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  4. > Apriso (Ulcerative Colitis) - Forecast and Market Analysis to 2022

Apriso (Ulcerative Colitis) - Forecast and Market Analysis to 2022

Summary

During the forecast period from 2012-2022, the growth of the UC market will be driven largely by the entry of Johnson & Johnson’s (J&J’s) Simponi and Takeda’s Entyvio, which will lead to an increase in the overall number of patients being treated with biologics in the US, 5EU, Japan, and Canada. Another key event affecting the UC market is the anticipated launch of biosimilars, given that the patent expiry of the UC blockbusters, Remicade and Humira are set to expire in the US in 2018 and 2016, respectively.

Apriso features an Intellicor-coated gel suspension of mesalamine. The Intellicor coating that enables the release of mesalamine exclusively in the colon, dissolving at pH =6. Therefore, the entire mesalamine concentration of the pill formulation is successfully administered to the colon, unlike a conventional mesalamine formulation, which would be partly depleted in the acidic environment of the stomach or mostly absorbed in the jejunum (the middle portion of the small intestine that connects the duodenum and the ileum, which are not part of the colon).

Scope

- Overview of Ulcerative Colitis, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Apriso including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Apriso for the top six countries from 2012 to 2022.
- Sales information covered for the US, Germany, Spain, the UK, China and India.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Ulcerative Colitis
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Apriso performance
- Obtain sales forecast for Apriso from 2012-2022 in the top six countries (the US, Germany, Spain, the UK, China and India)

Table Of Contents

Apriso (Ulcerative Colitis) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 9
2.3 Upcoming Related Reports 10
3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 14
3.2 Symptoms 15
3.2.1 Quality of Life 16
4 Disease Management 17
4.1 Diagnosis and Treatment Overview 17
4.1.1 Diagnosis 17
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 21
4.1.3 Clinical Practice 22
5 Competitive Assessment 26
5.1 Overview 26
5.2 Strategic Competitor Assessment 27
6 Apriso (mesalamine) 29
6.1 Overview 29
6.2 Efficacy 30
6.3 Safety 31
6.4 SWOT Analysis 31
6.5 Forecast 33
7 Appendix 34
7.1 Bibliography 34
7.2 Abbreviations 36
7.3 Methodology 39
7.4 Forecasting Methodology 39
7.4.1 Diagnosed UC Patients 39
7.4.2 Percent Drug-Treated Patients 40
7.4.3 General Pricing Assumptions 40
7.4.4 Individual Drug Assumptions 41
7.4.5 Generic Erosion 41
7.5 Physicians and Specialists Included in This Study 42
7.6 Primary Research - Prescriber Survey 43
7.7 About the Authors 44
7.7.1 Author 44
7.7.2 Global Head of Healthcare 45
7.8 About GlobalData 46
7.9 Disclaimer 46

1.1 List of Tables

Table 1: Genetic Factors That Confer a Predisposition to UC 13
Table 2: Typical Symptoms of UC 15
Table 3: Truelove and Witts UC Severity Index 19
Table 4: UCDAI 20
Table 5: Treatment Guidelines for UC Used in the 10MM 21
Table 6: Most Commonly Prescribed Drugs for UC by Class in the 10MM, 2013 22
Table 7: Leading Treatments for UC, 2014 28
Table 8: Product Profile - Apriso 30
Table 9: Apriso SWOT Analysis, 2014 32
Table 10: Global Sales Forecasts ($m) for Apriso, 2012-2022 33
Table 11: Annual Cost of Therapy for 5-ASAs ($) 41
Table 12: Physicians Surveyed, By Country 43

1.2 List of Figures

Figure 1: Cellular Mechanisms Involved in the Pathogenesis of UC 15
Figure 2: UC Disease Management Flowchart 25

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