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Markets for Advanced Wound Management Technologies

  • June 2014
  • -
  • BCC Research
  • -
  • 179 pages

This BCC Research report provides an overview of advanced wound care products, detailed market analyses and discussions of competitive environments. The study includes information about significant products, players, issues and trends and other information affecting the wound care industry.

Use this report to:
- Identify the major market trends and the factors driving or inhibiting the growth of the global pharmaceutical antibiotics market and its various submarkets.
- Learn about the challenges in the market including the higher price associated with advanced therapies over traditional, which have been augmented by decreasing hospital
and surgery center budgets due to economic downturns felt in many developed nations.
- Gain information on advanced wound care market growth rates which are determined through a compilation of data including past trends, future trends, demographics,
incidence, mortality, products in research, and development and current product growth.

Highlights
- The global market for advanced wound management totaled $8.6 billion in 2013, up from 2011’s value of $7.9 billion. By 2018, this market is likely to reach $11.3 billion, a compound annual growth rate (CAGR) of 5.6%.
- BCC Research predicts the advanced dressing technologies segment shall increase from $4.8 billion in 2013 to nearly $6 billion in 2018, a projected CAGR of 4.5% from 2013 to 2018.
- The wound healing devices/technologies segment will increase at a CAGR of 7.6% to reach $3.2 billion in 2018 from $2.2 billion in 2013.

INTRODUCTION
STUDY GOALS AND OBJECTIVES
This updated BCC Research report provides an overview of advanced wound care products, detailed market analyses and discussions of competitive environments. The
study includes information about significant products, players, issues and trends and other information affecting the wound care industry.

REASONS FOR DOING THE STUDY
Advanced wound management technologies have emerged from the shadows to become, in the last 30 years, significant products in the treatment and management of
wounds. While conventionally made wound management product proteins are considerable and generally less expensive, new products and biotechnological
advancements are continuing to revolutionize the wound management market. New technological products are competing in a fast track market that seeks to improve the
quality of life for millions of individuals needing both acute and chronic wound management.

Ongoing patient management studies will increase the number of indications, and keeping in touch with these applications for the various advanced wound management
products is good business practice. This study will provide its readers with the knowledge to adequately view and assess the advanced wound management
movement and provide insight into market potential.

SCOPE OF REPORT
This document is designed to be a helpful business tool that will provide a thorough evaluation of the advanced wound management market. The scope of this study is U.S.
based and identifies markets in four general segments:

- Advanced dressings.
- Surgical sealants.
- Anti-adhesion products and other related wound healing products.
- Wound healing devices.

Each market segment provides detailed information based on product categories, product use, forecasts and competitive analyses.
Advanced wound management deals with those products that involve new techniques and therapies, are of benefit in healing wounds, and result in overall lower costs for
management. They incorporate biotechnological advancements and improved methods for dealing with wounds. Products in this study are considered to be at the forefront of wound management technology.

Traditional wound management products, those that have previously been used in the marketplace, are not addressed in this analysis. Industry experts classify “advanced
wound management products” as those that include biological dressings, surgical sealants, synthetic dressings, anti-adhesion products and other related wound healing
products

METHODOLOGY
Information for this report was obtained through primary and secondary data collection methods. Primary methods included interviews with more than 50 key executives,
product managers, clinical specialists and other related key personnel involved in the wound management industry. Secondary methods included published literature,
investment reports, company literature, and various business journals that have emphases on wound management and related areas.

Data for this report relates to the global market in U.S. dollars at the manufacturers’ level. The base year of the report is 2013, with historical data provided for 2011 and
2012 and forecast data provided for 2018. Historical, base year and forecast data are provided for each market segment of the report.

Growth rates are determined through a compilation of data including past trends, future trends, demographics, incidence, mortality, products in research and
development, current product growth, etc. Competitor market share estimates are provided for each market segment for the 2013 base year.

Table Of Contents

Markets for Advanced Wound Management Technologies
TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
SCOPE OF REPORT 2
METHODOLOGY 3
PREVIOUS VERSIONS OF THIS REPORT INCLUDE: 3
RELATED BCC RESEARCH REPORTS 3
ANALYSTS' CREDENTIALS 4
TRACY COTTHOFF 4
MELISSA ELDER 4
BCC RESEARCH WEBSITE 4
DISCLAIMER 5

CHAPTER 2 SUMMARY 7

MAJOR MARKETS AND INTRODUCTION 7
SUMMARY TABLE GLOBAL ADVANCED WOUND MANAGEMENT MARKET BY MAJOR
MARKET SEGMENT, THROUGH 2018 ($ MILLIONS) 8
SUMMARY FIGURE GLOBAL ADVANCED WOUND MANAGEMENT MARKET BY MAJOR
MARKET SEGMENT, 2011-2018 ($ MILLIONS) 8

