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Ophthalmic Drugs; Data, Analysis and Forecasts to 2024

  • March 2014
  • -
  • GMR Data Ltd
  • -
  • 158 pages

Ophthalmic Drugs; Data, Analysis and Forecasts to 2024

Which ophthalmic drugs lead the market in 2013? Will the same drugs be as successful in 2018? How will this landscape change across the next 10 years? Which trial drugs are likely to make an impact? Only one report will tell you the answers. Simply by ordering and reading GMR Data’s new ‘Ophthalmic Drugs; Data, Analysis and Forecasts to 2024’ report, you can stay ahead of your competition. It really is that simple.

GMR Data forecasts that the global ophthalmic drugs market will reach $9.7bn by 2024. The US market growth will be slow compared to other markets predominantly due to major drug patent expiry and generic erosion. For example;

• Xalabrands from Pfizer used for treatment of Glaucoma expired in the US in March 2011.
• Azopt by Alcon used for treatment of Glaucoma expired in the US in October 2012.
• Lumigan by Allergan used for treatment of Glaucoma expired in the US in 2013.
• Restasis from Allergan used for treatment of Dry eye will expire in the US in May 2014.
• Travatan by Alcon used for treatment of Glaucoma will expire in the US in 2014.
• Combigan by Allergan used for treatment of Glaucoma will expire in the US in 2022.
• Lucentis from Novartis used for treatment of Retinal Disorder will expire in the US in June 2020.

Restasis by Allergan is the market-leading drug in the ophthalmic market with sales of $1bn across 2013. Will it be able to see off the competition for the next 5 years? The next 10 years? This report tells you. With an assessment of the leading markets, such as the US, and EU, GMR Data examine how Germany and France are the largest EU markets and what % of the global market they make up. Which other countries contribute most? This report tells you in a concise, focused and easily accessible format.

But how will these country’s markets develop? This report will tell you - TODAY

Global incidences of AMD, Glaucoma and Diabetic Retinopathy are all set to increase dramatically across the forecast period of 2014-2024; this will have the knock-on effect of driving sales of key drugs for treatment i.e. Lucentis and Eylea, as well as driving R&D. How much is being spent on R&D – and which drugs are likely to see a return? And how quickly?

Which new drugs will we see in the ophthalmic market across 2014-2024?
In December 2013 Santen announced that Ikervis (Ciclosporin / Cyclokat) was filed to the EMA, in doing so the EMA will begin its regulatory process. Diquas, which was launched in 2010 by Santen Pharma in Japan, China and other Asian markets, and despite US trials being unsuccessful, is expected to gain approval in the EU early in our forecast period.

Other key ophthalmic drugs currently under taking trials include;
• Sirolimus (By Santen, in Phase III US)
• Tafluprost/Timolol maleate (By Santen, filed for NDA)
• Catioprost (By Santen in Phase 2)

PLUS – In-depth country analysis – Discover which countries and regions will drive the ophthalmic drugs market to 2024?

Exclusive Industry sourced information, not available anywhere else

As well as primary and secondary research sources, GMR Data have interviewed leading ophthalmic specialists within big pharma, R&D, wholesalers, distributors, marketeers and key clinical organisations. From these interviews we have selected original, exclusive, transcribed interviews with leading specialists in their field – This information is not available anywhere else.

This GMR Data report is the single tool to equip you with the latest trends in all regional markets and why all stakeholders demand development of Ophthalmic Drugs. This report will arm you with all you and your company require to develop, price, launch and market an ophthalmic drug.

With over 150 pages, and over 140 charts, tables and graphs, this dedicated specialist report will ensure you remain equipped and fully informed, to succeed in this competitive market.

