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  5. > Azilect (Parkinson’s Disease) - Forecast and Market Analysis to 2022

Azilect (Parkinson’s Disease) - Forecast and Market Analysis to 2022

Summary

Parkinson’s disease is a progressive condition that is characterized by bradykinesia, muscular rigidity, tremor, and postural instability. As the second most common neurodegenerative disorder, Parkinson’s disease may affect individuals of any age but prevalence is increased with age and it is most common in the elderly. Dopaminergic therapies have been fairly effective in treating bradykinesia, but several unmet needs remain. Some needs will be met during the forecast period from 2012-2022, while others, such as the need for disease-modifying drugs, will remain. GlobalData expects that advancements will be made in levodopa administration and that four new molecular entities will be introduced to the market by 2022, these factors along with increased patient numbers from an aging population will drive the market during the forecast period.

Azilect (rasagiline) is a second-generation MAO-B inhibitor, developed by Teva Pharmaceuticals for the treatment of the signs and symptoms of Parkinson’s disease. Azilect is approved for use as a monotherapy in early Parkinson’s disease at a once-daily dosage of 1mg, or as an adjunctive therapy to levodopa at 0.5mg or 1mg, as needed, once daily (Azilect package insert, 2012).

Scope

- Overview of Parkinson’s disease, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Azilect including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Azilect for the top seven countries from 2012 to 2022.
- Sales information covered for the US, France, Germany, Italy, Spain, the UK and Brazil.

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Parkinson’s disease
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Azilect performance
- Obtain sales forecast for Azilect from 2012-2022 in the top seven countries (the US, France, Germany, Italy, Spain, the UK and Brazil).

Table Of Contents

Azilect (Parkinson’s Disease) - Forecast and Market Analysis to 2022
1 Table of Contents

2 Introduction 8
2.1 Catalyst 8
2.2 Related Reports 8
3 Disease Overview 11
3.1 Etiology and Pathophysiology 11
3.1.1 Etiology 11
3.1.2 Pathophysiology 14
3.1.3 Prognosis 16
3.1.4 Quality of Life 17
3.2 Symptoms 17
4 Disease Management 19
4.1 Overview 19
4.1.1 Diagnosis - The UK Brain Bank Criteria 19
4.1.2 Treatment Guidelines and Leading Prescribed Drugs 20
4.2 Treatment Synopsis 23
4.2.1 Dopaminergic Therapy Classes 23
4.2.2 Treatment of Parkinson's Disease by Stage 25
4.2.3 Other Treatment Options 28
4.3 Parkinson's Disease Assessment Scales 28
4.3.1 Unified Parkinson's Disease Rating Scale (UPDRS) 29
4.3.2 Hoehn and Yahr Clinical Staging 31
4.3.3 Other Clinical Assessments 32
5 Competitive Assessment 33
5.1 Overview 33
5.2 Strategic Competitor Assessment 35
5.3 Product Profiles - MAO-B Inhibitors 36
6 Azilect (rasagiline) 38
6.1 Overview 38
6.2 Efficacy 39
6.3 Safety 41
6.4 SWOT Analysis 43
6.5 Forecast 43
7 Appendix 45
7.1 Bibliography 45
7.2 Abbreviations 49
7.3 Methodology 52
7.4 Forecasting Methodology 52
7.4.1 Diagnosed Parkinson's Disease Patients 52
7.4.2 Percent Drug-Treated Patients 53
7.4.3 General Pricing Assumptions 53
7.4.4 Compliance Assumptions 54
7.4.5 Individual Drug Assumptions 54
7.4.6 Generic Erosion 55
7.5 Physicians and Specialists Included in this Study 56
7.6 About the Authors 58
7.6.1 Author 58
7.6.2 Global Head of Healthcare 59
7.7 About GlobalData 60
7.8 Disclaimer 60

1.1 List of Tables

Table 1: Symptoms of Parkinson's Disease 18
Table 2: UK Brain Bank Diagnostic Criteria 20
Table 3: Diagnosis and Treatment Guidelines for Parkinson's Disease 21
Table 4: Most Prescribed Drugs for Parkinson's Disease by Class in the Global Markets, 2014 22
Table 5: Dopaminergic Therapy in Parkinson's Disease 25
Table 6: UPDRS Clinical Assessment of Disease Severity 30
Table 7: Parkinson's Disease Assessment Scales Used in Clinical Trials 32
Table 8: Treatment of Motor Symptoms in Parkinson's Disease 34
Table 9: Leading Treatments for Parkinson's Disease, 2014 36
Table 10: Product Profile - Azilect 39
Table 11: Azilect SWOT Analysis, 2014 43
Table 12: Global Sales Forecasts ($m) for Azilect, 2012-2022 44

1.2 List of Figures

Figure 1: Overview - L-dopa Metabolism and Inhibitor Classes 24
Figure 2: Overview - Treatment of Motor Symptoms of Parkinson's Disease 26

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