CHAPTER 3 INDUSTRY OVERVIEW 10

HISTORICAL WOUND MANAGEMENT OVERVIEW 10
THE INTEGUMENTARY SYSTEM 11
FIGURE 1 SKIN LAYERS 12
WOUND CLASSIFICATIONS 13
THE PROCESS OF WOUND HEALING 13
STAGES OF HEALING 14
Inflammatory Phase 14
Destructive Phase 15
Proliferative Phase 15
Maturation 16
Healing by Secondary Intention 16
Factors Affecting Wound Healing 17
GENERAL HEALTH INDICATORS AFFECTING WOUND HEALING: U.S. DATA 17
SMOKING 17
TABLE 1 PERCENT OF SMOKERS IN THE U.S. POPULATION 18 AND OLDER BY AGE
AND GENDER, 2009 17
AGE 19
TABLE 2 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP,
1900-2050 (THOUSANDS) 20
FIGURE 2 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP,
1900-2050 (THOUSANDS) 20
TABLE 3 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 21
FIGURE 3 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 21
NUTRITIONAL STATUS 21
OBESITY 22
FLUID AND ELECTROLYTE BALANCE 22
IMMUNOSUPPRESSED OR COMPROMISED INDIVIDUALS 22
DRUG THERAPY 23
RADIATION THERAPY 23
NUTRITION IN WOUND HEALING 23
TABLE 4 PATIENT HISTORY FOR NUTRITIONAL ASSESSMENT 23
COMPLICATIONS OF WOUND HEALING 25
SCARRING 25
ADHESIONS 26
DEHISCENCE 26
EVISCERATION 26
INFECTION 26
HEMORRHAGE 27
FISTULAS 27
WOUND TYPES AND STATISTICS 27
ACUTE WOUNDS 28
Surgical Wounds/Incision 28
Surgical Wound Classifications 29
TABLE 5 SURGICAL WOUND CLASSIFICATIONS 29
Traumatic Wounds 30
Lacerations 30
Abrasions 30
Contusions 30
Necrotizing Fasciitis 30
Toxic Epidermal Necrolysis 31
CHRONIC WOUNDS 32
Pressure Ulcers 32
TABLE 6 COMMON SITES FOR PRESSURE ULCER DEVELOPMENT (% OF
OCCURRENCE) 33
Staging 34
TABLE 7 PRESSURE ULCER STAGING 34
Venous Insufficiency Ulcers 35
Arterial Ulcers 35
Diabetic or Neuropathic Ulcers 36
BURN WOUNDS 37
BURN CLASSIFICATIONS 37
TABLE 8 BURN CLASSIFICATIONS 38
STAGES OF BURN HEALING 39
WOUND FIGURES 39
Acute Wounds 39
Chronic Wounds 40
Burn Wounds 40
Age and Wounds by Type 40
TABLE 9 ESTIMATED INCIDENCE BY AGE GROUP AND WOUND TYPE (%
DISTRIBUTION) 41
FIGURE 4 ESTIMATED INCIDENCE BY AGE GROUP AND WOUND TYPE (%
DISTRIBUTION) 41

CHAPTER 4 MARKET TRENDS 43

REIMBURSEMENT ISSUES 43
DEMOGRAPHICS 44
TABLE 10 GLOBAL POPULATION BY SELECTED COUNTRY, THROUGH 2015
(MILLIONS) 44
FIGURE 5 GLOBAL POPULATION BY SELECTED COUNTRY, 2010 AND 2015
(MILLIONS) 44
THE AGING POPULATION 45
TABLE 11 ESTIMATED GLOBAL POPULATION AND ANNUAL GROWTH BY SELECTED
AGE GROUP AND SELECTED YEARS, THROUGH 2030 (MILLIONS) 46
FIGURE 6 ESTIMATED GLOBAL POPULATION BY SELECTED AGE GROUP AND
SELECTED YEARS, 2000-2030 (MILLIONS) 46
INCREASING LIFE EXPECTANCY 46
TABLE 12 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980 AND
2013 (YEARS) 47
FIGURE 7 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980 AND
2013 (YEARS) 47
ECONOMICS AND HEALTHCARE 48
TABLE 13 HEALTH EXPENDITURES AS PERCENTAGE OF GDP BY SELECT COUNTRY,
1980-2015 (%) 48
FIGURE 8 HEALTH EXPENDITURES AS PERCENTAGE OF GDP BY SELECT COUNTRY,
1980-2015 (%) 49
ECONOMIC IMPACT OF WOUNDS AND WOUND MANAGEMENT 49
GOVERNMENT REGULATION OF DEVICES 49
INTERNATIONAL STEM CELL RESEARCH 50