Table Of Contents

Ophthalmic Drugs; Data, Analysis and Forecasts to 2024
1. Executive Summary
1.1 Ophthalmic Drugs Market Review
1.2 Chapter Breakdown
1.3 Research and Analysis Methods

2. Causes and Treatments of Ophthalmic Disorders
2.1 Human Eye
2.2 Structure of Human Eye
2.3 Major Global Causes of Blindness and Vision Impairment
2.3.1 Primary Causes of Blindness
2.3.2 Primary Causes of Visual Impairment
2.3.3 Geographic Breakdown of Global Blindness and Vision Impairment
2.3.4 Primary Factors Contributing to Visual Impairment
2.4 The Most Common Type of Eye Disorders
2.4.1 Cataracts
2.4.2 Glaucoma
2.4.3 Retinal Detachment
2.4.4 Ophthalmic Allergies
2.4.5 Ophthalmic Inflammatory Disorders
2.4.6 Ophthalmic Infections
2.4.7 Diabetic Retinopathy/Diabetic Mellitus
2.4.8 Dry Eye
2.4.9 Age-related Macular Degeneration

3. Ophthalmology Pharmaceutical Market and Forecast
3.1 Major Trends and Issues
3.2 Global Ophthalmology Pharmaceuticals Market 2014-2024

4. Anti-Glaucoma Market 2014-2024
4.1 Types of Glaucoma Eye Drops
4.2 Major Trends and Issues
4.3 Market Size and Forecast
4.4 Major Drugs and Forecast
4.4.1 Xalatan/Xalacom
4.4.2 Lumigan
4.4.3 Cosopt/Trusopt
4.4.4 Alphagan P, Alphagan and Combigan
4.4.5 Travatan
4.4.6 Azopt

5. Ophthalmic Anti-Allergy/Inflammation/Infective Market 2014-2024
5.1 Major Trends and Issues
5.2 Market Size and Forecast
5.3 Major Drugs and Forecast
5.3.1 Patanol
5.3.2 Vigamox/Vegamox
5.3.3 TobraDex
5.3.4 Pataday
5.3.5 Cravit
5.3.6 Xibrom/Bromday/Bromfenac

6. Retinal Disorders Market 2014-2024
6.1 Major Trends and Issues
6.2 Market Size and Forecast
6.3 Major Drugs and Forecast
6.3.1 Lucentis
6.3.2 Eylea

7. Dry Eye Market 2014-2024
7.1 Major Trends and Issues
7.2 Market Size and Forecast
7.3 Major Drugs and Forecast
7.3.1 Restasis
7.3.2 Hyalein

8. Regional Landscape
8.1 The US Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.2 The UK Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.3 The French Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.4 The German Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.5 The Spanish Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.6 The Italian Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.7 The Japanese Ophthalmic Pharmaceutical Drugs Market 2013-2024
8.8 The ROW Ophthalmic Pharmaceutical Drugs Market 2013-2024

9. Ophthalmology R and D Pipeline
9.1 Ophthalmology Drug RandD Pipeline for Glaucoma
9.2 Ophthalmology Drug RandD Pipeline for Anti-Infectives
9.3 Ophthalmology Drug RandD Pipeline for Anti-Inflammatory Agents
9.4 Ophthalmology Drug RandD Pipeline for Dry Eye
9.5 Gene Therapy in Ophthalmology - Ongoing Clinical Trial Details

10. Leading Companies
10.1 Alcon
10.2 Allergan
10.3 Argentis Pharmaceuticals LLC
10.4 Bausch and Lomb
10.5 Bayer Healthcare Pharmaceuticals
10.6 Eagle Vision Inc.
10.7 Eyegate Pharmaceuticals
10.8 Merck and Co
10.9 Novagali Pharma
10.10 Oasis Medical Inc.
10.11 Pfizer
10.12 Regeneron Pharmaceuticals Inc.
10.13 Resolvyx Pharmaceuticals Inc.
10.14 Roche
10.15 Santen Pharmaceutical Co Ltd

11. Expert Opinion
11.1 Dr David Sullivan, Associate Professor at Harvard Medical School
11.2 Dr Sonja Prager, Head of Diabetic Retinopathy Research Group, Vienna

