second anti-TNF to launch for UC, its rise to the top of the anti-TNF class is due, in part, to its SC administration, along with AbbVie’s extensive marketing experience. Humira is marketed by AbbVie in the US and Europe, and by Eisai in Japan.

Scope

- Overview of Ulcerative Colitis, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Humira including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Humira for the top eight countries from 2012 to 2022.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK, Japan and Canada.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Ulcerative Colitis
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Humira performance
- Obtain sales forecast for Humira from 2012-2022 in the top eight countries (the US, France, Germany, Italy, Spain, the UK, Japan and Canada)

Table Of Contents

Humira (Ulcerative Colitis) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 8
2.3 Upcoming Related Reports 10
3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 13
3.2 Symptoms 15
3.2.1 Quality of Life 16
4 Disease Management 17
4.1 Diagnosis and Treatment Overview 17
4.1.1 Diagnosis 17
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 20
4.1.3 Clinical Practice 22
5 Competitive Assessment 26
5.1 Overview 26
5.2 Strategic Competitor Assessment 27
6 Humira (adalimumab) 29
6.1 Overview 29
6.2 Efficacy 30
6.3 Safety 31
6.4 SWOT Analysis 32
6.5 Forecast 33
7 Appendix 35
7.1 Bibliography 35
7.2 Abbreviations 37
7.3 Methodology 40
7.4 Forecasting Methodology 40
7.4.1 Diagnosed UC Patients 40
7.4.2 Percent Drug-Treated Patients 41
7.4.3 General Pricing Assumptions 41
7.4.4 Individual Drug Assumptions 42
7.4.5 Generic Erosion 42
7.5 Physicians and Specialists Included in This Study 43
7.6 Primary Research - Prescriber Survey 44
7.7 About the Authors 45
7.7.1 Author 45
7.7.2 Global Head of Healthcare 46
7.8 About GlobalData 47
7.9 Disclaimer 47

1.1 List of Tables

Table 1: Genetic Factors That Confer a Predisposition to UC 13
Table 2: Typical Symptoms of UC 15
Table 3: Truelove and Witts UC Severity Index 19
Table 4: UCDAI 20
Table 5: Treatment Guidelines for UC Used in the 10MM 21
Table 6: Most Commonly Prescribed Drugs for UC by Class in the 10MM, 2013 22
Table 7: Leading Treatments for UC, 2014 28
Table 8: Product Profile - Humira 30
Table 9: Humira Efficacy in the ULTRA 2 Trial 31
Table 10: Product Efficacy Comparison - Humira vs. Remicade 31
Table 11: Humira SWOT Analysis, 2014 33
Table 12: Global Sales Forecasts ($m) for Humira, 2012-2022 34
Table 13: Physicians Surveyed, By Country 44

1.2 List of Figures

Figure 1: Cellular Mechanisms Involved in the Pathogenesis of UC 14
Figure 2: UC Disease Management Flowchart 25

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