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Anti-Epileptics (Migraine) - Forecast and Market Analysis to 2023

Summary

The migraine market is saturated with generic drugs, and the remaining branded products already on the market are expected to lose exclusivity during the next few years, with the exception of Botox for chronic migraine, which is expected to maintain its leading position in terms of sales. However, reformulations of mature products as well as new classes of therapies are anticipated to launch during the forecast period and these will contribute to the market growth. By 2023, the migraine market will grow to $3.7 billion at a compound annual growth rate (CAGR) of 3.6%, with the US continuing to dominate the market as a result of higher drug prices and a large migraine population. Some of the new treatments are expected to target the key unmet needs but opportunities will remain for further treatment choices especially drugs that will offer an improved safety and side-effects profile.

Anti-epileptics were originally developed as treatments for epileptic seizures; however, due to the well-conducted placebo-controlled trials for migraine, they have demonstrated efficacy in the prophylaxis of migraine, with Depakene (valproic acid) and Topamax (topiramate) securing FDA approval for the prophylactic treatment of migraines.

Scope

- Overview of Migraine, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Anti-epileptics including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Anti-epileptics for the top seven countries from 2012 to 2023.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Migraine
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Anti-epileptics performance
- Obtain sales forecast for Anti-epileptics from 2012-2023 in the top seven countries (the US, France, Germany, Italy, Spain, the UK and Japan)

Table Of Contents

Anti-Epileptics (Migraine) - Forecast and Market Analysis to 2023
1 Table of Contents

2 Introduction 9
2.1 Catalyst 9
2.2 Related Reports 9
2.3 Upcoming Related Reports 11
3 Disease Overview 12
3.1 Etiology and Pathophysiology 14
3.1.1 Etiology 14
3.1.2 Pathophysiology 15
3.1.3 Prognosis 16
3.2 Symptoms 16
3.2.1 Premonitory Phase 17
3.2.2 Aura Phase 17
3.2.3 Headache Phase 18
3.2.4 Postdrome Phase 18
4 Disease Management 19
4.1 Treatment Overview 19
4.1.1 Acute Migraine Treatment 22
4.1.2 Preventive Migraine Treatment 23
5 Competitive Assessment 24
5.1 Overview 24
5.2 Strategic Competitor Assessment 25
6 Anti-Epileptics 27
6.1 Overview 27
6.2 Efficacy 29
6.3 Safety 29
6.4 SWOT Analysis 30
6.5 Forecast 30
7 Appendix 32
7.1 Bibliography 32
7.2 Abbreviations 35
7.3 Methodology 36
7.4 Forecasting Methodology 36
7.4.1 Diagnosed Migraine Patients 36
7.4.2 Percent Drug-treated Patients 36
7.4.3 General Pricing Assumptions 37
7.4.4 Individual Drug Assumptions 38
7.4.5 Generic Erosion 38
7.5 Physicians and Specialists Included in this Study 39
7.6 Survey of Prescribing Physicians 40
7.7 About the Authors 41
7.7.1 Author 41
7.7.2 Reviewer 41
7.7.3 Global Head of Healthcare 42
7.8 About GlobalData 43
7.9 Disclaimer 43

1.1 List of Tables

Table 1: Classification of Migraine Subtypes 13
Table 2: Diagnostic Criteria for Migraine with Aura 17
Table 3: Diagnostic Criteria for Migraine without Aura 18
Table 4: Treatment Guidelines for Migraine 20
Table 5: Most Prescribed Drugs for Migraine by Class in the Major Markets, 2013 21
Table 6: Product Profile - Anti-Epileptics 28
Table 7: Anti-Epileptics SWOT Analysis, 2013 30
Table 8: Global Sales Forecasts ($m) for Anti-Epileptics, 2012-2023 31
Table 9: Physicians Surveyed, By Country 40

1.2 List of Figures

Figure 1: Migraine Treatment Algorithm in the 7MM 21

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