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  4. > Antibiotics, medicinal plants, superbugs and the coming antimicrobial resistant drugs pandemic : global markets, competitors and opportuninites - 2014 - 2019 Analysis and Forecasts

An Antibiotic is an agent that either kills or inhibits the growth of a microorganism. The world is now facing a grave situation: it is losing the battle against infectious diseases; bacteria are fighting back and are becoming resistant to modern medicine; in short, pharmaceutical drugs don’t work. If resistance is allowed to increase, in a few decades people may start dying from the most commonplace of ailments that today can be treated easily. In fact, the ability of organisms to develop resistance to the effects of antimicrobial therapies developed to kill them is potentially the greatest challenge to healthcare in the 21st century.

Antimicrobial resistance (AMR) is a form of drug resistance whereby some sub-populations of a microorganism, usually a bacterial species, are able to survive after exposure to one or more antibiotics. Pathogens resistant to multiple antibiotics are considered multidrug resistant (MDR) or, more colloquially, superbugs.

The US and world are in the beginning of an emerging crisis of Antibiotic resistance for microbial pathogens. Epidemic antibiotic resistance has been described in numerous pathogens in varying contexts, including, but not limited to: MRSA (methicillin-resistant Staphylococcus aureus), common respiratory pathogens, including Streptococcus pneumoniae and Mycobacterium tuberculosis, and epidemic increases in multidrug-resistant and, increasingly, truly pan-resistant, gram-negative bacilli.

Why is the level of concern increasing now? It is because the increase in organisms resistant to multiple therapies is now coinciding with the reduction in new therapies coming to market to replace ineffective ones.

Herbal medicine, including medicinal plants, was the only way people could treat infectious diseases until the early 20th century. Since then, pharmaceutical drugs have become the main method for treating bacterial infections. However, the pharmaceutical drug pipeline is almost dry. At the same time, growing consumer awareness of the benefits of herbal medicine, along with a backlash against the exorbitant prices and dangerous side effects of pharmaceutical drugs, have led to a renaissance in the use of medicinal plants. Consumers are starting to focus on keeping healthy rather than dealing with acute situations that require the use of expensive pharmaceutical drugs. Medicinal plants fit perfectly into this new paradigm. And for this reason, their use is forecast to grow dramatically.

This report looks at the use of medicinal plants, rather than Antibiotics, to both treat and prevent bacterial infections.

Specifically, it provides:

• A detailed look at Antibiotics and Antimicrobial Resistant drugs.
• Analysis of the Antibiotics market.
• In-depth examination of Antibacterial Medicinal Plants.
• Analysis of the Medicinal Plants market.

Additionally, profiles of 127 private and public companies involved in the Antibiotics and Medicinal Plants industries as producers, distributors, and retailers are given. The report also includes 32 tables and 32 figures.

Table Of Contents

Antibiotics, medicinal plants, superbugs and the coming antimicrobial resistant drugs pandemic : global markets, competitors and opportuninites - 2014 - 2019 Analysis and Forecasts
INTRODUCTION

- Background, Spread of MRSA to Households, New Delhi Metallo, Consumers Moving Toward Herbal Medicine, Mainstream Medical Establishments Changing Their Thinking, Consumer Focus Now on Maintaining Health, Outlook for Medicinal Plants Vs. Antibiotic Drugs
- Report Objectives
- Methodology and Sources
- Statistical Notes

EXECUTIVE SUMMARY

ANTIBIOTICS AND ANTIMICROBIAL RESISTANT DRUGS

- Antibiotics
- Antibiotic Resistance
- Epidemic of Antibiotic-Resistant Infections
- Grave Situation
- Modern Healthcare Built on Antimicrobials
- History of Antimicrobial Resistance
- Putting the Problem in Context
- Fallacy of Antibiotic Overuse
- Decreasing Antibiotic Development
- Increasing Costs, Decreasing ROI
- Lack of FDA Guidance
- Companies Developing New Antibiotic Drugs
- Government Efforts
- Multi-Drug Resistance Growing
- Current Situation
- Number of AMR Cases Each Year by Type
- More Needs to Be Done
- Incentive Problems
- Economic Costs
- Cost of MRSA
- Paradox of Low Impact
- Limits of Costs of Resistance Assessments
- Outlook
- Reducing Uncertainty and Increasing Knowledge
- Developing Better Incentives
- International Activity

ANTIBIOTICS MARKET OVERVIEW

- Total Market
- Market by Type
- Market by Region
- Market by Application
- Market Commoditization
- Competitive Environment
- Market Opportunities
- Gram-negative Market
- Clostridium difficile-Associated Diarrhea (CDAD)
- Market Landscape for CDAD Treatments
- Fecal Matter Transplants (FMTs)
- Gram-positive Market

PROSPECTS FOR PLANT-DERIVED ANTIBACTERIALS

- Historical Context
- Single-Ingredient Drugs
- Big Pharma Lost Interest in Plants 20 Years Ago
- Need for New Strategies
- Case Against Plants
- Need for New Technologies
- FDA and Botanical Drugs
- First Botanical Drug NDA
- First Oral Botanical Drug NDA
- Future of Botanical Drug Products in the US
- International Botanical Drugs
- Why Biological Drugs Are Needed
- Future of Botanical Drugs in the US
- Scarcity of Disease in Wild Plants
- Why New Antimicrobial Substances from Plants
- Plants as a Source of Antimicrobials
- Plants Synthesize Target-Specific Antibacterials
- Synergy and Multidrug Resistance Pump Inhibitors
- Plant Antibacterials Function in Synergy
- Targeting Bacterial Virulence
- Future Directions
- Plant Antibacterials
- MDR Inhibitors
- Block Pathogen Virulence
- Antimicrobial Resistance and Phytochemicals
- New Therapy Against Resistance
- Phytotherapy
- Phytochemicals and Their Classes
- Secondary Metabolites
- Phenolics and Polyphenols
- Mode of Action of Phytochemicals
- Biofilms and Phytochemicals
- Quorum-Sensing
- Phytochemical Products as Antimicrobials and in Biofilm Control
- Anti-staphylococcal Plant Natural Products
- Resistance Modifying Agents
- Methicillin-resistance Reversing Agents
- Modulators of Multidrug Resistance
- Antibacterial Natural Products
- Topical Materials
- Biological Warfare
- List of Antimicrobial Plants

MEDICINAL PLANT MARKET

- Market Size Estimation Issues
- Global Medicinal Plant Production
- Global Medicinal Plant Exports
- Global Medicinal Plant Imports
- Global Medicinal Plant Production by Type
- Competitive Environment

COMPANY PROFILES

A.A. Sayia and Company, Inc.
A. Baur and Co (Pvt.) Ltd.
Adam Group
Adams Extract and Spice, LLC,
Afriplex
Akbar Brothers Ltd.
Alchem International
Alvita Tea
Ambo Exports
A. M. Todd Botanical Therapeutics, LLC
Asian Tea and Exports Ltd.
Balaji Agro International
Bart Ingredients Company Ltd
Bigelow Tea Company
Bio Foods Pvt Ltd
Brassica Teas
Cape Natural Tea Products
C

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