CHAPTER 5 TECHNOLOGY AND NEW DEVELOPMENTS 54

NEW DEVELOPMENTS AND RESEARCH 54
STEM CELL RESEARCH 54
GENE THERAPY 54
LIGHT-EMITTING DIODES 55
Light-emitting Diodes in Conjunction with Laser Diodes 55
TABLE 14 SELECT COMPANIES OFFERING LIGHT-EMITTING DIODE DEVICES FOR
WOUND MANAGEMENT 56
IN VIVO VS IN VITRO 57
TABLE 15 ADVANTAGES OF IN VIVO AND IN VITRO TISSUE GROWTH 57
IN VITRO 58
IN VIVO 59
MILITARY WOUND MANAGEMENT 60
BATTLEFIELD WOUND TREATMENT 60
One-Handed Tourniquet 61
Natural Fiber Bandages 61
Accelerated Blood-Clotting Products 61
High-tech Bandages 62
Mobile Medical Tents 63
Wound-Filler Hemostasis Products 63
ALTERNATIVE WOUND THERAPY 64
MAGGOT THERAPY 64
Reimbursement for Maggot Therapy [1] 67
LEECH THERAPY 67
APITHERAPY 68
TECHNOLOGY 69
CURRENT TECHNOLOGY USES 69
Negative Pressure Technology 69
Tissue-engineered Skin Substitutes 69
Tissue Regeneration 70
ACell-MatriStem 70
Darco International Inc. 70
PATENT ANALYSIS 71
TABLE 16 WOUND CARE/MANAGEMENT TECHNOLOGY PATENT GROWTH,
1979-2014 (NO./%) 71
FIGURE 9 WOUND CARE/MANAGEMENT TECHNOLOGY PATENT GROWTH (NO.) 72
TABLE 17 WOUND MANAGEMENT TECHNOLOGY PATENTS BY YEAR, 1979-2014* 72
FIGURE 10 WOUND MANAGEMENT TECHNOLOGY PATENTS BY YEAR, 1979-2014* 73
TABLE 18 U.S. PATENTS, SELECTED DEVELOPERS AND WOUND CARE-RELATED
TECHNOLOGIES 73
TABLE 19 ADVANCED WOUND MANAGEMENT RELATED TECHNOLOGIES BY PATENT
HOLDER, JANUARY 1, 2013-MARCH 18, 2014 (15 MONTHS) 75
FIGURE 11 ADVANCED WOUND MANAGEMENT RELATED TECHNOLOGIES BY
PATENT HOLDER, JANUARY 1, 2013-MARCH 18, 2014 (15 MONTHS) 75