List of Tables

Table 2.3 WHO Estimation of Blind/Vision impaired Population Globally, 1975-2010
Table 2.3.1 Breakdown of Global Blindness Cases as per Eye Disease
Table 2.3.2 Breakdown of Global Vision Impairment Cases as per Eye Disease 2010
Table 2.4.2.1 Major Glaucoma Drugs in the Market
Table 2.4.4.1 Major Ophthalmic Anti-allergy Drugs in the Market
Table 2.4.5.1 Major Ophthalmic Anti-inflammatory Drugs in the Market
Table 2.4.6.1 Major Ophthalmic Anti-infective Drugs in the Market
Table 2.4.7.1 Major Diabetic Retinopathy Drugs in the Market
Table 2.4.8.1 Major Dry Eye Treatment Drugs in the Market
Table 2.4.9.1 Major wet-AMD Treatment Drugs in the Market
Table 3.2.1 Global Ophthalmology Pharmaceutical Market 2014-2024 - Breakdown by Disease ($/bn)
Table 3.2.2 Market Size and Forecast - Global Ophthalmology Pharmaceutical Sales ($/bn)
Table 4.3.1 Global Anti-Glaucoma Market 2009-2013 ($/bn)
Table 4.3.2 Global Anti-Glaucoma Market 2014-2024 ($/bn)
Table 4.4.1.1 Xalatan/Xalacom Sales 2009-2013 ($/m)
Table 4.4.1.2 Xalatan/Xalacom Sales Forecast 2014-2024 ($/m)
Table 4.4.2.1 Lumigan Sales 2009-2013($/m)
Table 4.4.2.2 Lumigan Sales Forecast 2014-2024 ($/m)
Table 4.4.3.1 Cosopt/Trusopt Sales 2009-2013 ($/m)
Table 4.4.3.2 Cosopt/Trusopt Sales Forecast 2014-2024 ($/m)
Table 4.4.4.1 Alphagan P, Alphagan and Combigan Sales 2009-2013 ($/m)
Table 4.4.4.2 Alphagan P, Alphagan and Combigan Sales Forecast 2014-2024 ($/m)
Table 4.4.5.1 Travatan Sales 2009-2013 ($/m)
Table 4.4.5.2 Travatan Sales Forecast 2014-2024 ($/m)
Table 4.4.6.1 Azopt Market Size and Forecast 2012-2024 ($/m)
Table 5.1.1 ophthalmic Anti-Allergy/Inflammation/Infective RandD pipeline
Table 5.2.1 Global Ophthalmic Anti-Allergy/Inflammation/Infective Market 2013-2024 ($/bn)
Table 5.3.1.1 Patanol Market Size and Forecast 2012-2024 ($/m)
Table 5.3.2.1 Vigamox/Vegamox Market Size and Forecast 2012-2024 ($/m)
Table 5.3.3.1 TobraDex Market Size and Forecast 2012-2024 ($/m)
Table 5.3.4.1 Pataday Market Size and Forecast 2012-2024 ($/m)
Table 5.3.5.1 Cravit Sales 2009-2013 ($/m)
Table 5.3.5.2 Cravit Sales Forecast 2014-2024 ($/m)
Table 5.3.6.1 Xibrom/Bromday/Bromfenac Sales 2009-2013 ($/m)
Table 5.3.6.2 Xibrom/Bromday/Bromfenac Sales Forecast 2014-2024 ($/m)
Table 6.2.1 Global Anti-Retinal Disorders Drug Market 2009-2013 ($/bn )
Table 6.2.2 Global Anti-Retinal Disorders Drug Market 2014-2024 ($/bn)
Table 6.3.1.1 Lucentis Sales 2009-2013($/m)
Table 6.3.1.2 Lucentis Sales Forecast 2014-2024 ($/m)
Table 6.3.2.1 Eylea Market Size and Forecast 2012-2024 ($/m)
Table 7.2.1 Global Dry-Eye Market Size and Forecast 2012-2024 ($/bn)
Table 7.3.1.1 Restasis Sales 2009-2013 ($/m)
Table 7.3.1.2 Restasis Sales Forecast 2014-2024 ($/m)
Table 7.3.2.1 Hyalein Sales 2009-2013 ($/m)
Table 7.3.2.2 Hyalein Sales Forecast 2014-2024 ($/m)
