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US Next-generation Sequencing Market

  • June 2014
  • -
  • Frost & Sullivan
  • -
  • 111 pages

Marketplace Evolves in Preparation for Clinical Sequencing Windfall

The total market, as defined by this study, includes next-generation sequencing instruments and reagents in the United States. Instruments include those that use newer technology than traditional capillary electrophoresis (CE) sequencing, such as sequencing-by-synthesis, sequencing-by-ligation, single-molecule sequencing, and semiconductor sequencing. This research service offers a discussion of the key market drivers and restraints, revenue forecasts, and product types, as well as important trends affecting growth. This analysis also presents key companies to watch, major market dynamics, and strategic recommendations for competitors.

Methodology

The majority of the quantitative and qualitative information contained in this research service was acquired through primary research conducted with next-generation sequencing instruments and reagents providers. Most consultations were conducted with vice presidents (VPs) of business units, VPs of marketing, product managers, marketing managers, marketing directors, and business development directors from various competitors in the next-generation sequencing market. Industry-specific information obtained include:
-Next-generation sequencing revenue breakdowns by technology segments and regions
-Company revenues, market share estimates, and projected growth rates of various competitors
-Top-level customer, regional, and technology market trend information
-Market drivers, restraints, and challenges Supplementary research was conducted utilizing secondary sources including scientific journals, online media, Frost & Sullivan databases and research services, and publicly available corporate filings. Forecasts are based on the data and analyses regarding industry challenges, market drivers and restraints, and market trends. If specific revenues or market sizes were unavailable, estimates were derived through the consultations with industry experts, augmented by secondary research. Growth trends specific to certain market participants are based on consultations, past growth rates, and technology reviews.

Key Findings

-The total US market for next-generation sequencing (NGS) instruments and reagents generated revenue of $ million in 2013, it is expected to reach $ million in 2018. The market is expected to grow at a CAGR of % from 2013 to 2018.
-The US market accounted for% of global combined NGS instruments and reagents revenue in 2013, while Europe accounted for % and APAC/ROW generated % of market revenue.
-The US NGS instruments market generated $ million in 2013, with a CAGR of % expected to result in a market size of $ million in 2018. The US NGS reagents market totaled $ million in 2013 and is expected to grow at a CAGR of % to $ million in 2018.
-The United States holds the largest NGS instruments installed base of all countries globally, which continues to drive a large reagent pull-through. Adoption of NGS instruments in clinically applied settings, such as reference laboratories, hospitals, and translational research laboratories, will account for more growth over the next 5 years than in traditional labs.
-The United States leads the world in the use of NGS in clinical diagnostics, with NGS-based laboratory developed tests (LDT) already in use, and an expanding pipeline of NGS-based in vitro diagnostic (IVD) tests in the US Food and Drug Administration (FDA) approval process. Between % and % of clinical sequencing is panel-based, while exome sequencing accounts for % to % and whole genomes roughly % to %.
-Market revenues are restrained by the declining instrument costs and reagent costs per genome, yet this trend is also spurring wider accessibility and larger throughput projects. Increasing competition over the next 3 years will further drive down pricing.
-Key vendors in the NGS instrumentation space are Illumina, Life Technologies, Pacific Biosciences and Roche (until the company exits the market in 2015). Emerging competitors expected to enter the NGS instruments market in 2014 or beyond include Oxford Nanopore, Qiagen (Intelligent BioSystems), GnuBIO (acquired by Bio-Rad in 2014), GenapSys, DNA Electronics, NabSys, Genia Technologies, and Noblegen Biosciences.
-Key vendors in the NGS reagents market include Illumina, Life Technologies, Roche, Agilent, Qiagen, and New England Biolabs. This competitor base includes a number of smaller participants, and is expected to expand as companies develop NGS products to take advantage of strong market growth.