CHAPTER 6 MARKET SEGMENTS 77

ADVANCED DRESSING TECHNOLOGIES 77
TABLE 20 GLOBAL MARKET REVENUES FOR ADVANCED DRESSING TECHNOLOGIES,
THROUGH 2018 ($ MILLIONS) 77
FIGURE 12 GLOBAL MARKET REVENUES FOR ADVANCED DRESSING
TECHNOLOGIES, 2011-2018 ($ MILLIONS) 77
BIOLOGICAL WOUND HEALING 78
Product Description 80
Artificial Skin/Skin Replacement 80
TABLE 21 MANUFACTURERS OF ARTIFICIAL SKIN/SKIN REPLACEMENT DRESSINGS,
2013 80
Kinetic Concepts 80
Organogenesis 81
Smith and Nephew 81
Shire Regenerative Medicine 81
Genzyme 82
Integra Life Sciences 82
LifeCell (Kinetic Concepts) 83
Collagen Products 83
TABLE 22 MANUFACTURERS OF COLLAGEN DRESSINGS, 2013 83
Smith and Nephew 84
Kinetic Concepts 84
Integra Life Sciences 84
Forticell BioScience Inc. 85
DermaRite Industries 85
Cardium Therapeutics 85
TEI Biosciences 85
Southwest Technologies Inc. 86
Systagenix (Kinetic Concepts) 86
Medline Industries 86
Baxter International 86
Synovis Surgical Innovations 87
Growth Factors 87
TABLE 23 MANUFACTURERS OF GROWTH FACTOR WOUND MANAGEMENT
TECHNOLOGIES, 2013 87
Smith and Nephew 87
Cytomedix 87
Molnylcke 88
Products in development 88
TABLE 24 SELECT BIOLOGIC PRODUCTS IN DEVELOPMENT, 2013 88
Market Analysis and Conclusion 89
Total Market and Segments 89
TABLE 25 GLOBAL MARKET REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 ($ MILLIONS) 90
FIGURE 13 GLOBAL MARKET REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
PRODUCT SEGMENT, 2011-2018 ($ MILLIONS) 90
TABLE 26 DISTRIBUTION OF REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
WOUND TYPE, 2013 (%/$ MILLIONS) 92
FIGURE 14 DISTRIBUTION OF REVENUES FOR BIOLOGICAL DRESSINGS BY WOUND
TYPE, 2013 (%) 92
TABLE 27 SUMMARY OF BIOLOGICAL DRESSINGS MARKET BY COMPETITOR
REVENUES, 2013 (%/$ MILLIONS) 94
FIGURE 15 SUMMARY OF BIOLOGICAL DRESSINGS MARKET BY COMPETITOR
REVENUES, 2013 ($ MILLIONS) 94
SYNTHETIC DRESSINGS 94
Product Description 95
Alginate Dressings 95
TABLE 28 ALGINATE DRESSING MANUFACTURERS, 2013 95
Film Dressings 99
TABLE 29 FILM DRESSING MANUFACTURERS, 2013 99
Foam Dressings 103
TABLE 30 FOAM DRESSING MANUFACTURERS, 2013 103
Hydrocolloid Dressings 106
TABLE 31 HYDROCOLLOID DRESSING MANUFACTURERS, 2013 107
Hydrogel Dressings 109
TABLE 32 HYDROGEL DRESSING MANUFACTURERS, 2013 110
Market analysis and conclusion 114
Total Market and Segments 114
TABLE 33 GLOBAL MARKET REVENUES FOR SYNTHETIC TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 115
FIGURE 16 GLOBAL MARKET REVENUES FOR SYNTHETIC TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 ($ MILLIONS) 115
TABLE 34 REVENUE DISTRIBUTION FOR SYNTHETIC TECHNOLOGIES BY WOUND
TYPE, 2013 ($ MILLIONS) 116
FIGURE 17 REVENUE DISTRIBUTION FOR SYNTHETIC TECHNOLOGIES BY WOUND
TYPE, 2013 (%) 116
Competitive Summary 117
TABLE 35 SUMMARY OF SYNTHETIC TECHNOLOGIES BY COMPETITOR REVENUES,
2013 ($ MILLIONS) 117
FIGURE 18 SUMMARY OF SYNTHETIC TECHNOLOGIES BY COMPETITOR REVENUES,
2013 ($ MILLIONS) 118
NATURAL DRESSINGS 118
Product Description 118
TABLE 36 ALGINATE DRESSING MANUFACTURERS, 2013 119
Derma Sciences 120
DeRoyal Industries 120
Smith and Nephew 120
Medline Industries 121
Braun 121
Covidien 121
DermaRite 122
Systagenix (Kinetic Concepts) 122
Gentell Corp. 122
ConvaTec 122
Molnlycke Health Care 123
Hollister Wound Care 123
Coloplast 123
Hartmann Group 123
Mylan 123
3M Health Care 124
Market Analysis And Conclusions 124
Total Market and Segments 124
TABLE 37 GLOBAL MARKET REVENUES FOR NATURAL TECHNOLOGIES, THROUGH
2018 ($ MILLIONS) 124
FIGURE 19 GLOBAL MARKET REVENUES FOR NATURAL TECHNOLOGIES, 2011-2018
($ MILLIONS) 124
TABLE 38 REVENUE DISTRIBUTION FOR NATURAL DRESSINGS BY WOUND TYPE,
2013 (%/$ MILLIONS) 125
FIGURE 20 REVENUE DISTRIBUTION FOR NATURAL DRESSINGS BY WOUND TYPE,
2013 (%) 125