Table 8.1 The Global Ophthalmic Drug Market Forecast 2013-2024, by country ($/bn per annum)
Table 8.2 Key Countries CAGR 2014-2024 (%)
Table 8.3 Global Ophthalmic Pharmaceutical Drugs Market Share for Major Countries - 2014, 2019, 2024
Table 8.4 Total Health Care Spending and Health Care Expenditure per Capita 2011 ($ per annum)
Table 8.1.1 US Ophthalmic Pharmaceutical Drugs Market Forecast 2013-2024
Table 8.1.2 Details of Major Ophthalmic Drugs in the US
Table 8.2.1 UK Ophthalmic Pharmaceutical Drugs Market Forecast 2013-2024
Table 8.3.1 French Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.4.1 German Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.5.1 Spanish Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.6.1 Italian Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.7.1 Japanese Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.8.1 ROW Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Table 8.8.2 BRIC Population, Healthcare Expenditure per Capita
Table 9.1 Ophthalmology Drug RandD Pipeline for Glaucoma
Table 9.2 Ophthalmology Drug RandD Pipeline for Anti-infective Agents
Table 9.3 Ophthalmology Drug RandD Pipeline for Anti-inflammatory Agents
Table 9.4 Ophthalmology Drug RandD Pipeline for Dry Eye
Table 9.5 Gene Therapy in Ophthalmology - Ongoing Clinical Trial Details
Table 10.1.1 Alcon Sales 2010-2012
Table 10.1.2 Sales of Major Ophthalmic Drugs
Table 10.1.3 Product Categories by Ophthalmic Pharmaceuticals
Table 10.2.1 Allergan Sales 2010-2012 (Eye care Pharmaceuticals)
Table 10.2.2 Allergan's Key Ophthalmic Drug Sales 2012 ($/m)
Table 10.2.3 Allergan's Key Ophthalmic Drugs Portfolio 2014
Table 10.2.4 Allergan's Product Pipeline; Eye Care 2014
Table 10.3.1 Argentis Product Pipeline for Dry eye
Table 10.4.1 Bausch and Lomb Key Ophthalmic Drugs Portfolio 2014
Table 10.5.1 Bayer's Ophthalmic Products Overview 2014
Table 10.5.2 Bayer's Product Pipeline; Eye Care 2014
Table 10.6.1 Eagle Vision Key Ophthalmic Drugs Portfolio 2014
Table 10.7.1 Eyegate Product Pipeline; Eye Care 2014
Table 10.8.1 Merck and Co Key Ophthalmic Drugs Portfolio 2014
Table 10.8.2 Merck and Co Product Pipeline; Eye Care 2014
Table 10.9.1 Novagali Pharma Ophthalmic Drugs Portfolio 2014
Table 10.9.2 Novagali Pharma Product Pipeline; Eye Care 2014
Table 10.10.1 Oasis Medical Ophthalmic Drugs Portfolio 2014
Table 10.11.1 Pfizer Pharmaceuticals Ophthalmic Drugs Portfolio 2014
Table 10.12.1 Regeneron Pharmaceuticals Ophthalmic Drugs Portfolio 2014
Table 10.12.2 Regeneron Pharmaceuticals Product Pipeline; Eye Care 2014
Table 10.13.1 Resolvyx Pharmaceuticals Product Pipeline; Eye Care 2014
Table 10.14.1 Roche Ophthalmology Ophthalmic Drugs Portfolio 2014
Table 10.14.2 Roche Ophthalmology Product Pipeline; Eye Care 2014
Table 10.15.1 Santen Pharmaceuticals Ophthalmic Drugs Portfolio 2014
Table 10.15.2 Santen Pharmaceuticals Product Pipeline; Eye Care 2014