The key factors affecting the US NGS market forecast follows:

Application Drivers
oThe price of sequencing falling near the $ genome mark, making large, whole-human genome sequencing projects and population studies feasible
oExpanding use for clinical diagnostics in the form of LDTs, IVD test panels, exome sequencing, and to a lesser extent, whole genome sequencing
oIncreasing use in pharmaceutical applications (i.e., clinical trials, patient stratification, and toxicogenomics)
Technology Trends
oFast pace of technological advancements drives new product launches, making older platforms obsolete and spurring upgrades
oLaunch of clinically focused instruments
oAdvancements in commercially available reagents that increase speed of sample preparation, lower sample volume requirement, and improve project accuracy
oImproved and simplified bioinformatics that enable better data analysis and clinical interpretation
oCreation of very large databases of sequencing and clinical data to improve the clinical utility of genomic information
Macroeconomic Trends
oUS sequestration measures in 2013 negatively affected the academic and government sectors overall, yet the percent of federal funding going to NGS-based projects continues to grow at a much faster pace than funding itself
oGiven the growth potential of NGS and clinical sequencing in particular, this industry is highly advantageous for venture capital funding
Regulatory Trends
oFurther definition of clinical standards and guidelines is needed
oFDA approval of NGS-based IVD tests needs more efficient process

Table Of Contents

US Next-generation Sequencing Market
1. EXECUTIVE SUMMARY

Key Findings
Scope and Segmentation
Key Questions This Study Will Answer
Market Engineering Measurements
CEO's Perspective
Key Companies to Watch
Executive Summary—3 Big Predictions

2. MARKET OVERVIEW

Market Background
Market Segmentation
Global Market Perspective
Defining Healthcare Trends in the Future

3. COMPETITIVE PLAYBOOK

New Market Opportunities
Merger, Acquisition, and Partnership Assessment

4. DRIVERS, RESTRAINTS, AND TRENDS—TOTAL NEXT-GENERATION SEQUENCING MARKET

Market Drivers
Market Restraints
Market Impact of Top 10 Trends

5. FORECASTS AND TRENDS—TOTAL NEXT-GENERATION SEQUENCING MARKET

Market Engineering Measurements
Forecast Assumptions and Methodology
Total Next-generation Sequencing Market—Revenue Forecast
Total Next-generation Sequencing Market—Revenue Forecast by Product Type
Revenue Forecast by Product Type
Total Next-generation Sequencing Market—Percent Revenue Forecast by Product Type
Revenue Forecast Discussion
Procurement Process

6. COMPETITIVE ENVIRONMENT

Competitive Environment—Instruments
Instruments Product Analysis—Illumina
Instruments Product Analysis—Life Technologies
Instruments Product Analysis—Roche
Instruments Product Analysis—Pacific Biosciences
NGS Platform Trending—Instruments
Future Competitors—Instruments
NHGRI-funded Sequencing Technology Development
SWOT Analysis—Instruments
Competitive Environment—Reagents
Reagents Product Analysis
Reagents Product Trends

7. NEXT-GENERATION SEQUENCING INSTRUMENTS MARKET BREAKDOWN

Next-generation Sequencing Instruments Market—Market Engineering Measurements
Next-generation Sequencing Instruments Market—Revenue Forecast
Revenue Forecast Discussion
Next-generation Sequencing Instruments Market—Market Share Analysis

8. NEXT-GENERATION SEQUENCING REAGENTS MARKET BREAKDOWN

Next-generation Sequencing Reagents Market—Market Engineering Measurements
Next-generation Sequencing Reagents Market—Revenue Forecast
Revenue Forecast Discussion
Next-generation Sequencing Reagents Market—Percent Revenue Forecast by Usage
Next-generation Sequencing Reagents Market—Market Share Analysis

9. THE LAST WORD

The Last Word—3 Big Predictions
The Last Word—Competitor Base
The Last Word—Creation of Databases to Increase the Clinical Utility of the Genome
The Last Word—Payor and Physician Buy-in
Legal Disclaimer

10. APPENDIX

Drivers Explained
Restraints Explained
Additional Sources of Information
Market Engineering Methodology
Learn More—Next Steps

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