TABLE 39 SUMMARY OF NATURAL DRESSING TECHNOLOGIES MARKET BY
COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 127
FIGURE 21 SUMMARY OF NATURAL DRESSING TECHNOLOGIES MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 127
SURGICAL SEALANTS AND GLUES 127
PRODUCT DESCRIPTIONS 128
TABLE 40 MANUFACTURERS OF SURGICAL SEALANTS AND GLUES, 2011 128
Advanced Medical Solutions plc 129
Baxter 129
Integra Life Sciences 130
Cohera Medical 130
CryoLife Inc. 130
Johnson and Johnson 131
Davol/CR Bard. 131
Ocular Therapeutic Inc. 132
Takeda 132
Tenaxis Medical 132
Tissuemed Ltd. 132
TissueSeal LLC 132
PRODUCTS IN DEVELOPMENT 133
TABLE 41 SELECT SURGICAL/VASCULAR SEALANT PRODUCTS IN DEVELOPMENT 133
MARKET ANALYSIS AND CONCLUSIONS 133
Total Market and Segments 133
TABLE 42 GLOBAL MARKET REVENUES FOR SURGICAL SEALANTS AND GLUES,
THROUGH 2018 ($ MILLIONS) 134
FIGURE 22 GLOBAL MARKET REVENUES FOR SURGICAL SEALANTS AND GLUES,
2011-2018 ($ MILLIONS) 134
Competitive Summary 134
TABLE 43 SUMMARY OF THE GLOBAL SURGICAL SEALANTS AND GLUES MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 135
FIGURE 23 SUMMARY OF THE GLOBAL SURGICAL SEALANTS AND GLUES MARKET
BY COMPETITOR REVENUES, 2013 ($ MILLIONS) 135
ANTI-ADHESION AND OTHER RELATED WOUND HEALING PRODUCTS 136
ANTI-ADHESION PRODUCTS 136
ENZYMATIC/HYPERTONIC SALINE DEBRIDING AGENTS 136
PRODUCT DESCRIPTION 137
TABLE 44 MANUFACTURERS OF ANTI-ADHESION AND OTHER ADVANCED WOUND
MANAGEMENT PRODUCTS, 2013 137
Adhesion Barriers 138
TABLE 45 SURGEON EXPERIENCES WITH THE THREE LEADING ADHESION
BARRIERS IN THE UNITED STATES 138
Other Products 139
PRODUCTS IN DEVELOPMENT 140
TABLE 46 SELECT ANTI-ADHESION PRODUCTS AND OTHER ADVANCED WOUND
MANAGEMENT PRODUCTS IN DEVELOPMENT 140
MARKET ANALYSIS AND CONCLUSIONS 141
Total Market and Segments 141
TABLE 47 GLOBAL MARKET FOR ANTI-ADHESION AND OTHER WOUND HEALING
PRODUCTS BY SEGMENT, THROUGH 2018 ($ MILLIONS) 142
FIGURE 24 GLOBAL MARKET FOR ANTI-ADHESION AND OTHER WOUND HEALING
PRODUCTS BY SEGMENT, THROUGH 2018 ($ MILLIONS) 142
Markets by Wound Type 143
TABLE 48 REVENUE DISTRIBUTION FOR ANTI-ADHESION AND OTHER WOUND
HEALING PRODUCTS BY WOUND TYPE, 2013 (%/$ MILLIONS) 143
FIGURE 25 REVENUE DISTRIBUTION FOR ANTI-ADHESION AND OTHER WOUND
HEALING PRODUCTS BY WOUND TYPE, 2013 (%) 144
Competitive Summary 144
TABLE 49 SUMMARY OF GLOBAL ANTI-ADHESION AND OTHER WOUND HEALING
MARKETS BY COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 145
FIGURE 26 SUMMARY OF GLOBAL ANTI-ADHESION AND OTHER WOUND HEALING
MARKETS BY COMPETITOR REVENUES, 2013 ($ MILLIONS) 145
WOUND HEALING DEVICES 145
PRODUCT DESCRIPTIONS 146
TABLE 50 ADVANCED WOUND HEALING DEVICES, 2013 146
Electrical Stimulation Devices and Electromagnetic Therapy 147
Electromagnetic Therapy 147
Negative Pressure Wound Therapy (NPWT) or Vacuum Assisted
Closure (V.A.C.) 148
Hyperbaric Oxygen Devices 149
EpiFLO (Transdermal Sustained Oxygen Delivery) 150
Radio Frequency (RF) Stimulus 150
External Tissue Expander (Proxiderm) 151
Ultrasonic Wound Debridement 152
LED Therapy 152
Other Devices 152
MARKET ANALYSIS AND CONCLUSION 153
Total Market and Segments 153
TABLE 51 GLOBAL MARKET FOR WOUND HEALING DEVICES BY PRODUCT
SEGMENT, THROUGH 2018 ($ MILLIONS) 153
FIGURE 27 GLOBAL MARKET FOR WOUND HEALING DEVICES BY PRODUCT
SEGMENT, THROUGH 2018 ($ MILLIONS) 153
Markets by Wound Type 154
TABLE 52 REVENUE DISTRIBUTION FOR WOUND HEALING DEVICES BY WOUND
TYPE, 2013 (%/$ MILLIONS) 155
FIGURE 28 REVENUE DISTRIBUTION FOR WOUND HEALING DEVICES BY WOUND
TYPE, 2013 (%) 155
Competitive Summary 155
TABLE 53 SUMMARY OF THE GLOBAL WOUND HEALING DEVICE MARKET BY
COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 156
FIGURE 29 SUMMARY OF THE GLOBAL WOUND HEALING DEVICE MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 156