List of Figures

Figure 2.3 WHO Estimation of Blind/Vision impaired Population Globally, 1975-2010
Figure 2.3.1 Breakdown of Global Blindness Cases, as per Eye Disease, 2010
Figure 2.3.2 Breakdown of Global Vision Impairment Cases as per Eye Disease 2010
Figure 2.3.3 Breakdown of Global Blindness and Vision Impairment by Geography 2012
Figure 2.3.4 Projection of Global Blind People aged 50+ by 2019
Figure 3.2.1 Market Size and Forecast - Global Ophthalmology Pharmaceuticals Sales ($/m)
Figure 3.2.2 Global Ophthalmology Pharmaceuticals Drug Market Share 2014 to 2024 - (%)
Figure 4.2.1 Population of over 60's in Selected Nations 2009 (millions)
Figure 4.2.2 Market Share of Major Companies - by Sales of Anti-Glaucoma Drug 2012
Figure 4.3.1 Global Anti-Glaucoma Market 2009-2013 ($/bn)
Figure 4.3.2 Global Anti-Glaucoma Market 2014-2024 ($/bn)
Figure 4.4.1.1 Xalatan/Xalacom Sales 2009-2013 ($/m)
Figure 4.4.1.2 Xalatan/Xalacom Sales Forecast 2014-2024 ($/m)
Figure 4.4.2.1 Lumigan Sales 2009-2013 ($/m)
Figure 4.4.2.2 Lumigan Sales Forecast 2014-2024 ($/m)
Figure 4.4.3.1 Cosopt/Trusopt Sales 2009-2013 ($/m)
Figure 4.4.3.2 Cosopt/Trusopt Sales Forecast 2014-2024($/m)
Figure 4.4.4.1 Alphagan P, Alphagan and Combigan Sales 2009-2013 ($/m)
Figure 4.4.4.2 Alphagan P, Alphagan and Combigan Sales 2014-2024 ($/m)
Figure 4.4.5.1 Travatan Sales 2009-2014 ($/m)
Figure 4.4.5.2 Travatan Sales Forecast 2014-2024 ($/m)
Figure 4.4.6.1 Azopt Market Size and Forecast 2012-2024 ($/m)
Figure 5.2.2 Global Ophthalmic Anti-Allergy/Inflammation/Infective Market 2013-2024 ($/bn)
Figure 5.3.1.1 Patanol Market Size and Forecast 2012-2024 ($/m)
Figure 5.3.2.1 Vigamox/Vegamox Market Size and Forecast 2012-2024 ($/m)
Figure 5.3.3.1 TobraDex Market Size and Forecast 2012-2024 ($/m)
Figure 5.3.4.1 Pataday Market Size and Forecast 2012-2024 ($/m)
Figure 5.3.5.1 Cravit Sales 2009-2013 ($/m)
Figure 5.3.5.2 Cravit Sales Forecast 2014-2024 ($/m)
Figure 5.3.6.1 Xibrom/Bromday/Bromfenac Sales 2009-2013 ($/m)
Figure 5.3.6.2 Xibrom/Bromday/Bromfenac Sales Forecast 2014-2024 ($/m)
Figure 6.2.1 Population of over 60's in Selected Nations 2009 (millions)
Figure 6.2.2 Global Anti-Retinal Disorders Drug Market 2009-2013 ($/bn)
Figure 6.2.3 Global Anti-Retinal Disorders Drug Market 2014-2024 ($/bn)
Figure 6.3.1.1 Lucentis Sales 2009-2013 ($/m)
Figure 6.3.1.2 Lucentis Sales Forecast 2014-2024 ($/m)
Figure 6.3.2.1 Geographic Breakdown of Eylea Sales in US and ROW 2012/13
Figure 6.3.2.2 Eylea Market Size and Forecast 2012-2024 ($/m)
Figure 7.2.1 Global Dry-Eye Drug Market 2012-2024 ($/bn)
Figure 7.3.1.1 Restasis Sales 2009-2013 ($/m)
Figure 7.3.1.2 Restasis Sales Forecast 2014-2024 ($/m)
Figures 7.3.2.1 Hyalein Sales 2009-2013 ($/m)
Figure 7.3.2.2 Hyalein Sales Forecast 2014-2024 ($/m)
Figure 8.1 Global Ophthalmic Drug Market Share for Major Countries - 2014, 2019, 2024
Figure 8.1.1 US Ophthalmic Pharmaceutical Drugs Market Forecast 2013-2024 ($/bn)
Figure 8.2.1 UK Ophthalmic Pharmaceutical Drugs Market Forecast 2013-2024 ($/bn)
Figure 8.3.1 French Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Figure 8.4.1 German Ophthalmic Pharmaceutical Drugs Market Forecast 2013-2024 ($/bn)
Figure 8.5.1 Spanish Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Figure 8.6.1 Italian Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Figure 8.7.1 Japanese Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Figure 8.8.1 ROW Ophthalmic Pharmaceutical Drug Market Forecast 2013-2024 ($/bn)
Figure 10.1.1 Alcon Sales by Segments 2012 (%)
Figure 10.1.2 Surgical Segments Sales Breakdown 2012
Figure 10.1.3 Ophthalmic Pharmaceutical Segment Sales Breakdown 2012
Figure 10.1.4 Vision Care segment Sales Breakdown 2012
Figure 10.1.5 Alcon Sales Breakdown by Geography 2012