CHAPTER 7 MARKET SUMMARY 158

TOTAL ADVANCED WOUND MANAGEMENT MARKET ANALYSIS 158
TABLE 54 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS BY TYPE, THROUGH 2018 ($ MILLIONS) 158
FIGURE 30 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS BY TYPE, 2011-2018 ($ MILLIONS) 158
FIGURE 31 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS, DISTRIBUTION BY PRODUCT TYPE, 2013 (%) 159
MARKETS BY WOUND TYPE 160
TABLE 55 REVENUE DISTRIBUTION BY TYPE OF ADVANCED WOUND MANAGEMENT,
2013 (%/$ MILLIONS) 161
FIGURE 32 REVENUE DISTRIBUTION BY TYPE OF ADVANCED WOUND
MANAGEMENT, 2013 ($ MILLIONS) 161
GLOBAL MARKETS BY REGION 161
TABLE 56 REGIONAL MARKET ANALYSIS-ADVANCED WOUND MANAGEMENT,
THROUGH 2018 ($ MILLIONS) 162
FIGURE 33 PERCENT DISTRIBUTION OF THE TOTAL WOUND MANAGEMENT MARKET
BY REGION, 2013 (%) 162
INDUSTRY PARTICIPANTS BY TYPE 163
TABLE 57 MAJOR INDUSTRY PARTICIPANTS BY PRODUCT TYPE 163