Companies Mentioned

Acucela
Aerie Pharmaceuticals
Alcon
Allergan
Allergo
Altheos, Inc.,
Applied Genetic Technologies Corp
Asahi Kasei Pharma
Avalanche Biotechnologies
Bausch and Lomb
Bayer Healthcare
Bayer Yakuhin, Ltd
Bin Li and Huazhong University of Science and Technology
Children's Hospital Philadelphia
Coastal Pharmaceuticals
Daiichi Sankyo Company Ltd
Eagle Vision Inc.
Eleven Biotherapeutics
Enteroptyx
Eyegate Pharmaceuticals
Eyetech
Foresight Biotherapeutics
Genentech
Genzyme
Hadassah Medical Organization
Inception Sciences, Inc.
InSite Vision
ISTA
Johnson and Johnson
King Faisal Specialist Hospital
King Khaled Eye Hospital
Lions Eye Institute (Perth)
MacuCLEAR
Meda Pharmaceuticals
Merck
Mimetogen Pharmaceuticals Inc.
Moorfields Eye Hospital
Mylan Pharmaceuticals
Nantes University Hospital
National Eye Institute
NHS
Nova Bay Pharmaceuticals
Novagali Pharma
Novartis
Oasis Medical Inc.
OphthaliX Inc.
Ophthotech
Oregon Health and Science University
Otsuka Pharmaceuticals
Oxford BioMedica
Pfizer
QLT
Regeneron Pharmaceuticals, Inc.
Resolvyx Pharmaceuticals Inc.
Roche
SARcode Bioscience
Scheie Eye Institute, University of Pennsylvania
Senju Pharmaceuticals Company Ltd.
Sigma
Targeted Genetics Corporation (AmpliPhi BioSciences Corporation)
ThromboGenics
UniQure
University College London
University of Massachusetts
Valeant Pharmaceuticals Inc.
Versant Ventures
Vistakon Pharmaceuticals, LLC
Watson Pharma
WHO
Wyeth-Ayerst

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