CHAPTER 8 COMPANY PROFILES AND SNAPSHOTS 166

3M HEALTH CARE 166
BARD MEDICAL DIVISION 166
BAXTER INTERNATIONAL INC. 167
COLOPLAST A/S 168
CONVATEC INC. 168
COVIDIEN PLC 169
CRYOLIFE INC. 170
DERMA SCIENCES INC. 170
ETHICON INC. 171
GENZYME BIOSURGERY-A SANOFI COMPANY 171
HARTMANN GROUP 172
INTEGRA LIFE SCIENCES CORP. 172
KINETIC CONCEPTS INC. (LIFECELL) 173
ORGANOGENESIS INC. 174
MOLNLYCKE HEALTH CARE 174
SHIRE REGENERATIVE MEDICINE 174
SMITH and NEPHEW PLC 175
CHAPTER 9 APPENDIX: INFORMATION SOURCES 177
PHM011H - Markets for Advanced Wound Management Technologies


LIST OF TABLES

SUMMARY TABLE GLOBAL ADVANCED WOUND MANAGEMENT MARKET BY MAJOR
MARKET SEGMENT, THROUGH 2018 ($ MILLIONS) 8
TABLE 1 PERCENT OF SMOKERS IN THE U.S. POPULATION 18 AND OLDER BY AGE
AND GENDER, 2009 17
TABLE 2 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP,
1900-2050 (THOUSANDS) 20
TABLE 3 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 21
TABLE 4 PATIENT HISTORY FOR NUTRITIONAL ASSESSMENT 23
TABLE 5 SURGICAL WOUND CLASSIFICATIONS 29
TABLE 6 COMMON SITES FOR PRESSURE ULCER DEVELOPMENT (% OF OCCURRENCE) 33
TABLE 7 PRESSURE ULCER STAGING 34
TABLE 8 BURN CLASSIFICATIONS 38
TABLE 9 ESTIMATED INCIDENCE BY AGE GROUP AND WOUND TYPE (%
DISTRIBUTION) 41
TABLE 10 GLOBAL POPULATION BY SELECTED COUNTRY, THROUGH 2015 (MILLIONS) 44
TABLE 11 ESTIMATED GLOBAL POPULATION AND ANNUAL GROWTH BY SELECTED
AGE GROUP AND SELECTED YEARS, THROUGH 2030 (MILLIONS) 46
TABLE 12 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980 AND
2013 (YEARS) 47
TABLE 13 HEALTH EXPENDITURES AS PERCENTAGE OF GDP BY SELECT COUNTRY,
1980-2015 (%) 48
TABLE 14 SELECT COMPANIES OFFERING LIGHT-EMITTING DIODE DEVICES FOR
WOUND MANAGEMENT 56
TABLE 15 ADVANTAGES OF IN VIVO AND IN VITRO TISSUE GROWTH 57
TABLE 16 WOUND CARE/MANAGEMENT TECHNOLOGY PATENT GROWTH, 1979-2014
(NO./%) 71
TABLE 17 WOUND MANAGEMENT TECHNOLOGY PATENTS BY YEAR, 1979-2014* 72
TABLE 18 U.S. PATENTS, SELECTED DEVELOPERS AND WOUND CARE-RELATED
TECHNOLOGIES 73
TABLE 19 ADVANCED WOUND MANAGEMENT RELATED TECHNOLOGIES BY PATENT
HOLDER, JANUARY 1, 2013-MARCH 18, 2014 (15 MONTHS) 75
TABLE 20 GLOBAL MARKET REVENUES FOR ADVANCED DRESSING TECHNOLOGIES,
THROUGH 2018 ($ MILLIONS) 77
TABLE 21 MANUFACTURERS OF ARTIFICIAL SKIN/SKIN REPLACEMENT DRESSINGS,
2013 80
TABLE 22 MANUFACTURERS OF COLLAGEN DRESSINGS, 2013 83
TABLE 23 MANUFACTURERS OF GROWTH FACTOR WOUND MANAGEMENT
TECHNOLOGIES, 2013 87
TABLE 24 SELECT BIOLOGIC PRODUCTS IN DEVELOPMENT, 2013 88
TABLE 25 GLOBAL MARKET REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 ($ MILLIONS) 90
TABLE 26 DISTRIBUTION OF REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
WOUND TYPE, 2013 (%/$ MILLIONS) 92
TABLE 27 SUMMARY OF BIOLOGICAL DRESSINGS MARKET BY COMPETITOR
REVENUES, 2013 (%/$ MILLIONS) 94
TABLE 28 ALGINATE DRESSING MANUFACTURERS, 2013 95
TABLE 29 FILM DRESSING MANUFACTURERS, 2013 99
TABLE 30 FOAM DRESSING MANUFACTURERS, 2013 103
TABLE 31 HYDROCOLLOID DRESSING MANUFACTURERS, 2013 107
TABLE 32 HYDROGEL DRESSING MANUFACTURERS, 2013 110
TABLE 33 GLOBAL MARKET REVENUES FOR SYNTHETIC TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 115
TABLE 34 REVENUE DISTRIBUTION FOR SYNTHETIC TECHNOLOGIES BY WOUND
TYPE, 2013 ($ MILLIONS) 116
TABLE 35 SUMMARY OF SYNTHETIC TECHNOLOGIES BY COMPETITOR REVENUES,
2013 ($ MILLIONS) 117
TABLE 36 ALGINATE DRESSING MANUFACTURERS, 2013 119
TABLE 37 GLOBAL MARKET REVENUES FOR NATURAL TECHNOLOGIES, THROUGH
2018 ($ MILLIONS) 124
TABLE 38 REVENUE DISTRIBUTION FOR NATURAL DRESSINGS BY WOUND TYPE,
2013 (%/$ MILLIONS) 125
TABLE 39 SUMMARY OF NATURAL DRESSING TECHNOLOGIES MARKET BY
COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 127
TABLE 40 MANUFACTURERS OF SURGICAL SEALANTS AND GLUES, 2011 128
TABLE 41 SELECT SURGICAL/VASCULAR SEALANT PRODUCTS IN DEVELOPMENT 133
TABLE 42 GLOBAL MARKET REVENUES FOR SURGICAL SEALANTS AND GLUES,
THROUGH 2018 ($ MILLIONS) 134
TABLE 43 SUMMARY OF THE GLOBAL SURGICAL SEALANTS AND GLUES MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 135
TABLE 44 MANUFACTURERS OF ANTI-ADHESION AND OTHER ADVANCED WOUND
MANAGEMENT PRODUCTS, 2013 137
TABLE 45 SURGEON EXPERIENCES WITH THE THREE LEADING ADHESION BARRIERS
IN THE UNITED STATES 138
TABLE 46 SELECT ANTI-ADHESION PRODUCTS AND OTHER ADVANCED WOUND
MANAGEMENT PRODUCTS IN DEVELOPMENT 140
TABLE 47 GLOBAL MARKET FOR ANTI-ADHESION AND OTHER WOUND HEALING
PRODUCTS BY SEGMENT, THROUGH 2018 ($ MILLIONS) 142
TABLE 48 REVENUE DISTRIBUTION FOR ANTI-ADHESION AND OTHER WOUND
HEALING PRODUCTS BY WOUND TYPE, 2013 (%/$ MILLIONS) 143
TABLE 49 SUMMARY OF GLOBAL ANTI-ADHESION AND OTHER WOUND HEALING
MARKETS BY COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 145
TABLE 50 ADVANCED WOUND HEALING DEVICES, 2013 146
TABLE 51 GLOBAL MARKET FOR WOUND HEALING DEVICES BY PRODUCT SEGMENT,
THROUGH 2018 ($ MILLIONS) 153
TABLE 52 REVENUE DISTRIBUTION FOR WOUND HEALING DEVICES BY WOUND TYPE,
2013 (%/$ MILLIONS) 155
TABLE 53 SUMMARY OF THE GLOBAL WOUND HEALING DEVICE MARKET BY
COMPETITOR REVENUES, 2013 (%/$ MILLIONS) 156
TABLE 54 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS BY TYPE, THROUGH 2018 ($ MILLIONS) 158
TABLE 55 REVENUE DISTRIBUTION BY TYPE OF ADVANCED WOUND MANAGEMENT,
2013 (%/$ MILLIONS) 161
TABLE 56 REGIONAL MARKET ANALYSIS-ADVANCED WOUND MANAGEMENT,
THROUGH 2018 ($ MILLIONS) 162
TABLE 57 MAJOR INDUSTRY PARTICIPANTS BY PRODUCT TYPE 163


LIST OF FIGURES

SUMMARY FIGURE GLOBAL ADVANCED WOUND MANAGEMENT MARKET BY MAJOR
MARKET SEGMENT, 2011-2018 ($ MILLIONS) 8
FIGURE 1 SKIN LAYERS 12
FIGURE 2 U.S. POPULATION ESTIMATES AND PROJECTIONS BY AGE GROUP,
1900-2050 (THOUSANDS) 20
FIGURE 3 ESTIMATES OF EXPECTED U.S. LIFE EXPECTANCY AT BIRTH WITH
PROJECTIONS BY GENDER, 2000 AND 2020 (YEARS) 21
FIGURE 4 ESTIMATED INCIDENCE BY AGE GROUP AND WOUND TYPE (%
DISTRIBUTION) 41
FIGURE 5 GLOBAL POPULATION BY SELECTED COUNTRY, 2010 AND 2015 (MILLIONS) 44
FIGURE 6 ESTIMATED GLOBAL POPULATION BY SELECTED AGE GROUP AND
SELECTED YEARS, 2000-2030 (MILLIONS) 46
FIGURE 7 GLOBAL LIFE EXPECTANCY AT BIRTH BY SELECTED COUNTRY, 1980 AND
2013 (YEARS) 47
FIGURE 8 HEALTH EXPENDITURES AS PERCENTAGE OF GDP BY SELECT COUNTRY,
1980-2015 (%) 49
FIGURE 9 WOUND CARE/MANAGEMENT TECHNOLOGY PATENT GROWTH (NO.) 72
FIGURE 10 WOUND MANAGEMENT TECHNOLOGY PATENTS BY YEAR, 1979-2014* 73
FIGURE 11 ADVANCED WOUND MANAGEMENT RELATED TECHNOLOGIES BY PATENT
HOLDER, JANUARY 1, 2013-MARCH 18, 2014 (15 MONTHS) 75
FIGURE 12 GLOBAL MARKET REVENUES FOR ADVANCED DRESSING TECHNOLOGIES,
2011-2018 ($ MILLIONS) 77
FIGURE 13 GLOBAL MARKET REVENUES FOR BIOLOGICAL TECHNOLOGIES BY
PRODUCT SEGMENT, 2011-2018 ($ MILLIONS) 90
FIGURE 14 DISTRIBUTION OF REVENUES FOR BIOLOGICAL DRESSINGS BY WOUND
TYPE, 2013 (%) 92
FIGURE 15 SUMMARY OF BIOLOGICAL DRESSINGS MARKET BY COMPETITOR
REVENUES, 2013 ($ MILLIONS) 94
FIGURE 16 GLOBAL MARKET REVENUES FOR SYNTHETIC TECHNOLOGIES BY
PRODUCT SEGMENT, THROUGH 2018 ($ MILLIONS) 115
FIGURE 17 REVENUE DISTRIBUTION FOR SYNTHETIC TECHNOLOGIES BY WOUND
TYPE, 2013 (%) 116
FIGURE 18 SUMMARY OF SYNTHETIC TECHNOLOGIES BY COMPETITOR REVENUES,
2013 ($ MILLIONS) 118
FIGURE 19 GLOBAL MARKET REVENUES FOR NATURAL TECHNOLOGIES, 2011-2018
($ MILLIONS) 124
FIGURE 20 REVENUE DISTRIBUTION FOR NATURAL DRESSINGS BY WOUND TYPE,
2013 (%) 125
FIGURE 21 SUMMARY OF NATURAL DRESSING TECHNOLOGIES MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 127
FIGURE 22 GLOBAL MARKET REVENUES FOR SURGICAL SEALANTS AND GLUES,
2011-2018 ($ MILLIONS) 134
FIGURE 23 SUMMARY OF THE GLOBAL SURGICAL SEALANTS AND GLUES MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 135
FIGURE 24 GLOBAL MARKET FOR ANTI-ADHESION AND OTHER WOUND HEALING
PRODUCTS BY SEGMENT, THROUGH 2018 ($ MILLIONS) 142
FIGURE 25 REVENUE DISTRIBUTION FOR ANTI-ADHESION AND OTHER WOUND
HEALING PRODUCTS BY WOUND TYPE, 2013 (%) 144
FIGURE 26 SUMMARY OF GLOBAL ANTI-ADHESION AND OTHER WOUND HEALING
MARKETS BY COMPETITOR REVENUES, 2013 ($ MILLIONS) 145
FIGURE 27 GLOBAL MARKET FOR WOUND HEALING DEVICES BY PRODUCT SEGMENT,
THROUGH 2018 ($ MILLIONS) 153
FIGURE 28 REVENUE DISTRIBUTION FOR WOUND HEALING DEVICES BY WOUND
TYPE, 2013 (%) 155
FIGURE 29 SUMMARY OF THE GLOBAL WOUND HEALING DEVICE MARKET BY
COMPETITOR REVENUES, 2013 ($ MILLIONS) 156
FIGURE 30 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS BY TYPE, 2011-2018 ($ MILLIONS) 158
FIGURE 31 GLOBAL ANALYSIS-MARKET FOR ADVANCED WOUND MANAGEMENT
PRODUCTS, DISTRIBUTION BY PRODUCT TYPE, 2013 (%) 159
FIGURE 32 REVENUE DISTRIBUTION BY TYPE OF ADVANCED WOUND MANAGEMENT,
2013 ($ MILLIONS) 161
FIGURE 33 PERCENT DISTRIBUTION OF THE TOTAL WOUND MANAGEMENT MARKET
BY REGION, 2013 (%) 162

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